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P43359 (MAGA5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanoma-associated antigen 5
Alternative name(s):
Cancer/testis antigen 1.5
Short name=CT1.5
MAGE-5 antigen
Gene names
Name:MAGEA5
Synonyms:MAGE5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length124 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. Ref.3

Tissue specificity

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Sequence similarities

Contains 1 MAGE domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionTumor antigen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 124124Melanoma-associated antigen 5
PRO_0000156705

Regions

Domain3 – 124122MAGE
Compositional bias40 – 434Poly-Ser

Natural variations

Natural variant291Q → H.
Corresponds to variant rs188387 [ dbSNP | Ensembl ].
VAR_053492

Sequences

Sequence LengthMass (Da)Tools
P43359 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 3D8457AFBFD7531E

FASTA12413,016
        10         20         30         40         50         60 
MSLEQKSQHC KPEEGLDTQE EALGLVGVQA ATTEEQEAVS SSSPLVPGTL GEVPAAGSPG 

        70         80         90        100        110        120 
PLKSPQGASA IPTAIDFTLW RQSIKGSSNQ EEEGPSTSPD PESVFRAALS KKVADLIHFL 


LLKY 

« Hide

References

« Hide 'large scale' references
[1]"Structure, chromosomal localization, and expression of 12 genes of the MAGE family."
De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P., De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C., Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T.
Immunogenetics 40:360-369(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines."
Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M., Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., Peng H., Ivanov A.V., Simpson A.J., Longley B.J.
Cancer Res. 67:9954-9962(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10690 Genomic DNA. Translation: AAA68874.1.
U10689 Genomic DNA. Translation: AAA68873.1.
BC109187 mRNA. Translation: AAI09188.1.
PIRI38663.
RefSeqNP_001191740.1. NM_001204811.2.
NP_066387.1. NM_021049.4.
UniGeneHs.18048.
Hs.668021.

3D structure databases

ProteinModelPortalP43359.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP43359.

Polymorphism databases

DMDM1170859.

Proteomic databases

PRIDEP43359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100533997.
4104.
KEGGhsa:100533997.
hsa:4104.
UCSCuc004ffj.3. human.

Organism-specific databases

CTD100533997.
4104.
GeneCardsGC0XM151282.
HGNCHGNC:6803. MAGEA5.
MIM300340. gene.
neXtProtNX_P43359.
PharmGKBPA30549.
GenAtlasSearch...

Phylogenomic databases

InParanoidP43359.
PhylomeDBP43359.

Gene expression databases

CleanExHS_MAGEA5.
GenevestigatorP43359.

Family and domain databases

InterProIPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view]
PANTHERPTHR11736. PTHR11736. 1 hit.
PfamPF12440. MAGE_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio16106.
PROP43359.
SOURCESearch...

Entry information

Entry nameMAGA5_HUMAN
AccessionPrimary (citable) accession number: P43359
Secondary accession number(s): Q32MD0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM