P43359 (MAGA5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melanoma-associated antigen 5

Alternative name(s):
Cancer/testis antigen 1.5
Short name=CT1.5
MAGE-5 antigen

Gene names

Name:	MAGEA5
Synonyms:	MAGE5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. Ref.3
Tissue specificity	Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
Sequence similarities	Contains 1 MAGE domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Tumor antigen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 124	124	Melanoma-associated antigen 5		PRO_0000156705
Regions
	Domain	3 – 124	122	MAGE
	Compositional bias	40 – 43	4	Poly-Ser
Natural variations
	Natural variant	29	1	Q → H. Corresponds to variant rs188387 [ dbSNP | Ensembl ].		VAR_053492

Sequences

	Sequence		Length	Mass (Da)
	P43359 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 3D8457AFBFD7531E	FASTA	124	13,016
	10 20 30 40 50 60 MSLEQKSQHC KPEEGLDTQE EALGLVGVQA ATTEEQEAVS SSSPLVPGTL GEVPAAGSPG 70 80 90 100 110 120 PLKSPQGASA IPTAIDFTLW RQSIKGSSNQ EEEGPSTSPD PESVFRAALS KKVADLIHFL LLKY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, chromosomal localization, and expression of 12 genes of the MAGE family." De Plaen E., Arden K., Traversari C., Gaforio J.J., Szikora J.-P., De Smet C., Brasseur F., van der Bruggen P., Lethe B.G., Lurquin C., Brasseur R., Chomez P., de Backer O., Cavenee W., Boon T. Immunogenetics 40:360-369(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines." Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M., Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., Peng H., Ivanov A.V., Simpson A.J., Longley B.J. Cancer Res. 67:9954-9962(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10690 Genomic DNA. Translation: AAA68874.1. U10689 Genomic DNA. Translation: AAA68873.1. BC109187 mRNA. Translation: AAI09188.1.
IPI	IPI00018045.
PIR	I38663.
RefSeq	NP_001191740.1. NM_001204811.2. NP_066387.1. NM_021049.4.
UniGene	Hs.18048. Hs.668021.
3D structure databases
ProteinModelPortal	P43359.
ModBase	Search...
PTM databases
PhosphoSite	P43359.
Polymorphism databases
DMDM	1170859.
Proteomic databases
PRIDE	P43359.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100533997. 4104.
KEGG	hsa:100533997. hsa:4104.
UCSC	uc004ffj.3. human.
Organism-specific databases
CTD	100533997. 4104.
GeneCards	GC0XM151282.
HGNC	HGNC:6803. MAGEA5.
MIM	300340. gene.
neXtProt	NX_P43359.
PharmGKB	PA30549.
GenAtlas	Search...
Phylogenomic databases
InParanoid	P43359.
OrthoDB	EOG498V2W.
PhylomeDB	P43359.
Gene expression databases
CleanEx	HS_MAGEA5.
Genevestigator	P43359.
GermOnline	ENSG00000183686. Homo sapiens.
Family and domain databases
InterPro	IPR002190. MAGE. IPR021072. Melanoma_ass_antigen_N. [Graphical view]
PANTHER	PTHR11736. PTHR11736. 1 hit.
Pfam	PF12440. MAGE_N. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	16106.
SOURCE	Search...

Entry information

Entry name

MAGA5_HUMAN

Accession

Primary (citable) accession number: P43359
Secondary accession number(s): Q32MD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.