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Protein

Melanoma-associated antigen 5

Gene

MAGEA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.1 Publication

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 5
Alternative name(s):
Cancer/testis antigen 1.5
Short name:
CT1.5
MAGE-5 antigen
Gene namesi
Name:MAGEA5
Synonyms:MAGE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6803. MAGEA5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124Melanoma-associated antigen 5PRO_0000156705Add
BLAST

Proteomic databases

PRIDEiP43359.

PTM databases

PhosphoSiteiP43359.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

Gene expression databases

CleanExiHS_MAGEA5.
GenevestigatoriP43359.

Structurei

3D structure databases

ProteinModelPortaliP43359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 124122MAGEAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi40 – 434Poly-Ser

Sequence similaritiesi

Contains 1 MAGE domain.Curated

Phylogenomic databases

PhylomeDBiP43359.

Family and domain databases

InterProiIPR030098. MAGEA4/MAGEA5.
IPR021072. Melanoma_ass_antigen_N.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PTHR11736:SF48. PTHR11736:SF48. 1 hit.
PfamiPF12440. MAGE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEQKSQHC KPEEGLDTQE EALGLVGVQA ATTEEQEAVS SSSPLVPGTL
60 70 80 90 100
GEVPAAGSPG PLKSPQGASA IPTAIDFTLW RQSIKGSSNQ EEEGPSTSPD
110 120
PESVFRAALS KKVADLIHFL LLKY
Length:124
Mass (Da):13,016
Last modified:November 1, 1995 - v1
Checksum:i3D8457AFBFD7531E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291Q → H.
Corresponds to variant rs188387 [ dbSNP | Ensembl ].
VAR_053492

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10690 Genomic DNA. Translation: AAA68874.1.
U10689 Genomic DNA. Translation: AAA68873.1.
BC109187 mRNA. Translation: AAI09188.1.
PIRiI38663.
RefSeqiNP_001191740.1. NM_001204811.2.
NP_066387.1. NM_021049.4.
UniGeneiHs.18048.
Hs.668021.

Genome annotation databases

GeneIDi100533997.
4104.
KEGGihsa:100533997.
hsa:4104.
UCSCiuc004ffj.3. human.

Polymorphism databases

DMDMi1170859.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10690 Genomic DNA. Translation: AAA68874.1.
U10689 Genomic DNA. Translation: AAA68873.1.
BC109187 mRNA. Translation: AAI09188.1.
PIRiI38663.
RefSeqiNP_001191740.1. NM_001204811.2.
NP_066387.1. NM_021049.4.
UniGeneiHs.18048.
Hs.668021.

3D structure databases

ProteinModelPortaliP43359.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP43359.

Polymorphism databases

DMDMi1170859.

Proteomic databases

PRIDEiP43359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533997.
4104.
KEGGihsa:100533997.
hsa:4104.
UCSCiuc004ffj.3. human.

Organism-specific databases

CTDi100533997.
4104.
GeneCardsiGC0XM151282.
HGNCiHGNC:6803. MAGEA5.
MIMi300340. gene.
neXtProtiNX_P43359.
PharmGKBiPA30549.
GenAtlasiSearch...

Phylogenomic databases

PhylomeDBiP43359.

Miscellaneous databases

NextBioi16106.
PROiP43359.
SOURCEiSearch...

Gene expression databases

CleanExiHS_MAGEA5.
GenevestigatoriP43359.

Family and domain databases

InterProiIPR030098. MAGEA4/MAGEA5.
IPR021072. Melanoma_ass_antigen_N.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PTHR11736:SF48. PTHR11736:SF48. 1 hit.
PfamiPF12440. MAGE_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines."
    Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M., Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., Peng H., Ivanov A.V., Simpson A.J., Longley B.J.
    Cancer Res. 67:9954-9962(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiMAGA5_HUMAN
AccessioniPrimary (citable) accession number: P43359
Secondary accession number(s): Q32MD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.