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P43359

- MAGA5_HUMAN

UniProt

P43359 - MAGA5_HUMAN

Protein

Melanoma-associated antigen 5

Gene

MAGEA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.1 Publication

    Keywords - Molecular functioni

    Tumor antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen 5
    Alternative name(s):
    Cancer/testis antigen 1.5
    Short name:
    CT1.5
    MAGE-5 antigen
    Gene namesi
    Name:MAGEA5
    Synonyms:MAGE5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:6803. MAGEA5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30549.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 124124Melanoma-associated antigen 5PRO_0000156705Add
    BLAST

    Proteomic databases

    PRIDEiP43359.

    PTM databases

    PhosphoSiteiP43359.

    Expressioni

    Tissue specificityi

    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

    Gene expression databases

    CleanExiHS_MAGEA5.
    GenevestigatoriP43359.

    Structurei

    3D structure databases

    ProteinModelPortaliP43359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 124122MAGEAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi40 – 434Poly-Ser

    Sequence similaritiesi

    Contains 1 MAGE domain.Curated

    Phylogenomic databases

    InParanoidiP43359.
    PhylomeDBiP43359.

    Family and domain databases

    InterProiIPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PfamiPF12440. MAGE_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43359-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLEQKSQHC KPEEGLDTQE EALGLVGVQA ATTEEQEAVS SSSPLVPGTL    50
    GEVPAAGSPG PLKSPQGASA IPTAIDFTLW RQSIKGSSNQ EEEGPSTSPD 100
    PESVFRAALS KKVADLIHFL LLKY 124
    Length:124
    Mass (Da):13,016
    Last modified:November 1, 1995 - v1
    Checksum:i3D8457AFBFD7531E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291Q → H.
    Corresponds to variant rs188387 [ dbSNP | Ensembl ].
    VAR_053492

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10690 Genomic DNA. Translation: AAA68874.1.
    U10689 Genomic DNA. Translation: AAA68873.1.
    BC109187 mRNA. Translation: AAI09188.1.
    PIRiI38663.
    RefSeqiNP_001191740.1. NM_001204811.2.
    NP_066387.1. NM_021049.4.
    UniGeneiHs.18048.
    Hs.668021.

    Genome annotation databases

    GeneIDi100533997.
    4104.
    KEGGihsa:100533997.
    hsa:4104.
    UCSCiuc004ffj.3. human.

    Polymorphism databases

    DMDMi1170859.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10690 Genomic DNA. Translation: AAA68874.1 .
    U10689 Genomic DNA. Translation: AAA68873.1 .
    BC109187 mRNA. Translation: AAI09188.1 .
    PIRi I38663.
    RefSeqi NP_001191740.1. NM_001204811.2.
    NP_066387.1. NM_021049.4.
    UniGenei Hs.18048.
    Hs.668021.

    3D structure databases

    ProteinModelPortali P43359.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P43359.

    Polymorphism databases

    DMDMi 1170859.

    Proteomic databases

    PRIDEi P43359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100533997.
    4104.
    KEGGi hsa:100533997.
    hsa:4104.
    UCSCi uc004ffj.3. human.

    Organism-specific databases

    CTDi 100533997.
    4104.
    GeneCardsi GC0XM151282.
    HGNCi HGNC:6803. MAGEA5.
    MIMi 300340. gene.
    neXtProti NX_P43359.
    PharmGKBi PA30549.
    GenAtlasi Search...

    Phylogenomic databases

    InParanoidi P43359.
    PhylomeDBi P43359.

    Miscellaneous databases

    NextBioi 16106.
    PROi P43359.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_MAGEA5.
    Genevestigatori P43359.

    Family and domain databases

    InterProi IPR002190. MAGE.
    IPR021072. Melanoma_ass_antigen_N.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    Pfami PF12440. MAGE_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines."
      Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M., Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., Peng H., Ivanov A.V., Simpson A.J., Longley B.J.
      Cancer Res. 67:9954-9962(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiMAGA5_HUMAN
    AccessioniPrimary (citable) accession number: P43359
    Secondary accession number(s): Q32MD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3