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Protein

Melanoma-associated antigen 4

Gene

MAGEA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 4
Alternative name(s):
Cancer/testis antigen 1.4
Short name:
CT1.4
MAGE-4 antigen
MAGE-41 antigen
MAGE-X2 antigen
Gene namesi
Name:MAGEA4
Synonyms:MAGE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6802. MAGEA4.

Pathology & Biotechi

Organism-specific databases

DisGeNETi4103.
OpenTargetsiENSG00000147381.
PharmGKBiPA30548.

Polymorphism and mutation databases

BioMutaiMAGEA4.
DMDMi322510046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567041 – 317Melanoma-associated antigen 4Add BLAST317

Proteomic databases

EPDiP43358.
MaxQBiP43358.
PaxDbiP43358.
PeptideAtlasiP43358.
PRIDEiP43358.

PTM databases

iPTMnetiP43358.
PhosphoSitePlusiP43358.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.

Gene expression databases

BgeeiENSG00000147381.
CleanExiHS_MAGEA4.
ExpressionAtlasiP43358. baseline and differential.
GenevisibleiP43358. HS.

Organism-specific databases

HPAiCAB040535.
HPA021942.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-743122,EBI-752420
PSMD10O758325EBI-743122,EBI-752185
TEKT4Q8WW243EBI-743122,EBI-750487
UQCRBP149273EBI-743122,EBI-743128
ZBTB17Q131055EBI-743122,EBI-372156

Protein-protein interaction databases

BioGridi110277. 31 interactors.
IntActiP43358. 15 interactors.
MINTiMINT-254770.
STRINGi9606.ENSP00000276344.

Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi102 – 126Combined sources25
Helixi133 – 139Combined sources7
Helixi145 – 147Combined sources3
Helixi148 – 163Combined sources16
Beta strandi165 – 169Combined sources5
Beta strandi176 – 181Combined sources6
Helixi182 – 184Combined sources3
Helixi200 – 213Combined sources14
Helixi219 – 228Combined sources10
Turni238 – 240Combined sources3
Helixi243 – 248Combined sources6
Helixi250 – 253Combined sources4
Beta strandi256 – 260Combined sources5
Beta strandi271 – 274Combined sources4
Helixi276 – 281Combined sources6
Helixi284 – 295Combined sources12
Helixi305 – 309Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I4FX-ray1.40C230-239[»]
2WA0X-ray2.30A101-317[»]
ProteinModelPortaliP43358.
SMRiP43358.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43358.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 309MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 44Poly-Ser4

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43358.
OMAiWEELGVM.
OrthoDBiEOG091G0TJ0.
PhylomeDBiP43358.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030098. MAGEA4/MAGEA5.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF48. PTHR11736:SF48. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT
60 70 80 90 100
LEEVPAAESA GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP
110 120 130 140 150
DAESLFREAL SNKVDELAHF LLRKYRAKEL VTKAEMLERV IKNYKRCFPV
160 170 180 190 200
IFGKASESLK MIFGIDVKEV DPASNTYTLV TCLGLSYDGL LGNNQIFPKT
210 220 230 240 250
GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY GEPRKLLTQD
260 270 280 290 300
WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI
310
AYPSLREAAL LEEEEGV
Length:317
Mass (Da):34,899
Last modified:February 8, 2011 - v2
Checksum:iC6AA2EE306963E7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → L in BAA06841 (PubMed:7642112).Curated1
Sequence conflicti48P → L in BAA06841 (PubMed:7642112).Curated1
Sequence conflicti53E → K in BAA06841 (PubMed:7642112).Curated1
Sequence conflicti61G → D in BAA06841 (PubMed:7642112).Curated1
Sequence conflicti95 – 96GP → EA in BAA06841 (PubMed:7642112).Curated2
Sequence conflicti307E → Q in AAA19007 (PubMed:8037761).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076262137L → Q.1 Publication1
Natural variantiVAR_036582153G → D in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_004284173A → T.4 PublicationsCorresponds to variant rs1047251dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10687 Genomic DNA. Translation: AAA68871.1.
U10688 Genomic DNA. Translation: AAA68872.1.
U10340 mRNA. Translation: AAA19007.1.
D32075 mRNA. Translation: BAA06841.1.
D32077 mRNA. Translation: BAA06843.1.
AF274855 Genomic DNA. No translation available.
BC017723 mRNA. Translation: AAH17723.1.
CCDSiCCDS14702.1.
PIRiI38661.
RefSeqiNP_001011548.1. NM_001011548.1.
NP_001011549.1. NM_001011549.1.
NP_001011550.1. NM_001011550.1.
NP_002353.3. NM_002362.4.
XP_005274735.1. XM_005274678.3.
XP_005274736.1. XM_005274679.3.
UniGeneiHs.37107.

Genome annotation databases

EnsembliENST00000276344; ENSP00000276344; ENSG00000147381.
ENST00000360243; ENSP00000353379; ENSG00000147381.
ENST00000370335; ENSP00000359360; ENSG00000147381.
ENST00000370340; ENSP00000359365; ENSG00000147381.
ENST00000393920; ENSP00000377497; ENSG00000147381.
ENST00000393921; ENSP00000377498; ENSG00000147381.
GeneIDi4103.
KEGGihsa:4103.
UCSCiuc004ffa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10687 Genomic DNA. Translation: AAA68871.1.
U10688 Genomic DNA. Translation: AAA68872.1.
U10340 mRNA. Translation: AAA19007.1.
D32075 mRNA. Translation: BAA06841.1.
D32077 mRNA. Translation: BAA06843.1.
AF274855 Genomic DNA. No translation available.
BC017723 mRNA. Translation: AAH17723.1.
CCDSiCCDS14702.1.
PIRiI38661.
RefSeqiNP_001011548.1. NM_001011548.1.
NP_001011549.1. NM_001011549.1.
NP_001011550.1. NM_001011550.1.
NP_002353.3. NM_002362.4.
XP_005274735.1. XM_005274678.3.
XP_005274736.1. XM_005274679.3.
UniGeneiHs.37107.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I4FX-ray1.40C230-239[»]
2WA0X-ray2.30A101-317[»]
ProteinModelPortaliP43358.
SMRiP43358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110277. 31 interactors.
IntActiP43358. 15 interactors.
MINTiMINT-254770.
STRINGi9606.ENSP00000276344.

PTM databases

iPTMnetiP43358.
PhosphoSitePlusiP43358.

Polymorphism and mutation databases

BioMutaiMAGEA4.
DMDMi322510046.

Proteomic databases

EPDiP43358.
MaxQBiP43358.
PaxDbiP43358.
PeptideAtlasiP43358.
PRIDEiP43358.

Protocols and materials databases

DNASUi4103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276344; ENSP00000276344; ENSG00000147381.
ENST00000360243; ENSP00000353379; ENSG00000147381.
ENST00000370335; ENSP00000359360; ENSG00000147381.
ENST00000370340; ENSP00000359365; ENSG00000147381.
ENST00000393920; ENSP00000377497; ENSG00000147381.
ENST00000393921; ENSP00000377498; ENSG00000147381.
GeneIDi4103.
KEGGihsa:4103.
UCSCiuc004ffa.3. human.

Organism-specific databases

CTDi4103.
DisGeNETi4103.
GeneCardsiMAGEA4.
HGNCiHGNC:6802. MAGEA4.
HPAiCAB040535.
HPA021942.
MIMi300175. gene.
neXtProtiNX_P43358.
OpenTargetsiENSG00000147381.
PharmGKBiPA30548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43358.
OMAiWEELGVM.
OrthoDBiEOG091G0TJ0.
PhylomeDBiP43358.
TreeFamiTF328505.

Miscellaneous databases

ChiTaRSiMAGEA4. human.
EvolutionaryTraceiP43358.
GeneWikiiMAGEA4.
GenomeRNAii4103.
PROiP43358.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147381.
CleanExiHS_MAGEA4.
ExpressionAtlasiP43358. baseline and differential.
GenevisibleiP43358. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030098. MAGEA4/MAGEA5.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF48. PTHR11736:SF48. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGA4_HUMAN
AccessioniPrimary (citable) accession number: P43358
Secondary accession number(s): Q14798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 8, 2011
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.