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Protein

Melanoma-associated antigen 4

Gene

MAGEA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 4
Alternative name(s):
Cancer/testis antigen 1.4
Short name:
CT1.4
MAGE-4 antigen
MAGE-41 antigen
MAGE-X2 antigen
Gene namesi
Name:MAGEA4
Synonyms:MAGE4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6802. MAGEA4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30548.

Polymorphism and mutation databases

BioMutaiMAGEA4.
DMDMi322510046.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Melanoma-associated antigen 4PRO_0000156704Add
BLAST

Proteomic databases

EPDiP43358.
MaxQBiP43358.
PaxDbiP43358.
PeptideAtlasiP43358.
PRIDEiP43358.

PTM databases

iPTMnetiP43358.
PhosphoSiteiP43358.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.

Gene expression databases

BgeeiENSG00000147381.
CleanExiHS_MAGEA4.
ExpressionAtlasiP43358. baseline and differential.
GenevisibleiP43358. HS.

Organism-specific databases

HPAiCAB040535.
HPA021942.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-743122,EBI-752420
PSMD10O758325EBI-743122,EBI-752185
ZBTB17Q131055EBI-743122,EBI-372156

Protein-protein interaction databases

BioGridi110277. 31 interactions.
IntActiP43358. 6 interactions.
MINTiMINT-254770.
STRINGi9606.ENSP00000276344.

Structurei

Secondary structure

1
317
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi102 – 12625Combined sources
Helixi133 – 1397Combined sources
Helixi145 – 1473Combined sources
Helixi148 – 16316Combined sources
Beta strandi165 – 1695Combined sources
Beta strandi176 – 1816Combined sources
Helixi182 – 1843Combined sources
Helixi200 – 21314Combined sources
Helixi219 – 22810Combined sources
Turni238 – 2403Combined sources
Helixi243 – 2486Combined sources
Helixi250 – 2534Combined sources
Beta strandi256 – 2605Combined sources
Beta strandi271 – 2744Combined sources
Helixi276 – 2816Combined sources
Helixi284 – 29512Combined sources
Helixi305 – 3095Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I4FX-ray1.40C230-239[»]
2WA0X-ray2.30A101-317[»]
ProteinModelPortaliP43358.
SMRiP43358. Positions 99-312.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43358.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 309200MAGEPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 444Poly-Ser

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43358.
OMAiWEELGVM.
OrthoDBiEOG091G0TJ0.
PhylomeDBiP43358.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030098. MAGEA4/MAGEA5.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF48. PTHR11736:SF48. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEQKSQHC KPEEGVEAQE EALGLVGAQA PTTEEQEAAV SSSSPLVPGT
60 70 80 90 100
LEEVPAAESA GPPQSPQGAS ALPTTISFTC WRQPNEGSSS QEEEGPSTSP
110 120 130 140 150
DAESLFREAL SNKVDELAHF LLRKYRAKEL VTKAEMLERV IKNYKRCFPV
160 170 180 190 200
IFGKASESLK MIFGIDVKEV DPASNTYTLV TCLGLSYDGL LGNNQIFPKT
210 220 230 240 250
GLLIIVLGTI AMEGDSASEE EIWEELGVMG VYDGREHTVY GEPRKLLTQD
260 270 280 290 300
WVQENYLEYR QVPGSNPARY EFLWGPRALA ETSYVKVLEH VVRVNARVRI
310
AYPSLREAAL LEEEEGV
Length:317
Mass (Da):34,899
Last modified:February 8, 2011 - v2
Checksum:iC6AA2EE306963E7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31S → L in BAA06841 (PubMed:7642112).Curated
Sequence conflicti48 – 481P → L in BAA06841 (PubMed:7642112).Curated
Sequence conflicti53 – 531E → K in BAA06841 (PubMed:7642112).Curated
Sequence conflicti61 – 611G → D in BAA06841 (PubMed:7642112).Curated
Sequence conflicti95 – 962GP → EA in BAA06841 (PubMed:7642112).Curated
Sequence conflicti307 – 3071E → Q in AAA19007 (PubMed:8037761).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371L → Q.1 Publication
VAR_076262
Natural varianti153 – 1531G → D in a breast cancer sample; somatic mutation. 1 Publication
VAR_036582
Natural varianti173 – 1731A → T.4 Publications
Corresponds to variant rs1047251 [ dbSNP | Ensembl ].
VAR_004284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10687 Genomic DNA. Translation: AAA68871.1.
U10688 Genomic DNA. Translation: AAA68872.1.
U10340 mRNA. Translation: AAA19007.1.
D32075 mRNA. Translation: BAA06841.1.
D32077 mRNA. Translation: BAA06843.1.
AF274855 Genomic DNA. No translation available.
BC017723 mRNA. Translation: AAH17723.1.
CCDSiCCDS14702.1.
PIRiI38661.
RefSeqiNP_001011548.1. NM_001011548.1.
NP_001011549.1. NM_001011549.1.
NP_001011550.1. NM_001011550.1.
NP_002353.3. NM_002362.4.
XP_005274735.1. XM_005274678.3.
XP_005274736.1. XM_005274679.3.
UniGeneiHs.37107.

Genome annotation databases

EnsembliENST00000276344; ENSP00000276344; ENSG00000147381.
ENST00000360243; ENSP00000353379; ENSG00000147381.
ENST00000370335; ENSP00000359360; ENSG00000147381.
ENST00000370340; ENSP00000359365; ENSG00000147381.
ENST00000393920; ENSP00000377497; ENSG00000147381.
ENST00000393921; ENSP00000377498; ENSG00000147381.
GeneIDi4103.
KEGGihsa:4103.
UCSCiuc004ffa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10687 Genomic DNA. Translation: AAA68871.1.
U10688 Genomic DNA. Translation: AAA68872.1.
U10340 mRNA. Translation: AAA19007.1.
D32075 mRNA. Translation: BAA06841.1.
D32077 mRNA. Translation: BAA06843.1.
AF274855 Genomic DNA. No translation available.
BC017723 mRNA. Translation: AAH17723.1.
CCDSiCCDS14702.1.
PIRiI38661.
RefSeqiNP_001011548.1. NM_001011548.1.
NP_001011549.1. NM_001011549.1.
NP_001011550.1. NM_001011550.1.
NP_002353.3. NM_002362.4.
XP_005274735.1. XM_005274678.3.
XP_005274736.1. XM_005274679.3.
UniGeneiHs.37107.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I4FX-ray1.40C230-239[»]
2WA0X-ray2.30A101-317[»]
ProteinModelPortaliP43358.
SMRiP43358. Positions 99-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110277. 31 interactions.
IntActiP43358. 6 interactions.
MINTiMINT-254770.
STRINGi9606.ENSP00000276344.

PTM databases

iPTMnetiP43358.
PhosphoSiteiP43358.

Polymorphism and mutation databases

BioMutaiMAGEA4.
DMDMi322510046.

Proteomic databases

EPDiP43358.
MaxQBiP43358.
PaxDbiP43358.
PeptideAtlasiP43358.
PRIDEiP43358.

Protocols and materials databases

DNASUi4103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276344; ENSP00000276344; ENSG00000147381.
ENST00000360243; ENSP00000353379; ENSG00000147381.
ENST00000370335; ENSP00000359360; ENSG00000147381.
ENST00000370340; ENSP00000359365; ENSG00000147381.
ENST00000393920; ENSP00000377497; ENSG00000147381.
ENST00000393921; ENSP00000377498; ENSG00000147381.
GeneIDi4103.
KEGGihsa:4103.
UCSCiuc004ffa.3. human.

Organism-specific databases

CTDi4103.
GeneCardsiMAGEA4.
HGNCiHGNC:6802. MAGEA4.
HPAiCAB040535.
HPA021942.
MIMi300175. gene.
neXtProtiNX_P43358.
PharmGKBiPA30548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43358.
OMAiWEELGVM.
OrthoDBiEOG091G0TJ0.
PhylomeDBiP43358.
TreeFamiTF328505.

Miscellaneous databases

ChiTaRSiMAGEA4. human.
EvolutionaryTraceiP43358.
GeneWikiiMAGEA4.
GenomeRNAii4103.
PROiP43358.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147381.
CleanExiHS_MAGEA4.
ExpressionAtlasiP43358. baseline and differential.
GenevisibleiP43358. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030098. MAGEA4/MAGEA5.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF48. PTHR11736:SF48. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGA4_HUMAN
AccessioniPrimary (citable) accession number: P43358
Secondary accession number(s): Q14798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 8, 2011
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.