Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanoma-associated antigen 3

Gene

MAGEA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.1 Publication

GO - Molecular functioni

  • caspase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ParkinsonsUK-UCL
  • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
  • negative regulation of protein processing Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 3
Alternative name(s):
Antigen MZ2-D
Cancer/testis antigen 1.3
Short name:
CT1.3
MAGE-3 antigen
Gene namesi
Name:MAGEA3
Synonyms:MAGE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6801. MAGEA3.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: ParkinsonsUK-UCL
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi170 – 1701D → A: Abolishes HLA-A1 binding. 1 Publication
Mutagenesisi176 – 1761Y → A: Abolishes HLA-A1 binding. 1 Publication

Organism-specific databases

PharmGKBiPA30547.

Polymorphism and mutation databases

BioMutaiMAGEA3.
DMDMi1170857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Melanoma-associated antigen 3PRO_0000156703Add
BLAST

Proteomic databases

MaxQBiP43357.
PaxDbiP43357.
PRIDEiP43357.

PTM databases

iPTMnetiP43357.
PhosphoSiteiP43357.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.

Gene expression databases

BgeeiP43357.
CleanExiHS_MAGEA3.
ExpressionAtlasiP43357. baseline and differential.
GenevisibleiP43357. HS.

Interactioni

Subunit structurei

Interacts with TRIM28.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM28Q132633EBI-5651459,EBI-78139

GO - Molecular functioni

  • caspase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi110276. 5 interactions.
IntActiP43357. 1 interaction.
MINTiMINT-1537705.
STRINGi9606.ENSP00000359301.

Structurei

Secondary structure

1
314
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi104 – 12623Combined sources
Helixi132 – 1387Combined sources
Helixi141 – 1466Combined sources
Helixi147 – 16216Combined sources
Beta strandi164 – 1707Combined sources
Turni171 – 1744Combined sources
Beta strandi175 – 1806Combined sources
Helixi181 – 1833Combined sources
Helixi199 – 21214Combined sources
Helixi218 – 2258Combined sources
Helixi229 – 2313Combined sources
Helixi242 – 25211Combined sources
Beta strandi255 – 2606Combined sources
Beta strandi269 – 2735Combined sources
Helixi275 – 2806Combined sources
Helixi283 – 29210Combined sources
Turni293 – 2953Combined sources
Helixi304 – 3063Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QEWX-ray2.20C271-279[»]
4V0PX-ray2.07A104-314[»]
5BRZX-ray2.62C168-176[»]
ProteinModelPortaliP43357.
SMRiP43357. Positions 104-310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43357.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 308200MAGEPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi40 – 434Poly-Ser

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43357.
OMAiIAREGDC.
OrthoDBiEOG75F4GM.
PhylomeDBiP43357.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030097. MAGEA3/MAGEA6.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF60. PTHR11736:SF60. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLEQRSQHC KPEEGLEARG EALGLVGAQA PATEEQEAAS SSSTLVEVTL
60 70 80 90 100
GEVPAAESPD PPQSPQGASS LPTTMNYPLW SQSYEDSSNQ EEEGPSTFPD
110 120 130 140 150
LESEFQAALS RKVAELVHFL LLKYRAREPV TKAEMLGSVV GNWQYFFPVI
160 170 180 190 200
FSKASSSLQL VFGIELMEVD PIGHLYIFAT CLGLSYDGLL GDNQIMPKAG
210 220 230 240 250
LLIIVLAIIA REGDCAPEEK IWEELSVLEV FEGREDSILG DPKKLLTQHF
260 270 280 290 300
VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHM VKISGGPHIS
310
YPPLHEWVLR EGEE
Length:314
Mass (Da):34,747
Last modified:November 1, 1995 - v1
Checksum:i3F5EB13D1C9946A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03735 Genomic DNA. Translation: AAA17446.1.
U82671 Genomic DNA. No translation available.
CR541767 mRNA. Translation: CAG46566.1.
CR541774 mRNA. Translation: CAG46573.1.
AK292384 mRNA. Translation: BAF85073.1.
BC000340 mRNA. Translation: AAH00340.1.
BC005963 mRNA. Translation: AAH05963.1.
BC011744 mRNA. Translation: AAH11744.1.
BC016803 mRNA. Translation: AAH16803.1.
BC017389 mRNA. Translation: AAH17389.1.
CCDSiCCDS76045.1.
PIRiJC2361.
RefSeqiNP_005353.1. NM_005362.3.
XP_005274733.1. XM_005274676.2.
XP_006724881.1. XM_006724818.2.
XP_011529462.1. XM_011531160.1.
XP_011529463.1. XM_011531161.1.
UniGeneiHs.417816.

Genome annotation databases

EnsembliENST00000370278; ENSP00000359301; ENSG00000221867.
ENST00000598245; ENSP00000473093; ENSG00000221867.
GeneIDi4102.
KEGGihsa:4102.
UCSCiuc033faf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03735 Genomic DNA. Translation: AAA17446.1.
U82671 Genomic DNA. No translation available.
CR541767 mRNA. Translation: CAG46566.1.
CR541774 mRNA. Translation: CAG46573.1.
AK292384 mRNA. Translation: BAF85073.1.
BC000340 mRNA. Translation: AAH00340.1.
BC005963 mRNA. Translation: AAH05963.1.
BC011744 mRNA. Translation: AAH11744.1.
BC016803 mRNA. Translation: AAH16803.1.
BC017389 mRNA. Translation: AAH17389.1.
CCDSiCCDS76045.1.
PIRiJC2361.
RefSeqiNP_005353.1. NM_005362.3.
XP_005274733.1. XM_005274676.2.
XP_006724881.1. XM_006724818.2.
XP_011529462.1. XM_011531160.1.
XP_011529463.1. XM_011531161.1.
UniGeneiHs.417816.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QEWX-ray2.20C271-279[»]
4V0PX-ray2.07A104-314[»]
5BRZX-ray2.62C168-176[»]
ProteinModelPortaliP43357.
SMRiP43357. Positions 104-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110276. 5 interactions.
IntActiP43357. 1 interaction.
MINTiMINT-1537705.
STRINGi9606.ENSP00000359301.

PTM databases

iPTMnetiP43357.
PhosphoSiteiP43357.

Polymorphism and mutation databases

BioMutaiMAGEA3.
DMDMi1170857.

Proteomic databases

MaxQBiP43357.
PaxDbiP43357.
PRIDEiP43357.

Protocols and materials databases

DNASUi4102.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370278; ENSP00000359301; ENSG00000221867.
ENST00000598245; ENSP00000473093; ENSG00000221867.
GeneIDi4102.
KEGGihsa:4102.
UCSCiuc033faf.1. human.

Organism-specific databases

CTDi4102.
GeneCardsiMAGEA3.
HGNCiHGNC:6801. MAGEA3.
MIMi300174. gene.
neXtProtiNX_P43357.
PharmGKBiPA30547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43357.
OMAiIAREGDC.
OrthoDBiEOG75F4GM.
PhylomeDBiP43357.
TreeFamiTF328505.

Miscellaneous databases

EvolutionaryTraceiP43357.
GeneWikiiMAGEA3.
GenomeRNAii4102.
NextBioi16092.
PROiP43357.
SOURCEiSearch...

Gene expression databases

BgeeiP43357.
CleanExiHS_MAGEA3.
ExpressionAtlasiP43357. baseline and differential.
GenevisibleiP43357. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030097. MAGEA3/MAGEA6.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF60. PTHR11736:SF60. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes."
    Gaugler B., van den Eynde B., van der Bruggen P., Romero P., Gaforio J.J., De Plaen E., Lethe B.G., Brasseur F., Boon T.
    J. Exp. Med. 179:921-930(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS.
    Tissue: Blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow, Lung, Prostate and Skin.
  8. "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines."
    Yang B., O'Herrin S.M., Wu J., Reagan-Shaw S., Ma Y., Bhat K.M., Gravekamp C., Setaluri V., Peters N., Hoffmann F.M., Peng H., Ivanov A.V., Simpson A.J., Longley B.J.
    Cancer Res. 67:9954-9962(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRIM28.
  9. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."
    Doyle J.M., Gao J., Wang J., Yang M., Potts P.R.
    Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRIM28.
  10. "Human class I histocompatibility antigen (HLA-A complex with a nonameric peptide from melanoma-associated antigen 3 (residues 271-279)."
    Orth P., Alings C., Saenger W., Ziegler A.
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 271-279 IN COMPLEX WITH HLA CLASS I HISTOCOMPATIBILITY COMPLEX.

Entry informationi

Entry nameiMAGA3_HUMAN
AccessioniPrimary (citable) accession number: P43357
Secondary accession number(s): Q6FHI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In vitro experiments by PubMed:17942928 measuring cell viability in melanoma cell lines used siRNA specific for MAGEA3 and MAGEA6.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.