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Protein

Melanoma-associated antigen 1

Gene

MAGEA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB

GO - Biological processi

  • negative regulation of Notch signaling pathway Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126977-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen 1
Alternative name(s):
Antigen MZ2-E
Cancer/testis antigen 1.1
Short name:
CT1.1
MAGE-1 antigen
Gene namesi
Name:MAGEA1
Synonyms:MAGE1, MAGE1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:6796. MAGEA1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi163D → A: Abolishes HLA-A1 binding. 1 Publication1
Mutagenesisi169Y → A: Abolishes HLA-A1 binding. 1 Publication1

Organism-specific databases

DisGeNETi4100.
OpenTargetsiENSG00000198681.
PharmGKBiPA30542.

Polymorphism and mutation databases

BioMutaiMAGEA1.
DMDMi1170855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567011 – 309Melanoma-associated antigen 1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP43355.
MaxQBiP43355.
PaxDbiP43355.
PeptideAtlasiP43355.
PRIDEiP43355.

PTM databases

iPTMnetiP43355.
PhosphoSitePlusiP43355.

Expressioni

Tissue specificityi

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.

Gene expression databases

BgeeiENSG00000198681.
CleanExiHS_MAGEA1.
GenevisibleiP43355. HS.

Organism-specific databases

HPAiCAB002620.

Interactioni

Subunit structurei

Interacts with SNW1 and HDCA1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP57L1Q8IYX8-23EBI-740978,EBI-10181988
EID3Q8N1403EBI-740978,EBI-744483
HDAC1Q135472EBI-740978,EBI-301834
HYPKQ9NX553EBI-740978,EBI-1048743
MIEF1Q9NQG64EBI-740978,EBI-740987
PBX3Q5JS983EBI-740978,EBI-10244393
RAB17Q9H0T73EBI-740978,EBI-721615
RYDENQ9NUL53EBI-740978,EBI-10313866
SELPLGA0A0C4DFY03EBI-740978,EBI-10209116
SFNP319473EBI-740978,EBI-476295
SH3GLB2Q9NR463EBI-740978,EBI-749607
SNW1Q135733EBI-740978,EBI-632715
TRIM31Q2L6J13EBI-740978,EBI-10239267
TRIM31Q9BZY94EBI-740978,EBI-747544
ZNF564Q8TBZ83EBI-740978,EBI-10273713

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110274. 82 interactors.
DIPiDIP-54794N.
IntActiP43355. 40 interactors.
MINTiMINT-1455313.
STRINGi9606.ENSP00000349085.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W72X-ray2.15C/F161-169[»]
3BO8X-ray1.80C161-169[»]
ProteinModelPortaliP43355.
SMRiP43355.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 301MAGEPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 36Poly-Ser4

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43355.
OMAiVRFFFPS.
OrthoDBiEOG091G0TJ0.
PhylomeDBiP43355.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030093. MAGEA1.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF49. PTHR11736:SF49. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEQRSLHC KPEEALEAQQ EALGLVCVQA ATSSSSPLVL GTLEEVPTAG
60 70 80 90 100
STDPPQSPQG ASAFPTTINF TRQRQPSEGS SSREEEGPST SCILESLFRA
110 120 130 140 150
VITKKVADLV GFLLLKYRAR EPVTKAEMLE SVIKNYKHCF PEIFGKASES
160 170 180 190 200
LQLVFGIDVK EADPTGHSYV LVTCLGLSYD GLLGDNQIMP KTGFLIIVLV
210 220 230 240 250
MIAMEGGHAP EEEIWEELSV MEVYDGREHS AYGEPRKLLT QDLVQEKYLE
260 270 280 290 300
YRQVPDSDPA RYEFLWGPRA LAETSYVKVL EYVIKVSARV RFFFPSLREA

ALREEEEGV
Length:309
Mass (Da):34,342
Last modified:November 1, 1995 - v1
Checksum:i544EEB1F9F4E9D33
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00428332T → A Probable polymorphism. 3 PublicationsCorresponds to variant rs2008160dbSNPEnsembl.1
Natural variantiVAR_05349163A → T.Corresponds to variant rs2233044dbSNPEnsembl.1
Natural variantiVAR_01173772R → Q.Corresponds to variant rs2008144dbSNPEnsembl.1
Natural variantiVAR_036581278K → T in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77481 Genomic DNA. Translation: AAA03229.1.
AY148486 mRNA. Translation: AAN62752.1.
BT009789 mRNA. Translation: AAP88791.1.
AK314979 mRNA. Translation: BAG37478.1.
U82670 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72885.1.
BC017555 mRNA. Translation: AAH17555.1.
CCDSiCCDS76051.1.
PIRiJC2358.
RefSeqiNP_004979.3. NM_004988.4.
UniGeneiHs.72879.

Genome annotation databases

EnsembliENST00000356661; ENSP00000349085; ENSG00000198681.
GeneIDi4100.
KEGGihsa:4100.
UCSCiuc004fhf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77481 Genomic DNA. Translation: AAA03229.1.
AY148486 mRNA. Translation: AAN62752.1.
BT009789 mRNA. Translation: AAP88791.1.
AK314979 mRNA. Translation: BAG37478.1.
U82670 Genomic DNA. No translation available.
CH471172 Genomic DNA. Translation: EAW72885.1.
BC017555 mRNA. Translation: AAH17555.1.
CCDSiCCDS76051.1.
PIRiJC2358.
RefSeqiNP_004979.3. NM_004988.4.
UniGeneiHs.72879.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W72X-ray2.15C/F161-169[»]
3BO8X-ray1.80C161-169[»]
ProteinModelPortaliP43355.
SMRiP43355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110274. 82 interactors.
DIPiDIP-54794N.
IntActiP43355. 40 interactors.
MINTiMINT-1455313.
STRINGi9606.ENSP00000349085.

PTM databases

iPTMnetiP43355.
PhosphoSitePlusiP43355.

Polymorphism and mutation databases

BioMutaiMAGEA1.
DMDMi1170855.

Proteomic databases

EPDiP43355.
MaxQBiP43355.
PaxDbiP43355.
PeptideAtlasiP43355.
PRIDEiP43355.

Protocols and materials databases

DNASUi4100.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356661; ENSP00000349085; ENSG00000198681.
GeneIDi4100.
KEGGihsa:4100.
UCSCiuc004fhf.3. human.

Organism-specific databases

CTDi4100.
DisGeNETi4100.
GeneCardsiMAGEA1.
H-InvDBHIX0017126.
HGNCiHGNC:6796. MAGEA1.
HPAiCAB002620.
MIMi300016. gene.
neXtProtiNX_P43355.
OpenTargetsiENSG00000198681.
PharmGKBiPA30542.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiP43355.
OMAiVRFFFPS.
OrthoDBiEOG091G0TJ0.
PhylomeDBiP43355.
TreeFamiTF328505.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126977-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP43355.
GeneWikiiMAGEA1.
GenomeRNAii4100.
PROiP43355.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198681.
CleanExiHS_MAGEA1.
GenevisibleiP43355. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR030093. MAGEA1.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF49. PTHR11736:SF49. 1 hit.
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGA1_HUMAN
AccessioniPrimary (citable) accession number: P43355
Secondary accession number(s): B2RC81, O00346
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.