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P43354

- NR4A2_HUMAN

UniProt

P43354 - NR4A2_HUMAN

Protein

Nuclear receptor subfamily 4 group A member 2

Gene

NR4A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 158 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi260 – 33576Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri263 – 28321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding Source: Ensembl
    4. steroid hormone receptor activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. cellular response to extracellular stimulus Source: MGI
    3. cellular response to oxidative stress Source: Ensembl
    4. central nervous system projection neuron axonogenesis Source: Ensembl
    5. death Source: Ensembl
    6. dopamine biosynthetic process Source: Ensembl
    7. dopaminergic neuron differentiation Source: UniProtKB
    8. gene expression Source: Reactome
    9. general adaptation syndrome Source: Ensembl
    10. habenula development Source: Ensembl
    11. intracellular receptor signaling pathway Source: GOC
    12. negative regulation of neuron apoptotic process Source: Ensembl
    13. neuron maturation Source: Ensembl
    14. neuron migration Source: Ensembl
    15. positive regulation of catalytic activity Source: Ensembl
    16. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    17. post-embryonic development Source: Ensembl
    18. regulation of dopamine metabolic process Source: Ensembl
    19. regulation of respiratory gaseous exchange Source: Ensembl
    20. response to amphetamine Source: Ensembl
    21. response to hypoxia Source: Ensembl
    22. response to inorganic substance Source: Ensembl
    23. response to insecticide Source: Ensembl
    24. signal transduction Source: ProtInc
    25. transcription, DNA-templated Source: UniProtKB
    26. transcription initiation from RNA polymerase II promoter Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
    SignaLinkiP43354.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor subfamily 4 group A member 2
    Alternative name(s):
    Immediate-early response protein NOT
    Orphan nuclear receptor NURR1
    Transcriptionally-inducible nuclear receptor
    Gene namesi
    Name:NR4A2
    Synonyms:NOT, NURR1, TINUR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:7981. NR4A2.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Mostly nuclear; oxidative stress promotes cytoplasmic localization.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleoplasm Source: Reactome
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti2828. Young adult-onset Parkinsonism.
    PharmGKBiPA31762.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598Nuclear receptor subfamily 4 group A member 2PRO_0000053718Add
    BLAST

    Proteomic databases

    MaxQBiP43354.
    PaxDbiP43354.
    PRIDEiP43354.

    PTM databases

    PhosphoSiteiP43354.

    Expressioni

    Tissue specificityi

    Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

    Developmental stagei

    Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.

    Gene expression databases

    ArrayExpressiP43354.
    BgeeiP43354.
    CleanExiHS_NR4A2.
    GenevestigatoriP43354.

    Organism-specific databases

    HPAiCAB010481.
    HPA000543.

    Interactioni

    Subunit structurei

    Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TCEAL5Q5H9L22EBI-2681738,EBI-2681773

    Protein-protein interaction databases

    BioGridi110983. 14 interactions.
    IntActiP43354. 14 interactions.
    STRINGi9606.ENSP00000344479.

    Structurei

    Secondary structure

    1
    598
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi364 – 37411
    Helixi392 – 3943
    Helixi400 – 42223
    Helixi427 – 4293
    Helixi432 – 45423
    Turni457 – 4604
    Beta strandi461 – 4633
    Beta strandi467 – 4715
    Helixi472 – 4754
    Turni476 – 4783
    Helixi482 – 49413
    Helixi500 – 51112
    Helixi521 – 54020
    Helixi541 – 5433
    Turni544 – 5474
    Helixi551 – 57929
    Helixi586 – 59510

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OVLX-ray2.20A/B/C/D/E/F328-598[»]
    ProteinModelPortaliP43354.
    SMRiP43354. Positions 261-598.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43354.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni409 – 45951Ligand-bindingSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi287 – 31428Bipartite nuclear localization signal (NLS1)Add
    BLAST
    Motifi338 – 35013Nuclear localization signal (NLS1)1 PublicationAdd
    BLAST
    Motifi443 – 45210nuclear export sequence (NES1)
    Motifi568 – 57710nuclear export sequence (NES2)

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi80 – 13859Gln-richAdd
    BLAST
    Compositional biasi127 – 233107Pro-richAdd
    BLAST
    Compositional biasi346 – 39146Pro-richAdd
    BLAST

    Domaini

    the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (PubMed:12774125).1 Publication

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri263 – 28321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32325NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG245120.
    HOVERGENiHBG052663.
    InParanoidiP43354.
    KOiK08558.
    OrthoDBiEOG75XGKJ.
    PhylomeDBiP43354.
    TreeFamiTF315430.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003070. Nuc_orph_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003073. NURR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01284. NUCLEARECPTR.
    PR01287. NURRNUCRCPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43354-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE    50
    ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY 100
    QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH 150
    NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV 200
    PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS 250
    PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 300
    ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK 350
    SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT 400
    QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR 450
    LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI 500
    SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN 550
    YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF 598
    Length:598
    Mass (Da):66,591
    Last modified:November 1, 1995 - v1
    Checksum:i28D8199AACE3E211
    GO
    Isoform 2 (identifier: P43354-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-63: Missing.

    Show »
    Length:535
    Mass (Da):59,809
    Checksum:i41CB735EE1982523
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti465 – 4651C → W in AAB33999. (PubMed:7706727)Curated
    Sequence conflicti468 – 4681V → W in AAB33999. (PubMed:7706727)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6363Missing in isoform 2. 2 PublicationsVSP_056057Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75918 mRNA. Translation: CAA53518.1.
    AB017586 Genomic DNA. Translation: BAA75666.1.
    AB019433 Genomic DNA. Translation: BAA77328.1.
    AK291456 mRNA. Translation: BAF84145.1.
    AC074099 Genomic DNA. Translation: AAY24203.1.
    CH471058 Genomic DNA. Translation: EAX11454.1.
    CH471058 Genomic DNA. Translation: EAX11455.1.
    BC009288 mRNA. Translation: AAH09288.1.
    BC066890 mRNA. Translation: AAH66890.1.
    S77154 mRNA. Translation: AAB33999.1.
    CCDSiCCDS2201.1.
    PIRiA57040.
    RefSeqiNP_006177.1. NM_006186.3.
    XP_005246679.1. XM_005246622.1.
    UniGeneiHs.563344.

    Genome annotation databases

    EnsembliENST00000339562; ENSP00000344479; ENSG00000153234.
    ENST00000409572; ENSP00000386747; ENSG00000153234.
    ENST00000426264; ENSP00000389986; ENSG00000153234.
    GeneIDi4929.
    KEGGihsa:4929.
    UCSCiuc002tyx.4. human.

    Polymorphism databases

    DMDMi1171750.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75918 mRNA. Translation: CAA53518.1 .
    AB017586 Genomic DNA. Translation: BAA75666.1 .
    AB019433 Genomic DNA. Translation: BAA77328.1 .
    AK291456 mRNA. Translation: BAF84145.1 .
    AC074099 Genomic DNA. Translation: AAY24203.1 .
    CH471058 Genomic DNA. Translation: EAX11454.1 .
    CH471058 Genomic DNA. Translation: EAX11455.1 .
    BC009288 mRNA. Translation: AAH09288.1 .
    BC066890 mRNA. Translation: AAH66890.1 .
    S77154 mRNA. Translation: AAB33999.1 .
    CCDSi CCDS2201.1.
    PIRi A57040.
    RefSeqi NP_006177.1. NM_006186.3.
    XP_005246679.1. XM_005246622.1.
    UniGenei Hs.563344.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OVL X-ray 2.20 A/B/C/D/E/F 328-598 [» ]
    ProteinModelPortali P43354.
    SMRi P43354. Positions 261-598.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110983. 14 interactions.
    IntActi P43354. 14 interactions.
    STRINGi 9606.ENSP00000344479.

    Chemistry

    ChEMBLi CHEMBL5002.

    PTM databases

    PhosphoSitei P43354.

    Polymorphism databases

    DMDMi 1171750.

    Proteomic databases

    MaxQBi P43354.
    PaxDbi P43354.
    PRIDEi P43354.

    Protocols and materials databases

    DNASUi 4929.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339562 ; ENSP00000344479 ; ENSG00000153234 .
    ENST00000409572 ; ENSP00000386747 ; ENSG00000153234 .
    ENST00000426264 ; ENSP00000389986 ; ENSG00000153234 .
    GeneIDi 4929.
    KEGGi hsa:4929.
    UCSCi uc002tyx.4. human.

    Organism-specific databases

    CTDi 4929.
    GeneCardsi GC02M157180.
    GeneReviewsi NR4A2.
    HGNCi HGNC:7981. NR4A2.
    HPAi CAB010481.
    HPA000543.
    MIMi 601828. gene.
    neXtProti NX_P43354.
    Orphaneti 2828. Young adult-onset Parkinsonism.
    PharmGKBi PA31762.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245120.
    HOVERGENi HBG052663.
    InParanoidi P43354.
    KOi K08558.
    OrthoDBi EOG75XGKJ.
    PhylomeDBi P43354.
    TreeFami TF315430.

    Enzyme and pathway databases

    Reactomei REACT_15525. Nuclear Receptor transcription pathway.
    SignaLinki P43354.

    Miscellaneous databases

    ChiTaRSi NR4A2. human.
    EvolutionaryTracei P43354.
    GeneWikii Nuclear_receptor_related-1_protein.
    GenomeRNAii 4929.
    NextBioi 18989.
    PROi P43354.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43354.
    Bgeei P43354.
    CleanExi HS_NR4A2.
    Genevestigatori P43354.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003070. Nuc_orph_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003073. NURR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01284. NUCLEARECPTR.
    PR01287. NURRNUCRCPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3."
      Mages H.W., Rilke O., Bravo R., Senger G., Kroczek R.A.
      Mol. Endocrinol. 8:1583-1591(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Blood.
    2. "Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs."
      Ichinose H., Ohye T., Suzuki T., Sumi-Ichinose C., Nomura T., Hagino Y., Nagatsu T.
      Gene 230:233-239(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Fibroblast.
    3. "Organization of the human orphan nuclear receptor Nurr1 gene."
      Torii T., Kawarai T., Nakamura S., Kawakami H.
      Gene 230:225-232(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skin and Testis.
    8. "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line."
      Okabe T., Takayanagi R., Imasaki K., Haji M., Nawata H., Watanabe T.
      J. Immunol. 154:3871-3879(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-598 (ISOFORM 1).
    9. "Induction of tyrosine hydroxylase expression by the transcription factor Pitx3."
      Messmer K., Remington M.P., Skidmore F., Fishman P.S.
      Int. J. Dev. Neurosci. 25:29-37(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress."
      Garcia-Yague A.J., Rada P., Rojo A.I., Lastres-Becker I., Cuadrado A.
      J. Biol. Chem. 288:5506-5517(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNALS, NUCLEAR EXPORT SEQUENCES.
    12. "Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors."
      Wang Z., Benoit G., Liu J., Prasad S., Aarnisalo P., Liu X., Xu H., Walker N.P., Perlmann T.
      Nature 423:555-560(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 328-598.

    Entry informationi

    Entry nameiNR4A2_HUMAN
    AccessioniPrimary (citable) accession number: P43354
    Secondary accession number(s): Q16311, Q53RZ2, Q6NXU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 158 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3