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Protein

Nuclear receptor subfamily 4 group A member 2

Gene

NR4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi260 – 33576Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32325NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. steroid hormone receptor activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. cellular response to extracellular stimulus Source: MGI
  3. cellular response to oxidative stress Source: Ensembl
  4. central nervous system projection neuron axonogenesis Source: Ensembl
  5. death Source: Ensembl
  6. dopamine biosynthetic process Source: Ensembl
  7. dopaminergic neuron differentiation Source: UniProtKB
  8. gene expression Source: Reactome
  9. general adaptation syndrome Source: Ensembl
  10. habenula development Source: Ensembl
  11. intracellular receptor signaling pathway Source: GOC
  12. negative regulation of neuron apoptotic process Source: Ensembl
  13. neuron maturation Source: Ensembl
  14. neuron migration Source: Ensembl
  15. positive regulation of catalytic activity Source: Ensembl
  16. post-embryonic development Source: Ensembl
  17. regulation of dopamine metabolic process Source: Ensembl
  18. regulation of respiratory gaseous exchange Source: Ensembl
  19. response to amphetamine Source: Ensembl
  20. response to hypoxia Source: Ensembl
  21. response to inorganic substance Source: Ensembl
  22. response to insecticide Source: Ensembl
  23. signal transduction Source: ProtInc
  24. transcription, DNA-templated Source: UniProtKB
  25. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiP43354.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 2
Alternative name(s):
Immediate-early response protein NOT
Orphan nuclear receptor NURR1
Transcriptionally-inducible nuclear receptor
Gene namesi
Name:NR4A2
Synonyms:NOT, NURR1, TINUR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:7981. NR4A2.

Subcellular locationi

Cytoplasm. Nucleus
Note: Mostly nuclear; oxidative stress promotes cytoplasmic localization.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleoplasm Source: HPA
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Nuclear receptor subfamily 4 group A member 2PRO_0000053718Add
BLAST

Proteomic databases

MaxQBiP43354.
PaxDbiP43354.
PRIDEiP43354.

PTM databases

PhosphoSiteiP43354.

Expressioni

Tissue specificityi

Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Developmental stagei

Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.

Gene expression databases

BgeeiP43354.
CleanExiHS_NR4A2.
ExpressionAtlasiP43354. baseline and differential.
GenevestigatoriP43354.

Organism-specific databases

HPAiCAB010481.
HPA000543.

Interactioni

Subunit structurei

Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TCEAL5Q5H9L22EBI-2681738,EBI-2681773

Protein-protein interaction databases

BioGridi110983. 16 interactions.
IntActiP43354. 14 interactions.
STRINGi9606.ENSP00000344479.

Structurei

Secondary structure

1
598
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi364 – 37411Combined sources
Helixi392 – 3943Combined sources
Helixi400 – 42223Combined sources
Helixi427 – 4293Combined sources
Helixi432 – 45423Combined sources
Turni457 – 4604Combined sources
Beta strandi461 – 4633Combined sources
Beta strandi467 – 4715Combined sources
Helixi472 – 4754Combined sources
Turni476 – 4783Combined sources
Helixi482 – 49413Combined sources
Helixi500 – 51112Combined sources
Helixi521 – 54020Combined sources
Helixi541 – 5433Combined sources
Turni544 – 5474Combined sources
Helixi551 – 57929Combined sources
Helixi586 – 59510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVLX-ray2.20A/B/C/D/E/F328-598[»]
ProteinModelPortaliP43354.
SMRiP43354. Positions 261-598.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43354.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni409 – 45951Ligand-bindingSequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi287 – 31428Bipartite nuclear localization signal (NLS1)Add
BLAST
Motifi338 – 35013Nuclear localization signal (NLS1)1 PublicationAdd
BLAST
Motifi443 – 45210nuclear export sequence (NES1)
Motifi568 – 57710nuclear export sequence (NES2)

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 13859Gln-richAdd
BLAST
Compositional biasi127 – 233107Pro-richAdd
BLAST
Compositional biasi346 – 39146Pro-richAdd
BLAST

Domaini

the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (PubMed:12774125).1 Publication

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32325NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG245120.
GeneTreeiENSGT00760000118887.
HOVERGENiHBG052663.
InParanoidiP43354.
KOiK08558.
OrthoDBiEOG75XGKJ.
PhylomeDBiP43354.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43354-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE
60 70 80 90 100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY
110 120 130 140 150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH
160 170 180 190 200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV
210 220 230 240 250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS
260 270 280 290 300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL
310 320 330 340 350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK
360 370 380 390 400
SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT
410 420 430 440 450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR
460 470 480 490 500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI
510 520 530 540 550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN
560 570 580 590
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
Length:598
Mass (Da):66,591
Last modified:November 1, 1995 - v1
Checksum:i28D8199AACE3E211
GO
Isoform 2 (identifier: P43354-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Show »
Length:535
Mass (Da):59,809
Checksum:i41CB735EE1982523
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti465 – 4651C → W in AAB33999 (PubMed:7706727).Curated
Sequence conflicti468 – 4681V → W in AAB33999 (PubMed:7706727).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363Missing in isoform 2. 2 PublicationsVSP_056057Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75918 mRNA. Translation: CAA53518.1.
AB017586 Genomic DNA. Translation: BAA75666.1.
AB019433 Genomic DNA. Translation: BAA77328.1.
AK291456 mRNA. Translation: BAF84145.1.
AC074099 Genomic DNA. Translation: AAY24203.1.
CH471058 Genomic DNA. Translation: EAX11454.1.
CH471058 Genomic DNA. Translation: EAX11455.1.
BC009288 mRNA. Translation: AAH09288.1.
BC066890 mRNA. Translation: AAH66890.1.
S77154 mRNA. Translation: AAB33999.1.
CCDSiCCDS2201.1. [P43354-1]
PIRiA57040.
RefSeqiNP_006177.1. NM_006186.3. [P43354-1]
XP_005246679.1. XM_005246622.1. [P43354-2]
XP_005246680.1. XM_005246623.1. [P43354-2]
UniGeneiHs.563344.

Genome annotation databases

EnsembliENST00000339562; ENSP00000344479; ENSG00000153234. [P43354-1]
ENST00000409572; ENSP00000386747; ENSG00000153234. [P43354-1]
ENST00000426264; ENSP00000389986; ENSG00000153234. [P43354-2]
GeneIDi4929.
KEGGihsa:4929.
UCSCiuc002tyx.4. human. [P43354-1]

Polymorphism databases

DMDMi1171750.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75918 mRNA. Translation: CAA53518.1.
AB017586 Genomic DNA. Translation: BAA75666.1.
AB019433 Genomic DNA. Translation: BAA77328.1.
AK291456 mRNA. Translation: BAF84145.1.
AC074099 Genomic DNA. Translation: AAY24203.1.
CH471058 Genomic DNA. Translation: EAX11454.1.
CH471058 Genomic DNA. Translation: EAX11455.1.
BC009288 mRNA. Translation: AAH09288.1.
BC066890 mRNA. Translation: AAH66890.1.
S77154 mRNA. Translation: AAB33999.1.
CCDSiCCDS2201.1. [P43354-1]
PIRiA57040.
RefSeqiNP_006177.1. NM_006186.3. [P43354-1]
XP_005246679.1. XM_005246622.1. [P43354-2]
XP_005246680.1. XM_005246623.1. [P43354-2]
UniGeneiHs.563344.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVLX-ray2.20A/B/C/D/E/F328-598[»]
ProteinModelPortaliP43354.
SMRiP43354. Positions 261-598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110983. 16 interactions.
IntActiP43354. 14 interactions.
STRINGi9606.ENSP00000344479.

Chemistry

BindingDBiP43354.
ChEMBLiCHEMBL5002.

PTM databases

PhosphoSiteiP43354.

Polymorphism databases

DMDMi1171750.

Proteomic databases

MaxQBiP43354.
PaxDbiP43354.
PRIDEiP43354.

Protocols and materials databases

DNASUi4929.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339562; ENSP00000344479; ENSG00000153234. [P43354-1]
ENST00000409572; ENSP00000386747; ENSG00000153234. [P43354-1]
ENST00000426264; ENSP00000389986; ENSG00000153234. [P43354-2]
GeneIDi4929.
KEGGihsa:4929.
UCSCiuc002tyx.4. human. [P43354-1]

Organism-specific databases

CTDi4929.
GeneCardsiGC02M157180.
GeneReviewsiNR4A2.
HGNCiHGNC:7981. NR4A2.
HPAiCAB010481.
HPA000543.
MIMi601828. gene.
neXtProtiNX_P43354.
PharmGKBiPA31762.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG245120.
GeneTreeiENSGT00760000118887.
HOVERGENiHBG052663.
InParanoidiP43354.
KOiK08558.
OrthoDBiEOG75XGKJ.
PhylomeDBiP43354.
TreeFamiTF315430.

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiP43354.

Miscellaneous databases

ChiTaRSiNR4A2. human.
EvolutionaryTraceiP43354.
GeneWikiiNuclear_receptor_related-1_protein.
GenomeRNAii4929.
NextBioi18989.
PROiP43354.
SOURCEiSearch...

Gene expression databases

BgeeiP43354.
CleanExiHS_NR4A2.
ExpressionAtlasiP43354. baseline and differential.
GenevestigatoriP43354.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3."
    Mages H.W., Rilke O., Bravo R., Senger G., Kroczek R.A.
    Mol. Endocrinol. 8:1583-1591(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Blood.
  2. "Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs."
    Ichinose H., Ohye T., Suzuki T., Sumi-Ichinose C., Nomura T., Hagino Y., Nagatsu T.
    Gene 230:233-239(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Fibroblast.
  3. "Organization of the human orphan nuclear receptor Nurr1 gene."
    Torii T., Kawarai T., Nakamura S., Kawakami H.
    Gene 230:225-232(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skin and Testis.
  8. "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line."
    Okabe T., Takayanagi R., Imasaki K., Haji M., Nawata H., Watanabe T.
    J. Immunol. 154:3871-3879(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-598 (ISOFORM 1).
  9. "Induction of tyrosine hydroxylase expression by the transcription factor Pitx3."
    Messmer K., Remington M.P., Skidmore F., Fishman P.S.
    Int. J. Dev. Neurosci. 25:29-37(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress."
    Garcia-Yague A.J., Rada P., Rojo A.I., Lastres-Becker I., Cuadrado A.
    J. Biol. Chem. 288:5506-5517(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNALS, NUCLEAR EXPORT SEQUENCES.
  12. "Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors."
    Wang Z., Benoit G., Liu J., Prasad S., Aarnisalo P., Liu X., Xu H., Walker N.P., Perlmann T.
    Nature 423:555-560(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 328-598.

Entry informationi

Entry nameiNR4A2_HUMAN
AccessioniPrimary (citable) accession number: P43354
Secondary accession number(s): Q16311, Q53RZ2, Q6NXU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 4, 2015
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.