Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P43354

- NR4A2_HUMAN

UniProt

P43354 - NR4A2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nuclear receptor subfamily 4 group A member 2

Gene

NR4A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi260 – 33576Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32325NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. steroid hormone receptor activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. cellular response to extracellular stimulus Source: MGI
  3. cellular response to oxidative stress Source: Ensembl
  4. central nervous system projection neuron axonogenesis Source: Ensembl
  5. death Source: Ensembl
  6. dopamine biosynthetic process Source: Ensembl
  7. dopaminergic neuron differentiation Source: UniProtKB
  8. gene expression Source: Reactome
  9. general adaptation syndrome Source: Ensembl
  10. habenula development Source: Ensembl
  11. intracellular receptor signaling pathway Source: GOC
  12. negative regulation of neuron apoptotic process Source: Ensembl
  13. neuron maturation Source: Ensembl
  14. neuron migration Source: Ensembl
  15. positive regulation of catalytic activity Source: Ensembl
  16. post-embryonic development Source: Ensembl
  17. regulation of dopamine metabolic process Source: Ensembl
  18. regulation of respiratory gaseous exchange Source: Ensembl
  19. response to amphetamine Source: Ensembl
  20. response to hypoxia Source: Ensembl
  21. response to inorganic substance Source: Ensembl
  22. response to insecticide Source: Ensembl
  23. signal transduction Source: ProtInc
  24. transcription, DNA-templated Source: UniProtKB
  25. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
SignaLinkiP43354.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 2
Alternative name(s):
Immediate-early response protein NOT
Orphan nuclear receptor NURR1
Transcriptionally-inducible nuclear receptor
Gene namesi
Name:NR4A2
Synonyms:NOT, NURR1, TINUR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:7981. NR4A2.

Subcellular locationi

Cytoplasm. Nucleus
Note: Mostly nuclear; oxidative stress promotes cytoplasmic localization.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleoplasm Source: Reactome
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA31762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Nuclear receptor subfamily 4 group A member 2PRO_0000053718Add
BLAST

Proteomic databases

MaxQBiP43354.
PaxDbiP43354.
PRIDEiP43354.

PTM databases

PhosphoSiteiP43354.

Expressioni

Tissue specificityi

Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Developmental stagei

Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.

Gene expression databases

BgeeiP43354.
CleanExiHS_NR4A2.
ExpressionAtlasiP43354. baseline and differential.
GenevestigatoriP43354.

Organism-specific databases

HPAiCAB010481.
HPA000543.

Interactioni

Subunit structurei

Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TCEAL5Q5H9L22EBI-2681738,EBI-2681773

Protein-protein interaction databases

BioGridi110983. 14 interactions.
IntActiP43354. 14 interactions.
STRINGi9606.ENSP00000344479.

Structurei

Secondary structure

1
598
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi364 – 37411
Helixi392 – 3943
Helixi400 – 42223
Helixi427 – 4293
Helixi432 – 45423
Turni457 – 4604
Beta strandi461 – 4633
Beta strandi467 – 4715
Helixi472 – 4754
Turni476 – 4783
Helixi482 – 49413
Helixi500 – 51112
Helixi521 – 54020
Helixi541 – 5433
Turni544 – 5474
Helixi551 – 57929
Helixi586 – 59510

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OVLX-ray2.20A/B/C/D/E/F328-598[»]
ProteinModelPortaliP43354.
SMRiP43354. Positions 261-598.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43354.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni409 – 45951Ligand-bindingSequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi287 – 31428Bipartite nuclear localization signal (NLS1)Add
BLAST
Motifi338 – 35013Nuclear localization signal (NLS1)1 PublicationAdd
BLAST
Motifi443 – 45210nuclear export sequence (NES1)
Motifi568 – 57710nuclear export sequence (NES2)

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 13859Gln-richAdd
BLAST
Compositional biasi127 – 233107Pro-richAdd
BLAST
Compositional biasi346 – 39146Pro-richAdd
BLAST

Domaini

the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (PubMed:12774125).1 Publication

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32325NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG245120.
GeneTreeiENSGT00760000118837.
HOVERGENiHBG052663.
InParanoidiP43354.
KOiK08558.
OrthoDBiEOG75XGKJ.
PhylomeDBiP43354.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P43354-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE
60 70 80 90 100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY
110 120 130 140 150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH
160 170 180 190 200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV
210 220 230 240 250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS
260 270 280 290 300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL
310 320 330 340 350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK
360 370 380 390 400
SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT
410 420 430 440 450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR
460 470 480 490 500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI
510 520 530 540 550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN
560 570 580 590
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
Length:598
Mass (Da):66,591
Last modified:November 1, 1995 - v1
Checksum:i28D8199AACE3E211
GO
Isoform 2 (identifier: P43354-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Show »
Length:535
Mass (Da):59,809
Checksum:i41CB735EE1982523
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti465 – 4651C → W in AAB33999. (PubMed:7706727)Curated
Sequence conflicti468 – 4681V → W in AAB33999. (PubMed:7706727)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363Missing in isoform 2. 2 PublicationsVSP_056057Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75918 mRNA. Translation: CAA53518.1.
AB017586 Genomic DNA. Translation: BAA75666.1.
AB019433 Genomic DNA. Translation: BAA77328.1.
AK291456 mRNA. Translation: BAF84145.1.
AC074099 Genomic DNA. Translation: AAY24203.1.
CH471058 Genomic DNA. Translation: EAX11454.1.
CH471058 Genomic DNA. Translation: EAX11455.1.
BC009288 mRNA. Translation: AAH09288.1.
BC066890 mRNA. Translation: AAH66890.1.
S77154 mRNA. Translation: AAB33999.1.
CCDSiCCDS2201.1. [P43354-1]
PIRiA57040.
RefSeqiNP_006177.1. NM_006186.3.
XP_005246679.1. XM_005246622.1.
XP_005246680.1. XM_005246623.1.
UniGeneiHs.563344.

Genome annotation databases

EnsembliENST00000339562; ENSP00000344479; ENSG00000153234. [P43354-1]
ENST00000409572; ENSP00000386747; ENSG00000153234. [P43354-1]
ENST00000426264; ENSP00000389986; ENSG00000153234. [P43354-2]
GeneIDi4929.
KEGGihsa:4929.
UCSCiuc002tyx.4. human. [P43354-1]

Polymorphism databases

DMDMi1171750.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75918 mRNA. Translation: CAA53518.1 .
AB017586 Genomic DNA. Translation: BAA75666.1 .
AB019433 Genomic DNA. Translation: BAA77328.1 .
AK291456 mRNA. Translation: BAF84145.1 .
AC074099 Genomic DNA. Translation: AAY24203.1 .
CH471058 Genomic DNA. Translation: EAX11454.1 .
CH471058 Genomic DNA. Translation: EAX11455.1 .
BC009288 mRNA. Translation: AAH09288.1 .
BC066890 mRNA. Translation: AAH66890.1 .
S77154 mRNA. Translation: AAB33999.1 .
CCDSi CCDS2201.1. [P43354-1 ]
PIRi A57040.
RefSeqi NP_006177.1. NM_006186.3.
XP_005246679.1. XM_005246622.1.
XP_005246680.1. XM_005246623.1.
UniGenei Hs.563344.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OVL X-ray 2.20 A/B/C/D/E/F 328-598 [» ]
ProteinModelPortali P43354.
SMRi P43354. Positions 261-598.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110983. 14 interactions.
IntActi P43354. 14 interactions.
STRINGi 9606.ENSP00000344479.

Chemistry

ChEMBLi CHEMBL5002.

PTM databases

PhosphoSitei P43354.

Polymorphism databases

DMDMi 1171750.

Proteomic databases

MaxQBi P43354.
PaxDbi P43354.
PRIDEi P43354.

Protocols and materials databases

DNASUi 4929.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339562 ; ENSP00000344479 ; ENSG00000153234 . [P43354-1 ]
ENST00000409572 ; ENSP00000386747 ; ENSG00000153234 . [P43354-1 ]
ENST00000426264 ; ENSP00000389986 ; ENSG00000153234 . [P43354-2 ]
GeneIDi 4929.
KEGGi hsa:4929.
UCSCi uc002tyx.4. human. [P43354-1 ]

Organism-specific databases

CTDi 4929.
GeneCardsi GC02M157180.
GeneReviewsi NR4A2.
HGNCi HGNC:7981. NR4A2.
HPAi CAB010481.
HPA000543.
MIMi 601828. gene.
neXtProti NX_P43354.
Orphaneti 2828. Young adult-onset Parkinsonism.
PharmGKBi PA31762.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245120.
GeneTreei ENSGT00760000118837.
HOVERGENi HBG052663.
InParanoidi P43354.
KOi K08558.
OrthoDBi EOG75XGKJ.
PhylomeDBi P43354.
TreeFami TF315430.

Enzyme and pathway databases

Reactomei REACT_15525. Nuclear Receptor transcription pathway.
SignaLinki P43354.

Miscellaneous databases

ChiTaRSi NR4A2. human.
EvolutionaryTracei P43354.
GeneWikii Nuclear_receptor_related-1_protein.
GenomeRNAii 4929.
NextBioi 18989.
PROi P43354.
SOURCEi Search...

Gene expression databases

Bgeei P43354.
CleanExi HS_NR4A2.
ExpressionAtlasi P43354. baseline and differential.
Genevestigatori P43354.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3."
    Mages H.W., Rilke O., Bravo R., Senger G., Kroczek R.A.
    Mol. Endocrinol. 8:1583-1591(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Blood.
  2. "Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs."
    Ichinose H., Ohye T., Suzuki T., Sumi-Ichinose C., Nomura T., Hagino Y., Nagatsu T.
    Gene 230:233-239(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Fibroblast.
  3. "Organization of the human orphan nuclear receptor Nurr1 gene."
    Torii T., Kawarai T., Nakamura S., Kawakami H.
    Gene 230:225-232(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skin and Testis.
  8. "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line."
    Okabe T., Takayanagi R., Imasaki K., Haji M., Nawata H., Watanabe T.
    J. Immunol. 154:3871-3879(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-598 (ISOFORM 1).
  9. "Induction of tyrosine hydroxylase expression by the transcription factor Pitx3."
    Messmer K., Remington M.P., Skidmore F., Fishman P.S.
    Int. J. Dev. Neurosci. 25:29-37(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress."
    Garcia-Yague A.J., Rada P., Rojo A.I., Lastres-Becker I., Cuadrado A.
    J. Biol. Chem. 288:5506-5517(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNALS, NUCLEAR EXPORT SEQUENCES.
  12. "Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors."
    Wang Z., Benoit G., Liu J., Prasad S., Aarnisalo P., Liu X., Xu H., Walker N.P., Perlmann T.
    Nature 423:555-560(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 328-598.

Entry informationi

Entry nameiNR4A2_HUMAN
AccessioniPrimary (citable) accession number: P43354
Secondary accession number(s): Q16311, Q53RZ2, Q6NXU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3