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P43353 (AL3B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase family 3 member B1
EC=1.2.1.5
Alternative name(s):
Aldehyde dehydrogenase 7
Gene names
Name:ALDH3B1
Synonyms:ALDH7
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP+ and NAD+ as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. Ref.5

Catalytic activity

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Tissue specificity

Highest expression in kidney and lung.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P43353-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P43353-2)

The sequence of this isoform differs from the canonical sequence as follows:
     55-91: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Aldehyde dehydrogenase family 3 member B1
PRO_0000056481

Regions

Nucleotide binding188 – 1936NAD By similarity

Sites

Active site2101 By similarity
Active site2441 By similarity

Amino acid modifications

Modified residue3681Phosphoserine Ref.4

Natural variations

Alternative sequence55 – 9137Missing in isoform 2.
VSP_014040

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 30BEEB982395D2F7

FASTA46851,840
        10         20         30         40         50         60 
MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE 

        70         80         90        100        110        120 
VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL 

       130        140        150        160        170        180 
TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR 

       190        200        210        220        230        240 
FDYIFFTGSP RVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA 

       250        260        270        280        290        300 
GQTCVAPDYV LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC 

       310        320        330        340        350        360 
GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE AIEFINRREK 

       370        380        390        400        410        420 
PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL PFGGVGASGM GRYHGKFSFD 

       430        440        450        460 
TFSHHRACLL RSPGMEKLNA LRYPPQSPRR LRMLLVAMEA QGCSCTLL

« Hide

Isoform 2 [UniParc].

Checksum: 8B8E5587616158B4
Show »

FASTA43147,683

References

« Hide 'large scale' references
[1]"Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family."
Hsu L.C., Chang W.-C., Yoshida A.
Gene 151:285-289(1994) [PubMed: 7828891] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Kidney.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Lung and Prostate.
[4]"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.
Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[5]"Expression and initial characterization of human ALDH3B1."
Marchitti S.A., Orlicky D.J., Vasiliou V.
Biochem. Biophys. Res. Commun. 356:792-798(2007) [PubMed: 17382292] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U10868 mRNA. Translation: AAA83428.1.
BT009832 mRNA. Translation: AAP88834.1.
BC013584 mRNA. Translation: AAH13584.1.
BC014168 mRNA. Translation: AAH14168.2.
BC033099 mRNA. Translation: AAH33099.1.
IPIIPI00018031.
IPI00166751.
PIRI38669.
RefSeqNP_000685.1. NM_000694.2.
NP_001025181.1. NM_001030010.1.
NP_001154945.1. NM_001161473.1.
UniGeneHs.523841.

3D structure databases

ProteinModelPortalP43353.
SMRP43353. Positions 4-447.
ModBaseSearch...

Protein-protein interaction databases

IntActP43353. 1 interaction.
STRINGP43353.

PTM databases

PhosphoSiteP43353.

Polymorphism databases

DMDM1169285.

Proteomic databases

PRIDEP43353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID221.
KEGGhsa:221.

Organism-specific databases

CTD221.
GeneCardsGC11P067776.
H-InvDBHIX0009874.
HGNCHGNC:410. ALDH3B1.
MIM600466. gene.
neXtProtNX_P43353.
PharmGKBPA24699.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG752218.
HOVERGENHBG050483.
InParanoidP43353.
PhylomeDBP43353.

Gene expression databases

ArrayExpressP43353.
CleanExHS_ALDH3B1.
GenevestigatorP43353.
GermOnlineENSG00000006534. Homo sapiens.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00129.
PANTHERPTHR11699:SF15. ALDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF036492. ALDH. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

DrugBankDB00157. NADH.
NextBio894.
SOURCESearch...

Entry information

Entry nameAL3B1_HUMAN
AccessionPrimary (citable) accession number: P43353
Secondary accession number(s): Q53XL5, Q8N515, Q96CK8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents