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Protein

Aldehyde dehydrogenase family 3 member B1

Gene

ALDH3B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP+ and NAD+ as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.2 Publications

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, mitochondrial (ALDH2), Aldehyde dehydrogenase X, mitochondrial (ALDH1B1), Aldehyde dehydrogenase family 3 member B1 (ALDH3B1), Aldehyde dehydrogenase family 3 member B2 (ALDH3B2)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210By similarity1
Active sitei244By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NADBy similarity6

GO - Molecular functioni

  • 3-chloroallyl aldehyde dehydrogenase activity Source: ProtInc
  • aldehyde dehydrogenase (NAD) activity Source: GO_Central
  • aldehyde dehydrogenase [NAD(P)+] activity Source: MGI

GO - Biological processi

  • alcohol metabolic process Source: ProtInc
  • aldehyde catabolic process Source: MGI
  • cellular response to oxidative stress Source: MGI
  • ethanol catabolic process Source: UniProtKB-UniPathway
  • lipid metabolic process Source: ProtInc
  • oxidation-reduction process Source: MGI
  • sphingolipid biosynthetic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciZFISH:HS00182-MONOMER.
BRENDAi1.2.1.5. 2681.
ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.
R-HSA-6798695. Neutrophil degranulation.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member B1 (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 7
Gene namesi
Name:ALDH3B1
Synonyms:ALDH7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:410. ALDH3B1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: Reactome
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221.
OpenTargetsiENSG00000006534.
PharmGKBiPA24699.

Chemistry databases

ChEMBLiCHEMBL3542434.

Polymorphism and mutation databases

BioMutaiALDH3B1.
DMDMi1169285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564811 – 465Aldehyde dehydrogenase family 3 member B1Add BLAST465
PropeptideiPRO_0000424193466 – 468Removed in mature formCurated3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Lipidationi463S-palmitoyl cysteine1 Publication1
Modified residuei465Cysteine methyl esterCurated1
Lipidationi465S-geranylgeranyl cysteine1 Publication1

Post-translational modificationi

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiP43353.
MaxQBiP43353.
PeptideAtlasiP43353.
PRIDEiP43353.

PTM databases

iPTMnetiP43353.
PhosphoSitePlusiP43353.
SwissPalmiP43353.

Expressioni

Tissue specificityi

Highest expression in kidney and lung.

Gene expression databases

BgeeiENSG00000006534.
CleanExiHS_ALDH3B1.
ExpressionAtlasiP43353. baseline and differential.
GenevisibleiP43353. HS.

Organism-specific databases

HPAiHPA038525.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153233EBI-2558314,EBI-948001
KRT40Q6A1623EBI-2558314,EBI-10171697
KRTAP10-5P603703EBI-2558314,EBI-10172150
KRTAP10-7P604093EBI-2558314,EBI-10172290
KRTAP10-8P604105EBI-2558314,EBI-10171774
KRTAP10-9P604113EBI-2558314,EBI-10172052
NOTCH2NLQ7Z3S93EBI-2558314,EBI-945833

Protein-protein interaction databases

BioGridi106723. 42 interactors.
IntActiP43353. 16 interactors.

Structurei

3D structure databases

ProteinModelPortaliP43353.
SMRiP43353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000002825.
HOVERGENiHBG050483.
InParanoidiP43353.
KOiK00129.
OMAiRYPPQSP.
OrthoDBiEOG091G05HC.
PhylomeDBiP43353.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43353-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ
60 70 80 90 100
DLHKSAFESE VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI
110 120 130 140 150
RKEPFGLVLI IAPWNYPLNL TLVPLVGALA AGNCVVLKPS EISKNVEKIL
160 170 180 190 200
AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR FDYIFFTGSP RVGKIVMTAA
210 220 230 240 250
AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA GQTCVAPDYV
260 270 280 290 300
LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC
310 320 330 340 350
GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE
360 370 380 390 400
AIEFINRREK PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL
410 420 430 440 450
PFGGVGASGM GRYHGKFSFD TFSHHRACLL RSPGMEKLNA LRYPPQSPRR
460
LRMLLVAMEA QGCSCTLL
Length:468
Mass (Da):51,840
Last modified:November 1, 1995 - v1
Checksum:i30BEEB982395D2F7
GO
Isoform 2 (identifier: P43353-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-91: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):47,683
Checksum:i8B8E5587616158B4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01404055 – 91Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10868 mRNA. Translation: AAA83428.1.
EF411198 mRNA. Translation: ABN58743.1.
BT009832 mRNA. Translation: AAP88834.1.
AK291505 mRNA. Translation: BAF84194.1.
CH471076 Genomic DNA. Translation: EAW74680.1.
BC013584 mRNA. Translation: AAH13584.1.
BC014168 mRNA. Translation: AAH14168.2.
BC033099 mRNA. Translation: AAH33099.1.
CCDSiCCDS73335.1. [P43353-1]
CCDS73336.1. [P43353-2]
PIRiI38669.
RefSeqiNP_000685.1. NM_000694.3. [P43353-1]
NP_001025181.1. NM_001030010.2. [P43353-2]
NP_001154945.1. NM_001161473.2. [P43353-1]
NP_001276987.1. NM_001290058.1.
NP_001276988.1. NM_001290059.1.
UniGeneiHs.523841.

Genome annotation databases

EnsembliENST00000342456; ENSP00000473990; ENSG00000006534. [P43353-1]
ENST00000614849; ENSP00000478486; ENSG00000006534. [P43353-1]
ENST00000617288; ENSP00000481604; ENSG00000006534. [P43353-2]
GeneIDi221.
KEGGihsa:221.
UCSCiuc031xti.2. human. [P43353-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10868 mRNA. Translation: AAA83428.1.
EF411198 mRNA. Translation: ABN58743.1.
BT009832 mRNA. Translation: AAP88834.1.
AK291505 mRNA. Translation: BAF84194.1.
CH471076 Genomic DNA. Translation: EAW74680.1.
BC013584 mRNA. Translation: AAH13584.1.
BC014168 mRNA. Translation: AAH14168.2.
BC033099 mRNA. Translation: AAH33099.1.
CCDSiCCDS73335.1. [P43353-1]
CCDS73336.1. [P43353-2]
PIRiI38669.
RefSeqiNP_000685.1. NM_000694.3. [P43353-1]
NP_001025181.1. NM_001030010.2. [P43353-2]
NP_001154945.1. NM_001161473.2. [P43353-1]
NP_001276987.1. NM_001290058.1.
NP_001276988.1. NM_001290059.1.
UniGeneiHs.523841.

3D structure databases

ProteinModelPortaliP43353.
SMRiP43353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106723. 42 interactors.
IntActiP43353. 16 interactors.

Chemistry databases

ChEMBLiCHEMBL3542434.

PTM databases

iPTMnetiP43353.
PhosphoSitePlusiP43353.
SwissPalmiP43353.

Polymorphism and mutation databases

BioMutaiALDH3B1.
DMDMi1169285.

Proteomic databases

EPDiP43353.
MaxQBiP43353.
PeptideAtlasiP43353.
PRIDEiP43353.

Protocols and materials databases

DNASUi221.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342456; ENSP00000473990; ENSG00000006534. [P43353-1]
ENST00000614849; ENSP00000478486; ENSG00000006534. [P43353-1]
ENST00000617288; ENSP00000481604; ENSG00000006534. [P43353-2]
GeneIDi221.
KEGGihsa:221.
UCSCiuc031xti.2. human. [P43353-1]

Organism-specific databases

CTDi221.
DisGeNETi221.
GeneCardsiALDH3B1.
HGNCiHGNC:410. ALDH3B1.
HPAiHPA038525.
MIMi600466. gene.
neXtProtiNX_P43353.
OpenTargetsiENSG00000006534.
PharmGKBiPA24699.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000002825.
HOVERGENiHBG050483.
InParanoidiP43353.
KOiK00129.
OMAiRYPPQSP.
OrthoDBiEOG091G05HC.
PhylomeDBiP43353.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
BioCyciZFISH:HS00182-MONOMER.
BRENDAi1.2.1.5. 2681.
ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiALDH3B1. human.
GeneWikiiALDH3B1.
GenomeRNAii221.
PROiP43353.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006534.
CleanExiHS_ALDH3B1.
ExpressionAtlasiP43353. baseline and differential.
GenevisibleiP43353. HS.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL3B1_HUMAN
AccessioniPrimary (citable) accession number: P43353
Secondary accession number(s): A3FMP9
, Q53XL5, Q8N515, Q96CK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.