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P43352

- RAD52_MOUSE

UniProt

P43352 - RAD52_MOUSE

Protein

DNA repair protein RAD52 homolog

Gene

Rad52

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi153 – 1575By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA recombination Source: UniProtKB
    2. double-strand break repair via homologous recombination Source: MGI

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA repair protein RAD52 homolog
    Gene namesi
    Name:Rad52
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:101949. Rad52.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420DNA repair protein RAD52 homologPRO_0000173882Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei105 – 1051Phosphotyrosine; by ABL1By similarity
    Modified residuei200 – 2001PhosphoserineBy similarity
    Modified residuei339 – 3391PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP43352.
    PRIDEiP43352.

    PTM databases

    PhosphoSiteiP43352.

    Expressioni

    Gene expression databases

    BgeeiP43352.
    CleanExiMM_RAD52.
    GenevestigatoriP43352.

    Interactioni

    Subunit structurei

    The full-length protein forms heptameric rings. Interacts with ABL1. Interacts with RPA2; the interaction is direct and associates RAD52 with the RPA complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032269.

    Structurei

    3D structure databases

    ProteinModelPortaliP43352.
    SMRiP43352. Positions 25-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni222 – 29170Mediates interaction with RPA2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RAD52 family.Curated

    Phylogenomic databases

    eggNOGiCOG5055.
    GeneTreeiENSGT00390000008766.
    HOVERGENiHBG054676.
    InParanoidiP43352.
    KOiK10873.
    OMAiQARYSSC.
    OrthoDBiEOG74XS87.
    PhylomeDBiP43352.
    TreeFamiTF101221.

    Family and domain databases

    InterProiIPR004585. DNA_recomb/repair_Rad52.
    IPR007232. Rad52_Rad22.
    [Graphical view]
    PANTHERiPTHR12132. PTHR12132. 1 hit.
    PfamiPF04098. Rad52_Rad22. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00607. rad52. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P43352-1 [UniParc]FASTAAdd to Basket

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    MAGPEEAVHR GCDNHPPFVG GKSVLLFGQS QYTADEYQAI QKALRQRLGP    50
    EYISSRMAGG GQKVCYIEGH RVINLANEMF GYNGWAHSIT QQNVDFVDLN 100
    NGKFYVGVCA FVKVQLKDGS YHEDVGYGVS EGLRSKALSL EKARKEAVTD 150
    GLKRALRSFG NALGNCILDK DYLRSLNKLP RQLPLDVDLT KTKREDFEPS 200
    VEQARYNSCR QNEALGLPKP QEVTSPCRSS PPHDSNIKLQ GAKDISSSCS 250
    LAATLESDAT HQRKLRKLRQ KQLQQQFREQ METRRQSHAP AEEVAAKHAA 300
    VLPAPPKHST PVTAASELLQ EKVVFPDNLE ENLEMWDLTP DLEDIIKPLC 350
    RAEPAQTSAT RTFNNQDSVP HIHCHQKPQE KPGPGHLQTC NTNQHVLGSR 400
    EDSEPHRKSQ DLKKRKLDPS 420
    Length:420
    Mass (Da):46,910
    Last modified:November 1, 1995 - v1
    Checksum:i84514C8579072F98
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951E → K in AAA85794. (PubMed:7774919)Curated
    Sequence conflicti300 – 3001Missing in AAA85794. (PubMed:7774919)Curated
    Sequence conflicti352 – 3521A → G(PubMed:7829098)Curated
    Sequence conflicti352 – 3521A → G1 PublicationCurated
    Sequence conflicti401 – 4011Missing(PubMed:7829098)Curated
    Sequence conflicti401 – 4011Missing1 PublicationCurated
    Sequence conflicti418 – 4181D → N in CAA83659. (PubMed:7526206)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06837 mRNA. Translation: AAA75441.1.
    U12135 mRNA. Translation: AAA85794.1.
    Z32767 mRNA. Translation: CAA83659.1.
    AF004854 Genomic DNA. Translation: AAB69174.1.
    CCDSiCCDS51887.1.
    PIRiA55727.
    A56529.
    RefSeqiNP_001159853.1. NM_001166381.1.
    UniGeneiMm.149.

    Genome annotation databases

    EnsembliENSMUST00000162461; ENSMUSP00000125502; ENSMUSG00000030166.
    GeneIDi19365.
    KEGGimmu:19365.
    UCSCiuc009dmq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06837 mRNA. Translation: AAA75441.1 .
    U12135 mRNA. Translation: AAA85794.1 .
    Z32767 mRNA. Translation: CAA83659.1 .
    AF004854 Genomic DNA. Translation: AAB69174.1 .
    CCDSi CCDS51887.1.
    PIRi A55727.
    A56529.
    RefSeqi NP_001159853.1. NM_001166381.1.
    UniGenei Mm.149.

    3D structure databases

    ProteinModelPortali P43352.
    SMRi P43352. Positions 25-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032269.

    PTM databases

    PhosphoSitei P43352.

    Proteomic databases

    PaxDbi P43352.
    PRIDEi P43352.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000162461 ; ENSMUSP00000125502 ; ENSMUSG00000030166 .
    GeneIDi 19365.
    KEGGi mmu:19365.
    UCSCi uc009dmq.2. mouse.

    Organism-specific databases

    CTDi 5893.
    MGIi MGI:101949. Rad52.

    Phylogenomic databases

    eggNOGi COG5055.
    GeneTreei ENSGT00390000008766.
    HOVERGENi HBG054676.
    InParanoidi P43352.
    KOi K10873.
    OMAi QARYSSC.
    OrthoDBi EOG74XS87.
    PhylomeDBi P43352.
    TreeFami TF101221.

    Miscellaneous databases

    NextBioi 296437.
    PROi P43352.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43352.
    CleanExi MM_RAD52.
    Genevestigatori P43352.

    Family and domain databases

    InterProi IPR004585. DNA_recomb/repair_Rad52.
    IPR007232. Rad52_Rad22.
    [Graphical view ]
    PANTHERi PTHR12132. PTHR12132. 1 hit.
    Pfami PF04098. Rad52_Rad22. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00607. rad52. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52."
      Bendixen C., Sunjevaric I., Bauchwitz R., Rothstein R.
      Genomics 23:300-303(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues."
      Shen Z., Denison K., Lobb R., Gatewood J.M., Chen D.J.
      Genomics 25:199-206(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Thymus.
    4. Sunjevaric I., Bendixen C., Mortensen U.H., Miljkovic V., Rothstein R.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiRAD52_MOUSE
    AccessioniPrimary (citable) accession number: P43352
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3