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Protein

DNA repair protein RAD52 homolog

Gene

Rad52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi153 – 157By similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-5685938 HDR through Single Strand Annealing (SSA)

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD52 homolog
Gene namesi
Name:Rad52
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:101949 Rad52

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738821 – 420DNA repair protein RAD52 homologAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105Phosphotyrosine; by ABL1By similarity1
Modified residuei200PhosphoserineBy similarity1
Modified residuei339PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP43352
PRIDEiP43352

PTM databases

iPTMnetiP43352
PhosphoSitePlusiP43352

Expressioni

Gene expression databases

BgeeiENSMUSG00000030166
CleanExiMM_RAD52
ExpressionAtlasiP43352 baseline and differential
GenevisibleiP43352 MM

Interactioni

Subunit structurei

The full-length protein forms heptameric rings. Interacts with ABL1. Interacts with RPA2; the interaction is direct and associates RAD52 with the RPA complex (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125502

Structurei

3D structure databases

ProteinModelPortaliP43352
SMRiP43352
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 291Mediates interaction with RPA2By similarityAdd BLAST70

Sequence similaritiesi

Belongs to the RAD52 family.Curated

Phylogenomic databases

eggNOGiKOG4141 Eukaryota
COG5055 LUCA
GeneTreeiENSGT00390000008766
HOVERGENiHBG054676
InParanoidiP43352
KOiK10873
OMAiQARYSSC
OrthoDBiEOG091G0OIP
PhylomeDBiP43352
TreeFamiTF101221

Family and domain databases

InterProiView protein in InterPro
IPR004585 DNA_recomb/repair_Rad52
IPR007232 Rad52_Rad59_Rad22
PANTHERiPTHR12132 PTHR12132, 1 hit
PfamiView protein in Pfam
PF04098 Rad52_Rad22, 1 hit
TIGRFAMsiTIGR00607 rad52, 1 hit

Sequencei

Sequence statusi: Complete.

P43352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPEEAVHR GCDNHPPFVG GKSVLLFGQS QYTADEYQAI QKALRQRLGP
60 70 80 90 100
EYISSRMAGG GQKVCYIEGH RVINLANEMF GYNGWAHSIT QQNVDFVDLN
110 120 130 140 150
NGKFYVGVCA FVKVQLKDGS YHEDVGYGVS EGLRSKALSL EKARKEAVTD
160 170 180 190 200
GLKRALRSFG NALGNCILDK DYLRSLNKLP RQLPLDVDLT KTKREDFEPS
210 220 230 240 250
VEQARYNSCR QNEALGLPKP QEVTSPCRSS PPHDSNIKLQ GAKDISSSCS
260 270 280 290 300
LAATLESDAT HQRKLRKLRQ KQLQQQFREQ METRRQSHAP AEEVAAKHAA
310 320 330 340 350
VLPAPPKHST PVTAASELLQ EKVVFPDNLE ENLEMWDLTP DLEDIIKPLC
360 370 380 390 400
RAEPAQTSAT RTFNNQDSVP HIHCHQKPQE KPGPGHLQTC NTNQHVLGSR
410 420
EDSEPHRKSQ DLKKRKLDPS
Length:420
Mass (Da):46,910
Last modified:November 1, 1995 - v1
Checksum:i84514C8579072F98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195E → K in AAA85794 (PubMed:7774919).Curated1
Sequence conflicti300Missing in AAA85794 (PubMed:7774919).Curated1
Sequence conflicti352A → G (PubMed:7829098).Curated1
Sequence conflicti352A → G (Ref. 4) Curated1
Sequence conflicti401Missing (PubMed:7829098).Curated1
Sequence conflicti401Missing (Ref. 4) Curated1
Sequence conflicti418D → N in CAA83659 (PubMed:7526206).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06837 mRNA Translation: AAA75441.1
U12135 mRNA Translation: AAA85794.1
Z32767 mRNA Translation: CAA83659.1
AF004854 Genomic DNA Translation: AAB69174.1
CCDSiCCDS51887.1
PIRiA55727
A56529
RefSeqiNP_001159853.1, NM_001166381.1
UniGeneiMm.149

Genome annotation databases

EnsembliENSMUST00000162461; ENSMUSP00000125502; ENSMUSG00000030166
GeneIDi19365
KEGGimmu:19365
UCSCiuc009dmq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRAD52_MOUSE
AccessioniPrimary (citable) accession number: P43352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome