SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P43352

- RAD52_MOUSE

UniProt

P43352 - RAD52_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA repair protein RAD52 homolog

Gene
Rad52
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi153 – 1575 By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA recombination Source: UniProtKB
  2. double-strand break repair via homologous recombination Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD52 homolog
Gene namesi
Name:Rad52
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:101949. Rad52.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420DNA repair protein RAD52 homologPRO_0000173882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051Phosphotyrosine; by ABL1 By similarity
Modified residuei200 – 2001Phosphoserine By similarity
Modified residuei339 – 3391Phosphothreonine By similarity

Post-translational modificationi

Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP43352.
PRIDEiP43352.

PTM databases

PhosphoSiteiP43352.

Expressioni

Gene expression databases

BgeeiP43352.
CleanExiMM_RAD52.
GenevestigatoriP43352.

Interactioni

Subunit structurei

The full-length protein forms heptameric rings. Interacts with ABL1. Interacts with RPA2; the interaction is direct and associates RAD52 with the RPA complex By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032269.

Structurei

3D structure databases

ProteinModelPortaliP43352.
SMRiP43352. Positions 25-210.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni222 – 29170Mediates interaction with RPA2 By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the RAD52 family.

Phylogenomic databases

eggNOGiCOG5055.
GeneTreeiENSGT00390000008766.
HOVERGENiHBG054676.
InParanoidiP43352.
KOiK10873.
OMAiQARYSSC.
OrthoDBiEOG74XS87.
PhylomeDBiP43352.
TreeFamiTF101221.

Family and domain databases

InterProiIPR004585. DNA_recomb/repair_Rad52.
IPR007232. Rad52_Rad22.
[Graphical view]
PANTHERiPTHR12132. PTHR12132. 1 hit.
PfamiPF04098. Rad52_Rad22. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00607. rad52. 1 hit.

Sequencei

Sequence statusi: Complete.

P43352-1 [UniParc]FASTAAdd to Basket

« Hide

MAGPEEAVHR GCDNHPPFVG GKSVLLFGQS QYTADEYQAI QKALRQRLGP    50
EYISSRMAGG GQKVCYIEGH RVINLANEMF GYNGWAHSIT QQNVDFVDLN 100
NGKFYVGVCA FVKVQLKDGS YHEDVGYGVS EGLRSKALSL EKARKEAVTD 150
GLKRALRSFG NALGNCILDK DYLRSLNKLP RQLPLDVDLT KTKREDFEPS 200
VEQARYNSCR QNEALGLPKP QEVTSPCRSS PPHDSNIKLQ GAKDISSSCS 250
LAATLESDAT HQRKLRKLRQ KQLQQQFREQ METRRQSHAP AEEVAAKHAA 300
VLPAPPKHST PVTAASELLQ EKVVFPDNLE ENLEMWDLTP DLEDIIKPLC 350
RAEPAQTSAT RTFNNQDSVP HIHCHQKPQE KPGPGHLQTC NTNQHVLGSR 400
EDSEPHRKSQ DLKKRKLDPS 420
Length:420
Mass (Da):46,910
Last modified:November 1, 1995 - v1
Checksum:i84514C8579072F98
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951E → K in AAA85794. 1 Publication
Sequence conflicti300 – 3001Missing in AAA85794. 1 Publication
Sequence conflicti352 – 3521A → G1 Publication
Sequence conflicti352 – 3521A → G1 Publication
Sequence conflicti401 – 4011Missing1 Publication
Sequence conflicti401 – 4011Missing1 Publication
Sequence conflicti418 – 4181D → N in CAA83659. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06837 mRNA. Translation: AAA75441.1.
U12135 mRNA. Translation: AAA85794.1.
Z32767 mRNA. Translation: CAA83659.1.
AF004854 Genomic DNA. Translation: AAB69174.1.
CCDSiCCDS51887.1.
PIRiA55727.
A56529.
RefSeqiNP_001159853.1. NM_001166381.1.
UniGeneiMm.149.

Genome annotation databases

EnsembliENSMUST00000162461; ENSMUSP00000125502; ENSMUSG00000030166.
GeneIDi19365.
KEGGimmu:19365.
UCSCiuc009dmq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06837 mRNA. Translation: AAA75441.1 .
U12135 mRNA. Translation: AAA85794.1 .
Z32767 mRNA. Translation: CAA83659.1 .
AF004854 Genomic DNA. Translation: AAB69174.1 .
CCDSi CCDS51887.1.
PIRi A55727.
A56529.
RefSeqi NP_001159853.1. NM_001166381.1.
UniGenei Mm.149.

3D structure databases

ProteinModelPortali P43352.
SMRi P43352. Positions 25-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032269.

PTM databases

PhosphoSitei P43352.

Proteomic databases

PaxDbi P43352.
PRIDEi P43352.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000162461 ; ENSMUSP00000125502 ; ENSMUSG00000030166 .
GeneIDi 19365.
KEGGi mmu:19365.
UCSCi uc009dmq.2. mouse.

Organism-specific databases

CTDi 5893.
MGIi MGI:101949. Rad52.

Phylogenomic databases

eggNOGi COG5055.
GeneTreei ENSGT00390000008766.
HOVERGENi HBG054676.
InParanoidi P43352.
KOi K10873.
OMAi QARYSSC.
OrthoDBi EOG74XS87.
PhylomeDBi P43352.
TreeFami TF101221.

Miscellaneous databases

NextBioi 296437.
PROi P43352.
SOURCEi Search...

Gene expression databases

Bgeei P43352.
CleanExi MM_RAD52.
Genevestigatori P43352.

Family and domain databases

InterProi IPR004585. DNA_recomb/repair_Rad52.
IPR007232. Rad52_Rad22.
[Graphical view ]
PANTHERi PTHR12132. PTHR12132. 1 hit.
Pfami PF04098. Rad52_Rad22. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00607. rad52. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52."
    Bendixen C., Sunjevaric I., Bauchwitz R., Rothstein R.
    Genomics 23:300-303(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues."
    Shen Z., Denison K., Lobb R., Gatewood J.M., Chen D.J.
    Genomics 25:199-206(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Thymus.
  4. Sunjevaric I., Bendixen C., Mortensen U.H., Miljkovic V., Rothstein R.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6J.

Entry informationi

Entry nameiRAD52_MOUSE
AccessioniPrimary (citable) accession number: P43352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi