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Protein

Translationally-controlled tumor protein

Gene

TPT1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Gene namesi
Name:TPT1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Translationally-controlled tumor proteinPRO_0000211271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine; by PLK1By similarity
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei64 – 641Phosphoserine; by PLK1By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP43348.

Expressioni

Developmental stagei

Undergoes developmental regulation during mammary gland development.

Interactioni

Subunit structurei

Interacts with STEAP3.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000018089.

Structurei

3D structure databases

ProteinModelPortaliP43348.
SMRiP43348. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 172172TCTPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation
Contains 1 TCTP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiP43348.
OrthoDBiEOG091G0OTA.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYRDLISH DEMFSDIYKI REIAGGLCLE VEGKMVSRTE GNIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK
110 120 130 140 150
GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFYIGENM NPDGMVALLD
160 170
YREDGVTPFM IFFKDGLEME KC
Length:172
Mass (Da):19,537
Last modified:July 15, 1999 - v2
Checksum:i7E3209A92C601452
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41Y → D in CAA86826 (Ref. 1) Curated
Sequence conflicti13 – 131M → T in CAA86826 (Ref. 1) Curated
Sequence conflicti129 – 1291F → L in CAA86826 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791Q → R.
Natural varianti153 – 1531E → G.
Natural varianti169 – 1691M → V.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46805 mRNA. Translation: CAA86826.1.
AJ225898 Genomic DNA. Translation: CAA12650.1.
AJ131951 mRNA. Translation: CAB41990.1.
AJ277092 mRNA. Translation: CAC01239.1.
AJ277093 mRNA. Translation: CAC01240.1.
PIRiA38956.
RefSeqiNP_001075598.1. NM_001082129.2.
XP_002709520.1. XM_002709474.2.
XP_002718363.1. XM_002718317.2.
XP_002720179.1. XM_002720133.2.
UniGeneiOcu.3689.

Genome annotation databases

EnsembliENSOCUT00000024631; ENSOCUP00000018202; ENSOCUG00000023773.
GeneIDi100008854.
100344007.
100353956.
100357892.
KEGGiocu:100008854.
ocu:100344007.
ocu:100353956.
ocu:100357892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46805 mRNA. Translation: CAA86826.1.
AJ225898 Genomic DNA. Translation: CAA12650.1.
AJ131951 mRNA. Translation: CAB41990.1.
AJ277092 mRNA. Translation: CAC01239.1.
AJ277093 mRNA. Translation: CAC01240.1.
PIRiA38956.
RefSeqiNP_001075598.1. NM_001082129.2.
XP_002709520.1. XM_002709474.2.
XP_002718363.1. XM_002718317.2.
XP_002720179.1. XM_002720133.2.
UniGeneiOcu.3689.

3D structure databases

ProteinModelPortaliP43348.
SMRiP43348. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000018089.

Proteomic databases

PRIDEiP43348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000024631; ENSOCUP00000018202; ENSOCUG00000023773.
GeneIDi100008854.
100344007.
100353956.
100357892.
KEGGiocu:100008854.
ocu:100344007.
ocu:100353956.
ocu:100357892.

Organism-specific databases

CTDi7178.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiP43348.
OrthoDBiEOG091G0OTA.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCTP_RABIT
AccessioniPrimary (citable) accession number: P43348
Secondary accession number(s): O77730, Q9MYT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1999
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.