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Protein

Translationally-controlled tumor protein homolog

Gene

TPT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein homolog
Short name:
TCTP
Alternative name(s):
p23
pCHK23
Gene namesi
Name:TPT1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Translationally-controlled tumor protein homologPRO_0000211273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461Phosphoserine; by PLK1By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP43347.
PRIDEiP43347.

Interactioni

Protein-protein interaction databases

BioGridi676616. 1 interaction.
STRINGi9031.ENSGALP00000035709.

Structurei

3D structure databases

ProteinModelPortaliP43347.
SMRiP43347. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCTP family.Curated

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiP43347.
OMAiCAMIEEG.
PhylomeDBiP43347.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYRDCISQ DEMFSDIYKI REVANGLCLE VEGKMVTRTE GQIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTEATVITGV DIVINHHLQE TSFTKESYKK YIKDYMKAIK
110 120 130 140 150
ARLEEHKPER VKPFMTGAAE QIKHILANFK NYQFFVGENM NPDGMVALLD
160 170
FREDGVTPYM IFFKDGLEIE KC
Length:172
Mass (Da):19,530
Last modified:November 1, 1995 - v1
Checksum:i3D3DB669AC8E58F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25954 mRNA. Translation: AAA67296.1.
D26312 mRNA. Translation: BAA05374.1.
PIRiA38960.
RefSeqiNP_990729.1. NM_205398.1.
UniGeneiGga.4312.

Genome annotation databases

EnsembliENSGALT00000044027; ENSGALP00000042618; ENSGALG00000028872.
GeneIDi396363.
KEGGigga:396363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25954 mRNA. Translation: AAA67296.1.
D26312 mRNA. Translation: BAA05374.1.
PIRiA38960.
RefSeqiNP_990729.1. NM_205398.1.
UniGeneiGga.4312.

3D structure databases

ProteinModelPortaliP43347.
SMRiP43347. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676616. 1 interaction.
STRINGi9031.ENSGALP00000035709.

Proteomic databases

PaxDbiP43347.
PRIDEiP43347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000044027; ENSGALP00000042618; ENSGALG00000028872.
GeneIDi396363.
KEGGigga:396363.

Organism-specific databases

CTDi7178.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiP43347.
OMAiCAMIEEG.
PhylomeDBiP43347.
TreeFamiTF300238.

Miscellaneous databases

PROiP43347.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and nucleotide sequence of differentiation-related gene (pCHK23) from chick embryonic myoblasts:cDNA pCHK23 is homologous to translationally controlled protein p23 in mouse EAT cells."
    Kang B.-S., Jang S., Yoo B., Yang J.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Myoblast.
  2. Sawada K., Agata K., Eguchi G.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lens.

Entry informationi

Entry nameiTCTP_CHICK
AccessioniPrimary (citable) accession number: P43347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.