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Protein

T-cell leukemia homeobox protein 1

Gene

Tlx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi203 – 262HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • animal organ formation Source: MGI
  • cell fate commitment Source: MGI
  • central nervous system development Source: MGI
  • lymph node development Source: MGI
  • neuron differentiation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • spleen development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 1
Alternative name(s):
Homeobox TLX-1
Homeobox protein Hox-11
Gene namesi
Name:Tlx1
Synonyms:Hox11, Tlx-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98769. Tlx1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493341 – 332T-cell leukemia homeobox protein 1Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP43345.

PTM databases

PhosphoSitePlusiP43345.

Expressioni

Tissue specificityi

Expressed in various embryonic tissues, including branchial arches, some component of the nervous system and spleen.

Gene expression databases

CleanExiMM_TLX1.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

Structurei

3D structure databases

ProteinModelPortaliP43345.
SMRiP43345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG036206.
InParanoidiP43345.
PhylomeDBiP43345.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHLGPHHLH PGHAEPISFG IEQILNSPDQ GGCMGPNSRL QDGDYGLGCL
60 70 80 90 100
VPGAYTYGGG GSAAGAGAGG TGAYGAGGPG GPGGPAGGGG GACSMGPLPG
110 120 130 140 150
SYNVNMDLAG GPGPGGDGGG GGAARRALSA AGVIRVPAHR PLAGAVAHPQ
160 170 180 190 200
PLATGLPTVP SVPAVPGVNN LTGLTFPWME SNRRYTKDRF TGLPYQNRTP
210 220 230 240 250
PKKKKPRTSF TRLQICELEK RFHRQKYLAS AERAALAKAL KMTDAQVKTW
260 270 280 290 300
FQNRRTKWRR QTAEEREAES EQANRILLQL QQEAFQKSLA QPLPADPLCV
310 320 330
HNSSLFALQN LQPWSDDSTK ITSVTSVASA CE
Length:332
Mass (Da):34,644
Last modified:November 1, 1995 - v1
Checksum:i79FC71E2E44E6F82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70632, S70756, S70629 Genomic DNA. Translation: AAB30542.1.
UniGeneiMm.391203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70632, S70756, S70629 Genomic DNA. Translation: AAB30542.1.
UniGeneiMm.391203.

3D structure databases

ProteinModelPortaliP43345.
SMRiP43345.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiP43345.

Proteomic databases

PRIDEiP43345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98769. Tlx1.

Phylogenomic databases

HOVERGENiHBG036206.
InParanoidiP43345.
PhylomeDBiP43345.

Miscellaneous databases

PROiP43345.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TLX1.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLX1_MOUSE
AccessioniPrimary (citable) accession number: P43345
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.