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Protein

Uncharacterized Nudix hydrolase NudL

Gene

nudL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Magnesium or manganeseUniRule annotation1
Metal bindingi87Magnesium or manganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12693-MONOMER.
MetaCyc:EG12693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized Nudix hydrolase NudLUniRule annotation (EC:3.6.1.-UniRule annotation)
Gene namesi
Name:nudLUniRule annotation
Synonyms:yeaB
Ordered Locus Names:b1813, JW1802
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12693. nudL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571451 – 192Uncharacterized Nudix hydrolase NudLAdd BLAST192

Proteomic databases

PaxDbiP43337.
PRIDEiP43337.

Interactioni

Protein-protein interaction databases

BioGridi4263367. 24 interactors.
DIPiDIP-11783N.
IntActiP43337. 5 interactors.
MINTiMINT-1232423.
STRINGi316385.ECDH10B_1951.

Structurei

3D structure databases

ProteinModelPortaliP43337.
SMRiP43337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 160Nudix hydrolaseUniRule annotationAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi67 – 89Nudix boxAdd BLAST23

Sequence similaritiesi

Belongs to the Nudix hydrolase family. PCD1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105P8F. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000250455.
InParanoidiP43337.
PhylomeDBiP43337.

Family and domain databases

HAMAPiMF_01592. Nudix_NudL. 1 hit.
InterProiView protein in InterPro
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR000059. NUDIX_hydrolase_NudL_CS.
IPR023735. Nudix_NudL.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS01293. NUDIX_COA. 1 hit.

Sequencei

Sequence statusi: Complete.

P43337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYRSLTLDD FLSRFQLLRP QINRETLNHR QAAVLIPIVR RPQPGLLLTQ
60 70 80 90 100
RSIHLRKHAG QVAFPGGAVD DTDASAIAAA LREAEEEVAI PPSAVEVIGV
110 120 130 140 150
LPPVDSVTGY QVTPVVGIIP PDLPYRASED EVSAVFEMPL AQALHLGRYH
160 170 180 190
PLDIYRRGDS HRVWLSWYEQ YFVWGMTAGI IRELALQIGV KP
Length:192
Mass (Da):21,436
Last modified:November 1, 1995 - v1
Checksum:iA4CAEC50B1767ECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74883.1.
AP009048 Genomic DNA. Translation: BAA15620.1.
K02673 Genomic DNA. No translation available.
M28695 Genomic DNA. No translation available.
PIRiE64942.
RefSeqiNP_416327.1. NC_000913.3.
WP_000456715.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74883; AAC74883; b1813.
BAA15620; BAA15620; BAA15620.
GeneIDi946330.
KEGGiecj:JW1802.
eco:b1813.
PATRICifig|1411691.4.peg.439.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNUDL_ECOLI
AccessioniPrimary (citable) accession number: P43337
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families