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Protein

Uncharacterized Nudix hydrolase NudL

Gene

nudL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Magnesium or manganeseUniRule annotation
Metal bindingi87 – 871Magnesium or manganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12693-MONOMER.
ECOL316407:JW1802-MONOMER.
MetaCyc:EG12693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized Nudix hydrolase NudLUniRule annotation (EC:3.6.1.-UniRule annotation)
Gene namesi
Name:nudLUniRule annotation
Synonyms:yeaB
Ordered Locus Names:b1813, JW1802
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12693. nudL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Uncharacterized Nudix hydrolase NudLPRO_0000057145Add
BLAST

Proteomic databases

PaxDbiP43337.
PRIDEiP43337.

Interactioni

Protein-protein interaction databases

BioGridi4263367. 24 interactions.
DIPiDIP-11783N.
IntActiP43337. 5 interactions.
MINTiMINT-1232423.
STRINGi511145.b1813.

Structurei

3D structure databases

ProteinModelPortaliP43337.
SMRiP43337. Positions 29-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 160132Nudix hydrolaseUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 8923Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family. PCD1 subfamily.UniRule annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105P8F. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000250455.
InParanoidiP43337.
OMAiWRDHGDH.
PhylomeDBiP43337.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_01592. Nudix_NudL. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR000059. NUDIX_hydrolase_NudL_CS.
IPR023735. Nudix_NudL.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS01293. NUDIX_COA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYRSLTLDD FLSRFQLLRP QINRETLNHR QAAVLIPIVR RPQPGLLLTQ
60 70 80 90 100
RSIHLRKHAG QVAFPGGAVD DTDASAIAAA LREAEEEVAI PPSAVEVIGV
110 120 130 140 150
LPPVDSVTGY QVTPVVGIIP PDLPYRASED EVSAVFEMPL AQALHLGRYH
160 170 180 190
PLDIYRRGDS HRVWLSWYEQ YFVWGMTAGI IRELALQIGV KP
Length:192
Mass (Da):21,436
Last modified:November 1, 1995 - v1
Checksum:iA4CAEC50B1767ECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74883.1.
AP009048 Genomic DNA. Translation: BAA15620.1.
K02673 Genomic DNA. No translation available.
M28695 Genomic DNA. No translation available.
PIRiE64942.
RefSeqiNP_416327.1. NC_000913.3.
WP_000456715.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74883; AAC74883; b1813.
BAA15620; BAA15620; BAA15620.
GeneIDi946330.
KEGGiecj:JW1802.
eco:b1813.
PATRICi32118945. VBIEscCol129921_1890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74883.1.
AP009048 Genomic DNA. Translation: BAA15620.1.
K02673 Genomic DNA. No translation available.
M28695 Genomic DNA. No translation available.
PIRiE64942.
RefSeqiNP_416327.1. NC_000913.3.
WP_000456715.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP43337.
SMRiP43337. Positions 29-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263367. 24 interactions.
DIPiDIP-11783N.
IntActiP43337. 5 interactions.
MINTiMINT-1232423.
STRINGi511145.b1813.

Proteomic databases

PaxDbiP43337.
PRIDEiP43337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74883; AAC74883; b1813.
BAA15620; BAA15620; BAA15620.
GeneIDi946330.
KEGGiecj:JW1802.
eco:b1813.
PATRICi32118945. VBIEscCol129921_1890.

Organism-specific databases

EchoBASEiEB2556.
EcoGeneiEG12693. nudL.

Phylogenomic databases

eggNOGiENOG4105P8F. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000250455.
InParanoidiP43337.
OMAiWRDHGDH.
PhylomeDBiP43337.

Enzyme and pathway databases

BioCyciEcoCyc:EG12693-MONOMER.
ECOL316407:JW1802-MONOMER.
MetaCyc:EG12693-MONOMER.

Miscellaneous databases

PROiP43337.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_01592. Nudix_NudL. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR000059. NUDIX_hydrolase_NudL_CS.
IPR023735. Nudix_NudL.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS01293. NUDIX_COA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDL_ECOLI
AccessioniPrimary (citable) accession number: P43337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.