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Protein

ATP-dependent RNA helicase HrpA

Gene

hrpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Not yet known.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: EcoCyc
  • helicase activity Source: EcoliWiki
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • mRNA processing Source: EcoCyc
  • RNA modification Source: EcoliWiki

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6732-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase HrpA (EC:3.6.4.13)
Gene namesi
Name:hrpA
Ordered Locus Names:b1413, JW5905
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12936 hrpA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551781 – 1300ATP-dependent RNA helicase HrpAAdd BLAST1300

Proteomic databases

PaxDbiP43329
PRIDEiP43329

Interactioni

Protein-protein interaction databases

BioGridi4261507, 128 interactors
DIPiDIP-9937N
IntActiP43329, 26 interactors
STRINGi316385.ECDH10B_1539

Structurei

3D structure databases

ProteinModelPortaliP43329
SMRiP43329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 250Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST164
Domaini274 – 444Helicase C-terminalPROSITE-ProRule annotationAdd BLAST171

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi197 – 200DEAH box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CQ7 Bacteria
COG1643 LUCA
HOGENOMiHOG000247272
InParanoidiP43329
KOiK03578
OMAiYIKLMTD
PhylomeDBiP43329

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011545 DEAD/DEAH_box_helicase_dom
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR024590 HrpA_C
IPR027417 P-loop_NTPase
IPR010222 RNA_helicase_HrpA
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF11898 DUF3418, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01967 DEAH_box_HrpA, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

P43329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQQKLTFT ALQQRLDSLM LRDRLRFSRR LHGVKKVKNP DAQQAIFQEM
60 70 80 90 100
AKEIDQAAGK VLLREAARPE ITYPDNLPVS QKKQDILEAI RDHQVVIVAG
110 120 130 140 150
ETGSGKTTQL PKICMELGRG IKGLIGHTQP RRLAARTVAN RIAEELKTEP
160 170 180 190 200
GGCIGYKVRF SDHVSDNTMV KLMTDGILLA EIQQDRLLMQ YDTIIIDEAH
210 220 230 240 250
ERSLNIDFLL GYLKELLPRR PDLKIIITSA TIDPERFSRH FNNAPIIEVS
260 270 280 290 300
GRTYPVEVRY RPIVEEADDT ERDQLQAIFD AVDELSQESH GDILIFMSGE
310 320 330 340 350
REIRDTADAL NKLNLRHTEI LPLYARLSNS EQNRVFQSHS GRRIVLATNV
360 370 380 390 400
AETSLTVPGI KYVIDPGTAR ISRYSYRTKV QRLPIEPISQ ASANQRKGRC
410 420 430 440 450
GRVSEGICIR LYSEDDFLSR PEFTDPEILR TNLASVILQM TALGLGDIAA
460 470 480 490 500
FPFVEAPDKR NIQDGVRLLE ELGAITTDEQ ASAYKLTPLG RQLSQLPVDP
510 520 530 540 550
RLARMVLEAQ KHGCVREAMI ITSALSIQDP RERPMDKQQA SDEKHRRFHD
560 570 580 590 600
KESDFLAFVN LWNYLGEQQK ALSSNAFRRL CRTDYLNYLR VREWQDIYTQ
610 620 630 640 650
LRQVVKELGI PVNSEPAEYR EIHIALLTGL LSHIGMKDAD KQEYTGARNA
660 670 680 690 700
RFSIFPGSGL FKKPPKWVMV AELVETSRLW GRIAARIDPE WVEPVAQHLI
710 720 730 740 750
KRTYSEPHWE RAQGAVMATE KVTVYGLPIV AARKVNYSQI DPALCRELFI
760 770 780 790 800
RHALVEGDWQ TRHAFFRENL KLRAEVEELE HKSRRRDILV DDETLFEFYD
810 820 830 840 850
QRISHDVISA RHFDSWWKKV SRETPDLLNF EKSMLIKEGA EKISKLDYPN
860 870 880 890 900
FWHQGNLKLR LSYQFEPGAD ADGVTVHIPL PLLNQVEESG FEWQIPGLRR
910 920 930 940 950
ELVIALIKSL PKPVRRNFVP APNYAEAFLG RVKPLELPLL DSLERELRRM
960 970 980 990 1000
TGVTVDREDW HWDQVPDHLK ITFRVVDDKN KKLKEGRSLQ DLKDALKGKV
1010 1020 1030 1040 1050
QETLSAVADD GIEQSGLHIW SFGQLPESYE QKRGNYKVKA WPALVDERDS
1060 1070 1080 1090 1100
VAIKLFDNPL EQKQAMWNGL RRLLLLNIPS PIKYLHEKLP NKAKLGLYFN
1110 1120 1130 1140 1150
PYGKVLELID DCISCGVDKL IDANGGPVWT EEGFAALHEK VRAELNDTVV
1160 1170 1180 1190 1200
DIAKQVEQIL TAVFNINKRL KGRVDMTMAL GLSDIKAQMG GLVYRGFVTG
1210 1220 1230 1240 1250
NGFKRLGDTL RYLQAIEKRL EKLAVDPHRD RAQMLKVENV QQAWQQWINK
1260 1270 1280 1290 1300
LPPARREDED VKEIRWMIEE LRVSYFAQQL GTPYPISDKR ILQAMEQISG
Length:1,300
Mass (Da):149,028
Last modified:April 27, 2001 - v3
Checksum:iA26601266D771638
GO

Sequence cautioni

The sequence BAA07685 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA15029 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152G → V in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti202R → H in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti301Missing in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti304R → P in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti681 – 694GRIAA…EWVEP → AHCCVSTRNGGA (PubMed:7899078).CuratedAdd BLAST14
Sequence conflicti705S → T in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti712 – 713AQ → E in BAA07685 (PubMed:7899078).Curated2
Sequence conflicti869A → P in BAA07685 (PubMed:7899078).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42105 Genomic DNA Translation: BAA07685.1 Different initiation.
U00096 Genomic DNA Translation: AAC74495.2
AP009048 Genomic DNA Translation: BAA15029.1 Different initiation.
PIRiH64892
RefSeqiNP_415931.4, NC_000913.3
WP_000139543.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74495; AAC74495; b1413
BAA15029; BAA15029; BAA15029
GeneIDi948444
KEGGiecj:JW5905
eco:b1413
PATRICifig|1411691.4.peg.858

Similar proteinsi

Entry informationi

Entry nameiHRPA_ECOLI
AccessioniPrimary (citable) accession number: P43329
Secondary accession number(s): P76861, P76863, P77479
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: March 28, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health