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Protein

Uncharacterized fimbrial-like protein YraK

Gene

yraK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon.1 Publication

GO - Biological processi

  • cell adhesion involved in single-species biofilm formation Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7640-MONOMER.
ECOL316407:JW3114-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YraK
Gene namesi
Name:yraK
Ordered Locus Names:b3145, JW3114
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12776. yraK.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020PROSITE-ProRule annotationAdd
BLAST
Chaini21 – 363343Uncharacterized fimbrial-like protein YraKPRO_0000013908Add
BLAST

Proteomic databases

PaxDbiP43319.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261994. 426 interactions.
STRINGi511145.b3145.

Structurei

3D structure databases

ProteinModelPortaliP43319.
SMRiP43319. Positions 216-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105I74. Bacteria.
ENOG4111TBD. LUCA.
HOGENOMiHOG000009602.
OMAiTHHTDAN.
OrthoDBiEOG615VFM.
PhylomeDBiP43319.

Family and domain databases

InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAPLITGL LLISTSCAYA SSGGCGADST SGATNYSSVV DDVTVNQTDN
60 70 80 90 100
VTGREFTSAT LSSTNWQYAC SCSAGKAVKL VYMVSPVLTT TGHQTGYYKL
110 120 130 140 150
NDSLDIKTTL QANDIPGLTT DQVVSVNTRF TQIKNNTVYS AATQTGVCQG
160 170 180 190 200
DTSRYGPVNI GANTTFTLYV TKPFLGSMTI PKTDIAVIKG AWVDGMGSPS
210 220 230 240 250
TGDFHDLVKL SIQGNLTAPQ SCKINQGDVI KVNFGFINGQ KFTTRNAMPD
260 270 280 290 300
GFTPVDFDIT YDCGDTSKIK NSLQMRIDGT TGVVDQYNLV ARRRSSDNVP
310 320 330 340 350
DVGIRIENLG GGVANIPFQN GILPVDPSGH GTVNMRAWPV NLVGGELETG
360
KFQGTATITV IVR
Length:363
Mass (Da):38,535
Last modified:November 1, 1995 - v1
Checksum:i33CAE8050D4088E2
GO

Sequence cautioni

The sequence AAA57948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57948.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76179.1.
AP009048 Genomic DNA. Translation: BAE77191.1.
PIRiE65104.
RefSeqiNP_417614.1. NC_000913.3.
WP_000816992.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76179; AAC76179; b3145.
BAE77191; BAE77191; BAE77191.
GeneIDi947654.
KEGGiecj:JW3114.
eco:b3145.
PATRICi32121708. VBIEscCol129921_3240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57948.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76179.1.
AP009048 Genomic DNA. Translation: BAE77191.1.
PIRiE65104.
RefSeqiNP_417614.1. NC_000913.3.
WP_000816992.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP43319.
SMRiP43319. Positions 216-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261994. 426 interactions.
STRINGi511145.b3145.

Proteomic databases

PaxDbiP43319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76179; AAC76179; b3145.
BAE77191; BAE77191; BAE77191.
GeneIDi947654.
KEGGiecj:JW3114.
eco:b3145.
PATRICi32121708. VBIEscCol129921_3240.

Organism-specific databases

EchoBASEiEB2629.
EcoGeneiEG12776. yraK.

Phylogenomic databases

eggNOGiENOG4105I74. Bacteria.
ENOG4111TBD. LUCA.
HOGENOMiHOG000009602.
OMAiTHHTDAN.
OrthoDBiEOG615VFM.
PhylomeDBiP43319.

Enzyme and pathway databases

BioCyciEcoCyc:G7640-MONOMER.
ECOL316407:JW3114-MONOMER.

Miscellaneous databases

PROiP43319.

Family and domain databases

InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
    Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
    Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYRAK_ECOLI
AccessioniPrimary (citable) accession number: P43319
Secondary accession number(s): Q2M965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 13, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.