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Protein

Uncharacterized fimbrial-like protein YraK

Gene

yraK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

GO - Biological processi

  • cell adhesion involved in single-species biofilm formation Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7640-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein YraK
Gene namesi
Name:yraK
Ordered Locus Names:b3145, JW3114
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12776 yraK

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20PROSITE-ProRule annotationAdd BLAST20
ChainiPRO_000001390821 – 363Uncharacterized fimbrial-like protein YraKAdd BLAST343

Proteomic databases

PaxDbiP43319
PRIDEiP43319

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261994, 426 interactors
STRINGi316385.ECDH10B_3318

Structurei

3D structure databases

ProteinModelPortaliP43319
SMRiP43319
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105I74 Bacteria
ENOG4111TBD LUCA
HOGENOMiHOG000009602
OMAiNISMTAY
PhylomeDBiP43319

Family and domain databases

Gene3Di2.60.40.1090, 1 hit
InterProiView protein in InterPro
IPR000259 Adhesion_dom_fimbrial
IPR036937 Adhesion_dom_fimbrial_sf
IPR008966 Adhesion_dom_sf
PfamiView protein in Pfam
PF00419 Fimbrial, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRAPLITGL LLISTSCAYA SSGGCGADST SGATNYSSVV DDVTVNQTDN
60 70 80 90 100
VTGREFTSAT LSSTNWQYAC SCSAGKAVKL VYMVSPVLTT TGHQTGYYKL
110 120 130 140 150
NDSLDIKTTL QANDIPGLTT DQVVSVNTRF TQIKNNTVYS AATQTGVCQG
160 170 180 190 200
DTSRYGPVNI GANTTFTLYV TKPFLGSMTI PKTDIAVIKG AWVDGMGSPS
210 220 230 240 250
TGDFHDLVKL SIQGNLTAPQ SCKINQGDVI KVNFGFINGQ KFTTRNAMPD
260 270 280 290 300
GFTPVDFDIT YDCGDTSKIK NSLQMRIDGT TGVVDQYNLV ARRRSSDNVP
310 320 330 340 350
DVGIRIENLG GGVANIPFQN GILPVDPSGH GTVNMRAWPV NLVGGELETG
360
KFQGTATITV IVR
Length:363
Mass (Da):38,535
Last modified:November 1, 1995 - v1
Checksum:i33CAE8050D4088E2
GO

Sequence cautioni

The sequence AAA57948 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57948.1 Different initiation.
U00096 Genomic DNA Translation: AAC76179.1
AP009048 Genomic DNA Translation: BAE77191.1
PIRiE65104
RefSeqiNP_417614.1, NC_000913.3
WP_000816992.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76179; AAC76179; b3145
BAE77191; BAE77191; BAE77191
GeneIDi947654
KEGGiecj:JW3114
eco:b3145
PATRICifig|1411691.4.peg.3585

Similar proteinsi

Entry informationi

Entry nameiYRAK_ECOLI
AccessioniPrimary (citable) accession number: P43319
Secondary accession number(s): Q2M965
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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