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P43317

- GUN5_HYPJE

UniProt

P43317 - GUN5_HYPJE

Protein

Endoglucanase-5

Gene

egl5

Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei27 – 271NucleophilePROSITE-ProRule annotation
    Active sitei134 – 1341Proton donorBy similarity

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC
    2. cellulose binding Source: InterPro

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-16505.

    Protein family/group databases

    CAZyiCBM1. Carbohydrate-Binding Module Family 1.
    GH45. Glycoside Hydrolase Family 45.
    mycoCLAPiEGL45E_TRIRE.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase-5 (EC:3.2.1.4)
    Alternative name(s):
    Cellulase V
    Endo-1,4-beta-glucanase V
    Short name:
    EG V
    Endoglucanase V
    Gene namesi
    Name:egl5
    OrganismiHypocrea jecorina (Trichoderma reesei)
    Taxonomic identifieri51453 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 242225Endoglucanase-5PRO_0000008022Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi213 ↔ 230PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 240PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi51453.JGI49976.

    Structurei

    3D structure databases

    ProteinModelPortaliP43317.
    SMRiP43317. Positions 207-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini205 – 24137CBM1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni18 – 182165CatalyticAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi183 – 20523Pro/Ser-rich (linker)Add
    BLAST

    Sequence similaritiesi

    Contains 1 CBM1 (fungal-type carbohydrate-binding) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG321569.
    OMAiCPGQATS.

    Family and domain databases

    Gene3Di2.40.40.10. 1 hit.
    InterProiIPR014733. Barwin-like_endoglucanase.
    IPR000254. Cellulose-bd_dom_fun.
    IPR007112. Expansin/allergen_DPBB_dom.
    IPR000334. Glyco_hydro_45.
    IPR009009. RlpA-like_DPBB.
    [Graphical view]
    PfamiPF00734. CBM_1. 1 hit.
    PF02015. Glyco_hydro_45. 1 hit.
    [Graphical view]
    ProDomiPD001821. CBD_fun. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00236. fCBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF50685. SSF50685. 1 hit.
    SSF57180. SSF57180. 1 hit.
    PROSITEiPS00562. CBM1_1. 1 hit.
    PS51164. CBM1_2. 1 hit.
    PS50842. EXPANSIN_EG45. 1 hit.
    PS01140. GLYCOSYL_HYDROL_F45. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43317-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKATLVLGSL IVGAVSAYKA TTTRYYDGQE GACGCGSSSG AFPWQLGIGN    50
    GVYTAAGSQA LFDTAGASWC GAGCGKCYQL TSTGQAPCSS CGTGGAAGQS 100
    IIVMVTNLCP NNGNAQWCPV VGGTNQYGYS YHFDIMAQNE IFGDNVVVDF 150
    EPIACPGQAA SDWGTCLCVG QQETDPTPVL GNDTGSTPPG SSPPATSSSP 200
    PSGGGQQTLY GQCGGAGWTG PTTCQAPGTC KVQNQWYSQC LP 242
    Length:242
    Mass (Da):24,411
    Last modified:November 1, 1995 - v1
    Checksum:iCC033FC51326C71D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z33381 Genomic DNA. Translation: CAA83846.1.
    PIRiS60143.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z33381 Genomic DNA. Translation: CAA83846.1 .
    PIRi S60143.

    3D structure databases

    ProteinModelPortali P43317.
    SMRi P43317. Positions 207-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 51453.JGI49976.

    Protein family/group databases

    CAZyi CBM1. Carbohydrate-Binding Module Family 1.
    GH45. Glycoside Hydrolase Family 45.
    mycoCLAPi EGL45E_TRIRE.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG321569.
    OMAi CPGQATS.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-16505.

    Family and domain databases

    Gene3Di 2.40.40.10. 1 hit.
    InterProi IPR014733. Barwin-like_endoglucanase.
    IPR000254. Cellulose-bd_dom_fun.
    IPR007112. Expansin/allergen_DPBB_dom.
    IPR000334. Glyco_hydro_45.
    IPR009009. RlpA-like_DPBB.
    [Graphical view ]
    Pfami PF00734. CBM_1. 1 hit.
    PF02015. Glyco_hydro_45. 1 hit.
    [Graphical view ]
    ProDomi PD001821. CBD_fun. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00236. fCBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50685. SSF50685. 1 hit.
    SSF57180. SSF57180. 1 hit.
    PROSITEi PS00562. CBM1_1. 1 hit.
    PS51164. CBM1_2. 1 hit.
    PS50842. EXPANSIN_EG45. 1 hit.
    PS01140. GLYCOSYL_HYDROL_F45. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel, small endoglucanase gene, egl5, from Trichoderma reesei isolated by expression in yeast."
      Saloheimo A., Henrissat B., Hoffren A.-M., Teleman O., Penttilae M.
      Mol. Microbiol. 13:219-228(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 26921 / CBS 392.92 / QM9414.

    Entry informationi

    Entry nameiGUN5_HYPJE
    AccessioniPrimary (citable) accession number: P43317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3