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P43317

- GUN5_HYPJE

UniProt

P43317 - GUN5_HYPJE

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Protein

Endoglucanase-5

Gene

egl5

Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei27 – 271NucleophilePROSITE-ProRule annotation
Active sitei134 – 1341Proton donorBy similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC
  2. cellulose binding Source: InterPro

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16505.

Protein family/group databases

CAZyiCBM1. Carbohydrate-Binding Module Family 1.
GH45. Glycoside Hydrolase Family 45.
mycoCLAPiEGL45E_TRIRE.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase-5 (EC:3.2.1.4)
Alternative name(s):
Cellulase V
Endo-1,4-beta-glucanase V
Short name:
EG V
Endoglucanase V
Gene namesi
Name:egl5
OrganismiHypocrea jecorina (Trichoderma reesei)
Taxonomic identifieri51453 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 242225Endoglucanase-5PRO_0000008022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi213 ↔ 230PROSITE-ProRule annotation
Disulfide bondi224 ↔ 240PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi51453.JGI49976.

Structurei

3D structure databases

ProteinModelPortaliP43317.
SMRiP43317. Positions 207-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini205 – 24137CBM1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni18 – 182165CatalyticAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 20523Pro/Ser-rich (linker)Add
BLAST

Sequence similaritiesi

Contains 1 CBM1 (fungal-type carbohydrate-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG321569.
OMAiCPGQATS.

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
InterProiIPR014733. Barwin-like_endoglucanase.
IPR000254. Cellulose-bd_dom_fun.
IPR007112. Expansin/allergen_DPBB_dom.
IPR000334. Glyco_hydro_45.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF00734. CBM_1. 1 hit.
PF02015. Glyco_hydro_45. 1 hit.
[Graphical view]
ProDomiPD001821. CBD_fun. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00236. fCBD. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.
SSF57180. SSF57180. 1 hit.
PROSITEiPS00562. CBM1_1. 1 hit.
PS51164. CBM1_2. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
PS01140. GLYCOSYL_HYDROL_F45. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43317-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKATLVLGSL IVGAVSAYKA TTTRYYDGQE GACGCGSSSG AFPWQLGIGN
60 70 80 90 100
GVYTAAGSQA LFDTAGASWC GAGCGKCYQL TSTGQAPCSS CGTGGAAGQS
110 120 130 140 150
IIVMVTNLCP NNGNAQWCPV VGGTNQYGYS YHFDIMAQNE IFGDNVVVDF
160 170 180 190 200
EPIACPGQAA SDWGTCLCVG QQETDPTPVL GNDTGSTPPG SSPPATSSSP
210 220 230 240
PSGGGQQTLY GQCGGAGWTG PTTCQAPGTC KVQNQWYSQC LP
Length:242
Mass (Da):24,411
Last modified:November 1, 1995 - v1
Checksum:iCC033FC51326C71D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33381 Genomic DNA. Translation: CAA83846.1.
PIRiS60143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33381 Genomic DNA. Translation: CAA83846.1 .
PIRi S60143.

3D structure databases

ProteinModelPortali P43317.
SMRi P43317. Positions 207-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 51453.JGI49976.

Protein family/group databases

CAZyi CBM1. Carbohydrate-Binding Module Family 1.
GH45. Glycoside Hydrolase Family 45.
mycoCLAPi EGL45E_TRIRE.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG321569.
OMAi CPGQATS.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-16505.

Family and domain databases

Gene3Di 2.40.40.10. 1 hit.
InterProi IPR014733. Barwin-like_endoglucanase.
IPR000254. Cellulose-bd_dom_fun.
IPR007112. Expansin/allergen_DPBB_dom.
IPR000334. Glyco_hydro_45.
IPR009009. RlpA-like_DPBB.
[Graphical view ]
Pfami PF00734. CBM_1. 1 hit.
PF02015. Glyco_hydro_45. 1 hit.
[Graphical view ]
ProDomi PD001821. CBD_fun. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00236. fCBD. 1 hit.
[Graphical view ]
SUPFAMi SSF50685. SSF50685. 1 hit.
SSF57180. SSF57180. 1 hit.
PROSITEi PS00562. CBM1_1. 1 hit.
PS51164. CBM1_2. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
PS01140. GLYCOSYL_HYDROL_F45. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel, small endoglucanase gene, egl5, from Trichoderma reesei isolated by expression in yeast."
    Saloheimo A., Henrissat B., Hoffren A.-M., Teleman O., Penttilae M.
    Mol. Microbiol. 13:219-228(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26921 / CBS 392.92 / QM9414.

Entry informationi

Entry nameiGUN5_HYPJE
AccessioniPrimary (citable) accession number: P43317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3