Reviewed,
UniProtKB/Swiss-Prot P43317 (GUN5_TRIRE)
Last modified
June 16, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Endoglucanase-5 EC=3.2.1.4 Alternative name(s): Endoglucanase V Endo-1,4-beta-glucanase V Short name=EG V Cellulase V | ||
| Gene names |
| ||
| Organism | Trichoderma reesei (Hypocrea jecorina) | ||
| Taxonomic identifier | 51453 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Hypocreaceae › Hypocrea |
Protein attributes
| Sequence length | 242 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. |
| Sequence similarities | Belongs to the glycosyl hydrolase 45 (cellulase K) family. Contains 1 CBM1 (fungal-type carbohydrate-binding) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Cellulose degradation Polysaccharide degradation |
| Domain | Signal |
| Molecular function | Glycosidase Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | cellulose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: InterPro |
| Molecular function | cellulase activity Inferred from electronic annotation. Source: EC cellulose bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | ||||||||
| Chain | 18 – 242 | 225 | Endoglucanase-5 | PRO_0000008022 | |||||||
Regions | |||||||||||
| Domain | 205 – 241 | 37 | CBM1 | ||||||||
| Region | 18 – 182 | 165 | Catalytic | ||||||||
| Compositional bias | 183 – 205 | 23 | Pro/Ser-rich (linker) | ||||||||
Sites | |||||||||||
| Active site | 27 | 1 | Nucleophile By similarity | ||||||||
| Active site | 134 | 1 | Proton donor By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 182 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 213 ↔ 230 | By similarity | |||||||||
| Disulfide bond | 224 ↔ 240 | By similarity | |||||||||
Sequences
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References
| [1] | "A novel, small endoglucanase gene, egl5, from Trichoderma reesei isolated by expression in yeast." Saloheimo A., Henrissat B., Hoffren A.-M., Teleman O., Penttilae M. Mol. Microbiol. 13:219-228(1994) [PubMed: 7984103] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: QM9414 / Rut C-30. |
Cross-references
Sequence databases | |
|---|---|
| Z33381 Genomic DNA. Translation: CAA83846.1. | |
| PIR | S60143. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2CBH based on UniProtKB P00725. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | CBM1. Carbohydrate-Binding Module Family 1. GH45. Glycoside Hydrolase Family 45. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.4. 280374. |
Family and domain databases | |
| InterPro | IPR000254. CBD_fun. IPR007112. Expan_endogl. IPR000334. Glyco_hydro_45. [Graphical view] |
| Pfam | PF00734. CBM_1. 1 hit. PF02015. Glyco_hydro_45. 1 hit. [Graphical view] |
| ProDom | PD001821. CBD_fungal. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00236. fCBD. 1 hit. [Graphical view] |
| PROSITE | PS00562. CBM1_1. 1 hit. PS51164. CBM1_2. 1 hit. PS50842. EXPANSIN_EG45. 1 hit. PS01140. GLYCOSYL_HYDROL_F45. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GUN5_TRIRE | ||||||||
| Accession | Primary (citable) accession number: P43317 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


