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Protein

Endoglucanase-5

Gene
N/A
Organism
Humicola insolens (Soft-rot fungus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10Nucleophile1
Active sitei121Proton donor1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiCBM1. Carbohydrate-Binding Module Family 1.
GH45. Glycoside Hydrolase Family 45.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase-5 (EC:3.2.1.4)
Alternative name(s):
Cellulase V
Endo-1,4-beta-glucanase V
Short name:
EG V
Endoglucanase V
OrganismiHumicola insolens (Soft-rot fungus)
Taxonomic identifieri34413 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesChaetomiaceaeHumicola

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840741 – 213Endoglucanase-5Add BLAST213

Interactioni

Chemistry databases

BindingDBiP43316.

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 8Combined sources7
Helixi15 – 17Combined sources3
Beta strandi21 – 26Combined sources6
Beta strandi62 – 65Combined sources4
Beta strandi68 – 76Combined sources9
Helixi82 – 85Combined sources4
Beta strandi89 – 94Combined sources6
Helixi97 – 99Combined sources3
Beta strandi103 – 110Combined sources8
Beta strandi119 – 123Combined sources5
Turni130 – 132Combined sources3
Helixi135 – 139Combined sources5
Beta strandi143 – 145Combined sources3
Turni146 – 148Combined sources3
Helixi153 – 158Combined sources6
Helixi161 – 163Combined sources3
Helixi164 – 171Combined sources8
Turni172 – 176Combined sources5
Beta strandi181 – 187Combined sources7
Helixi191 – 197Combined sources7
Helixi204 – 206Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HD5X-ray1.66A5-213[»]
2ENGX-ray1.50A1-210[»]
3ENGX-ray1.90A1-213[»]
4ENGX-ray1.90A1-210[»]
ProteinModelPortaliP43316.
SMRiP43316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43316.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
InterProiIPR000334. Glyco_hydro_45.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF02015. Glyco_hydro_45. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.
PROSITEiPS01140. GLYCOSYL_HYDROL_F45. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ADGRSTRYWD CCKPSCGWAK KAPVNQPVFS CNANFQRITD FDAKSGCEPG
60 70 80 90 100
GVAYSCADQT PWAVNDDFAL GFAATSIAGS NEAGWCCACY ELTFTSGPVA
110 120 130 140 150
GKKMVVQSTS TGGDLGSNHF DLNIPGGGVG IFDGCTPQFG GLPGQRYGGI
160 170 180 190 200
SSRNECDRFP DALKPGCYWR FDWFKNADNP SFSFRQVQCP AELVARTGCR
210
RNDDGNFPAV QIP
Length:213
Mass (Da):22,864
Last modified:November 1, 1995 - v1
Checksum:i24334301BA3BC804
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HD5X-ray1.66A5-213[»]
2ENGX-ray1.50A1-210[»]
3ENGX-ray1.90A1-213[»]
4ENGX-ray1.90A1-210[»]
ProteinModelPortaliP43316.
SMRiP43316.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP43316.
ChEMBLiCHEMBL1795107.

Protein family/group databases

CAZyiCBM1. Carbohydrate-Binding Module Family 1.
GH45. Glycoside Hydrolase Family 45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP43316.

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
InterProiIPR000334. Glyco_hydro_45.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF02015. Glyco_hydro_45. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.
PROSITEiPS01140. GLYCOSYL_HYDROL_F45. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUN5_HUMIN
AccessioniPrimary (citable) accession number: P43316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.