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P43315

- BFR_MYCLE

UniProt

P43315 - BFR_MYCLE

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Protein

Bacterioferritin

Gene

bfr

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex (By similarity). Probably plays a crucial role in the intracellular existence of this organism by functioning as a temporary depository for iron in iron deprivation.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Binds 1 heme B (iron-protoporphyrin IX) group per dimer.By similarity
Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Iron 1PROSITE-ProRule annotation
Metal bindingi51 – 511Iron 1PROSITE-ProRule annotation
Metal bindingi51 – 511Iron 2PROSITE-ProRule annotation
Metal bindingi52 – 521Iron (heme axial ligand); shared with dimeric partnerPROSITE-ProRule annotation
Metal bindingi54 – 541Iron 1PROSITE-ProRule annotation
Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
Metal bindingi127 – 1271Iron 1PROSITE-ProRule annotation
Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation
Metal bindingi130 – 1301Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Alternative name(s):
Major membrane protein II
Short name:
MMP-II
Gene namesi
Name:bfr
Synonyms:bfrA
Ordered Locus Names:ML2038
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML2038.

Subcellular locationi

Cytoplasmcytosol Curated. Membrane Curated; Peripheral membrane protein Curated
Note: Soluble or peripheral membrane protein.Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159BacterioferritinPRO_0000192599Add
BLAST

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.By similarity

Protein-protein interaction databases

STRINGi272631.ML2038.

Structurei

3D structure databases

ProteinModelPortaliP43315.
SMRiP43315. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bacterioferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2193.
HOGENOMiHOG000262383.
KOiK03594.
OMAiAGDYVSM.
OrthoDBiEOG6WDSKP.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43315-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQGDPDVLRL LNEQLTSELT AINQYFLHSK MQENWGFTEL AERTRVESFD
60 70 80 90 100
EMRHAEAITD RILLLDGLPN YQRIGSLRVG QTLREQFEAD LAIEYEVMSR
110 120 130 140 150
LKPGIIMCRE KQDSTSAVLL EKIVADEEEH IDYLETQLAL MGQLGEELYS

AQCVSRPPS
Length:159
Mass (Da):18,263
Last modified:November 1, 1995 - v1
Checksum:iD07C474A65E3AD64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01095 Genomic DNA. Translation: AAA21339.1.
AL583924 Genomic DNA. Translation: CAC30993.1.
PIRiA87164.
RefSeqiNP_302363.1. NC_002677.1.
WP_010908683.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30993; CAC30993; CAC30993.
GeneIDi909017.
KEGGimle:ML2038.
PATRICi18057832. VBIMycLep78757_3840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01095 Genomic DNA. Translation: AAA21339.1 .
AL583924 Genomic DNA. Translation: CAC30993.1 .
PIRi A87164.
RefSeqi NP_302363.1. NC_002677.1.
WP_010908683.1. NC_002677.1.

3D structure databases

ProteinModelPortali P43315.
SMRi P43315. Positions 1-158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML2038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30993 ; CAC30993 ; CAC30993 .
GeneIDi 909017.
KEGGi mle:ML2038.
PATRICi 18057832. VBIMycLep78757_3840.

Organism-specific databases

Lepromai ML2038.

Phylogenomic databases

eggNOGi COG2193.
HOGENOMi HOG000262383.
KOi K03594.
OMAi AGDYVSM.
OrthoDBi EOG6WDSKP.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002560. Bacterioferritin. 1 hit.
PRINTSi PR00601. BACFERRITIN.
SUPFAMi SSF47240. SSF47240. 1 hit.
TIGRFAMsi TIGR00754. bfr. 1 hit.
PROSITEi PS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, characterization, gene sequence, and significance of a bacterioferritin from Mycobacterium leprae."
    Pessolani M.C.V., Smith D.R., Rivoire B., McCormick J., Hefta S.A., Cole S.T., Brennan P.J.
    J. Exp. Med. 180:319-327(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.
  3. "The major native proteins of the leprosy bacillus."
    Hunter S.W., Rivoire B., Mehra V., Bloom B.R., Brennan P.J.
    J. Biol. Chem. 265:14065-14068(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 1-14.

Entry informationi

Entry nameiBFR_MYCLE
AccessioniPrimary (citable) accession number: P43315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3