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P43315

- BFR_MYCLE

UniProt

P43315 - BFR_MYCLE

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Protein
Bacterioferritin
Gene
bfr, bfrA, ML2038
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex By similarity. Probably plays a crucial role in the intracellular existence of this organism by functioning as a temporary depository for iron in iron deprivation.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Iron 1 By similarity
Metal bindingi51 – 511Iron 1 By similarity
Metal bindingi51 – 511Iron 2 By similarity
Metal bindingi52 – 521Iron (heme axial ligand); shared with dimeric partner By similarity
Metal bindingi54 – 541Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi127 – 1271Iron 1 By similarity
Metal bindingi127 – 1271Iron 2 By similarity
Metal bindingi130 – 1301Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Alternative name(s):
Major membrane protein II
Short name:
MMP-II
Gene namesi
Name:bfr
Synonyms:bfrA
Ordered Locus Names:ML2038
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML2038.

Subcellular locationi

Cytoplasmcytosol Inferred. Membrane; Peripheral membrane protein Inferred
Note: Soluble or peripheral membrane protein Inferred.

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Bacterioferritin
PRO_0000192599Add
BLAST

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited By similarity.

Protein-protein interaction databases

STRINGi272631.ML2038.

Structurei

3D structure databases

ProteinModelPortaliP43315.
SMRiP43315. Positions 1-158.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the bacterioferritin family.

Phylogenomic databases

eggNOGiCOG2193.
HOGENOMiHOG000262383.
KOiK03594.
OMAiAGDYVSM.
OrthoDBiEOG6WDSKP.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43315-1 [UniParc]FASTAAdd to Basket

« Hide

MQGDPDVLRL LNEQLTSELT AINQYFLHSK MQENWGFTEL AERTRVESFD    50
EMRHAEAITD RILLLDGLPN YQRIGSLRVG QTLREQFEAD LAIEYEVMSR 100
LKPGIIMCRE KQDSTSAVLL EKIVADEEEH IDYLETQLAL MGQLGEELYS 150
AQCVSRPPS 159
Length:159
Mass (Da):18,263
Last modified:November 1, 1995 - v1
Checksum:iD07C474A65E3AD64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01095 Genomic DNA. Translation: AAA21339.1.
AL583924 Genomic DNA. Translation: CAC30993.1.
PIRiA87164.
RefSeqiNP_302363.1. NC_002677.1.
WP_010908683.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30993; CAC30993; CAC30993.
GeneIDi909017.
KEGGimle:ML2038.
PATRICi18057832. VBIMycLep78757_3840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01095 Genomic DNA. Translation: AAA21339.1 .
AL583924 Genomic DNA. Translation: CAC30993.1 .
PIRi A87164.
RefSeqi NP_302363.1. NC_002677.1.
WP_010908683.1. NC_002677.1.

3D structure databases

ProteinModelPortali P43315.
SMRi P43315. Positions 1-158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML2038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30993 ; CAC30993 ; CAC30993 .
GeneIDi 909017.
KEGGi mle:ML2038.
PATRICi 18057832. VBIMycLep78757_3840.

Organism-specific databases

Lepromai ML2038.

Phylogenomic databases

eggNOGi COG2193.
HOGENOMi HOG000262383.
KOi K03594.
OMAi AGDYVSM.
OrthoDBi EOG6WDSKP.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002560. Bacterioferritin. 1 hit.
PRINTSi PR00601. BACFERRITIN.
SUPFAMi SSF47240. SSF47240. 1 hit.
TIGRFAMsi TIGR00754. bfr. 1 hit.
PROSITEi PS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, characterization, gene sequence, and significance of a bacterioferritin from Mycobacterium leprae."
    Pessolani M.C.V., Smith D.R., Rivoire B., McCormick J., Hefta S.A., Cole S.T., Brennan P.J.
    J. Exp. Med. 180:319-327(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.
  3. "The major native proteins of the leprosy bacillus."
    Hunter S.W., Rivoire B., Mehra V., Bloom B.R., Brennan P.J.
    J. Biol. Chem. 265:14065-14068(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 1-14.

Entry informationi

Entry nameiBFR_MYCLE
AccessioniPrimary (citable) accession number: P43315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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