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Protein

Bacterioferritin

Gene

bfr

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex (By similarity). Probably plays a crucial role in the intracellular existence of this organism by functioning as a temporary depository for iron in iron deprivation.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.By similarity
  • Fe cationBy similarityNote: Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Iron 1PROSITE-ProRule annotation1
Metal bindingi51Iron 1PROSITE-ProRule annotation1
Metal bindingi51Iron 2PROSITE-ProRule annotation1
Metal bindingi52Iron (heme axial ligand); shared with dimeric partnerPROSITE-ProRule annotation1
Metal bindingi54Iron 1PROSITE-ProRule annotation1
Metal bindingi94Iron 2PROSITE-ProRule annotation1
Metal bindingi127Iron 1PROSITE-ProRule annotation1
Metal bindingi127Iron 2PROSITE-ProRule annotation1
Metal bindingi130Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Alternative name(s):
Major membrane protein II
Short name:
MMP-II
Gene namesi
Name:bfr
Synonyms:bfrA
Ordered Locus Names:ML2038
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2038.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001925991 – 159BacterioferritinAdd BLAST159

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.By similarity

Protein-protein interaction databases

STRINGi272631.ML2038.

Structurei

3D structure databases

ProteinModelPortaliP43315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 145Ferritin-like diironPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Belongs to the bacterioferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UQY. Bacteria.
COG2193. LUCA.
HOGENOMiHOG000262383.
KOiK03594.
OMAiEMKHADQ.
OrthoDBiPOG091H0B0I.

Family and domain databases

CDDicd00907. Bacterioferritin. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGDPDVLRL LNEQLTSELT AINQYFLHSK MQENWGFTEL AERTRVESFD
60 70 80 90 100
EMRHAEAITD RILLLDGLPN YQRIGSLRVG QTLREQFEAD LAIEYEVMSR
110 120 130 140 150
LKPGIIMCRE KQDSTSAVLL EKIVADEEEH IDYLETQLAL MGQLGEELYS

AQCVSRPPS
Length:159
Mass (Da):18,263
Last modified:November 1, 1995 - v1
Checksum:iD07C474A65E3AD64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01095 Genomic DNA. Translation: AAA21339.1.
AL583924 Genomic DNA. Translation: CAC30993.1.
PIRiA87164.
RefSeqiNP_302363.1. NC_002677.1.
WP_010908683.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30993; CAC30993; CAC30993.
GeneIDi909017.
KEGGimle:ML2038.
PATRICi18057832. VBIMycLep78757_3840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01095 Genomic DNA. Translation: AAA21339.1.
AL583924 Genomic DNA. Translation: CAC30993.1.
PIRiA87164.
RefSeqiNP_302363.1. NC_002677.1.
WP_010908683.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP43315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30993; CAC30993; CAC30993.
GeneIDi909017.
KEGGimle:ML2038.
PATRICi18057832. VBIMycLep78757_3840.

Organism-specific databases

LepromaiML2038.

Phylogenomic databases

eggNOGiENOG4108UQY. Bacteria.
COG2193. LUCA.
HOGENOMiHOG000262383.
KOiK03594.
OMAiEMKHADQ.
OrthoDBiPOG091H0B0I.

Family and domain databases

CDDicd00907. Bacterioferritin. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBFR_MYCLE
AccessioniPrimary (citable) accession number: P43315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.