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P43312

- SODF_HELPY

UniProt

P43312 - SODF_HELPY

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Protein

Superoxide dismutase [Fe]

Gene

sodB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261IronBy similarity
Metal bindingi73 – 731IronBy similarity
Metal bindingi156 – 1561IronBy similarity
Metal bindingi160 – 1601IronBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0389-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:sodB
Ordered Locus Names:HP_0389
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Superoxide dismutase [Fe]PRO_0000159985Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

DIPiDIP-3411N.
IntActiP43312. 4 interactions.
MINTiMINT-165096.
STRINGi85962.HP0389.

Structurei

Secondary structure

1
213
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni15 – 173Combined sources
Helixi20 – 267Combined sources
Turni27 – 293Combined sources
Helixi30 – 4213Combined sources
Turni46 – 494Combined sources
Helixi52 – 587Combined sources
Helixi61 – 7818Combined sources
Helixi89 – 9911Combined sources
Helixi102 – 11514Combined sources
Beta strandi118 – 1269Combined sources
Turni128 – 1303Combined sources
Beta strandi133 – 1397Combined sources
Helixi144 – 1474Combined sources
Beta strandi150 – 1567Combined sources
Helixi159 – 1613Combined sources
Helixi163 – 1664Combined sources
Helixi170 – 17910Combined sources
Helixi183 – 19614Combined sources
Helixi199 – 20810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CEIX-ray2.40A/B1-212[»]
ProteinModelPortaliP43312.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43312.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43312-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFTLRELPFA KDSMGDFLSP VAFDFHHGKH HQTYVNNLNN LIKGTDFEKS
60 70 80 90 100
SLFDILTKSS GGVFNNAAQI YNHDFYWDCL SPKATALSDE LKGALEKDFG
110 120 130 140 150
SLEKFKEDFI KSATTLFGSG WNWAAYNLDT QKIEIIQTSN AQTPVTDKKV
160 170 180 190 200
PLLVVDVWEH AYYIDHKNAR PVYLEKFYGH INWHFVSQCY EWAKKEGLGS
210
VDYYINELVH KKA
Length:213
Mass (Da):24,518
Last modified:November 1, 1995 - v1
Checksum:i59ABCC4C82C2B1B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041K → Q in AAD07454. (PubMed:9252185)Curated
Sequence conflicti112 – 1121S → R in CAA51195. (PubMed:8225605)Curated
Sequence conflicti124 – 1241A → V in AAD07454. (PubMed:9252185)Curated
Sequence conflicti125 – 1251A → P in CAA51195. (PubMed:8225605)Curated
Sequence conflicti179 – 1791G → E in AAD07454. (PubMed:9252185)Curated
Sequence conflicti213 – 2131A → LE in CAA51195. (PubMed:8225605)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24801 Unassigned DNA. Translation: AAC36885.1.
X72618 Genomic DNA. Translation: CAA51195.1.
AE000511 Genomic DNA. Translation: AAD07454.1.
AJ132687 Genomic DNA. Translation: CAA10728.1.
PIRiE64568.
RefSeqiNP_207187.1. NC_000915.1.
YP_006934313.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07454; AAD07454; HP_0389.
GeneIDi13869575.
900274.
KEGGiheo:C694_01975.
hpy:HP0389.
PATRICi20592017. VBIHelPyl33062_0402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24801 Unassigned DNA. Translation: AAC36885.1 .
X72618 Genomic DNA. Translation: CAA51195.1 .
AE000511 Genomic DNA. Translation: AAD07454.1 .
AJ132687 Genomic DNA. Translation: CAA10728.1 .
PIRi E64568.
RefSeqi NP_207187.1. NC_000915.1.
YP_006934313.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CEI X-ray 2.40 A/B 1-212 [» ]
ProteinModelPortali P43312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3411N.
IntActi P43312. 4 interactions.
MINTi MINT-165096.
STRINGi 85962.HP0389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07454 ; AAD07454 ; HP_0389 .
GeneIDi 13869575.
900274.
KEGGi heo:C694_01975.
hpy:HP0389.
PATRICi 20592017. VBIHelPyl33062_0402.

Phylogenomic databases

eggNOGi COG0605.
KOi K04564.
OrthoDBi EOG63NMNT.

Enzyme and pathway databases

BioCyci HPY:HP0389-MONOMER.

Miscellaneous databases

EvolutionaryTracei P43312.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic organization and enzymatic activity of a superoxide dismutase from the microaerophilic human pathogen, Helicobacter pylori."
    Pesci E.C., Pickett C.L.
    Gene 143:111-116(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene."
    Spiegelhalder C., Gerstenecker B., Kersten A., Schiltz E., Kist M.
    Infect. Immun. 61:5315-5325(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: 2012.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  4. "Identification and molecular analysis of superoxide dismutase isoforms in Helicobacter pylori."
    Bereswill S., Neuner O., Strobel S., Kist M.
    FEMS Microbiol. Lett. 183:241-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 151.

Entry informationi

Entry nameiSODF_HELPY
AccessioniPrimary (citable) accession number: P43312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3