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P43312 (SODF_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Fe]

EC=1.15.1.1
Gene names
Name:sodB
Ordered Locus Names:HP_0389
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 iron ion per subunit By similarity.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Superoxide dismutase [Fe]
PRO_0000159985

Sites

Metal binding261Iron By similarity
Metal binding731Iron By similarity
Metal binding1561Iron By similarity
Metal binding1601Iron By similarity

Experimental info

Sequence conflict1041K → Q in AAD07454. Ref.3
Sequence conflict1121S → R in CAA51195. Ref.2
Sequence conflict1241A → V in AAD07454. Ref.3
Sequence conflict1251A → P in CAA51195. Ref.2
Sequence conflict1791G → E in AAD07454. Ref.3
Sequence conflict2131A → LE in CAA51195. Ref.2

Secondary structure

..................................... 213
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43312 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 59ABCC4C82C2B1B2

FASTA21324,518
        10         20         30         40         50         60 
MFTLRELPFA KDSMGDFLSP VAFDFHHGKH HQTYVNNLNN LIKGTDFEKS SLFDILTKSS 

        70         80         90        100        110        120 
GGVFNNAAQI YNHDFYWDCL SPKATALSDE LKGALEKDFG SLEKFKEDFI KSATTLFGSG 

       130        140        150        160        170        180 
WNWAAYNLDT QKIEIIQTSN AQTPVTDKKV PLLVVDVWEH AYYIDHKNAR PVYLEKFYGH 

       190        200        210 
INWHFVSQCY EWAKKEGLGS VDYYINELVH KKA 

« Hide

References

« Hide 'large scale' references
[1]"Genetic organization and enzymatic activity of a superoxide dismutase from the microaerophilic human pathogen, Helicobacter pylori."
Pesci E.C., Pickett C.L.
Gene 143:111-116(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene."
Spiegelhalder C., Gerstenecker B., Kersten A., Schiltz E., Kist M.
Infect. Immun. 61:5315-5325(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
Strain: 2012.
[3]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
[4]"Identification and molecular analysis of superoxide dismutase isoforms in Helicobacter pylori."
Bereswill S., Neuner O., Strobel S., Kist M.
FEMS Microbiol. Lett. 183:241-245(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 151.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L24801 Unassigned DNA. Translation: AAC36885.1.
X72618 Genomic DNA. Translation: CAA51195.1.
AE000511 Genomic DNA. Translation: AAD07454.1.
AJ132687 Genomic DNA. Translation: CAA10728.1.
PIRE64568.
RefSeqNP_207187.1. NC_000915.1.
YP_006934313.1. NC_018939.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3CEIX-ray2.40A/B1-212[»]
ProteinModelPortalP43312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3411N.
IntActP43312. 4 interactions.
MINTMINT-165096.
STRING85962.HP0389.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07454; AAD07454; HP_0389.
GeneID900274.
KEGGheo:C694_01975.
hpy:HP0389.
PATRIC20592017. VBIHelPyl33062_0402.

Phylogenomic databases

eggNOGCOG0605.
KOK04564.
OrthoDBEOG63NMNT.

Enzyme and pathway databases

BioCycHPY:HP0389-MONOMER.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERPTHR11404. PTHR11404. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
PRINTSPR01703. MNSODISMTASE.
SUPFAMSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP43312.

Entry information

Entry nameSODF_HELPY
AccessionPrimary (citable) accession number: P43312
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names