Superoxide dismutase [Fe] - Helicobacter pylori (strain ATCC 700392 / 26695)

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P43312 (SODF_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Fe]
EC=1.15.1.1

Gene names

Name:	sodB
Ordered Locus Names:	HP_0389

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H⁺ = O₂ + H₂O₂.
Cofactor	Binds 1 iron ion per subunit By similarity.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 213

213

Superoxide dismutase [Fe]

PRO_0000159985

Sites

Metal binding

Iron By similarity

Metal binding

Iron By similarity

Metal binding

156

Iron By similarity

Metal binding

160

Iron By similarity

Experimental info

Sequence conflict

104

K → Q in AAD07454. Ref.3

Sequence conflict

112

S → R in CAA51195. Ref.2

Sequence conflict

124

A → V in AAD07454. Ref.3

Sequence conflict

125

A → P in CAA51195. Ref.2

Sequence conflict

179

G → E in AAD07454. Ref.3

Sequence conflict

213

A → LE in CAA51195. Ref.2

Secondary structure

213

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P43312 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 59ABCC4C82C2B1B2
Show »

FASTA

213

24,518

        10         20         30         40         50         60 
MFTLRELPFA KDSMGDFLSP VAFDFHHGKH HQTYVNNLNN LIKGTDFEKS SLFDILTKSS 

        70         80         90        100        110        120 
GGVFNNAAQI YNHDFYWDCL SPKATALSDE LKGALEKDFG SLEKFKEDFI KSATTLFGSG 

       130        140        150        160        170        180 
WNWAAYNLDT QKIEIIQTSN AQTPVTDKKV PLLVVDVWEH AYYIDHKNAR PVYLEKFYGH 

       190        200        210 
INWHFVSQCY EWAKKEGLGS VDYYINELVH KKA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic organization and enzymatic activity of a superoxide dismutase from the microaerophilic human pathogen, Helicobacter pylori." Pesci E.C., Pickett C.L. Gene 143:111-116(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene." Spiegelhalder C., Gerstenecker B., Kersten A., Schiltz E., Kist M. Infect. Immun. 61:5315-5325(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION. Strain: 2012.
[3]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[4]	"Identification and molecular analysis of superoxide dismutase isoforms in Helicobacter pylori." Bereswill S., Neuner O., Strobel S., Kist M. FEMS Microbiol. Lett. 183:241-245(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 151.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L24801 Unassigned DNA. Translation: AAC36885.1.
X72618 Genomic DNA. Translation: CAA51195.1.
AE000511 Genomic DNA. Translation: AAD07454.1.
AJ132687 Genomic DNA. Translation: CAA10728.1.

PIR

E64568.

RefSeq

NP_207187.1. NC_000915.1.
YP_006934313.1. NC_018939.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3CEI	X-ray	2.40	A/B	1-212	[»]

ProteinModelPortal

P43312.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-3411N.

MINT

MINT-165096.

STRING

85962.HP0389.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAD07454; AAD07454; HP_0389.

GeneID

13869575.
900274.

KEGG

heo:C694_01975.
hpy:HP0389.

PATRIC

20592017. VBIHelPyl33062_0402.

Phylogenomic databases

eggNOG

COG0605.

K04564.

ProtClustDB

CLSK872490.

Family and domain databases

InterPro

IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]

PANTHER

PTHR11404. PTHR11404. 1 hit.

Pfam

PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000349. SODismutase. 1 hit.

PRINTS

PR01703. MNSODISMTASE.

SUPFAM

SSF46609. SODismutase. 1 hit.
SSF54719. SODismutase. 1 hit.

PROSITE

PS00088. SOD_MN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P43312.

Entry information

Entry name

SODF_HELPY

Accession

Primary (citable) accession number: P43312

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents