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P43312

- SODF_HELPY

UniProt

P43312 - SODF_HELPY

Protein

Superoxide dismutase [Fe]

Gene

sodB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi26 – 261IronBy similarity
    Metal bindingi73 – 731IronBy similarity
    Metal bindingi156 – 1561IronBy similarity
    Metal bindingi160 – 1601IronBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0389-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Fe] (EC:1.15.1.1)
    Gene namesi
    Name:sodB
    Ordered Locus Names:HP_0389
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Superoxide dismutase [Fe]PRO_0000159985Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    DIPiDIP-3411N.
    IntActiP43312. 4 interactions.
    MINTiMINT-165096.
    STRINGi85962.HP0389.

    Structurei

    Secondary structure

    1
    213
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni15 – 173
    Helixi20 – 267
    Turni27 – 293
    Helixi30 – 4213
    Turni46 – 494
    Helixi52 – 587
    Helixi61 – 7818
    Helixi89 – 9911
    Helixi102 – 11514
    Beta strandi118 – 1269
    Turni128 – 1303
    Beta strandi133 – 1397
    Helixi144 – 1474
    Beta strandi150 – 1567
    Helixi159 – 1613
    Helixi163 – 1664
    Helixi170 – 17910
    Helixi183 – 19614
    Helixi199 – 20810

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CEIX-ray2.40A/B1-212[»]
    ProteinModelPortaliP43312.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43312.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0605.
    KOiK04564.
    OrthoDBiEOG63NMNT.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43312-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTLRELPFA KDSMGDFLSP VAFDFHHGKH HQTYVNNLNN LIKGTDFEKS    50
    SLFDILTKSS GGVFNNAAQI YNHDFYWDCL SPKATALSDE LKGALEKDFG 100
    SLEKFKEDFI KSATTLFGSG WNWAAYNLDT QKIEIIQTSN AQTPVTDKKV 150
    PLLVVDVWEH AYYIDHKNAR PVYLEKFYGH INWHFVSQCY EWAKKEGLGS 200
    VDYYINELVH KKA 213
    Length:213
    Mass (Da):24,518
    Last modified:November 1, 1995 - v1
    Checksum:i59ABCC4C82C2B1B2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041K → Q in AAD07454. (PubMed:9252185)Curated
    Sequence conflicti112 – 1121S → R in CAA51195. (PubMed:8225605)Curated
    Sequence conflicti124 – 1241A → V in AAD07454. (PubMed:9252185)Curated
    Sequence conflicti125 – 1251A → P in CAA51195. (PubMed:8225605)Curated
    Sequence conflicti179 – 1791G → E in AAD07454. (PubMed:9252185)Curated
    Sequence conflicti213 – 2131A → LE in CAA51195. (PubMed:8225605)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24801 Unassigned DNA. Translation: AAC36885.1.
    X72618 Genomic DNA. Translation: CAA51195.1.
    AE000511 Genomic DNA. Translation: AAD07454.1.
    AJ132687 Genomic DNA. Translation: CAA10728.1.
    PIRiE64568.
    RefSeqiNP_207187.1. NC_000915.1.
    YP_006934313.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07454; AAD07454; HP_0389.
    GeneIDi13869575.
    900274.
    KEGGiheo:C694_01975.
    hpy:HP0389.
    PATRICi20592017. VBIHelPyl33062_0402.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24801 Unassigned DNA. Translation: AAC36885.1 .
    X72618 Genomic DNA. Translation: CAA51195.1 .
    AE000511 Genomic DNA. Translation: AAD07454.1 .
    AJ132687 Genomic DNA. Translation: CAA10728.1 .
    PIRi E64568.
    RefSeqi NP_207187.1. NC_000915.1.
    YP_006934313.1. NC_018939.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CEI X-ray 2.40 A/B 1-212 [» ]
    ProteinModelPortali P43312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3411N.
    IntActi P43312. 4 interactions.
    MINTi MINT-165096.
    STRINGi 85962.HP0389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07454 ; AAD07454 ; HP_0389 .
    GeneIDi 13869575.
    900274.
    KEGGi heo:C694_01975.
    hpy:HP0389.
    PATRICi 20592017. VBIHelPyl33062_0402.

    Phylogenomic databases

    eggNOGi COG0605.
    KOi K04564.
    OrthoDBi EOG63NMNT.

    Enzyme and pathway databases

    BioCyci HPY:HP0389-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P43312.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic organization and enzymatic activity of a superoxide dismutase from the microaerophilic human pathogen, Helicobacter pylori."
      Pesci E.C., Pickett C.L.
      Gene 143:111-116(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene."
      Spiegelhalder C., Gerstenecker B., Kersten A., Schiltz E., Kist M.
      Infect. Immun. 61:5315-5325(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
      Strain: 2012.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    4. "Identification and molecular analysis of superoxide dismutase isoforms in Helicobacter pylori."
      Bereswill S., Neuner O., Strobel S., Kist M.
      FEMS Microbiol. Lett. 183:241-245(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 151.

    Entry informationi

    Entry nameiSODF_HELPY
    AccessioniPrimary (citable) accession number: P43312
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3