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Protein

Superoxide dismutase [Fe]

Gene

sodB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26IronBy similarity1
Metal bindingi73IronBy similarity1
Metal bindingi156IronBy similarity1
Metal bindingi160IronBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0389-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:sodB
Ordered Locus Names:HP_0389
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001599851 – 213Superoxide dismutase [Fe]Add BLAST213

Proteomic databases

PaxDbiP43312.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

DIPiDIP-3411N.
IntActiP43312. 4 interactors.
MINTiMINT-165096.
STRINGi85962.HP0389.

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni15 – 17Combined sources3
Helixi20 – 26Combined sources7
Turni27 – 29Combined sources3
Helixi30 – 42Combined sources13
Turni46 – 49Combined sources4
Helixi52 – 58Combined sources7
Helixi61 – 78Combined sources18
Helixi89 – 99Combined sources11
Helixi102 – 115Combined sources14
Beta strandi118 – 126Combined sources9
Turni128 – 130Combined sources3
Beta strandi133 – 139Combined sources7
Helixi144 – 147Combined sources4
Beta strandi150 – 156Combined sources7
Helixi159 – 161Combined sources3
Helixi163 – 166Combined sources4
Helixi170 – 179Combined sources10
Helixi183 – 196Combined sources14
Helixi199 – 208Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CEIX-ray2.40A/B1-212[»]
ProteinModelPortaliP43312.
SMRiP43312.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43312.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
KOiK04564.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTLRELPFA KDSMGDFLSP VAFDFHHGKH HQTYVNNLNN LIKGTDFEKS
60 70 80 90 100
SLFDILTKSS GGVFNNAAQI YNHDFYWDCL SPKATALSDE LKGALEKDFG
110 120 130 140 150
SLEKFKEDFI KSATTLFGSG WNWAAYNLDT QKIEIIQTSN AQTPVTDKKV
160 170 180 190 200
PLLVVDVWEH AYYIDHKNAR PVYLEKFYGH INWHFVSQCY EWAKKEGLGS
210
VDYYINELVH KKA
Length:213
Mass (Da):24,518
Last modified:November 1, 1995 - v1
Checksum:i59ABCC4C82C2B1B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104K → Q in AAD07454 (PubMed:9252185).Curated1
Sequence conflicti112S → R in CAA51195 (PubMed:8225605).Curated1
Sequence conflicti124A → V in AAD07454 (PubMed:9252185).Curated1
Sequence conflicti125A → P in CAA51195 (PubMed:8225605).Curated1
Sequence conflicti179G → E in AAD07454 (PubMed:9252185).Curated1
Sequence conflicti213A → LE in CAA51195 (PubMed:8225605).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24801 Unassigned DNA. Translation: AAC36885.1.
X72618 Genomic DNA. Translation: CAA51195.1.
AE000511 Genomic DNA. Translation: AAD07454.1.
AJ132687 Genomic DNA. Translation: CAA10728.1.
PIRiE64568.
RefSeqiNP_207187.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD07454; AAD07454; HP_0389.
GeneIDi900274.
KEGGihpy:HP0389.
PATRICi20592017. VBIHelPyl33062_0402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24801 Unassigned DNA. Translation: AAC36885.1.
X72618 Genomic DNA. Translation: CAA51195.1.
AE000511 Genomic DNA. Translation: AAD07454.1.
AJ132687 Genomic DNA. Translation: CAA10728.1.
PIRiE64568.
RefSeqiNP_207187.1. NC_000915.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CEIX-ray2.40A/B1-212[»]
ProteinModelPortaliP43312.
SMRiP43312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3411N.
IntActiP43312. 4 interactors.
MINTiMINT-165096.
STRINGi85962.HP0389.

Proteomic databases

PaxDbiP43312.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07454; AAD07454; HP_0389.
GeneIDi900274.
KEGGihpy:HP0389.
PATRICi20592017. VBIHelPyl33062_0402.

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
KOiK04564.

Enzyme and pathway databases

BioCyciHPY:HP0389-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP43312.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODF_HELPY
AccessioniPrimary (citable) accession number: P43312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.