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P43312

- SODF_HELPY

UniProt

P43312 - SODF_HELPY

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Protein
Superoxide dismutase [Fe]
Gene
sodB, HP_0389
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 iron ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261Iron By similarity
Metal bindingi73 – 731Iron By similarity
Metal bindingi156 – 1561Iron By similarity
Metal bindingi160 – 1601Iron By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0389-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:sodB
Ordered Locus Names:HP_0389
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Superoxide dismutase [Fe]
PRO_0000159985Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

DIPiDIP-3411N.
IntActiP43312. 4 interactions.
MINTiMINT-165096.
STRINGi85962.HP0389.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni15 – 173
Helixi20 – 267
Turni27 – 293
Helixi30 – 4213
Turni46 – 494
Helixi52 – 587
Helixi61 – 7818
Helixi89 – 9911
Helixi102 – 11514
Beta strandi118 – 1269
Turni128 – 1303
Beta strandi133 – 1397
Helixi144 – 1474
Beta strandi150 – 1567
Helixi159 – 1613
Helixi163 – 1664
Helixi170 – 17910
Helixi183 – 19614
Helixi199 – 20810

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CEIX-ray2.40A/B1-212[»]
ProteinModelPortaliP43312.

Miscellaneous databases

EvolutionaryTraceiP43312.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43312-1 [UniParc]FASTAAdd to Basket

« Hide

MFTLRELPFA KDSMGDFLSP VAFDFHHGKH HQTYVNNLNN LIKGTDFEKS    50
SLFDILTKSS GGVFNNAAQI YNHDFYWDCL SPKATALSDE LKGALEKDFG 100
SLEKFKEDFI KSATTLFGSG WNWAAYNLDT QKIEIIQTSN AQTPVTDKKV 150
PLLVVDVWEH AYYIDHKNAR PVYLEKFYGH INWHFVSQCY EWAKKEGLGS 200
VDYYINELVH KKA 213
Length:213
Mass (Da):24,518
Last modified:November 1, 1995 - v1
Checksum:i59ABCC4C82C2B1B2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041K → Q in AAD07454. 1 Publication
Sequence conflicti112 – 1121S → R in CAA51195. 1 Publication
Sequence conflicti124 – 1241A → V in AAD07454. 1 Publication
Sequence conflicti125 – 1251A → P in CAA51195. 1 Publication
Sequence conflicti179 – 1791G → E in AAD07454. 1 Publication
Sequence conflicti213 – 2131A → LE in CAA51195. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24801 Unassigned DNA. Translation: AAC36885.1.
X72618 Genomic DNA. Translation: CAA51195.1.
AE000511 Genomic DNA. Translation: AAD07454.1.
AJ132687 Genomic DNA. Translation: CAA10728.1.
PIRiE64568.
RefSeqiNP_207187.1. NC_000915.1.
YP_006934313.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07454; AAD07454; HP_0389.
GeneIDi13869575.
900274.
KEGGiheo:C694_01975.
hpy:HP0389.
PATRICi20592017. VBIHelPyl33062_0402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24801 Unassigned DNA. Translation: AAC36885.1 .
X72618 Genomic DNA. Translation: CAA51195.1 .
AE000511 Genomic DNA. Translation: AAD07454.1 .
AJ132687 Genomic DNA. Translation: CAA10728.1 .
PIRi E64568.
RefSeqi NP_207187.1. NC_000915.1.
YP_006934313.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CEI X-ray 2.40 A/B 1-212 [» ]
ProteinModelPortali P43312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3411N.
IntActi P43312. 4 interactions.
MINTi MINT-165096.
STRINGi 85962.HP0389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07454 ; AAD07454 ; HP_0389 .
GeneIDi 13869575.
900274.
KEGGi heo:C694_01975.
hpy:HP0389.
PATRICi 20592017. VBIHelPyl33062_0402.

Phylogenomic databases

eggNOGi COG0605.
KOi K04564.
OrthoDBi EOG63NMNT.

Enzyme and pathway databases

BioCyci HPY:HP0389-MONOMER.

Miscellaneous databases

EvolutionaryTracei P43312.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic organization and enzymatic activity of a superoxide dismutase from the microaerophilic human pathogen, Helicobacter pylori."
    Pesci E.C., Pickett C.L.
    Gene 143:111-116(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene."
    Spiegelhalder C., Gerstenecker B., Kersten A., Schiltz E., Kist M.
    Infect. Immun. 61:5315-5325(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: 2012.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  4. "Identification and molecular analysis of superoxide dismutase isoforms in Helicobacter pylori."
    Bereswill S., Neuner O., Strobel S., Kist M.
    FEMS Microbiol. Lett. 183:241-245(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 151.

Entry informationi

Entry nameiSODF_HELPY
AccessioniPrimary (citable) accession number: P43312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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