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P43308

- SSRB_HUMAN

UniProt

P43308 - SSRB_HUMAN

Protein

Translocon-associated protein subunit beta

Gene

SSR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. cotranslational protein targeting to membrane Source: ProtInc
    3. gene expression Source: Reactome
    4. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    5. translation Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translocon-associated protein subunit beta
    Short name:
    TRAP-beta
    Alternative name(s):
    Signal sequence receptor subunit beta
    Short name:
    SSR-beta
    Gene namesi
    Name:SSR2
    Synonyms:TRAPB
    ORF Names:HSD25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11324. SSR2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ProtInc
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: ProtInc

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36148.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717By similarityAdd
    BLAST
    Chaini18 – 183166Translocon-associated protein subunit betaPRO_0000033290Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)2 Publications
    Glycosylationi104 – 1041N-linked (GlcNAc...)2 Publications

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP43308.
    PRIDEiP43308.

    PTM databases

    PhosphoSiteiP43308.

    Expressioni

    Gene expression databases

    ArrayExpressiP43308.
    BgeeiP43308.
    CleanExiHS_SSR2.
    GenevestigatoriP43308.

    Organism-specific databases

    HPAiHPA037787.

    Interactioni

    Subunit structurei

    Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING.1 Publication

    Protein-protein interaction databases

    BioGridi112624. 2 interactions.
    DIPiDIP-60652N.
    IntActiP43308. 1 interaction.
    STRINGi9606.ENSP00000295702.

    Structurei

    3D structure databases

    ProteinModelPortaliP43308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 149132LumenalSequence AnalysisAdd
    BLAST
    Topological domaini170 – 18314CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei150 – 16920HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TRAP-beta family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292722.
    HOVERGENiHBG000858.
    InParanoidiP43308.
    KOiK13250.
    OMAiHARWNTI.
    OrthoDBiEOG7X0VK4.
    PhylomeDBiP43308.
    TreeFamiTF314461.

    Family and domain databases

    InterProiIPR008856. TRAP_beta.
    [Graphical view]
    PANTHERiPTHR12861. PTHR12861. 1 hit.
    PfamiPF05753. TRAP_beta. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016400. TRAP_beta. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43308-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLSFVVLA LFAVTQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG    50
    SSAALDVELS DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA 100
    GYFNFTSATI TYLAQEDGPV VIGSTSAPGQ GGILAQREFD RRFSPHFLDW 150
    AAFGVMTLPS IGIPLLLWYS SKRKYDTPKT KKN 183
    Length:183
    Mass (Da):20,135
    Last modified:November 1, 1995 - v1
    Checksum:i575715449B8586D8
    GO

    Sequence cautioni

    The sequence CAH72631.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAH72632.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461I → T in BAD96320. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74104 mRNA. Translation: CAA52207.1.
    D37991 mRNA. Translation: BAA07206.1.
    AY251536 mRNA. Translation: AAP20059.1.
    CR456973 mRNA. Translation: CAG33254.1.
    AK222600 mRNA. Translation: BAD96320.1.
    AK313821 mRNA. Translation: BAG36556.1.
    AL355388 Genomic DNA. Translation: CAH72631.1. Sequence problems.
    AL355388 Genomic DNA. Translation: CAH72632.1. Sequence problems.
    CH471121 Genomic DNA. Translation: EAW53010.1.
    CH471121 Genomic DNA. Translation: EAW53011.1.
    BC000341 mRNA. Translation: AAH00341.2.
    CCDSiCCDS1126.1.
    PIRiS41063.
    RefSeqiNP_003136.1. NM_003145.3.
    UniGeneiHs.74564.

    Genome annotation databases

    EnsembliENST00000295702; ENSP00000295702; ENSG00000163479.
    ENST00000480567; ENSP00000434306; ENSG00000163479.
    GeneIDi6746.
    KEGGihsa:6746.
    UCSCiuc001fmx.3. human.

    Polymorphism databases

    DMDMi1174451.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74104 mRNA. Translation: CAA52207.1 .
    D37991 mRNA. Translation: BAA07206.1 .
    AY251536 mRNA. Translation: AAP20059.1 .
    CR456973 mRNA. Translation: CAG33254.1 .
    AK222600 mRNA. Translation: BAD96320.1 .
    AK313821 mRNA. Translation: BAG36556.1 .
    AL355388 Genomic DNA. Translation: CAH72631.1 . Sequence problems.
    AL355388 Genomic DNA. Translation: CAH72632.1 . Sequence problems.
    CH471121 Genomic DNA. Translation: EAW53010.1 .
    CH471121 Genomic DNA. Translation: EAW53011.1 .
    BC000341 mRNA. Translation: AAH00341.2 .
    CCDSi CCDS1126.1.
    PIRi S41063.
    RefSeqi NP_003136.1. NM_003145.3.
    UniGenei Hs.74564.

    3D structure databases

    ProteinModelPortali P43308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112624. 2 interactions.
    DIPi DIP-60652N.
    IntActi P43308. 1 interaction.
    STRINGi 9606.ENSP00000295702.

    PTM databases

    PhosphoSitei P43308.

    Polymorphism databases

    DMDMi 1174451.

    Proteomic databases

    PaxDbi P43308.
    PRIDEi P43308.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295702 ; ENSP00000295702 ; ENSG00000163479 .
    ENST00000480567 ; ENSP00000434306 ; ENSG00000163479 .
    GeneIDi 6746.
    KEGGi hsa:6746.
    UCSCi uc001fmx.3. human.

    Organism-specific databases

    CTDi 6746.
    GeneCardsi GC01M155983.
    HGNCi HGNC:11324. SSR2.
    HPAi HPA037787.
    MIMi 600867. gene.
    neXtProti NX_P43308.
    PharmGKBi PA36148.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292722.
    HOVERGENi HBG000858.
    InParanoidi P43308.
    KOi K13250.
    OMAi HARWNTI.
    OrthoDBi EOG7X0VK4.
    PhylomeDBi P43308.
    TreeFami TF314461.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.

    Miscellaneous databases

    ChiTaRSi SSR2. human.
    GeneWikii SSR2.
    GenomeRNAii 6746.
    NextBioi 26314.
    PROi P43308.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43308.
    Bgeei P43308.
    CleanExi HS_SSR2.
    Genevestigatori P43308.

    Family and domain databases

    InterProi IPR008856. TRAP_beta.
    [Graphical view ]
    PANTHERi PTHR12861. PTHR12861. 1 hit.
    Pfami PF05753. TRAP_beta. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016400. TRAP_beta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of the beta subunit of the human translocon-associated protein."
      Bodescot M., Brison O.
      Biochim. Biophys. Acta 1217:101-102(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon carcinoma.
    2. "Isolation and mapping of the human beta-signal sequence receptor gene (SSR2)."
      Chinen K., Sudo K., Takahashi E., Nakamura Y.
      Cytogenet. Cell Genet. 70:215-217(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. "A new spermatogenesis-related gene."
      Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Coronary artery.
    7. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    10. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-88 AND ASN-104.
    11. "STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling."
      Ishikawa H., Barber G.N.
      Nature 455:674-678(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TMEM173.
    12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88 AND ASN-104.
      Tissue: Liver.

    Entry informationi

    Entry nameiSSRB_HUMAN
    AccessioniPrimary (citable) accession number: P43308
    Secondary accession number(s): B2R9K9
    , D3DVA7, Q53HI0, Q5VY95, Q5VY96, Q6IB31, Q9BWE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3