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Protein

Parvalbumin, thymic CPV3

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds two calcium ions.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi52 – 63121Add
BLAST
Calcium bindingi91 – 102122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin, thymic CPV3
Alternative name(s):
Parvalbumin-3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109109Parvalbumin, thymic CPV3PRO_0000073627Add
BLAST

Proteomic databases

PaxDbiP43305.

Expressioni

Tissue specificityi

Restricted to the thymic stroma.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005475.

Structurei

Secondary structure

1
109
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 73Combined sources
Helixi9 – 168Combined sources
Turni22 – 243Combined sources
Helixi27 – 304Combined sources
Turni31 – 355Combined sources
Beta strandi41 – 433Combined sources
Helixi44 – 474Combined sources
Beta strandi49 – 513Combined sources
Beta strandi56 – 605Combined sources
Helixi61 – 633Combined sources
Turni64 – 663Combined sources
Helixi68 – 714Combined sources
Beta strandi72 – 743Combined sources
Turni80 – 834Combined sources
Helixi84 – 874Combined sources
Turni88 – 903Combined sources
Beta strandi93 – 964Combined sources
Helixi102 – 1087Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KYCNMR-A2-109[»]
2KYFNMR-A2-109[»]
ProteinModelPortaliP43305.
SMRiP43305. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43305.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 10932EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP43305.
OMAiKFFETSG.
OrthoDBiEOG7TF7C9.
PhylomeDBiP43305.
TreeFamiTF332342.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTDILSPS DIAAALRDCQ APDSFSPKKF FQISGMSKKS SSQLKEIFRI
60 70 80 90 100
LDNDQSGFIE EDELKYFLQR FECGARVLTA SETKTFLAAA DHDGDGKIGA

EEFQEMVQS
Length:109
Mass (Da):12,107
Last modified:February 1, 1996 - v2
Checksum:iFDA3BB1907D59757
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03850 mRNA. Translation: AAA17518.1.
PIRiA53341.
RefSeqiNP_989753.1. NM_204422.1.
XP_015149613.1. XM_015294127.1.
UniGeneiGga.887.

Genome annotation databases

EnsembliENSGALT00000005485; ENSGALP00000005475; ENSGALG00000003462.
GeneIDi386586.
KEGGigga:386586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03850 mRNA. Translation: AAA17518.1.
PIRiA53341.
RefSeqiNP_989753.1. NM_204422.1.
XP_015149613.1. XM_015294127.1.
UniGeneiGga.887.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KYCNMR-A2-109[»]
2KYFNMR-A2-109[»]
ProteinModelPortaliP43305.
SMRiP43305. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005475.

Proteomic databases

PaxDbiP43305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005485; ENSGALP00000005475; ENSGALG00000003462.
GeneIDi386586.
KEGGigga:386586.

Organism-specific databases

CTDi654231.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP43305.
OMAiKFFETSG.
OrthoDBiEOG7TF7C9.
PhylomeDBiP43305.
TreeFamiTF332342.

Miscellaneous databases

EvolutionaryTraceiP43305.
NextBioi20813948.
PROiP43305.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel avian thymic parvalbumin displays high degree of sequence homology to oncomodulin."
    Hapak R.C., Zhao H., Boschi J.M., Henzl M.T.
    J. Biol. Chem. 269:5288-5296(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "Solution structures of chicken parvalbumin 3 in the Ca(2+)-free and Ca(2+)-bound states."
    Henzl M.T., Tanner J.J., Tan A.
    Proteins 79:752-764(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2-109 OF APOPROTEIN AND IN COMPLEX WITH CALCIUM IONS, FUNCTION.

Entry informationi

Entry nameiPRVU_CHICK
AccessioniPrimary (citable) accession number: P43305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This parvalbumin has an isoelectric point of 4.6.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.