Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 receptor type 2

Gene

Il1r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-446652. Interleukin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 2
Short name:
IL-1R-2
Short name:
IL-1RT-2
Short name:
IL-1RT2
Alternative name(s):
CD121 antigen-like family member B
IL-1 type II receptor
Interleukin-1 receptor beta
Short name:
IL-1R-beta
Interleukin-1 receptor type II
CD_antigen: CD121b
Cleaved into the following 2 chains:
Interleukin-1 receptor type 2, membrane form
Short name:
mIL-1R2
Short name:
mIL-1RII
Interleukin-1 receptor type 2, soluble form
Short name:
sIL-1R2
Short name:
sIL-1RII
Gene namesi
Name:Il1r2
Synonyms:Il-1r2, Il1rb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621147. Il1r2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 355342ExtracellularSequence analysisAdd
BLAST
Transmembranei356 – 38126HelicalSequence analysisAdd
BLAST
Topological domaini382 – 41635CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313Sequence analysisAdd
BLAST
Chaini14 – 416403Interleukin-1 receptor type 2, membrane formPRO_0000015441Add
BLAST
Chaini14 – ?Interleukin-1 receptor type 2, soluble formPRO_0000415350

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 128PROSITE-ProRule annotation
Disulfide bondi64 ↔ 120PROSITE-ProRule annotation
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi164 ↔ 219PROSITE-ProRule annotation
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi270 ↔ 338PROSITE-ProRule annotation
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43303.
PRIDEiP43303.

Expressioni

Gene expression databases

GenevisibleiP43303. RN.

Interactioni

Subunit structurei

Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019415.

Structurei

3D structure databases

ProteinModelPortaliP43303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 136108Ig-like C2-type 1Add
BLAST
Domaini146 – 23388Ig-like C2-type 2Add
BLAST
Domaini249 – 357109Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCQ. Eukaryota.
ENOG410YQDP. LUCA.
HOGENOMiHOG000113036.
HOVERGENiHBG052104.
InParanoidiP43303.
KOiK04387.
OMAiRQEYSEN.
OrthoDBiEOG77HDDW.
PhylomeDBiP43303.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFILLVLVTG VSAFTTPAVV HTGRVSESPV TSEKHPVLGD DCWFRGRDFK
60 70 80 90 100
SELRLEGEPV VLRCPLVPHS DTSSSSRSLL TWSKSDSSQL IPGDEPRMWV
110 120 130 140 150
KDDTLWVLPA VQQDSGTYIC TFRNASHCEQ MSLELKVFKN TEASFPLVSY
160 170 180 190 200
LQISALSSTG LLVCPDLKEF ISSRTDGKIQ WYKGSILLDK GNKKFLSAGD
210 220 230 240 250
PTRLLISNTS MGDAGYYRCV MTFTYEGKEY NITRNIELRV KGITTEPIPV
260 270 280 290 300
IISPLETIPA SLGSRLIVPC KVFLGTGTSS NTIVWWMANS TFISVAYPRG
310 320 330 340 350
RVTEGLHHQY SENDENYVEV SLIFDPVTKE DLNTDFKCVA TNPRSFQSLH
360 370 380 390 400
TTVKEVSSTF SWGIALAPLS LIILVVGAIW IRRRCKRQAG KTYGLTKLPT
410
DNQDFPSSPN QIKEMK
Length:416
Mass (Da):46,353
Last modified:November 1, 1995 - v1
Checksum:i50EFBA48881C5D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22812 mRNA. Translation: CAA80465.1.
BC091564 mRNA. Translation: AAH91564.1.
PIRiS33473.
RefSeqiNP_446405.1. NM_053953.1.
XP_008765206.1. XM_008766984.1.
UniGeneiRn.10758.

Genome annotation databases

GeneIDi117022.
KEGGirno:117022.
UCSCiRGD:621147. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22812 mRNA. Translation: CAA80465.1.
BC091564 mRNA. Translation: AAH91564.1.
PIRiS33473.
RefSeqiNP_446405.1. NM_053953.1.
XP_008765206.1. XM_008766984.1.
UniGeneiRn.10758.

3D structure databases

ProteinModelPortaliP43303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019415.

Proteomic databases

PaxDbiP43303.
PRIDEiP43303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117022.
KEGGirno:117022.
UCSCiRGD:621147. rat.

Organism-specific databases

CTDi7850.
RGDi621147. Il1r2.

Phylogenomic databases

eggNOGiENOG410IJCQ. Eukaryota.
ENOG410YQDP. LUCA.
HOGENOMiHOG000113036.
HOVERGENiHBG052104.
InParanoidiP43303.
KOiK04387.
OMAiRQEYSEN.
OrthoDBiEOG77HDDW.
PhylomeDBiP43303.
TreeFamiTF325519.

Enzyme and pathway databases

ReactomeiR-RNO-446652. Interleukin-1 signaling.

Miscellaneous databases

NextBioi619779.
PROiP43303.

Gene expression databases

GenevisibleiP43303. RN.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF00047. ig. 1 hit.
[Graphical view]
PRINTSiPR01539. INTRLEUKN1R2.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA."
    Bristulf J., Gatti S., Malinowsky D., Bjork L., Sundgren A.K., Bartfai T.
    Eur. Cytokine Netw. 5:319-330(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiIL1R2_RAT
AccessioniPrimary (citable) accession number: P43303
Secondary accession number(s): Q5BJ99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.