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Protein

Interleukin-1 receptor type 2

Gene

Il1r2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 2
Short name:
IL-1R-2
Short name:
IL-1RT-2
Short name:
IL-1RT2
Alternative name(s):
CD121 antigen-like family member B
IL-1 type II receptor
Interleukin-1 receptor beta
Short name:
IL-1R-beta
Interleukin-1 receptor type II
CD_antigen: CD121b
Cleaved into the following 2 chains:
Interleukin-1 receptor type 2, membrane form
Short name:
mIL-1R2
Short name:
mIL-1RII
Interleukin-1 receptor type 2, soluble form
Short name:
sIL-1R2
Short name:
sIL-1RII
Gene namesi
Name:Il1r2
Synonyms:Il-1r2, Il1rb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621147. Il1r2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 355ExtracellularSequence analysisAdd BLAST342
Transmembranei356 – 381HelicalSequence analysisAdd BLAST26
Topological domaini382 – 416CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Sequence analysisAdd BLAST13
ChainiPRO_000001544114 – 416Interleukin-1 receptor type 2, membrane formAdd BLAST403
ChainiPRO_000041535014 – ?Interleukin-1 receptor type 2, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 128PROSITE-ProRule annotation
Disulfide bondi64 ↔ 120PROSITE-ProRule annotation
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 219PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi270 ↔ 338PROSITE-ProRule annotation
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43303.
PRIDEiP43303.

Expressioni

Gene expression databases

GenevisibleiP43303. RN.

Interactioni

Subunit structurei

Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019415.

Structurei

3D structure databases

ProteinModelPortaliP43303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 136Ig-like C2-type 1Add BLAST108
Domaini146 – 233Ig-like C2-type 2Add BLAST88
Domaini249 – 357Ig-like C2-type 3Add BLAST109

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCQ. Eukaryota.
ENOG410YQDP. LUCA.
HOGENOMiHOG000113036.
HOVERGENiHBG052104.
InParanoidiP43303.
KOiK04387.
OrthoDBiEOG091G077L.
PhylomeDBiP43303.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR004077. IL-1_rcpt_II-typ.
IPR013151. Immunoglobulin.
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PRINTSiPR01539. INTRLEUKN1R2.
PR01536. INTRLKN1R12F.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFILLVLVTG VSAFTTPAVV HTGRVSESPV TSEKHPVLGD DCWFRGRDFK
60 70 80 90 100
SELRLEGEPV VLRCPLVPHS DTSSSSRSLL TWSKSDSSQL IPGDEPRMWV
110 120 130 140 150
KDDTLWVLPA VQQDSGTYIC TFRNASHCEQ MSLELKVFKN TEASFPLVSY
160 170 180 190 200
LQISALSSTG LLVCPDLKEF ISSRTDGKIQ WYKGSILLDK GNKKFLSAGD
210 220 230 240 250
PTRLLISNTS MGDAGYYRCV MTFTYEGKEY NITRNIELRV KGITTEPIPV
260 270 280 290 300
IISPLETIPA SLGSRLIVPC KVFLGTGTSS NTIVWWMANS TFISVAYPRG
310 320 330 340 350
RVTEGLHHQY SENDENYVEV SLIFDPVTKE DLNTDFKCVA TNPRSFQSLH
360 370 380 390 400
TTVKEVSSTF SWGIALAPLS LIILVVGAIW IRRRCKRQAG KTYGLTKLPT
410
DNQDFPSSPN QIKEMK
Length:416
Mass (Da):46,353
Last modified:November 1, 1995 - v1
Checksum:i50EFBA48881C5D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22812 mRNA. Translation: CAA80465.1.
BC091564 mRNA. Translation: AAH91564.1.
PIRiS33473.
RefSeqiNP_446405.1. NM_053953.1.
XP_008765206.1. XM_008766984.2.
XP_017451737.1. XM_017596248.1.
UniGeneiRn.10758.

Genome annotation databases

GeneIDi117022.
KEGGirno:117022.
UCSCiRGD:621147. rat.

Similar proteinsi

Entry informationi

Entry nameiIL1R2_RAT
AccessioniPrimary (citable) accession number: P43303
Secondary accession number(s): Q5BJ99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families