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P43300

- EGR3_MOUSE

UniProt

P43300 - EGR3_MOUSE

Protein

Early growth response protein 3

Gene

Egr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (09 May 2003)
      Previous versions | rss
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    Functioni

    Probable transcription factor involved in muscle spindle development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri275 – 29925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell migration involved in sprouting angiogenesis Source: Ensembl
    2. cellular response to cAMP Source: RefGenome
    3. cellular response to fibroblast growth factor stimulus Source: Ensembl
    4. cellular response to gonadotropin stimulus Source: RefGenome
    5. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
    6. endothelial cell chemotaxis Source: Ensembl
    7. negative regulation of apoptotic process Source: RefGenome
    8. neuromuscular synaptic transmission Source: MGI
    9. peripheral nervous system development Source: MGI
    10. positive regulation of endothelial cell proliferation Source: Ensembl
    11. positive regulation of T cell differentiation in thymus Source: MGI
    12. regulation of gamma-delta T cell differentiation Source: MGI
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Early growth response protein 3
    Short name:
    EGR-3
    Gene namesi
    Name:Egr3
    Synonyms:Egr-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1306780. Egr3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Early growth response protein 3PRO_0000047126Add
    BLAST

    Proteomic databases

    PRIDEiP43300.

    PTM databases

    PhosphoSiteiP43300.

    Expressioni

    Gene expression databases

    ArrayExpressiP43300.
    BgeeiP43300.
    CleanExiMM_EGR3.
    GenevestigatoriP43300.

    Structurei

    3D structure databases

    ProteinModelPortaliP43300.
    SMRiP43300. Positions 273-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri275 – 29925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00550000074455.
    HOGENOMiHOG000036856.
    HOVERGENiHBG003909.
    InParanoidiP43300.
    KOiK12497.
    OMAiQTMDPIR.
    OrthoDBiEOG75XGKR.
    PhylomeDBiP43300.
    TreeFamiTF318980.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR021849. DUF3446.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF11928. DUF3446. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43300-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYNQMA    50
    TENVMDIGLT NEKPNPELSY SSSFQPAPGN KTVTYLGKFA FDSPSNWCQD 100
    NIISLMSAGI LGVPPASGAL STQTSTASMV QPPQGDVEAM YPALPPYSNC 150
    GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP 200
    NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP 250
    LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT 300
    GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR 350
    HAKIHLKQKE KKSEKGGAPS ASSAPTVSLA PVVTTCA 387
    Length:387
    Mass (Da):42,635
    Last modified:May 9, 2003 - v2
    Checksum:iD6EE31B8D4F26949
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti324 – 3252IR → TH(PubMed:1906159)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132128 mRNA. Translation: AAD28261.1.
    S40835 mRNA. Translation: AAB19318.1.
    CCDSiCCDS27246.1.
    PIRiB43819.
    RefSeqiNP_061251.1. NM_018781.3.
    UniGeneiMm.103737.
    Mm.440893.

    Genome annotation databases

    EnsembliENSMUST00000035908; ENSMUSP00000037042; ENSMUSG00000033730.
    GeneIDi13655.
    KEGGimmu:13655.
    UCSCiuc007unb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132128 mRNA. Translation: AAD28261.1 .
    S40835 mRNA. Translation: AAB19318.1 .
    CCDSi CCDS27246.1.
    PIRi B43819.
    RefSeqi NP_061251.1. NM_018781.3.
    UniGenei Mm.103737.
    Mm.440893.

    3D structure databases

    ProteinModelPortali P43300.
    SMRi P43300. Positions 273-356.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P43300.

    Proteomic databases

    PRIDEi P43300.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035908 ; ENSMUSP00000037042 ; ENSMUSG00000033730 .
    GeneIDi 13655.
    KEGGi mmu:13655.
    UCSCi uc007unb.1. mouse.

    Organism-specific databases

    CTDi 1960.
    MGIi MGI:1306780. Egr3.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00550000074455.
    HOGENOMi HOG000036856.
    HOVERGENi HBG003909.
    InParanoidi P43300.
    KOi K12497.
    OMAi QTMDPIR.
    OrthoDBi EOG75XGKR.
    PhylomeDBi P43300.
    TreeFami TF318980.

    Miscellaneous databases

    NextBioi 284392.
    PROi P43300.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43300.
    Bgeei P43300.
    CleanExi MM_EGR3.
    Genevestigatori P43300.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR021849. DUF3446.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF11928. DUF3446. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3."
      Tourtellotte W.G., Milbrandt J.
      Nat. Genet. 20:87-91(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors."
      Patwardhan S., Gashler A., Siegel M.G., Chang L.C., Joseph L.J., Shows T.B., le Beau M.M., Sukhatme V.P.
      Oncogene 6:917-928(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-327.

    Entry informationi

    Entry nameiEGR3_MOUSE
    AccessioniPrimary (citable) accession number: P43300
    Secondary accession number(s): Q9R276
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: May 9, 2003
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3