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P43300 (EGR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Early growth response protein 3

Short name=EGR-3
Gene names
Name:Egr3
Synonyms:Egr-3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription factor involved in muscle spindle development.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the EGR C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

cellular response to cAMP

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to fibroblast growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to gonadotropin stimulus

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to vascular endothelial growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

endothelial cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

neuromuscular synaptic transmission

Inferred from mutant phenotype PubMed 11978828. Source: MGI

peripheral nervous system development

Inferred from mutant phenotype PubMed 15582775. Source: MGI

positive regulation of T cell differentiation in thymus

Inferred from mutant phenotype PubMed 21737317. Source: MGI

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of gamma-delta T cell differentiation

Inferred from direct assay PubMed 21737317. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

nucleus

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Early growth response protein 3
PRO_0000047126

Regions

Zinc finger275 – 29925C2H2-type 1
Zinc finger305 – 32723C2H2-type 2
Zinc finger333 – 35523C2H2-type 3

Experimental info

Sequence conflict324 – 3252IR → TH Ref.2

Sequences

Sequence LengthMass (Da)Tools
P43300 [UniParc].

Last modified May 9, 2003. Version 2.
Checksum: D6EE31B8D4F26949

FASTA38742,635
        10         20         30         40         50         60 
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYNQMA TENVMDIGLT 

        70         80         90        100        110        120 
NEKPNPELSY SSSFQPAPGN KTVTYLGKFA FDSPSNWCQD NIISLMSAGI LGVPPASGAL 

       130        140        150        160        170        180 
STQTSTASMV QPPQGDVEAM YPALPPYSNC GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK 

       190        200        210        220        230        240 
PALDSNLFPM IPDYNLYHHP NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH 

       250        260        270        280        290        300 
PGFGSLPQPP LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT 

       310        320        330        340        350        360 
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR HAKIHLKQKE 

       370        380 
KKSEKGGAPS ASSAPTVSLA PVVTTCA 

« Hide

References

[1]"Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3."
Tourtellotte W.G., Milbrandt J.
Nat. Genet. 20:87-91(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors."
Patwardhan S., Gashler A., Siegel M.G., Chang L.C., Joseph L.J., Shows T.B., le Beau M.M., Sukhatme V.P.
Oncogene 6:917-928(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-327.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132128 mRNA. Translation: AAD28261.1.
S40835 mRNA. Translation: AAB19318.1.
PIRB43819.
RefSeqNP_061251.1. NM_018781.3.
UniGeneMm.103737.
Mm.440893.

3D structure databases

ProteinModelPortalP43300.
SMRP43300. Positions 273-356.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP43300.

Proteomic databases

PRIDEP43300.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035908; ENSMUSP00000037042; ENSMUSG00000033730.
GeneID13655.
KEGGmmu:13655.
UCSCuc007unb.1. mouse.

Organism-specific databases

CTD1960.
MGIMGI:1306780. Egr3.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00550000074455.
HOGENOMHOG000036856.
HOVERGENHBG003909.
InParanoidP43300.
KOK12497.
OMAQTMDPIR.
OrthoDBEOG75XGKR.
PhylomeDBP43300.
TreeFamTF318980.

Gene expression databases

ArrayExpressP43300.
BgeeP43300.
CleanExMM_EGR3.
GenevestigatorP43300.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio284392.
PROP43300.
SOURCESearch...

Entry information

Entry nameEGR3_MOUSE
AccessionPrimary (citable) accession number: P43300
Secondary accession number(s): Q9R276
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 9, 2003
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot