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Protein

Early growth response protein 3

Gene

Egr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in muscle spindle development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri275 – 29925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. cell migration involved in sprouting angiogenesis Source: MGI
  2. cellular response to cAMP Source: GO_Central
  3. cellular response to fibroblast growth factor stimulus Source: MGI
  4. cellular response to gonadotropin stimulus Source: GO_Central
  5. cellular response to vascular endothelial growth factor stimulus Source: MGI
  6. endothelial cell chemotaxis Source: MGI
  7. negative regulation of apoptotic process Source: MGI
  8. neuromuscular synaptic transmission Source: MGI
  9. peripheral nervous system development Source: MGI
  10. positive regulation of endothelial cell proliferation Source: MGI
  11. positive regulation of T cell differentiation in thymus Source: MGI
  12. regulation of gamma-delta T cell differentiation Source: MGI
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 3
Short name:
EGR-3
Gene namesi
Name:Egr3
Synonyms:Egr-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1306780. Egr3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Early growth response protein 3PRO_0000047126Add
BLAST

Proteomic databases

PRIDEiP43300.

PTM databases

PhosphoSiteiP43300.

Expressioni

Gene expression databases

BgeeiP43300.
CleanExiMM_EGR3.
ExpressionAtlasiP43300. baseline and differential.
GenevestigatoriP43300.

Structurei

3D structure databases

ProteinModelPortaliP43300.
SMRiP43300. Positions 273-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri275 – 29925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiP43300.
KOiK12497.
OMAiDYNLFHH.
OrthoDBiEOG75XGKR.
PhylomeDBiP43300.
TreeFamiTF318980.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYNQMA
60 70 80 90 100
TENVMDIGLT NEKPNPELSY SSSFQPAPGN KTVTYLGKFA FDSPSNWCQD
110 120 130 140 150
NIISLMSAGI LGVPPASGAL STQTSTASMV QPPQGDVEAM YPALPPYSNC
160 170 180 190 200
GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP
210 220 230 240 250
NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP
260 270 280 290 300
LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT
310 320 330 340 350
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR
360 370 380
HAKIHLKQKE KKSEKGGAPS ASSAPTVSLA PVVTTCA
Length:387
Mass (Da):42,635
Last modified:May 8, 2003 - v2
Checksum:iD6EE31B8D4F26949
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3252IR → TH (PubMed:1906159).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132128 mRNA. Translation: AAD28261.1.
S40835 mRNA. Translation: AAB19318.1.
CCDSiCCDS27246.1.
PIRiB43819.
RefSeqiNP_061251.1. NM_018781.3.
UniGeneiMm.103737.
Mm.440893.

Genome annotation databases

EnsembliENSMUST00000035908; ENSMUSP00000037042; ENSMUSG00000033730.
GeneIDi13655.
KEGGimmu:13655.
UCSCiuc007unb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132128 mRNA. Translation: AAD28261.1.
S40835 mRNA. Translation: AAB19318.1.
CCDSiCCDS27246.1.
PIRiB43819.
RefSeqiNP_061251.1. NM_018781.3.
UniGeneiMm.103737.
Mm.440893.

3D structure databases

ProteinModelPortaliP43300.
SMRiP43300. Positions 273-356.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP43300.

Proteomic databases

PRIDEiP43300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035908; ENSMUSP00000037042; ENSMUSG00000033730.
GeneIDi13655.
KEGGimmu:13655.
UCSCiuc007unb.1. mouse.

Organism-specific databases

CTDi1960.
MGIiMGI:1306780. Egr3.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074455.
HOGENOMiHOG000036856.
HOVERGENiHBG003909.
InParanoidiP43300.
KOiK12497.
OMAiDYNLFHH.
OrthoDBiEOG75XGKR.
PhylomeDBiP43300.
TreeFamiTF318980.

Miscellaneous databases

NextBioi284392.
PROiP43300.
SOURCEiSearch...

Gene expression databases

BgeeiP43300.
CleanExiMM_EGR3.
ExpressionAtlasiP43300. baseline and differential.
GenevestigatoriP43300.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR021849. DUF3446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF11928. DUF3446. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3."
    Tourtellotte W.G., Milbrandt J.
    Nat. Genet. 20:87-91(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors."
    Patwardhan S., Gashler A., Siegel M.G., Chang L.C., Joseph L.J., Shows T.B., le Beau M.M., Sukhatme V.P.
    Oncogene 6:917-928(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-327.

Entry informationi

Entry nameiEGR3_MOUSE
AccessioniPrimary (citable) accession number: P43300
Secondary accession number(s): Q9R276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: May 8, 2003
Last modified: February 3, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.