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P43290

- CDC2_PETHY

UniProt

P43290 - CDC2_PETHY

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Protein

Cell division control protein 2 homolog

Gene
CDC2
Organism
Petunia hybrida (Petunia)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation inactivates the enzyme By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
p34cdc2
Gene namesi
Name:CDC2
OrganismiPetunia hybrida (Petunia)
Taxonomic identifieri4102 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›90›90Cell division control protein 2 homologPRO_0000085759Add
BLAST

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Differentially expressed in leaves, protoplasts.

Structurei

3D structure databases

ProteinModelPortaliP43290.
SMRiP43290. Positions 1-90.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›90›90Protein kinaseAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P43290-1 [UniParc]FASTAAdd to Basket

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EGVPSTAIRE ISLLKEMQHA NIVRLQDVVH SEKRLYLVFE YLDLDLKKHM   50
DSSPEFSKDP RLVKMFLYQI LRGIAYCHSH RVLHRDLKPQ 90
Length:90
Mass (Da):10,671
Last modified:November 1, 1995 - v1
Checksum:i5C7E9F18C9C2736D
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei90 – 901

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64321 mRNA. Translation: CAA45606.1.
PIRiS28413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64321 mRNA. Translation: CAA45606.1 .
PIRi S28413.

3D structure databases

ProteinModelPortali P43290.
SMRi P43290. Positions 1-90.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A cdc2 gene of Petunia hybrida is differentially expressed in leaves, protoplasts and during various cell cycle phases."
    Bergounioux C., Perennes C., Hemerly A.S., Qin L.X., Sarda C., Inze D., Gadal P.
    Plant Mol. Biol. 20:1121-1130(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. P X PC6.

Entry informationi

Entry nameiCDC2_PETHY
AccessioniPrimary (citable) accession number: P43290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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