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P43290 (CDC2_PETHY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
p34cdc2
Gene names
Name:CDC2
OrganismPetunia hybrida (Petunia)
Taxonomic identifier4102 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

Protein attributes

Sequence length90 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation inactivates the enzyme By similarity.

Tissue specificity

Differentially expressed in leaves, protoplasts.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›90›90Cell division control protein 2 homolog
PRO_0000085759

Regions

Domain‹1 – ›90›90Protein kinase

Sites

Active site861Proton acceptor By similarity

Experimental info

Non-terminal residue11
Non-terminal residue901

Sequences

Sequence LengthMass (Da)Tools
P43290 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5C7E9F18C9C2736D

FASTA9010,671
        10         20         30         40         50         60 
EGVPSTAIRE ISLLKEMQHA NIVRLQDVVH SEKRLYLVFE YLDLDLKKHM DSSPEFSKDP 

        70         80         90 
RLVKMFLYQI LRGIAYCHSH RVLHRDLKPQ 

« Hide

References

[1]"A cdc2 gene of Petunia hybrida is differentially expressed in leaves, protoplasts and during various cell cycle phases."
Bergounioux C., Perennes C., Hemerly A.S., Qin L.X., Sarda C., Inze D., Gadal P.
Plant Mol. Biol. 20:1121-1130(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. P X PC6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64321 mRNA. Translation: CAA45606.1.
PIRS28413.

3D structure databases

ProteinModelPortalP43290.
SMRP43290. Positions 1-90.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC2_PETHY
AccessionPrimary (citable) accession number: P43290
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families