Reviewed, UniProtKB/Swiss-Prot P43290 (CDC2_PETHY)

Names and origin

Protein names

Recommended name:
    Cell division control protein 2 homolog
    EC=2.7.11.22
    EC=2.7.11.23
Alternative name(s):
    p34cdc2

Gene names

Name:

CDC2

Organism

Petunia hybrida (Petunia)

Taxonomic identifier

4102 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Petunioideae › Petunia

Protein attributes

Sequence length	90 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Enzyme regulation	Phosphorylation inactivates the enzyme By similarity.
Tissue specificity	Differentially expressed in leaves, protoplasts.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: EC cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›90	›90	Cell division control protein 2 homolog		PRO_0000085759
Regions
	Domain	‹1 – ›90	›90	Protein kinase
Sites
	Active site	86	1	Proton acceptor By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	90	1

Sequences

	Sequence		Length	Mass (Da)
	P43290-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5C7E9F18C9C2736D	FASTA	90	10,671
	10 20 30 40 50 60 EGVPSTAIRE ISLLKEMQHA NIVRLQDVVH SEKRLYLVFE YLDLDLKKHM DSSPEFSKDP 70 80 90 RLVKMFLYQI LRGIAYCHSH RVLHRDLKPQ

References

[1]

"A cdc2 gene of Petunia hybrida is differentially expressed in leaves, protoplasts and during various cell cycle phases." Bergounioux C., Perennes C., Hemerly A.S., Qin L.X., Sarda C., Inze D., Gadal P. Plant Mol. Biol. 20:1121-1130(1992) [PubMed: 1361156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. P X PC6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64321 mRNA. Translation: CAA45606.1.
PIR	S28413.
3D structure databases
SMR	P43290. Positions 1-90.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.22. 2263. 2.7.11.23. 2263.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_prot_kinase-like_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDC2_PETHY

Accession

Primary (citable) accession number: P43290

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 19, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)