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Protein

Shaggy-related protein kinase gamma

Gene

ASK3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate extracellular signals to regulate transcription in differentiating cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102ATPPROSITE-ProRule annotation1
Active sitei198Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 87ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  • meristem structural organization Source: TAIR
  • protein autophosphorylation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.26. 399.
ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Shaggy-related protein kinase gamma (EC:2.7.11.1)
Alternative name(s):
ASK-gamma
Gene namesi
Name:ASK3
Ordered Locus Names:At3g05840
ORF Names:F10A16.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G05840.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000862182 – 409Shaggy-related protein kinase gammaAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei233PhosphotyrosineBy similarity1

Post-translational modificationi

Autophosphorylated mainly on threonine and serine residues.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP43289.

PTM databases

iPTMnetiP43289.

Expressioni

Tissue specificityi

Roots, shoots and leaves.

Gene expression databases

ExpressionAtlasiP43289. baseline and differential.
GenevisibleiP43289. AT.

Interactioni

Protein-protein interaction databases

BioGridi5088. 1 interactor.
IntActiP43289. 2 interactors.
STRINGi3702.AT3G05840.1.

Structurei

3D structure databases

ProteinModelPortaliP43289.
SMRiP43289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 357Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0658. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233017.
InParanoidiP43289.
OMAiDMKIQDD.
OrthoDBiEOG093609V0.
PhylomeDBiP43289.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVGIEPSA AVRESTGNVT DADRLPEEMK DMKIQDDKEM EATIVNGNVT
60 70 80 90 100
ETGHIIVTTI GGRNGQPKQT ISYMAERVVG HGSFGVVFQA KCLETGETVA
110 120 130 140 150
IKKVLQDRRY KNRELQTMRL LDHPNVVSLK HCFFSTTEKD ELYLNLVLEY
160 170 180 190 200
VPETVHRVIK HYNKLNQRMP LVYVKLYTYQ IFRSLSYIHR CIGVCHRDIK
210 220 230 240 250
PQNLLVNPHT HQVKLCDFGS AKVLVKGEPN ISYICSRYYR APELIFGATE
260 270 280 290 300
YTTAIDVWSA GCVLAELLLG QPLFPGESGV DQLVEIIKVL GTPTREEIKC
310 320 330 340 350
MNPNYTEFKF PQIKAHPWHK IFHKRMPPEA VDLVSRLLQY SPNLRCAALD
360 370 380 390 400
SLVHPFFDEL RDPNARLPNG RFLPPLFNFK PHELKGVPVE MVAKLVPEHA

RKQCPWLSL
Length:409
Mass (Da):46,587
Last modified:November 1, 1995 - v1
Checksum:i3A7950B183D8C33B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22A → V in AAM62970 (PubMed:14593172).Curated1
Sequence conflicti44I → V in AAM62970 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75431 mRNA. Translation: CAA53180.1.
Y12710 Genomic DNA. Translation: CAA73247.1.
AC012393 Genomic DNA. Translation: AAF26086.1.
CP002686 Genomic DNA. Translation: AEE74303.1.
CP002686 Genomic DNA. Translation: AEE74304.1.
AY093347 mRNA. Translation: AAM13346.1.
AY062713 mRNA. Translation: AAL32791.1.
AY085752 mRNA. Translation: AAM62970.1.
PIRiS41597.
RefSeqiNP_187235.1. NM_111458.5.
NP_850520.1. NM_180189.4.
UniGeneiAt.132.
At.20895.

Genome annotation databases

EnsemblPlantsiAT3G05840.1; AT3G05840.1; AT3G05840.
AT3G05840.2; AT3G05840.2; AT3G05840.
GeneIDi819753.
GrameneiAT3G05840.1; AT3G05840.1; AT3G05840.
AT3G05840.2; AT3G05840.2; AT3G05840.
KEGGiath:AT3G05840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75431 mRNA. Translation: CAA53180.1.
Y12710 Genomic DNA. Translation: CAA73247.1.
AC012393 Genomic DNA. Translation: AAF26086.1.
CP002686 Genomic DNA. Translation: AEE74303.1.
CP002686 Genomic DNA. Translation: AEE74304.1.
AY093347 mRNA. Translation: AAM13346.1.
AY062713 mRNA. Translation: AAL32791.1.
AY085752 mRNA. Translation: AAM62970.1.
PIRiS41597.
RefSeqiNP_187235.1. NM_111458.5.
NP_850520.1. NM_180189.4.
UniGeneiAt.132.
At.20895.

3D structure databases

ProteinModelPortaliP43289.
SMRiP43289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5088. 1 interactor.
IntActiP43289. 2 interactors.
STRINGi3702.AT3G05840.1.

PTM databases

iPTMnetiP43289.

Proteomic databases

PaxDbiP43289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G05840.1; AT3G05840.1; AT3G05840.
AT3G05840.2; AT3G05840.2; AT3G05840.
GeneIDi819753.
GrameneiAT3G05840.1; AT3G05840.1; AT3G05840.
AT3G05840.2; AT3G05840.2; AT3G05840.
KEGGiath:AT3G05840.

Organism-specific databases

TAIRiAT3G05840.

Phylogenomic databases

eggNOGiKOG0658. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233017.
InParanoidiP43289.
OMAiDMKIQDD.
OrthoDBiEOG093609V0.
PhylomeDBiP43289.

Enzyme and pathway databases

BRENDAi2.7.11.26. 399.
ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

PROiP43289.

Gene expression databases

ExpressionAtlasiP43289. baseline and differential.
GenevisibleiP43289. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKSG3_ARATH
AccessioniPrimary (citable) accession number: P43289
Secondary accession number(s): Q8L5U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.