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Protein

Shaggy-related protein kinase alpha

Gene

ASK1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate extracellular signals to regulate transcription in differentiating cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98ATPPROSITE-ProRule annotation1
Active sitei194Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 83ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  • hyperosmotic salinity response Source: TAIR
  • meristem structural organization Source: TAIR
  • positive regulation of response to salt stress Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.26 399
ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Shaggy-related protein kinase alpha1 Publication (EC:2.7.11.1)
Alternative name(s):
ASK-alpha1 Publication
Shaggy-related protein kinase 111 Publication
Short name:
AtSK111 Publication
Gene namesi
Name:ASK11 Publication
Synonyms:SK111 Publication
Ordered Locus Names:At5g26751Imported
ORF Names:F2P16.21Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G26751
TAIRilocus:2832141 AT5G26751

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000862162 – 405Shaggy-related protein kinase alphaAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei229PhosphotyrosineBy similarity1

Post-translational modificationi

Autophosphorylated mainly on threonine and serine residues.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP43288
PRIDEiP43288

PTM databases

iPTMnetiP43288

Expressioni

Tissue specificityi

Roots, shoots and leaves.

Gene expression databases

ExpressionAtlasiP43288 baseline and differential
GenevisibleiP43288 AT

Interactioni

Subunit structurei

Binds to KIB1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CUL1Q94AH62EBI-4463633,EBI-532411

Protein-protein interaction databases

BioGridi18008, 1 interactor
DIPiDIP-46124N
IntActiP43288, 3 interactors
STRINGi3702.AT5G26751.1

Structurei

3D structure databases

ProteinModelPortaliP43288
SMRiP43288
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 353Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0658 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233017
InParanoidiP43288
KOiK00924
OMAiKSHELNG
OrthoDBiEOG093609V0
PhylomeDBiP43288

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVGIAPNP GARDSTGVDK LPEEMNDMKI RDDKEMEATV VDGNGTETGH
60 70 80 90 100
IIVTTIGGRN GQPKQTISYM AERVVGHGSF GVVFQAKCLE TGETVAIKKV
110 120 130 140 150
LQDRRYKNRE LQTMRLLDHP NVVSLKHCFF STTEKDELYL NLVLEYVPET
160 170 180 190 200
VHRVIKHYNK LNQRMPLIYV KLYTYQIFRA LSYIHRCIGV CHRDIKPQNL
210 220 230 240 250
LVNPHTHQVK LCDFGSAKVL VKGEPNISYI CSRYYRAPEL IFGATEYTTA
260 270 280 290 300
IDVWSAGCVL AELLLGQPLF PGESGVDQLV EIIKVLGTPT REEIKCMNPN
310 320 330 340 350
YTEFKFPQIK AHPWHKIFHK RMPPEAVDLV SRLLQYSPNL RSAALDTLVH
360 370 380 390 400
PFFDELRDPN ARLPNGRFLP PLFNFKPHEL KGVPLEMVAK LVPEHARKQC

PWLGL
Length:405
Mass (Da):46,035
Last modified:January 10, 2003 - v3
Checksum:iACC949DD58479FBB
GO

Sequence cautioni

The sequence AAB61055 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA04265 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti281E → H in CAA53181 (PubMed:7509023).Curated1
Sequence conflicti281E → H in CAA48538 (PubMed:7509023).Curated1
Sequence conflicti281E → H in CAA04265 (Ref. 2) Curated1
Sequence conflicti372 – 374LFN → AFH in CAA53181 (PubMed:7509023).Curated3
Sequence conflicti372 – 374LFN → AFH in CAA48538 (PubMed:7509023).Curated3
Sequence conflicti372 – 374LFN → AFH in CAA04265 (Ref. 2) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68525 mRNA Translation: CAA48538.1
X75432 mRNA Translation: CAA53181.1
AJ000732 Genomic DNA Translation: CAA04265.1 Sequence problems.
AF007270 Genomic DNA Translation: AAB61055.1 Sequence problems.
CP002688 Genomic DNA Translation: AED93596.1
AF428327 mRNA Translation: AAL16257.1
AY046024 mRNA Translation: AAK76698.1
AY142595 mRNA Translation: AAN13164.1
PIRiS41596
T01756
RefSeqiNP_568486.1, NM_122557.3
UniGeneiAt.132

Genome annotation databases

EnsemblPlantsiAT5G26751.1; AT5G26751.1; AT5G26751
GeneIDi832733
GrameneiAT5G26751.1; AT5G26751.1; AT5G26751
KEGGiath:AT5G26751

Similar proteinsi

Entry informationi

Entry nameiKSG1_ARATH
AccessioniPrimary (citable) accession number: P43288
Secondary accession number(s): O04625, O23151, Q93VJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 10, 2003
Last modified: May 23, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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