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Protein

Histone H1.0

Gene

H1f0

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.0
Alternative name(s):
Histone H1'
Histone H1(0)
Cleaved into the following chain:
Gene namesi
Name:H1f0
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2777 H1f0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001959231 – 194Histone H1.0Add BLAST194
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004232102 – 194Histone H1.0, N-terminally processedAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in Histone H1.0, N-terminally processedBy similarity1
Modified residuei42CitrullineBy similarity1
Modified residuei104ADP-ribosylserineBy similarity1

Post-translational modificationi

ADP-ribosylated on Ser-104 in response to DNA damage.By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Citrullination

Proteomic databases

PaxDbiP43278
PRIDEiP43278

PTM databases

iPTMnetiP43278
PhosphoSitePlusiP43278

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053053

Structurei

3D structure databases

ProteinModelPortaliP43278
SMRiP43278
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 97H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
HOGENOMiHOG000251627
InParanoidiP43278
KOiK11275
PhylomeDBiP43278
TreeFamiTF313664

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENSTSTPA AKPKRAKAAK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI
60 70 80 90 100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKGDE
110 120 130 140 150
PKRSVAFKKT KKEVKKVATP KKAAKPKKAA SKAPSKKPKA TPVKKAKKKP
160 170 180 190
AATPKKAKKP KIVKVKPVKA SKPKKAKPVK PKAKSSAKRA SKKK
Length:194
Mass (Da):20,885
Last modified:January 23, 2007 - v2
Checksum:i352B696568B95171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72624 mRNA Translation: CAA51199.1
BC061842 mRNA Translation: AAH61842.1
X70685 mRNA Translation: CAA50020.1
PIRiS47348
RefSeqiNP_036710.1, NM_012578.2
UniGeneiRn.3129

Genome annotation databases

GeneIDi24437
KEGGirno:24437
UCSCiRGD:2777 rat

Similar proteinsi

Entry informationi

Entry nameiH10_RAT
AccessioniPrimary (citable) accession number: P43278
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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