P43275 (H11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone H1.1

Alternative name(s):
H1 VAR.3
Histone H1a
Short name=H1a

Gene names

Name:	Hist1h1a
Synonyms:	H1a, H1f1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation By similarity.
Subunit structure	Interacts with DFFB By similarity.
Subcellular location	Nucleus. Chromosome. Note: Mainly localizes in euchromatin By similarity.
Tissue specificity	Restricted to thymus, testis and spleen. Present also in lymphocytic and neuronal cells. Increases in testis starting with a low level at day 5 and reaching high concentrations in 20-day old and adult animals. Ref.2
Domain	The C-terminal domain is required for high-affinity binding to chromatin By similarity.
Post-translational modification	H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Ref.7
Disruption phenotype	Deficient-mice developed normally until the adult stage. No anatomic abnormalities are detected, mice are fertile and they show normal spermatogenesis and testicular morphology. The lack of phenotype may be due to a compensatory function of other histone H1 subtypes. Ref.8
Sequence similarities	Belongs to the histone H1/H5 family. Contains 1 H15 (linker histone H1/H5 globular) domain.

Ontologies

Keywords
Cellular component	Chromosome Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleosome assembly Inferred from electronic annotation. Source: InterPro spermatogenesis Inferred from genetic interaction PubMed 15051954. Source: MGI
Cellular_component	nuclear chromatin Inferred from electronic annotation. Source: Compara nucleosome Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from direct assay PubMed 15562002. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Histone H1.1		PRO_0000195914
Regions
	Domain	38 – 111	74	H15
Amino acid modifications
	Modified residue	106	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43275 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 03A46320A100B203	FASTA	213	21,785
	10 20 30 40 50 60 MSETAPVAQA ASTATEKPAA AKKTKKPAKA AAPRKKPAGP SVSELIVQAV SSSKERSGVS 70 80 90 100 110 120 LAALKKSLAA AGYDVEKNNS RIKLGLKSLV NKGTLVQTKG TGAAGSFKLN KKAESKAITT 130 140 150 160 170 180 KVSVKAKASG AAKKPKKTAG AAAKKTVKTP KKPKKPAVSK KTSKSPKKPK VVKAKKVAKS 190 200 210 PAKAKAVKPK ASKAKVTKPK TPAKPKKAAP KKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of two replication-dependent mouse H1 histone genes." Dong Y., Sirotkin A.M., Yang Y.-S., Brown D.T., Sittman D.B., Skoultchi A.I. Nucleic Acids Res. 22:1421-1428(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[2]	"Expression of murine H1 histone genes during postnatal development." Franke K., Drabent B., Doenecke D. Biochim. Biophys. Acta 1398:232-242(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY. Strain: 129/Sv.
[3]	"The human and mouse replication-dependent histone genes." Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J. Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"In vivo phosphorylation of histone H1 variants during the cell cycle." Talasz H., Helliger W., Puschendorf B., Lindner H. Biochemistry 35:1761-1767(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION.
[8]	"Spermatogenesis in mice is not affected by histone H1.1 deficiency." Rabini S., Franke K., Saftig P., Bode C., Doenecke D., Drabent B. Exp. Cell Res. 255:114-124(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L26164 Genomic DNA. Translation: AAA37761.1. Y12290 Genomic DNA. Translation: CAA72969.1. AY158903 Genomic DNA. Translation: AAO06214.1. AL590388 Genomic DNA. Translation: CAI25836.1. CH466561 Genomic DNA. Translation: EDL32534.1. BC116820 mRNA. Translation: AAI16821.1. BC116850 mRNA. Translation: AAI16851.1.
IPI	IPI00228616.
PIR	S43949.
RefSeq	NP_085112.1. NM_030609.2.
UniGene	Mm.377137. Mm.480242.
3D structure databases
ProteinModelPortal	P43275.
SMR	P43275. Positions 38-111.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000062030.
PTM databases
PhosphoSite	P43275.
Proteomic databases
PaxDb	P43275.
PRIDE	P43275.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000055770; ENSMUSP00000062030; ENSMUSG00000049539.
GeneID	80838.
KEGG	mmu:80838.
Organism-specific databases
CTD	3024.
MGI	MGI:1931523. Hist1h1a.
Phylogenomic databases
eggNOG	NOG258621.
GeneTree	ENSGT00670000097781.
HOGENOM	HOG000251627.
HOVERGEN	HBG009035.
InParanoid	P43275.
KO	K11275.
OMA	FKLAKRT.
OrthoDB	EOG4H19XG.
Gene expression databases
ArrayExpress	P43275.
Bgee	P43275.
CleanEx	MM_HIST1H1A.
Genevestigator	P43275.
GermOnline	ENSMUSG00000049539. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR005818. Histone_H1/H5. IPR005819. Histone_H5. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00538. Linker_histone. 1 hit. [Graphical view]
PRINTS	PR00624. HISTONEH5.
SMART	SM00526. H15. 1 hit. [Graphical view]
PROSITE	PS51504. H15. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	350151.
SOURCE	Search...

Entry information

Entry name

H11_MOUSE

Accession

Primary (citable) accession number: P43275
Secondary accession number(s): Q5SZ98

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program