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P43275

- H11_MOUSE

UniProt

P43275 - H11_MOUSE

Protein

Histone H1.1

Gene

Hist1h1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. nucleosome assembly Source: InterPro
    2. spermatogenesis Source: MGI

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H1.1
    Alternative name(s):
    H1 VAR.3
    Histone H1a
    Short name:
    H1a
    Gene namesi
    Name:Hist1h1a
    Synonyms:H1a, H1f1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1931523. Hist1h1a.

    Subcellular locationi

    Nucleus. Chromosome
    Note: Mainly localizes in euchromatin.By similarity

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl
    2. nucleosome Source: InterPro

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Deficient-mice developed normally until the adult stage. No anatomic abnormalities are detected, mice are fertile and they show normal spermatogenesis and testicular morphology. The lack of phenotype may be due to a compensatory function of other histone H1 subtypes.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 213212Histone H1.1PRO_0000195914Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei17 – 171N6-acetyllysine1 Publication
    Modified residuei56 – 561Citrulline1 Publication
    Modified residuei77 – 771N6-acetyllysine1 Publication
    Modified residuei92 – 921N6-acetyllysine1 Publication
    Modified residuei106 – 1061PhosphoserineBy similarity
    Modified residuei121 – 1211N6-acetyllysine1 Publication

    Post-translational modificationi

    H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.1 Publication
    Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.1 Publication

    Keywords - PTMi

    Acetylation, Citrullination, Phosphoprotein

    Proteomic databases

    MaxQBiP43275.
    PaxDbiP43275.
    PRIDEiP43275.

    PTM databases

    PhosphoSiteiP43275.

    Expressioni

    Tissue specificityi

    Restricted to thymus, testis and spleen. Present also in lymphocytic and neuronal cells. Increases in testis starting with a low level at day 5 and reaching high concentrations in 20-day old and adult animals.1 Publication

    Gene expression databases

    BgeeiP43275.
    CleanExiMM_HIST1H1A.
    GenevestigatoriP43275.

    Interactioni

    Subunit structurei

    Interacts with DFFB.By similarity

    Protein-protein interaction databases

    BioGridi219818. 9 interactions.
    IntActiP43275. 1 interaction.
    MINTiMINT-1868385.
    STRINGi10090.ENSMUSP00000062030.

    Structurei

    3D structure databases

    ProteinModelPortaliP43275.
    SMRiP43275. Positions 38-111.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 11174H15PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The C-terminal domain is required for high-affinity binding to chromatin.By similarity

    Sequence similaritiesi

    Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
    Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258621.
    GeneTreeiENSGT00670000097781.
    HOGENOMiHOG000251627.
    HOVERGENiHBG009035.
    InParanoidiP43275.
    KOiK11275.
    OrthoDBiEOG74TX2T.
    TreeFamiTF313664.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR005818. Histone_H1/H5_H15.
    IPR005819. Histone_H5.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00538. Linker_histone. 1 hit.
    [Graphical view]
    PRINTSiPR00624. HISTONEH5.
    SMARTiSM00526. H15. 1 hit.
    [Graphical view]
    PROSITEiPS51504. H15. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43275-1 [UniParc]FASTAAdd to Basket

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    MSETAPVAQA ASTATEKPAA AKKTKKPAKA AAPRKKPAGP SVSELIVQAV    50
    SSSKERSGVS LAALKKSLAA AGYDVEKNNS RIKLGLKSLV NKGTLVQTKG 100
    TGAAGSFKLN KKAESKAITT KVSVKAKASG AAKKPKKTAG AAAKKTVKTP 150
    KKPKKPAVSK KTSKSPKKPK VVKAKKVAKS PAKAKAVKPK ASKAKVTKPK 200
    TPAKPKKAAP KKK 213
    Length:213
    Mass (Da):21,785
    Last modified:January 23, 2007 - v2
    Checksum:i03A46320A100B203
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26164 Genomic DNA. Translation: AAA37761.1.
    Y12290 Genomic DNA. Translation: CAA72969.1.
    AY158903 Genomic DNA. Translation: AAO06214.1.
    AL590388 Genomic DNA. Translation: CAI25836.1.
    CH466561 Genomic DNA. Translation: EDL32534.1.
    BC116820 mRNA. Translation: AAI16821.1.
    BC116850 mRNA. Translation: AAI16851.1.
    CCDSiCCDS26369.1.
    PIRiS43949.
    RefSeqiNP_085112.1. NM_030609.3.
    UniGeneiMm.480242.

    Genome annotation databases

    EnsembliENSMUST00000055770; ENSMUSP00000062030; ENSMUSG00000049539.
    GeneIDi80838.
    KEGGimmu:80838.
    UCSCiuc007puz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26164 Genomic DNA. Translation: AAA37761.1 .
    Y12290 Genomic DNA. Translation: CAA72969.1 .
    AY158903 Genomic DNA. Translation: AAO06214.1 .
    AL590388 Genomic DNA. Translation: CAI25836.1 .
    CH466561 Genomic DNA. Translation: EDL32534.1 .
    BC116820 mRNA. Translation: AAI16821.1 .
    BC116850 mRNA. Translation: AAI16851.1 .
    CCDSi CCDS26369.1.
    PIRi S43949.
    RefSeqi NP_085112.1. NM_030609.3.
    UniGenei Mm.480242.

    3D structure databases

    ProteinModelPortali P43275.
    SMRi P43275. Positions 38-111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 219818. 9 interactions.
    IntActi P43275. 1 interaction.
    MINTi MINT-1868385.
    STRINGi 10090.ENSMUSP00000062030.

    PTM databases

    PhosphoSitei P43275.

    Proteomic databases

    MaxQBi P43275.
    PaxDbi P43275.
    PRIDEi P43275.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055770 ; ENSMUSP00000062030 ; ENSMUSG00000049539 .
    GeneIDi 80838.
    KEGGi mmu:80838.
    UCSCi uc007puz.1. mouse.

    Organism-specific databases

    CTDi 3024.
    MGIi MGI:1931523. Hist1h1a.

    Phylogenomic databases

    eggNOGi NOG258621.
    GeneTreei ENSGT00670000097781.
    HOGENOMi HOG000251627.
    HOVERGENi HBG009035.
    InParanoidi P43275.
    KOi K11275.
    OrthoDBi EOG74TX2T.
    TreeFami TF313664.

    Miscellaneous databases

    NextBioi 350151.
    PROi P43275.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43275.
    CleanExi MM_HIST1H1A.
    Genevestigatori P43275.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR005818. Histone_H1/H5_H15.
    IPR005819. Histone_H5.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00538. Linker_histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00624. HISTONEH5.
    SMARTi SM00526. H15. 1 hit.
    [Graphical view ]
    PROSITEi PS51504. H15. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of two replication-dependent mouse H1 histone genes."
      Dong Y., Sirotkin A.M., Yang Y.-S., Brown D.T., Sittman D.B., Skoultchi A.I.
      Nucleic Acids Res. 22:1421-1428(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    2. "Expression of murine H1 histone genes during postnatal development."
      Franke K., Drabent B., Doenecke D.
      Biochim. Biophys. Acta 1398:232-242(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129/Sv.
    3. "The human and mouse replication-dependent histone genes."
      Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.
      Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "In vivo phosphorylation of histone H1 variants during the cell cycle."
      Talasz H., Helliger W., Puschendorf B., Lindner H.
      Biochemistry 35:1761-1767(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    8. "Spermatogenesis in mice is not affected by histone H1.1 deficiency."
      Rabini S., Franke K., Saftig P., Bode C., Doenecke D., Drabent B.
      Exp. Cell Res. 255:114-124(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    9. Cited for: CITRULLINATION AT ARG-56.
    10. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-17; LYS-77; LYS-92 AND LYS-121, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiH11_MOUSE
    AccessioniPrimary (citable) accession number: P43275
    Secondary accession number(s): Q5SZ98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3