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P43273

- TGA2_ARATH

UniProt

P43273 - TGA2_ARATH

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Protein

Transcription factor TGA2

Gene

TGA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Required to induce the systemic acquired resistance (SAR) via the regulation of pathogenesis-related genes expression. Binding to the as-1 element of PR-1 promoter is salicylic acid-inducible and mediated by NPR1. Could also bind to the C-boxes (5'-ATGACGTCAT-3') with high affinity.1 Publication

GO - Molecular functioni

  1. DNA binding Source: TAIR
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: TAIR
  2. plant-type hypersensitive response Source: UniProtKB-KW
  3. positive regulation of transcription, DNA-templated Source: TAIR
  4. response to xenobiotic stimulus Source: TAIR
  5. systemic acquired resistance, salicylic acid mediated signaling pathway Source: TAIR
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Hypersensitive response, Plant defense, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor TGA2
Alternative name(s):
HBP-1b homolog
Short name:
AHBP-1b
bZIP transcription factor 20
Short name:
AtbZIP20
Gene namesi
Name:TGA2
Synonyms:BZIP20, HBP1B
Ordered Locus Names:At5g06950
ORF Names:MOJ9.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G06950.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Transcription factor TGA2PRO_0000076554Add
BLAST

Expressioni

Tissue specificityi

Expressed in the whole plant.

Gene expression databases

ExpressionAtlasiP43273. baseline and differential.
GenevestigatoriP43273.

Interactioni

Subunit structurei

Binds DNA as a dimer. Interacts with NPR1, NPR3 and NPR4. Interacts with GRXC7/ROXY1 and GRXC9/GRX480.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GRXC7Q963053EBI-541307,EBI-2257898
GRXC8Q8LF892EBI-541307,EBI-4434651
GRXC9Q9SGP63EBI-541307,EBI-1545762
NPR1P930027EBI-541307,EBI-1392127
NPR1Q8L9W47EBI-541307,EBI-541093

Protein-protein interaction databases

BioGridi15865. 25 interactions.
IntActiP43273. 14 interactions.

Structurei

3D structure databases

ProteinModelPortaliP43273.
SMRiP43273. Positions 42-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 10764bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 6621Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni72 – 8615Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili45 – 14298Sequence AnalysisAdd
BLAST
Coiled coili217 – 24428Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG278920.
HOGENOMiHOG000116597.
InParanoidiP43273.
KOiK14431.
OMAiMTERQLM.
PhylomeDBiP43273.

Family and domain databases

InterProiIPR004827. bZIP.
IPR025422. TGA_domain.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF14144. DOG1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43273-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADTSPRTDV STDDDTDHPD LGSEGALVNT AASDSSDRSK GKMDQKTLRR
60 70 80 90 100
LAQNREAARK SRLRKKAYVQ QLENSRLKLT QLEQELQRAR QQGVFISGTG
110 120 130 140 150
DQAHSTGGNG ALAFDAEHSR WLEEKNKQMN ELRSALNAHA GDSELRIIVD
160 170 180 190 200
GVMAHYEELF RIKSNAAKND VFHLLSGMWK TPAERCFLWL GGFRSSELLK
210 220 230 240 250
LLANQLEPMT ERQLMGINNL QQTSQQAEDA LSQGMESLQQ SLADTLSSGT
260 270 280 290 300
LGSSSSGNVA SYMGQMAMAM GKLGTLEGFI RQADNLRLQT LQQMIRVLTT
310 320 330
RQSARALLAI HDYFSRLRAL SSLWLARPRE
Length:330
Mass (Da):36,684
Last modified:November 1, 1995 - v1
Checksum:iD3033153BCE932C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10042 mRNA. Translation: BAA00933.1.
AB010697 Genomic DNA. Translation: BAB11153.1.
CP002688 Genomic DNA. Translation: AED91085.1.
CP002688 Genomic DNA. Translation: AED91086.1.
CP002688 Genomic DNA. Translation: AED91087.1.
CP002688 Genomic DNA. Translation: AED91088.1.
AK117686 mRNA. Translation: BAC42338.1.
BT006134 mRNA. Translation: AAP04119.1.
PIRiS35439.
RefSeqiNP_001031845.1. NM_001036768.1.
NP_001078539.1. NM_001085070.1.
NP_196312.1. NM_120777.2.
NP_974744.1. NM_203015.1.
UniGeneiAt.23884.

Genome annotation databases

EnsemblPlantsiAT5G06950.1; AT5G06950.1; AT5G06950.
AT5G06950.2; AT5G06950.2; AT5G06950.
AT5G06950.3; AT5G06950.3; AT5G06950.
AT5G06950.4; AT5G06950.4; AT5G06950.
GeneIDi830586.
KEGGiath:AT5G06950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10042 mRNA. Translation: BAA00933.1 .
AB010697 Genomic DNA. Translation: BAB11153.1 .
CP002688 Genomic DNA. Translation: AED91085.1 .
CP002688 Genomic DNA. Translation: AED91086.1 .
CP002688 Genomic DNA. Translation: AED91087.1 .
CP002688 Genomic DNA. Translation: AED91088.1 .
AK117686 mRNA. Translation: BAC42338.1 .
BT006134 mRNA. Translation: AAP04119.1 .
PIRi S35439.
RefSeqi NP_001031845.1. NM_001036768.1.
NP_001078539.1. NM_001085070.1.
NP_196312.1. NM_120777.2.
NP_974744.1. NM_203015.1.
UniGenei At.23884.

3D structure databases

ProteinModelPortali P43273.
SMRi P43273. Positions 42-79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 15865. 25 interactions.
IntActi P43273. 14 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G06950.1 ; AT5G06950.1 ; AT5G06950 .
AT5G06950.2 ; AT5G06950.2 ; AT5G06950 .
AT5G06950.3 ; AT5G06950.3 ; AT5G06950 .
AT5G06950.4 ; AT5G06950.4 ; AT5G06950 .
GeneIDi 830586.
KEGGi ath:AT5G06950.

Organism-specific databases

GeneFarmi 2992. 292.
TAIRi AT5G06950.

Phylogenomic databases

eggNOGi NOG278920.
HOGENOMi HOG000116597.
InParanoidi P43273.
KOi K14431.
OMAi MTERQLM.
PhylomeDBi P43273.

Gene expression databases

ExpressionAtlasi P43273. baseline and differential.
Genevestigatori P43273.

Family and domain databases

InterProi IPR004827. bZIP.
IPR025422. TGA_domain.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF14144. DOG1. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cDNA clone encoding HBP-1b homologue in Arabidopsis thaliana."
    Kawata T., Imada T., Shiraishi H., Okada K., Shimura Y., Iwabuchi M.
    Nucleic Acids Res. 20:1141-1141(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Landsberg erecta.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
    Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Binding site requirements and differential representation of TGF factors in nuclear ASF-1 activity."
    Lam E., Lam Y.K.
    Nucleic Acids Res. 23:3778-3785(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  7. "Binding specificity and tissue-specific expression pattern of the Arabidopsis bZIP transcription factor TGA2."
    de Pater S., Pham K., Memelink J., Kijne J.
    Mol. Gen. Genet. 250:237-239(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. "NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid."
    Zhou J.-M., Trifa Y., Silva H., Pontier D., Lam E., Shah J., Klessig D.F.
    Mol. Plant Microbe Interact. 13:191-202(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NPR1.
  9. Cited for: GENE FAMILY, NOMENCLATURE.
  10. "Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis."
    Johnson C., Boden E., Arias J.
    Plant Cell 15:1846-1858(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance."
    Liu G., Holub E.B., Alonso J.M., Ecker J.R., Fobert P.R.
    Plant J. 41:304-318(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NPR1 AND NPR4.
  12. "Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs."
    Zhang Y., Cheng Y.T., Qu N., Zhao Q., Bi D., Li X.
    Plant J. 48:647-656(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NPR3 AND NPR4.
  13. "SA-inducible Arabidopsis glutaredoxin interacts with TGA factors and suppresses JA-responsive PDF1.2 transcription."
    Ndamukong I., Abdallat A.A., Thurow C., Fode B., Zander M., Weigel R., Gatz C.
    Plant J. 50:128-139(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRXC9/GRX480.
  14. "Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana."
    Li S., Lauri A., Ziemann M., Busch A., Bhave M., Zachgo S.
    Plant Cell 21:429-441(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRXC7/ROXY1.

Entry informationi

Entry nameiTGA2_ARATH
AccessioniPrimary (citable) accession number: P43273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3