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P43273

- TGA2_ARATH

UniProt

P43273 - TGA2_ARATH

Protein

Transcription factor TGA2

Gene

TGA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds specifically to the DNA sequence 5'-TGACG-3'. Recognizes ocs elements like the as-1 motif of the cauliflower mosaic virus 35S promoter. Binding to the as-1-like cis elements mediate auxin- and salicylic acid-inducible transcription. Required to induce the systemic acquired resistance (SAR) via the regulation of pathogenesis-related genes expression. Binding to the as-1 element of PR-1 promoter is salicylic acid-inducible and mediated by NPR1. Could also bind to the C-boxes (5'-ATGACGTCAT-3') with high affinity.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: TAIR
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: TAIR

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: TAIR
    2. plant-type hypersensitive response Source: UniProtKB-KW
    3. positive regulation of transcription, DNA-templated Source: TAIR
    4. response to xenobiotic stimulus Source: TAIR
    5. systemic acquired resistance, salicylic acid mediated signaling pathway Source: TAIR
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Hypersensitive response, Plant defense, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor TGA2
    Alternative name(s):
    HBP-1b homolog
    Short name:
    AHBP-1b
    bZIP transcription factor 20
    Short name:
    AtbZIP20
    Gene namesi
    Name:TGA2
    Synonyms:BZIP20, HBP1B
    Ordered Locus Names:At5g06950
    ORF Names:MOJ9.12
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G06950.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Transcription factor TGA2PRO_0000076554Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in the whole plant.

    Gene expression databases

    GenevestigatoriP43273.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Interacts with NPR1, NPR3 and NPR4. Interacts with GRXC7/ROXY1 and GRXC9/GRX480.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GRXC7Q963053EBI-541307,EBI-2257898
    GRXC8Q8LF892EBI-541307,EBI-4434651
    GRXC9Q9SGP63EBI-541307,EBI-1545762
    NPR1P930027EBI-541307,EBI-1392127
    NPR1Q8L9W47EBI-541307,EBI-541093

    Protein-protein interaction databases

    BioGridi15865. 25 interactions.
    IntActiP43273. 14 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP43273.
    SMRiP43273. Positions 48-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 10764bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni46 – 6621Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni72 – 8615Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili45 – 14298Sequence AnalysisAdd
    BLAST
    Coiled coili217 – 24428Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG278920.
    HOGENOMiHOG000116597.
    InParanoidiP43273.
    KOiK14431.
    OMAiMTERQLM.
    PhylomeDBiP43273.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR025422. TGA_domain.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF14144. DOG1. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADTSPRTDV STDDDTDHPD LGSEGALVNT AASDSSDRSK GKMDQKTLRR    50
    LAQNREAARK SRLRKKAYVQ QLENSRLKLT QLEQELQRAR QQGVFISGTG 100
    DQAHSTGGNG ALAFDAEHSR WLEEKNKQMN ELRSALNAHA GDSELRIIVD 150
    GVMAHYEELF RIKSNAAKND VFHLLSGMWK TPAERCFLWL GGFRSSELLK 200
    LLANQLEPMT ERQLMGINNL QQTSQQAEDA LSQGMESLQQ SLADTLSSGT 250
    LGSSSSGNVA SYMGQMAMAM GKLGTLEGFI RQADNLRLQT LQQMIRVLTT 300
    RQSARALLAI HDYFSRLRAL SSLWLARPRE 330
    Length:330
    Mass (Da):36,684
    Last modified:November 1, 1995 - v1
    Checksum:iD3033153BCE932C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10042 mRNA. Translation: BAA00933.1.
    AB010697 Genomic DNA. Translation: BAB11153.1.
    CP002688 Genomic DNA. Translation: AED91085.1.
    CP002688 Genomic DNA. Translation: AED91086.1.
    CP002688 Genomic DNA. Translation: AED91087.1.
    CP002688 Genomic DNA. Translation: AED91088.1.
    AK117686 mRNA. Translation: BAC42338.1.
    BT006134 mRNA. Translation: AAP04119.1.
    PIRiS35439.
    RefSeqiNP_001031845.1. NM_001036768.1.
    NP_001078539.1. NM_001085070.1.
    NP_196312.1. NM_120777.2.
    NP_974744.1. NM_203015.1.
    UniGeneiAt.23884.

    Genome annotation databases

    EnsemblPlantsiAT5G06950.1; AT5G06950.1; AT5G06950.
    AT5G06950.2; AT5G06950.2; AT5G06950.
    AT5G06950.3; AT5G06950.3; AT5G06950.
    AT5G06950.4; AT5G06950.4; AT5G06950.
    GeneIDi830586.
    KEGGiath:AT5G06950.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10042 mRNA. Translation: BAA00933.1 .
    AB010697 Genomic DNA. Translation: BAB11153.1 .
    CP002688 Genomic DNA. Translation: AED91085.1 .
    CP002688 Genomic DNA. Translation: AED91086.1 .
    CP002688 Genomic DNA. Translation: AED91087.1 .
    CP002688 Genomic DNA. Translation: AED91088.1 .
    AK117686 mRNA. Translation: BAC42338.1 .
    BT006134 mRNA. Translation: AAP04119.1 .
    PIRi S35439.
    RefSeqi NP_001031845.1. NM_001036768.1.
    NP_001078539.1. NM_001085070.1.
    NP_196312.1. NM_120777.2.
    NP_974744.1. NM_203015.1.
    UniGenei At.23884.

    3D structure databases

    ProteinModelPortali P43273.
    SMRi P43273. Positions 48-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 15865. 25 interactions.
    IntActi P43273. 14 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G06950.1 ; AT5G06950.1 ; AT5G06950 .
    AT5G06950.2 ; AT5G06950.2 ; AT5G06950 .
    AT5G06950.3 ; AT5G06950.3 ; AT5G06950 .
    AT5G06950.4 ; AT5G06950.4 ; AT5G06950 .
    GeneIDi 830586.
    KEGGi ath:AT5G06950.

    Organism-specific databases

    GeneFarmi 2992. 292.
    TAIRi AT5G06950.

    Phylogenomic databases

    eggNOGi NOG278920.
    HOGENOMi HOG000116597.
    InParanoidi P43273.
    KOi K14431.
    OMAi MTERQLM.
    PhylomeDBi P43273.

    Gene expression databases

    Genevestigatori P43273.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR025422. TGA_domain.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF14144. DOG1. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cDNA clone encoding HBP-1b homologue in Arabidopsis thaliana."
      Kawata T., Imada T., Shiraishi H., Okada K., Shimura Y., Iwabuchi M.
      Nucleic Acids Res. 20:1141-1141(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Landsberg erecta.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones."
      Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N., Tabata S.
      DNA Res. 5:131-145(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Binding site requirements and differential representation of TGF factors in nuclear ASF-1 activity."
      Lam E., Lam Y.K.
      Nucleic Acids Res. 23:3778-3785(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    7. "Binding specificity and tissue-specific expression pattern of the Arabidopsis bZIP transcription factor TGA2."
      de Pater S., Pham K., Memelink J., Kijne J.
      Mol. Gen. Genet. 250:237-239(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid."
      Zhou J.-M., Trifa Y., Silva H., Pontier D., Lam E., Shah J., Klessig D.F.
      Mol. Plant Microbe Interact. 13:191-202(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NPR1.
    9. Cited for: GENE FAMILY, NOMENCLATURE.
    10. "Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis."
      Johnson C., Boden E., Arias J.
      Plant Cell 15:1846-1858(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance."
      Liu G., Holub E.B., Alonso J.M., Ecker J.R., Fobert P.R.
      Plant J. 41:304-318(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NPR1 AND NPR4.
    12. "Negative regulation of defense responses in Arabidopsis by two NPR1 paralogs."
      Zhang Y., Cheng Y.T., Qu N., Zhao Q., Bi D., Li X.
      Plant J. 48:647-656(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NPR3 AND NPR4.
    13. "SA-inducible Arabidopsis glutaredoxin interacts with TGA factors and suppresses JA-responsive PDF1.2 transcription."
      Ndamukong I., Abdallat A.A., Thurow C., Fode B., Zander M., Weigel R., Gatz C.
      Plant J. 50:128-139(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRXC9/GRX480.
    14. "Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana."
      Li S., Lauri A., Ziemann M., Busch A., Bhave M., Zachgo S.
      Plant Cell 21:429-441(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GRXC7/ROXY1.

    Entry informationi

    Entry nameiTGA2_ARATH
    AccessioniPrimary (citable) accession number: P43273
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3