ID   ETV4_HUMAN              Reviewed;         484 AA.
AC   P43268; A8K314; Q96AW9;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 3.
DT   09-FEB-2010, entry version 80.
DE   RecName: Full=ETS translocation variant 4;
DE   AltName: Full=Adenovirus E1A enhancer-binding protein;
DE   AltName: Full=E1A-F;
GN   Name=ETV4; Synonyms=E1AF;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=95293380; PubMed=7774926; DOI=10.1016/0888-7543(95)80133-7;
RA   Friedman L.S., Ostermeyer E.A., Lynch E.D., Szabo C.I., Meza J.E.,
RA   Anderson L.A., Dowd P., Lee M.K., Rowell S.E., Ellison J., Boyd J.,
RA   King M.-C.;
RT   "22 genes from chromosome 17q21: cloning, sequencing, and
RT   characterization of mutations in breast cancer families and tumors.";
RL   Genomics 25:256-263(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=20033563; PubMed=10564827; DOI=10.1016/S0378-1119(99)00400-X;
RA   Coutte L., Monte D., Baert J.-L., de Launoit Y.;
RT   "Genomic organization of the human e1af gene, a member of Ets
RT   transcription factors.";
RL   Gene 240:201-207(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 23-484.
RX   MEDLINE=93181246; PubMed=8441666; DOI=10.1093/nar/21.3.547;
RA   Higashino F., Yoshida K., Fujinaga K., Kamio K., Fujinaga K.;
RT   "Isolation of a cDNA encoding the adenovirus E1A enhancer binding
RT   protein: a new human member of the ets oncogene family.";
RL   Nucleic Acids Res. 21:547-553(1993).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140 AND SER-149, AND
RP   MASS SPECTROMETRY.
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: Transcriptional activator that binds to the enhancer of
CC       the adenovirus E1A gene; the core-binding sequence is
CC       5'[AC]GGA[AT]GT-3'.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC   -!- SIMILARITY: Contains 1 ETS DNA-binding domain.
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DR   EMBL; U18018; AAA95991.1; ALT_INIT; mRNA.
DR   EMBL; AF095890; AAD09186.1; -; Genomic_DNA.
DR   EMBL; AF095887; AAD09186.1; JOINED; Genomic_DNA.
DR   EMBL; AF095888; AAD09186.1; JOINED; Genomic_DNA.
DR   EMBL; AF095889; AAD09186.1; JOINED; Genomic_DNA.
DR   EMBL; AK290429; BAF83118.1; -; mRNA.
DR   EMBL; BC016623; AAH16623.1; -; mRNA.
DR   EMBL; D12765; BAA02234.1; -; mRNA.
DR   IPI; IPI00017382; -.
DR   PIR; S35534; S35534.
DR   RefSeq; NP_001073143.1; -.
DR   RefSeq; NP_001977.1; -.
DR   UniGene; Hs.434059; -.
DR   SMR; P43268; 341-428.
DR   DIP; DIP-748N; -.
DR   STRING; P43268; -.
DR   PhosphoSite; P43268; -.
DR   PRIDE; P43268; -.
DR   Ensembl; ENST00000319349; ENSP00000321835; ENSG00000175832; Homo sapiens.
DR   Ensembl; ENST00000393664; ENSP00000377273; ENSG00000175832; Homo sapiens.
DR   GeneID; 2118; -.
DR   KEGG; hsa:2118; -.
DR   UCSC; uc002idw.1; human.
DR   CTD; 2118; -.
DR   GeneCards; GC17M038960; -.
DR   H-InvDB; HIX0019239; -.
DR   HGNC; HGNC:3493; ETV4.
DR   HPA; HPA005768; -.
DR   MIM; 600711; gene.
DR   PharmGKB; PA27907; -.
DR   eggNOG; prNOG09615; -.
DR   HOGENOM; HBG443839; -.
DR   HOVERGEN; P43268; -.
DR   InParanoid; P43268; -.
DR   OMA; PFPRAEQ; -.
DR   OrthoDB; EOG976NKF; -.
DR   NextBio; 8559; -.
DR   ArrayExpress; P43268; -.
DR   Bgee; P43268; -.
DR   CleanEx; HS_ETV4; -.
DR   Genevestigator; P43268; -.
DR   GermOnline; ENSG00000175832; Homo sapiens.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0016563; F:transcription activator activity; NAS:UniProtKB.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR000418; Ets.
DR   InterPro; IPR006715; ETS_PEA3_N.
DR   InterPro; IPR011991; WHTH_trsnscrt_rep_DNA-bd.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF04621; ETS_PEA3_N; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   1: Evidence at protein level;
KW   Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein;
KW   Polymorphism; Transcription; Transcription regulation.
FT   CHAIN         1    484       ETS translocation variant 4.
FT                                /FTId=PRO_0000204116.
FT   DNA_BIND    341    421       ETS.
FT   COMPBIAS     49     75       Asp/Glu-rich (acidic).
FT   COMPBIAS    148    244       Gln-rich.
FT   MOD_RES     140    140       Phosphoserine.
FT   MOD_RES     149    149       Phosphoserine.
FT   VARIANT     437    437       R -> C (in dbSNP:rs34260468).
FT                                /FTId=VAR_048950.
FT   CONFLICT     24     27       GNGS -> EMSD (in Ref. 5).
SQ   SEQUENCE   484 AA;  53938 MW;  BA9864F3C690A8C1 CRC64;
     MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS EDLFQDLSHF
     QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ SPRTDPALSC SRKPPLPYHH
     GEQCLYSSAY DPPRQIAIKS PAPGALGQSP LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE
     HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP
     AVDQGGVNGH RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE
     KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL LDDPTNAHFI
     AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR YYYEKGIMQK VAGERYVYKF
     VCEPEALFSL AFPDNQRPAL KAEFDRPVSE EDTVPLSHLD ESPAYLPELA GPAQPFGPKG
     GYSY
//