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P43268

- ETV4_HUMAN

UniProt

P43268 - ETV4_HUMAN

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Protein
ETS translocation variant 4
Gene
ETV4, E1AF, PEA3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi341 – 42181ETS
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. branching involved in mammary gland duct morphogenesis Source: Ensembl
  2. cell differentiation Source: RefGenome
  3. motor neuron axon guidance Source: Ensembl
  4. negative regulation of mammary gland epithelial cell proliferation Source: Ensembl
  5. positive regulation of transcription, DNA-templated Source: Ensembl
  6. regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
  7. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  8. stem cell differentiation Source: Ensembl
  9. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP43268.

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 4
Alternative name(s):
Adenovirus E1A enhancer-binding protein
E1A-F
Polyomavirus enhancer activator 3 homolog
Short name:
Protein PEA3
Gene namesi
Name:ETV4
Synonyms:E1AF, PEA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:3493. ETV4.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi96 – 961K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-226 and R-260. 1 Publication
Mutagenesisi98 – 981E → A: Loss of polysumoylation and ubiquitination; when associated with A-228; A-262; A-324 and A-443. 1 Publication
Mutagenesisi101 – 1011S → A: Loss of sumoylation at K-96. 1 Publication
Mutagenesisi101 – 1011S → E: Normal sumoylation at K-96. 1 Publication
Mutagenesisi102 – 1021P → A: Loss of sumoylation at K-96. 1 Publication
Mutagenesisi226 – 2261K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-96 and R-260. 1 Publication
Mutagenesisi228 – 2281E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-262; A-324 and A-443. 1 Publication
Mutagenesisi260 – 2601K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-96 and R-226. 1 Publication
Mutagenesisi262 – 2621E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-324 and A-443. 1 Publication
Mutagenesisi324 – 3241E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-262 and A-443. 1 Publication
Mutagenesisi443 – 4431E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-262 and A-324. 1 Publication

Organism-specific databases

Orphaneti319. Ewing sarcoma.
PharmGKBiPA27907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484ETS translocation variant 4
PRO_0000204116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki96 – 96Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei101 – 1011Phosphoserine1 Publication
Cross-linki226 – 226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki260 – 260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Post-translational modificationi

Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP43268.
PaxDbiP43268.
PRIDEiP43268.

PTM databases

PhosphoSiteiP43268.

Expressioni

Gene expression databases

ArrayExpressiP43268.
BgeeiP43268.
CleanExiHS_ETV4.
GenevestigatoriP43268.

Organism-specific databases

HPAiHPA005768.

Interactioni

Protein-protein interaction databases

BioGridi108419. 13 interactions.
DIPiDIP-748N.
IntActiP43268. 2 interactions.
STRINGi9606.ENSP00000321835.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi343 – 35210
Helixi354 – 3563
Turni357 – 3593
Beta strandi360 – 3623
Beta strandi368 – 3736
Helixi374 – 38512
Helixi392 – 40413
Beta strandi407 – 4104
Beta strandi415 – 4206
Helixi424 – 4318

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CO8X-ray1.05A338-470[»]
ProteinModelPortaliP43268.
SMRiP43268. Positions 338-434.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 7527Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi148 – 24497Gln-rich
Add
BLAST

Sequence similaritiesi

Belongs to the ETS family.

Phylogenomic databases

eggNOGiNOG258471.
HOGENOMiHOG000230986.
HOVERGENiHBG000231.
InParanoidiP43268.
KOiK15592.
OMAiHEVGIAS.
OrthoDBiEOG7K9K2M.
PhylomeDBiP43268.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P43268-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS    50
EDLFQDLSHF QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ 100
SPRTDPALSC SRKPPLPYHH GEQCLYSSAY DPPRQIAIKS PAPGALGQSP 150
LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE HSSVFQQPLD ICHSFTSQGG 200
GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP AVDQGGVNGH 250
RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE 300
KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL 350
LDDPTNAHFI AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR 400
YYYEKGIMQK VAGERYVYKF VCEPEALFSL AFPDNQRPAL KAEFDRPVSE 450
EDTVPLSHLD ESPAYLPELA GPAQPFGPKG GYSY 484
Length:484
Mass (Da):53,938
Last modified:April 12, 2005 - v3
Checksum:iBA9864F3C690A8C1
GO
Isoform 2 (identifier: P43268-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Note: No experimental confirmation available.

Show »
Length:445
Mass (Da):49,659
Checksum:i391745C2ADC1C064
GO
Isoform 3 (identifier: P43268-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.

Note: No experimental confirmation available.

Show »
Length:207
Mass (Da):23,422
Checksum:iF06C459C28B09DF5
GO

Sequence cautioni

The sequence AAA95991.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti195 – 1951F → I.1 Publication
Corresponds to variant rs150119757 [ dbSNP | Ensembl ].
VAR_069110
Natural varianti437 – 4371R → C.
Corresponds to variant rs34260468 [ dbSNP | Ensembl ].
VAR_048950

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 277277Missing in isoform 3.
VSP_055314Add
BLAST
Alternative sequencei1 – 3939Missing in isoform 2.
VSP_046036Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 274GNGS → EMSD in BAA02234. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18018 mRNA. Translation: AAA95991.1. Different initiation.
AF095890
, AF095887, AF095888, AF095889 Genomic DNA. Translation: AAD09186.1.
AK290429 mRNA. Translation: BAF83118.1.
AK299019 mRNA. Translation: BAH12929.1.
AK315961 mRNA. Translation: BAH14332.1.
AC068675 Genomic DNA. No translation available.
BC007242 mRNA. No translation available.
BC016623 mRNA. Translation: AAH16623.1.
D12765 mRNA. Translation: BAA02234.1.
CCDSiCCDS11465.1. [P43268-1]
CCDS58553.1. [P43268-2]
PIRiS35534.
RefSeqiNP_001073143.1. NM_001079675.2. [P43268-1]
NP_001248366.1. NM_001261437.1. [P43268-2]
NP_001248367.1. NM_001261438.1. [P43268-2]
NP_001248368.1. NM_001261439.1.
NP_001977.1. NM_001986.2. [P43268-1]
UniGeneiHs.434059.

Genome annotation databases

EnsembliENST00000319349; ENSP00000321835; ENSG00000175832. [P43268-1]
ENST00000393664; ENSP00000377273; ENSG00000175832. [P43268-1]
ENST00000538265; ENSP00000443846; ENSG00000175832. [P43268-2]
ENST00000545954; ENSP00000440023; ENSG00000175832. [P43268-2]
ENST00000591713; ENSP00000465718; ENSG00000175832. [P43268-1]
GeneIDi2118.
KEGGihsa:2118.
UCSCiuc002idw.3. human. [P43268-1]

Polymorphism databases

DMDMi62512145.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18018 mRNA. Translation: AAA95991.1 . Different initiation.
AF095890
, AF095887 , AF095888 , AF095889 Genomic DNA. Translation: AAD09186.1 .
AK290429 mRNA. Translation: BAF83118.1 .
AK299019 mRNA. Translation: BAH12929.1 .
AK315961 mRNA. Translation: BAH14332.1 .
AC068675 Genomic DNA. No translation available.
BC007242 mRNA. No translation available.
BC016623 mRNA. Translation: AAH16623.1 .
D12765 mRNA. Translation: BAA02234.1 .
CCDSi CCDS11465.1. [P43268-1 ]
CCDS58553.1. [P43268-2 ]
PIRi S35534.
RefSeqi NP_001073143.1. NM_001079675.2. [P43268-1 ]
NP_001248366.1. NM_001261437.1. [P43268-2 ]
NP_001248367.1. NM_001261438.1. [P43268-2 ]
NP_001248368.1. NM_001261439.1.
NP_001977.1. NM_001986.2. [P43268-1 ]
UniGenei Hs.434059.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CO8 X-ray 1.05 A 338-470 [» ]
ProteinModelPortali P43268.
SMRi P43268. Positions 338-434.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108419. 13 interactions.
DIPi DIP-748N.
IntActi P43268. 2 interactions.
STRINGi 9606.ENSP00000321835.

PTM databases

PhosphoSitei P43268.

Polymorphism databases

DMDMi 62512145.

Proteomic databases

MaxQBi P43268.
PaxDbi P43268.
PRIDEi P43268.

Protocols and materials databases

DNASUi 2118.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319349 ; ENSP00000321835 ; ENSG00000175832 . [P43268-1 ]
ENST00000393664 ; ENSP00000377273 ; ENSG00000175832 . [P43268-1 ]
ENST00000538265 ; ENSP00000443846 ; ENSG00000175832 . [P43268-2 ]
ENST00000545954 ; ENSP00000440023 ; ENSG00000175832 . [P43268-2 ]
ENST00000591713 ; ENSP00000465718 ; ENSG00000175832 . [P43268-1 ]
GeneIDi 2118.
KEGGi hsa:2118.
UCSCi uc002idw.3. human. [P43268-1 ]

Organism-specific databases

CTDi 2118.
GeneCardsi GC17M041605.
HGNCi HGNC:3493. ETV4.
HPAi HPA005768.
MIMi 600711. gene.
neXtProti NX_P43268.
Orphaneti 319. Ewing sarcoma.
PharmGKBi PA27907.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258471.
HOGENOMi HOG000230986.
HOVERGENi HBG000231.
InParanoidi P43268.
KOi K15592.
OMAi HEVGIAS.
OrthoDBi EOG7K9K2M.
PhylomeDBi P43268.
TreeFami TF316214.

Enzyme and pathway databases

SignaLinki P43268.

Miscellaneous databases

ChiTaRSi ETV4. human.
GeneWikii ETV4.
GenomeRNAii 2118.
NextBioi 8559.
PROi P43268.
SOURCEi Search...

Gene expression databases

ArrayExpressi P43268.
Bgeei P43268.
CleanExi HS_ETV4.
Genevestigatori P43268.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors."
    Friedman L.S., Ostermeyer E.A., Lynch E.D., Szabo C.I., Meza J.E., Anderson L.A., Dowd P., Lee M.K., Rowell S.E., Ellison J., Boyd J., King M.-C.
    Genomics 25:256-263(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Genomic organization of the human e1af gene, a member of Ets transcription factors."
    Coutte L., Monte D., Baert J.-L., de Launoit Y.
    Gene 240:201-207(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-195.
    Tissue: Amygdala.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Colon.
  6. "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family."
    Higashino F., Yoshida K., Fujinaga K., Kamio K., Fujinaga K.
    Nucleic Acids Res. 21:547-553(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-484 (ISOFORM 1).
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3."
    Guo B., Sharrocks A.D.
    Mol. Cell. Biol. 29:3204-3218(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUMOYLATION AT LYS-96; LYS-226 AND LYS-260, DESUMOYLATION BY SENP1, PHOSPHORYLATION AT SER-101, UBIQUITINATION BY RNF4, DEUBIQUITINATION BY UPS2, MUTAGENESIS OF LYS-96; GLU-98; SER-101; PRO-102; LYS-226; GLU-228; LYS-260; GLU-262; GLU-324 AND GLU-443.

Entry informationi

Entry nameiETV4_HUMAN
AccessioniPrimary (citable) accession number: P43268
Secondary accession number(s): A8K314
, B7Z5J3, B7Z9J6, Q96AW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 12, 2005
Last modified: September 3, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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