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P43268

- ETV4_HUMAN

UniProt

P43268 - ETV4_HUMAN

Protein

ETS translocation variant 4

Gene

ETV4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi341 – 42181ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. branching involved in mammary gland duct morphogenesis Source: Ensembl
    2. cell differentiation Source: RefGenome
    3. motor neuron axon guidance Source: Ensembl
    4. negative regulation of mammary gland epithelial cell proliferation Source: Ensembl
    5. positive regulation of transcription from RNA polymerase II promoter Source: GOC
    6. regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
    7. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    8. stem cell differentiation Source: Ensembl
    9. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiP43268.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS translocation variant 4
    Alternative name(s):
    Adenovirus E1A enhancer-binding protein
    E1A-F
    Polyomavirus enhancer activator 3 homolog
    Short name:
    Protein PEA3
    Gene namesi
    Name:ETV4
    Synonyms:E1AF, PEA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:3493. ETV4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi96 – 961K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-226 and R-260. 1 Publication
    Mutagenesisi98 – 981E → A: Loss of polysumoylation and ubiquitination; when associated with A-228; A-262; A-324 and A-443. 1 Publication
    Mutagenesisi101 – 1011S → A: Loss of sumoylation at K-96. 1 Publication
    Mutagenesisi101 – 1011S → E: Normal sumoylation at K-96. 1 Publication
    Mutagenesisi102 – 1021P → A: Loss of sumoylation at K-96. 1 Publication
    Mutagenesisi226 – 2261K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-96 and R-260. 1 Publication
    Mutagenesisi228 – 2281E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-262; A-324 and A-443. 1 Publication
    Mutagenesisi260 – 2601K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-96 and R-226. 1 Publication
    Mutagenesisi262 – 2621E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-324 and A-443. 1 Publication
    Mutagenesisi324 – 3241E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-262 and A-443. 1 Publication
    Mutagenesisi443 – 4431E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-262 and A-324. 1 Publication

    Organism-specific databases

    Orphaneti319. Ewing sarcoma.
    PharmGKBiPA27907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484ETS translocation variant 4PRO_0000204116Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki96 – 96Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
    Modified residuei101 – 1011Phosphoserine1 Publication
    Cross-linki226 – 226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
    Cross-linki260 – 260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

    Post-translational modificationi

    Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2.1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP43268.
    PaxDbiP43268.
    PRIDEiP43268.

    PTM databases

    PhosphoSiteiP43268.

    Expressioni

    Gene expression databases

    ArrayExpressiP43268.
    BgeeiP43268.
    CleanExiHS_ETV4.
    GenevestigatoriP43268.

    Organism-specific databases

    HPAiHPA005768.

    Interactioni

    Protein-protein interaction databases

    BioGridi108419. 13 interactions.
    DIPiDIP-748N.
    IntActiP43268. 2 interactions.
    STRINGi9606.ENSP00000321835.

    Structurei

    Secondary structure

    1
    484
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi343 – 35210
    Helixi354 – 3563
    Turni357 – 3593
    Beta strandi360 – 3623
    Beta strandi368 – 3736
    Helixi374 – 38512
    Helixi392 – 40413
    Beta strandi407 – 4104
    Beta strandi415 – 4206
    Helixi424 – 4318

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CO8X-ray1.05A338-470[»]
    ProteinModelPortaliP43268.
    SMRiP43268. Positions 338-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi49 – 7527Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi148 – 24497Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258471.
    HOGENOMiHOG000230986.
    HOVERGENiHBG000231.
    InParanoidiP43268.
    KOiK15592.
    OMAiHEVGIAS.
    OrthoDBiEOG7K9K2M.
    PhylomeDBiP43268.
    TreeFamiTF316214.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR006715. ETS_PEA3_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF04621. ETS_PEA3_N. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43268-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS    50
    EDLFQDLSHF QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ 100
    SPRTDPALSC SRKPPLPYHH GEQCLYSSAY DPPRQIAIKS PAPGALGQSP 150
    LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE HSSVFQQPLD ICHSFTSQGG 200
    GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP AVDQGGVNGH 250
    RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE 300
    KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL 350
    LDDPTNAHFI AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR 400
    YYYEKGIMQK VAGERYVYKF VCEPEALFSL AFPDNQRPAL KAEFDRPVSE 450
    EDTVPLSHLD ESPAYLPELA GPAQPFGPKG GYSY 484
    Length:484
    Mass (Da):53,938
    Last modified:April 12, 2005 - v3
    Checksum:iBA9864F3C690A8C1
    GO
    Isoform 2 (identifier: P43268-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-39: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:445
    Mass (Da):49,659
    Checksum:i391745C2ADC1C064
    GO
    Isoform 3 (identifier: P43268-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-277: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:207
    Mass (Da):23,422
    Checksum:iF06C459C28B09DF5
    GO

    Sequence cautioni

    The sequence AAA95991.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 274GNGS → EMSD in BAA02234. (PubMed:8441666)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti195 – 1951F → I.1 Publication
    Corresponds to variant rs150119757 [ dbSNP | Ensembl ].
    VAR_069110
    Natural varianti437 – 4371R → C.
    Corresponds to variant rs34260468 [ dbSNP | Ensembl ].
    VAR_048950

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 277277Missing in isoform 3. 1 PublicationVSP_055314Add
    BLAST
    Alternative sequencei1 – 3939Missing in isoform 2. 1 PublicationVSP_046036Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18018 mRNA. Translation: AAA95991.1. Different initiation.
    AF095890
    , AF095887, AF095888, AF095889 Genomic DNA. Translation: AAD09186.1.
    AK290429 mRNA. Translation: BAF83118.1.
    AK299019 mRNA. Translation: BAH12929.1.
    AK315961 mRNA. Translation: BAH14332.1.
    AC068675 Genomic DNA. No translation available.
    BC007242 mRNA. No translation available.
    BC016623 mRNA. Translation: AAH16623.1.
    D12765 mRNA. Translation: BAA02234.1.
    CCDSiCCDS11465.1. [P43268-1]
    CCDS58553.1. [P43268-2]
    CCDS59292.1. [P43268-3]
    PIRiS35534.
    RefSeqiNP_001073143.1. NM_001079675.2. [P43268-1]
    NP_001248366.1. NM_001261437.1. [P43268-2]
    NP_001248367.1. NM_001261438.1. [P43268-2]
    NP_001248368.1. NM_001261439.1.
    NP_001977.1. NM_001986.2. [P43268-1]
    UniGeneiHs.434059.

    Genome annotation databases

    EnsembliENST00000319349; ENSP00000321835; ENSG00000175832. [P43268-1]
    ENST00000393664; ENSP00000377273; ENSG00000175832. [P43268-1]
    ENST00000538265; ENSP00000443846; ENSG00000175832. [P43268-2]
    ENST00000545954; ENSP00000440023; ENSG00000175832. [P43268-2]
    ENST00000586826; ENSP00000468636; ENSG00000175832. [P43268-3]
    ENST00000591713; ENSP00000465718; ENSG00000175832. [P43268-1]
    GeneIDi2118.
    KEGGihsa:2118.
    UCSCiuc002idw.3. human. [P43268-1]

    Polymorphism databases

    DMDMi62512145.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18018 mRNA. Translation: AAA95991.1 . Different initiation.
    AF095890
    , AF095887 , AF095888 , AF095889 Genomic DNA. Translation: AAD09186.1 .
    AK290429 mRNA. Translation: BAF83118.1 .
    AK299019 mRNA. Translation: BAH12929.1 .
    AK315961 mRNA. Translation: BAH14332.1 .
    AC068675 Genomic DNA. No translation available.
    BC007242 mRNA. No translation available.
    BC016623 mRNA. Translation: AAH16623.1 .
    D12765 mRNA. Translation: BAA02234.1 .
    CCDSi CCDS11465.1. [P43268-1 ]
    CCDS58553.1. [P43268-2 ]
    CCDS59292.1. [P43268-3 ]
    PIRi S35534.
    RefSeqi NP_001073143.1. NM_001079675.2. [P43268-1 ]
    NP_001248366.1. NM_001261437.1. [P43268-2 ]
    NP_001248367.1. NM_001261438.1. [P43268-2 ]
    NP_001248368.1. NM_001261439.1.
    NP_001977.1. NM_001986.2. [P43268-1 ]
    UniGenei Hs.434059.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4CO8 X-ray 1.05 A 338-470 [» ]
    ProteinModelPortali P43268.
    SMRi P43268. Positions 338-434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108419. 13 interactions.
    DIPi DIP-748N.
    IntActi P43268. 2 interactions.
    STRINGi 9606.ENSP00000321835.

    PTM databases

    PhosphoSitei P43268.

    Polymorphism databases

    DMDMi 62512145.

    Proteomic databases

    MaxQBi P43268.
    PaxDbi P43268.
    PRIDEi P43268.

    Protocols and materials databases

    DNASUi 2118.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319349 ; ENSP00000321835 ; ENSG00000175832 . [P43268-1 ]
    ENST00000393664 ; ENSP00000377273 ; ENSG00000175832 . [P43268-1 ]
    ENST00000538265 ; ENSP00000443846 ; ENSG00000175832 . [P43268-2 ]
    ENST00000545954 ; ENSP00000440023 ; ENSG00000175832 . [P43268-2 ]
    ENST00000586826 ; ENSP00000468636 ; ENSG00000175832 . [P43268-3 ]
    ENST00000591713 ; ENSP00000465718 ; ENSG00000175832 . [P43268-1 ]
    GeneIDi 2118.
    KEGGi hsa:2118.
    UCSCi uc002idw.3. human. [P43268-1 ]

    Organism-specific databases

    CTDi 2118.
    GeneCardsi GC17M041605.
    HGNCi HGNC:3493. ETV4.
    HPAi HPA005768.
    MIMi 600711. gene.
    neXtProti NX_P43268.
    Orphaneti 319. Ewing sarcoma.
    PharmGKBi PA27907.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258471.
    HOGENOMi HOG000230986.
    HOVERGENi HBG000231.
    InParanoidi P43268.
    KOi K15592.
    OMAi HEVGIAS.
    OrthoDBi EOG7K9K2M.
    PhylomeDBi P43268.
    TreeFami TF316214.

    Enzyme and pathway databases

    SignaLinki P43268.

    Miscellaneous databases

    ChiTaRSi ETV4. human.
    GeneWikii ETV4.
    GenomeRNAii 2118.
    NextBioi 8559.
    PROi P43268.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43268.
    Bgeei P43268.
    CleanExi HS_ETV4.
    Genevestigatori P43268.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR006715. ETS_PEA3_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF04621. ETS_PEA3_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors."
      Friedman L.S., Ostermeyer E.A., Lynch E.D., Szabo C.I., Meza J.E., Anderson L.A., Dowd P., Lee M.K., Rowell S.E., Ellison J., Boyd J., King M.-C.
      Genomics 25:256-263(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Genomic organization of the human e1af gene, a member of Ets transcription factors."
      Coutte L., Monte D., Baert J.-L., de Launoit Y.
      Gene 240:201-207(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-195.
      Tissue: Amygdala.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Colon.
    6. "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family."
      Higashino F., Yoshida K., Fujinaga K., Kamio K., Fujinaga K.
      Nucleic Acids Res. 21:547-553(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-484 (ISOFORM 1).
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3."
      Guo B., Sharrocks A.D.
      Mol. Cell. Biol. 29:3204-3218(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUMOYLATION AT LYS-96; LYS-226 AND LYS-260, DESUMOYLATION BY SENP1, PHOSPHORYLATION AT SER-101, UBIQUITINATION BY RNF4, DEUBIQUITINATION BY UPS2, MUTAGENESIS OF LYS-96; GLU-98; SER-101; PRO-102; LYS-226; GLU-228; LYS-260; GLU-262; GLU-324 AND GLU-443.

    Entry informationi

    Entry nameiETV4_HUMAN
    AccessioniPrimary (citable) accession number: P43268
    Secondary accession number(s): A8K314
    , B7Z5J3, B7Z9J6, Q96AW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3