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Protein

Protein SOX-15

Gene

Sox15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 11569HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. protein heterodimerization activity Source: MGI
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. myoblast development Source: MGI
  3. negative regulation of striated muscle tissue development Source: MGI
  4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  5. positive regulation of G0 to G1 transition Source: BHF-UCL
  6. positive regulation of myoblast proliferation Source: BHF-UCL
  7. positive regulation of satellite cell activation involved in skeletal muscle regeneration Source: BHF-UCL
  8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  9. skeletal muscle tissue regeneration Source: MGI
  10. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOX-15
Gene namesi
Name:Sox15
Synonyms:Sox-15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98363. Sox15.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear transcription factor complex Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Protein SOX-15PRO_0000048763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43267.
PRIDEiP43267.

PTM databases

PhosphoSiteiP43267.

Expressioni

Gene expression databases

BgeeiP43267.
CleanExiMM_SOX15.
ExpressionAtlasiP43267. baseline and differential.
GenevestigatoriP43267.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Fhl3Q9R0597EBI-7332587,EBI-7332617

Protein-protein interaction databases

BioGridi203402. 5 interactions.
IntActiP43267. 1 interaction.
MINTiMINT-4788454.

Structurei

3D structure databases

ProteinModelPortaliP43267.
SMRiP43267. Positions 45-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG311451.
HOVERGENiHBG055512.
InParanoidiP43267.
KOiK09271.
OMAiYGSSHCK.
OrthoDBiEOG7H793V.
PhylomeDBiP43267.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43267-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALTSSSQAE TWSLHPRAST ASLPLGPQEQ EAGGSPGASG GLPLEKVKRP
60 70 80 90 100
MNAFMVWSSV QRRQMAQQNP KMHNSEISKR LGAQWKLLGD EEKRPFVEEA
110 120 130 140 150
KRLRARHLRD YPDYKYRPRR KSKNSSTGSV PFSQEGGGLA CGGSHWGPGY
160 170 180 190 200
TTTQGSRGFG YQPPNYSTAY LPGSYTSSHC RPEAPLPCTF PQSDPRLQGE
210 220 230
LRPSFSPYLS PDSSTPYNTS LAGAPMPVTH L
Length:231
Mass (Da):25,311
Last modified:December 8, 2000 - v3
Checksum:iFCFE87C3BB458645
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711K → E in BAA28604. (PubMed:10524236)Curated
Sequence conflicti97 – 971V → M in CAB37848. (PubMed:8479922)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351E → G in strain: various strains.
Natural varianti224 – 2241A → S in strain: various strains.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014474 Genomic DNA. Translation: BAA28604.1.
AF182945 mRNA. Translation: AAF72108.1.
AB039214 Genomic DNA. Translation: BAB68738.1.
AB039215 Genomic DNA. Translation: BAB68739.1.
AB039216 Genomic DNA. Translation: BAB68740.1.
AB039217 Genomic DNA. Translation: BAB68741.1.
AB039218 Genomic DNA. Translation: BAB68742.1.
AB039219 Genomic DNA. Translation: BAB68743.1.
AB039220 Genomic DNA. Translation: BAB68744.1.
AB039221 Genomic DNA. Translation: BAB68745.1.
AB039222 Genomic DNA. Translation: BAB68746.1.
U70443 mRNA. Translation: AAC52861.1.
X70909 Genomic DNA. Translation: CAB37848.1.
X98369 mRNA. Translation: CAA67015.1.
CCDSiCCDS24902.1.
PIRiS33715.
RefSeqiNP_033261.1. NM_009235.2.
UniGeneiMm.347499.

Genome annotation databases

EnsembliENSMUST00000047373; ENSMUSP00000048524; ENSMUSG00000041287.
GeneIDi20670.
KEGGimmu:20670.
UCSCiuc007jqu.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014474 Genomic DNA. Translation: BAA28604.1.
AF182945 mRNA. Translation: AAF72108.1.
AB039214 Genomic DNA. Translation: BAB68738.1.
AB039215 Genomic DNA. Translation: BAB68739.1.
AB039216 Genomic DNA. Translation: BAB68740.1.
AB039217 Genomic DNA. Translation: BAB68741.1.
AB039218 Genomic DNA. Translation: BAB68742.1.
AB039219 Genomic DNA. Translation: BAB68743.1.
AB039220 Genomic DNA. Translation: BAB68744.1.
AB039221 Genomic DNA. Translation: BAB68745.1.
AB039222 Genomic DNA. Translation: BAB68746.1.
U70443 mRNA. Translation: AAC52861.1.
X70909 Genomic DNA. Translation: CAB37848.1.
X98369 mRNA. Translation: CAA67015.1.
CCDSiCCDS24902.1.
PIRiS33715.
RefSeqiNP_033261.1. NM_009235.2.
UniGeneiMm.347499.

3D structure databases

ProteinModelPortaliP43267.
SMRiP43267. Positions 45-121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203402. 5 interactions.
IntActiP43267. 1 interaction.
MINTiMINT-4788454.

PTM databases

PhosphoSiteiP43267.

Proteomic databases

MaxQBiP43267.
PRIDEiP43267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047373; ENSMUSP00000048524; ENSMUSG00000041287.
GeneIDi20670.
KEGGimmu:20670.
UCSCiuc007jqu.2. mouse.

Organism-specific databases

CTDi6665.
MGIiMGI:98363. Sox15.

Phylogenomic databases

eggNOGiNOG311451.
HOVERGENiHBG055512.
InParanoidiP43267.
KOiK09271.
OMAiYGSSHCK.
OrthoDBiEOG7H793V.
PhylomeDBiP43267.
TreeFamiTF351735.

Miscellaneous databases

NextBioi299147.
PROiP43267.
SOURCEiSearch...

Gene expression databases

BgeeiP43267.
CleanExiMM_SOX15.
ExpressionAtlasiP43267. baseline and differential.
GenevestigatoriP43267.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11."
    Miyashita A., Shimizu N., Endo N., Hanyuu T., Ishii N., Ito K., Itoh Y., Shirai M., Nakajima T., Odani S., Kuwano R.
    Gene 237:53-60(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. "Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family."
    Beranger F., Mejean C., Moniot B., Berta P., Vandromme M.
    J. Biol. Chem. 275:16103-16109(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
    Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-231.
    Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
  4. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
    Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
    Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-110.
    Strain: Swiss Webster.
    Tissue: Embryonic tooth.
  5. "Sox 15, a novel member of the murine Sox family of HMG box transcription factors."
    van de Wetering M., Clevers H.
    Nucleic Acids Res. 21:1669-1669(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-111.
    Strain: C57BL/6.
  6. Lim F.L.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-231.
    Tissue: Pancreatic islet.

Entry informationi

Entry nameiSOX15_MOUSE
AccessioniPrimary (citable) accession number: P43267
Secondary accession number(s): O70204
, P70418, Q62246, Q91V00, Q91V43, Q920T1, Q9JLG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 8, 2000
Last modified: January 7, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.