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P43267

- SOX15_MOUSE

UniProt

P43267 - SOX15_MOUSE

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Protein
Protein SOX-15
Gene
Sox15, Sox-15
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 11569HMG box
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. chromatin binding Source: MGI
  3. protein binding Source: IntAct
  4. protein heterodimerization activity Source: MGI
  5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. myoblast development Source: MGI
  3. negative regulation of striated muscle tissue development Source: MGI
  4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  5. positive regulation of G0 to G1 transition Source: BHF-UCL
  6. positive regulation of myoblast proliferation Source: BHF-UCL
  7. positive regulation of satellite cell activation involved in skeletal muscle regeneration Source: BHF-UCL
  8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  9. skeletal muscle tissue regeneration Source: MGI
  10. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOX-15
Gene namesi
Name:Sox15
Synonyms:Sox-15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98363. Sox15.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear transcription factor complex Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Protein SOX-15
PRO_0000048763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP43267.

PTM databases

PhosphoSiteiP43267.

Expressioni

Gene expression databases

ArrayExpressiP43267.
BgeeiP43267.
CleanExiMM_SOX15.
GenevestigatoriP43267.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Fhl3Q9R0597EBI-7332587,EBI-7332617

Protein-protein interaction databases

BioGridi203402. 5 interactions.
IntActiP43267. 1 interaction.
MINTiMINT-4788454.

Structurei

3D structure databases

ProteinModelPortaliP43267.
SMRiP43267. Positions 45-121.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG311451.
HOVERGENiHBG055512.
InParanoidiP43267.
KOiK09271.
OMAiYGSSHCK.
OrthoDBiEOG7H793V.
PhylomeDBiP43267.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43267-1 [UniParc]FASTAAdd to Basket

« Hide

MALTSSSQAE TWSLHPRAST ASLPLGPQEQ EAGGSPGASG GLPLEKVKRP    50
MNAFMVWSSV QRRQMAQQNP KMHNSEISKR LGAQWKLLGD EEKRPFVEEA 100
KRLRARHLRD YPDYKYRPRR KSKNSSTGSV PFSQEGGGLA CGGSHWGPGY 150
TTTQGSRGFG YQPPNYSTAY LPGSYTSSHC RPEAPLPCTF PQSDPRLQGE 200
LRPSFSPYLS PDSSTPYNTS LAGAPMPVTH L 231
Length:231
Mass (Da):25,311
Last modified:December 8, 2000 - v3
Checksum:iFCFE87C3BB458645
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351E → G in strain: various strains.
Natural varianti224 – 2241A → S in strain: various strains.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711K → E in BAA28604. 1 Publication
Sequence conflicti97 – 971V → M in CAB37848. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB014474 Genomic DNA. Translation: BAA28604.1.
AF182945 mRNA. Translation: AAF72108.1.
AB039214 Genomic DNA. Translation: BAB68738.1.
AB039215 Genomic DNA. Translation: BAB68739.1.
AB039216 Genomic DNA. Translation: BAB68740.1.
AB039217 Genomic DNA. Translation: BAB68741.1.
AB039218 Genomic DNA. Translation: BAB68742.1.
AB039219 Genomic DNA. Translation: BAB68743.1.
AB039220 Genomic DNA. Translation: BAB68744.1.
AB039221 Genomic DNA. Translation: BAB68745.1.
AB039222 Genomic DNA. Translation: BAB68746.1.
U70443 mRNA. Translation: AAC52861.1.
X70909 Genomic DNA. Translation: CAB37848.1.
X98369 mRNA. Translation: CAA67015.1.
CCDSiCCDS24902.1.
PIRiS33715.
RefSeqiNP_033261.1. NM_009235.2.
UniGeneiMm.347499.

Genome annotation databases

EnsembliENSMUST00000047373; ENSMUSP00000048524; ENSMUSG00000041287.
GeneIDi20670.
KEGGimmu:20670.
UCSCiuc007jqu.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB014474 Genomic DNA. Translation: BAA28604.1 .
AF182945 mRNA. Translation: AAF72108.1 .
AB039214 Genomic DNA. Translation: BAB68738.1 .
AB039215 Genomic DNA. Translation: BAB68739.1 .
AB039216 Genomic DNA. Translation: BAB68740.1 .
AB039217 Genomic DNA. Translation: BAB68741.1 .
AB039218 Genomic DNA. Translation: BAB68742.1 .
AB039219 Genomic DNA. Translation: BAB68743.1 .
AB039220 Genomic DNA. Translation: BAB68744.1 .
AB039221 Genomic DNA. Translation: BAB68745.1 .
AB039222 Genomic DNA. Translation: BAB68746.1 .
U70443 mRNA. Translation: AAC52861.1 .
X70909 Genomic DNA. Translation: CAB37848.1 .
X98369 mRNA. Translation: CAA67015.1 .
CCDSi CCDS24902.1.
PIRi S33715.
RefSeqi NP_033261.1. NM_009235.2.
UniGenei Mm.347499.

3D structure databases

ProteinModelPortali P43267.
SMRi P43267. Positions 45-121.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203402. 5 interactions.
IntActi P43267. 1 interaction.
MINTi MINT-4788454.

PTM databases

PhosphoSitei P43267.

Proteomic databases

PRIDEi P43267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047373 ; ENSMUSP00000048524 ; ENSMUSG00000041287 .
GeneIDi 20670.
KEGGi mmu:20670.
UCSCi uc007jqu.2. mouse.

Organism-specific databases

CTDi 6665.
MGIi MGI:98363. Sox15.

Phylogenomic databases

eggNOGi NOG311451.
HOVERGENi HBG055512.
InParanoidi P43267.
KOi K09271.
OMAi YGSSHCK.
OrthoDBi EOG7H793V.
PhylomeDBi P43267.
TreeFami TF351735.

Miscellaneous databases

NextBioi 299147.
PROi P43267.
SOURCEi Search...

Gene expression databases

ArrayExpressi P43267.
Bgeei P43267.
CleanExi MM_SOX15.
Genevestigatori P43267.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11."
    Miyashita A., Shimizu N., Endo N., Hanyuu T., Ishii N., Ito K., Itoh Y., Shirai M., Nakajima T., Odani S., Kuwano R.
    Gene 237:53-60(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. "Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family."
    Beranger F., Mejean C., Moniot B., Berta P., Vandromme M.
    J. Biol. Chem. 275:16103-16109(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
    Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-231.
    Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
  4. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
    Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
    Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-110.
    Strain: Swiss Webster.
    Tissue: Embryonic tooth.
  5. "Sox 15, a novel member of the murine Sox family of HMG box transcription factors."
    van de Wetering M., Clevers H.
    Nucleic Acids Res. 21:1669-1669(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-111.
    Strain: C57BL/6.
  6. Lim F.L.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-231.
    Tissue: Pancreatic islet.

Entry informationi

Entry nameiSOX15_MOUSE
AccessioniPrimary (citable) accession number: P43267
Secondary accession number(s): O70204
, P70418, Q62246, Q91V00, Q91V43, Q920T1, Q9JLG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 8, 2000
Last modified: July 9, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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