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P43267

- SOX15_MOUSE

UniProt

P43267 - SOX15_MOUSE

Protein

Protein SOX-15

Gene

Sox15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (08 Dec 2000)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi47 – 11569HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. protein binding Source: IntAct
    4. protein heterodimerization activity Source: MGI
    5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. myoblast development Source: MGI
    3. negative regulation of striated muscle tissue development Source: MGI
    4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    5. positive regulation of G0 to G1 transition Source: BHF-UCL
    6. positive regulation of myoblast proliferation Source: BHF-UCL
    7. positive regulation of satellite cell activation involved in skeletal muscle regeneration Source: BHF-UCL
    8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    9. skeletal muscle tissue regeneration Source: MGI
    10. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SOX-15
    Gene namesi
    Name:Sox15
    Synonyms:Sox-15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98363. Sox15.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nuclear transcription factor complex Source: MGI
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Protein SOX-15PRO_0000048763Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP43267.

    PTM databases

    PhosphoSiteiP43267.

    Expressioni

    Gene expression databases

    ArrayExpressiP43267.
    BgeeiP43267.
    CleanExiMM_SOX15.
    GenevestigatoriP43267.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Fhl3Q9R0597EBI-7332587,EBI-7332617

    Protein-protein interaction databases

    BioGridi203402. 5 interactions.
    IntActiP43267. 1 interaction.
    MINTiMINT-4788454.

    Structurei

    3D structure databases

    ProteinModelPortaliP43267.
    SMRiP43267. Positions 45-121.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG311451.
    HOVERGENiHBG055512.
    InParanoidiP43267.
    KOiK09271.
    OMAiYGSSHCK.
    OrthoDBiEOG7H793V.
    PhylomeDBiP43267.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43267-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALTSSSQAE TWSLHPRAST ASLPLGPQEQ EAGGSPGASG GLPLEKVKRP    50
    MNAFMVWSSV QRRQMAQQNP KMHNSEISKR LGAQWKLLGD EEKRPFVEEA 100
    KRLRARHLRD YPDYKYRPRR KSKNSSTGSV PFSQEGGGLA CGGSHWGPGY 150
    TTTQGSRGFG YQPPNYSTAY LPGSYTSSHC RPEAPLPCTF PQSDPRLQGE 200
    LRPSFSPYLS PDSSTPYNTS LAGAPMPVTH L 231
    Length:231
    Mass (Da):25,311
    Last modified:December 8, 2000 - v3
    Checksum:iFCFE87C3BB458645
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711K → E in BAA28604. (PubMed:10524236)Curated
    Sequence conflicti97 – 971V → M in CAB37848. (PubMed:8479922)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti135 – 1351E → G in strain: various strains.
    Natural varianti224 – 2241A → S in strain: various strains.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014474 Genomic DNA. Translation: BAA28604.1.
    AF182945 mRNA. Translation: AAF72108.1.
    AB039214 Genomic DNA. Translation: BAB68738.1.
    AB039215 Genomic DNA. Translation: BAB68739.1.
    AB039216 Genomic DNA. Translation: BAB68740.1.
    AB039217 Genomic DNA. Translation: BAB68741.1.
    AB039218 Genomic DNA. Translation: BAB68742.1.
    AB039219 Genomic DNA. Translation: BAB68743.1.
    AB039220 Genomic DNA. Translation: BAB68744.1.
    AB039221 Genomic DNA. Translation: BAB68745.1.
    AB039222 Genomic DNA. Translation: BAB68746.1.
    U70443 mRNA. Translation: AAC52861.1.
    X70909 Genomic DNA. Translation: CAB37848.1.
    X98369 mRNA. Translation: CAA67015.1.
    CCDSiCCDS24902.1.
    PIRiS33715.
    RefSeqiNP_033261.1. NM_009235.2.
    UniGeneiMm.347499.

    Genome annotation databases

    EnsembliENSMUST00000047373; ENSMUSP00000048524; ENSMUSG00000041287.
    GeneIDi20670.
    KEGGimmu:20670.
    UCSCiuc007jqu.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB014474 Genomic DNA. Translation: BAA28604.1 .
    AF182945 mRNA. Translation: AAF72108.1 .
    AB039214 Genomic DNA. Translation: BAB68738.1 .
    AB039215 Genomic DNA. Translation: BAB68739.1 .
    AB039216 Genomic DNA. Translation: BAB68740.1 .
    AB039217 Genomic DNA. Translation: BAB68741.1 .
    AB039218 Genomic DNA. Translation: BAB68742.1 .
    AB039219 Genomic DNA. Translation: BAB68743.1 .
    AB039220 Genomic DNA. Translation: BAB68744.1 .
    AB039221 Genomic DNA. Translation: BAB68745.1 .
    AB039222 Genomic DNA. Translation: BAB68746.1 .
    U70443 mRNA. Translation: AAC52861.1 .
    X70909 Genomic DNA. Translation: CAB37848.1 .
    X98369 mRNA. Translation: CAA67015.1 .
    CCDSi CCDS24902.1.
    PIRi S33715.
    RefSeqi NP_033261.1. NM_009235.2.
    UniGenei Mm.347499.

    3D structure databases

    ProteinModelPortali P43267.
    SMRi P43267. Positions 45-121.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203402. 5 interactions.
    IntActi P43267. 1 interaction.
    MINTi MINT-4788454.

    PTM databases

    PhosphoSitei P43267.

    Proteomic databases

    PRIDEi P43267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047373 ; ENSMUSP00000048524 ; ENSMUSG00000041287 .
    GeneIDi 20670.
    KEGGi mmu:20670.
    UCSCi uc007jqu.2. mouse.

    Organism-specific databases

    CTDi 6665.
    MGIi MGI:98363. Sox15.

    Phylogenomic databases

    eggNOGi NOG311451.
    HOVERGENi HBG055512.
    InParanoidi P43267.
    KOi K09271.
    OMAi YGSSHCK.
    OrthoDBi EOG7H793V.
    PhylomeDBi P43267.
    TreeFami TF351735.

    Miscellaneous databases

    NextBioi 299147.
    PROi P43267.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43267.
    Bgeei P43267.
    CleanExi MM_SOX15.
    Genevestigatori P43267.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11."
      Miyashita A., Shimizu N., Endo N., Hanyuu T., Ishii N., Ito K., Itoh Y., Shirai M., Nakajima T., Odani S., Kuwano R.
      Gene 237:53-60(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    2. "Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family."
      Beranger F., Mejean C., Moniot B., Berta P., Vandromme M.
      J. Biol. Chem. 275:16103-16109(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
      Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-231.
      Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
    4. "Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
      Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
      Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-110.
      Strain: Swiss Webster.
      Tissue: Embryonic tooth.
    5. "Sox 15, a novel member of the murine Sox family of HMG box transcription factors."
      van de Wetering M., Clevers H.
      Nucleic Acids Res. 21:1669-1669(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-111.
      Strain: C57BL/6.
    6. Lim F.L.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-231.
      Tissue: Pancreatic islet.

    Entry informationi

    Entry nameiSOX15_MOUSE
    AccessioniPrimary (citable) accession number: P43267
    Secondary accession number(s): O70204
    , P70418, Q62246, Q91V00, Q91V43, Q920T1, Q9JLG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: December 8, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3