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P43267 (SOX15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SOX-15
Gene names
Name:Sox15
Synonyms:Sox-15
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from genetic interaction PubMed 16759287. Source: MGI

myoblast development

Inferred from mutant phenotype PubMed 15367664. Source: MGI

negative regulation of striated muscle tissue development

Inferred from direct assay Ref.2. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 17363903. Source: BHF-UCL

positive regulation of G0 to G1 transition

Inferred from mutant phenotype PubMed 17363903. Source: BHF-UCL

positive regulation of myoblast proliferation

Inferred from mutant phenotype PubMed 17363903. Source: BHF-UCL

positive regulation of satellite cell activation involved in skeletal muscle regeneration

Inferred from mutant phenotype PubMed 17363903. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 17363903. Source: BHF-UCL

skeletal muscle tissue regeneration

Inferred from mutant phenotype PubMed 15367664. Source: MGI

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 22344693. Source: GOC

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 12915303. Source: MGI

nuclear transcription factor complex

Inferred from direct assay PubMed 22344693. Source: MGI

nucleus

Inferred from direct assay Ref.2PubMed 15367664PubMed 15863505. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay Ref.2. Source: MGI

chromatin binding

Inferred from direct assay PubMed 15863505. Source: MGI

protein binding

Inferred from physical interaction PubMed 17363903. Source: IntAct

protein heterodimerization activity

Inferred from direct assay PubMed 22344693. Source: MGI

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from direct assay PubMed 22344693. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Fhl3Q9R0597EBI-7332587,EBI-7332617

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Protein SOX-15
PRO_0000048763

Regions

DNA binding47 – 11569HMG box

Amino acid modifications

Modified residue351Phosphoserine By similarity

Natural variations

Natural variant1351E → G in strain: various strains.
Natural variant2241A → S in strain: various strains.

Experimental info

Sequence conflict711K → E in BAA28604. Ref.1
Sequence conflict971V → M in CAB37848. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P43267 [UniParc].

Last modified December 8, 2000. Version 3.
Checksum: FCFE87C3BB458645

FASTA23125,311
        10         20         30         40         50         60 
MALTSSSQAE TWSLHPRAST ASLPLGPQEQ EAGGSPGASG GLPLEKVKRP MNAFMVWSSV 

        70         80         90        100        110        120 
QRRQMAQQNP KMHNSEISKR LGAQWKLLGD EEKRPFVEEA KRLRARHLRD YPDYKYRPRR 

       130        140        150        160        170        180 
KSKNSSTGSV PFSQEGGGLA CGGSHWGPGY TTTQGSRGFG YQPPNYSTAY LPGSYTSSHC 

       190        200        210        220        230 
RPEAPLPCTF PQSDPRLQGE LRPSFSPYLS PDSSTPYNTS LAGAPMPVTH L 

« Hide

References

[1]"Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11."
Miyashita A., Shimizu N., Endo N., Hanyuu T., Ishii N., Ito K., Itoh Y., Shirai M., Nakajima T., Odani S., Kuwano R.
Gene 237:53-60(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[2]"Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family."
Beranger F., Mejean C., Moniot B., Berta P., Vandromme M.
J. Biol. Chem. 275:16103-16109(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-231.
Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
[4]"Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth."
Stock D.W., Buchanan A.V., Zhao Z., Weiss K.M.
Genomics 37:234-237(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-110.
Strain: Swiss Webster.
Tissue: Embryonic tooth.
[5]"Sox 15, a novel member of the murine Sox family of HMG box transcription factors."
van de Wetering M., Clevers H.
Nucleic Acids Res. 21:1669-1669(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-111.
Strain: C57BL/6.
[6]Lim F.L.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 92-231.
Tissue: Pancreatic islet.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB014474 Genomic DNA. Translation: BAA28604.1.
AF182945 mRNA. Translation: AAF72108.1.
AB039214 Genomic DNA. Translation: BAB68738.1.
AB039215 Genomic DNA. Translation: BAB68739.1.
AB039216 Genomic DNA. Translation: BAB68740.1.
AB039217 Genomic DNA. Translation: BAB68741.1.
AB039218 Genomic DNA. Translation: BAB68742.1.
AB039219 Genomic DNA. Translation: BAB68743.1.
AB039220 Genomic DNA. Translation: BAB68744.1.
AB039221 Genomic DNA. Translation: BAB68745.1.
AB039222 Genomic DNA. Translation: BAB68746.1.
U70443 mRNA. Translation: AAC52861.1.
X70909 Genomic DNA. Translation: CAB37848.1.
X98369 mRNA. Translation: CAA67015.1.
CCDSCCDS24902.1.
PIRS33715.
RefSeqNP_033261.1. NM_009235.2.
UniGeneMm.347499.

3D structure databases

ProteinModelPortalP43267.
SMRP43267. Positions 45-121.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203402. 5 interactions.
IntActP43267. 1 interaction.
MINTMINT-4788454.

PTM databases

PhosphoSiteP43267.

Proteomic databases

PRIDEP43267.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000047373; ENSMUSP00000048524; ENSMUSG00000041287.
GeneID20670.
KEGGmmu:20670.
UCSCuc007jqu.2. mouse.

Organism-specific databases

CTD6665.
MGIMGI:98363. Sox15.

Phylogenomic databases

eggNOGNOG311451.
HOVERGENHBG055512.
InParanoidP43267.
KOK09271.
OMAYGSSHCK.
OrthoDBEOG7H793V.
PhylomeDBP43267.
TreeFamTF351735.

Gene expression databases

ArrayExpressP43267.
BgeeP43267.
CleanExMM_SOX15.
GenevestigatorP43267.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio299147.
PROP43267.
SOURCESearch...

Entry information

Entry nameSOX15_MOUSE
AccessionPrimary (citable) accession number: P43267
Secondary accession number(s): O70204 expand/collapse secondary AC list , P70418, Q62246, Q91V00, Q91V43, Q920T1, Q9JLG2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 8, 2000
Last modified: July 9, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot