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Protein

Prostacyclin receptor

Gene

Ptgir

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-392851. Prostacyclin signalling through prostacyclin receptor.
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostacyclin receptor
Alternative name(s):
Prostaglandin I2 receptor
Short name:
PGI receptor
Short name:
PGI2 receptor
Prostanoid IP receptor
Gene namesi
Name:Ptgir
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310890. Ptgir.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 67Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini68 – 80CytoplasmicSequence analysisAdd BLAST13
Transmembranei81 – 105Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini106 – 123ExtracellularSequence analysisAdd BLAST18
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 163CytoplasmicSequence analysisAdd BLAST19
Transmembranei164 – 187Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini188 – 215ExtracellularSequence analysisAdd BLAST28
Transmembranei216 – 237Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini238 – 264CytoplasmicSequence analysisAdd BLAST27
Transmembranei265 – 289Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini290 – 302ExtracellularSequence analysisAdd BLAST13
Transmembranei303 – 323Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini324 – 416CytoplasmicSequence analysisAdd BLAST93

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3322.
GuidetoPHARMACOLOGYi345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700771 – 413Prostacyclin receptorAdd BLAST413
PropeptideiPRO_0000240006414 – 416Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 194PROSITE-ProRule annotation
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 199PROSITE-ProRule annotation
Lipidationi336S-palmitoyl cysteineBy similarity1
Lipidationi339S-palmitoyl cysteineBy similarity1
Modified residuei366PhosphoserineCombined sources1
Modified residuei413Cysteine methyl esterBy similarity1
Lipidationi413S-farnesyl cysteineBy similarity1

Post-translational modificationi

Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP43253.
PRIDEiP43253.

PTM databases

iPTMnetiP43253.
PhosphoSitePlusiP43253.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016756.

Interactioni

Subunit structurei

Interacts (non-isoprenylated C-terminus) with PDZK1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022461.

Chemistry databases

BindingDBiP43253.

Structurei

3D structure databases

ProteinModelPortaliP43253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43253.
KOiK04263.
OMAiFTQAIAP.
OrthoDBiEOG091G0F07.
PhylomeDBiP43253.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVASGGRPDG PPSITPESPL IVGGREWQGM AGSCWNITYV QDSVGPATST
60 70 80 90 100
LMFVAGVVGN GLALGILGAR RRSHPSAFAV LVTGLAVTDL LGTCFLSPAV
110 120 130 140 150
FVAYARNSSL LGLAHGGTML CDTFAFAMTF FGLASTLILF AMAVERCLAL
160 170 180 190 200
SHPYLYAQLD GPRCARLALP AIYAFCCLFC SLPLLGLGEH QQYCPGSWCF
210 220 230 240 250
IRMRSPQPGG CAFSLAYASL MALLVTSIFF CNGSVTLSLC HMYRQQRRHH
260 270 280 290 300
GSFVPTSRAR EDEVYHLILL ALMTGIMAVC SLPLTIRGFT QAIAPDSREM
310 320 330 340 350
GDLHAFRFNA FNPILDPWVF ILFRKAVFQR LKFWLCCLCA RSVHGDLQTP
360 370 380 390 400
LSRPVSGRRD TLAPDSLQAK EGNWVPLSTW GTGQVAPLTA VPLSGGDGCS
410
VGMPSKTEAV VACSLC
Length:416
Mass (Da):44,662
Last modified:November 1, 1995 - v1
Checksum:i03171B5ED21C4171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28966 mRNA. Translation: BAA06091.1.
PIRiS52078.
RefSeqiNP_001071112.1. NM_001077644.1.
UniGeneiRn.225777.

Genome annotation databases

EnsembliENSRNOT00000022461; ENSRNOP00000022461; ENSRNOG00000016756.
GeneIDi292661.
KEGGirno:292661.
UCSCiRGD:1310890. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28966 mRNA. Translation: BAA06091.1.
PIRiS52078.
RefSeqiNP_001071112.1. NM_001077644.1.
UniGeneiRn.225777.

3D structure databases

ProteinModelPortaliP43253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022461.

Chemistry databases

BindingDBiP43253.
ChEMBLiCHEMBL3322.
GuidetoPHARMACOLOGYi345.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP43253.
PhosphoSitePlusiP43253.

Proteomic databases

PaxDbiP43253.
PRIDEiP43253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022461; ENSRNOP00000022461; ENSRNOG00000016756.
GeneIDi292661.
KEGGirno:292661.
UCSCiRGD:1310890. rat.

Organism-specific databases

CTDi5739.
RGDi1310890. Ptgir.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43253.
KOiK04263.
OMAiFTQAIAP.
OrthoDBiEOG091G0F07.
PhylomeDBiP43253.

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-392851. Prostacyclin signalling through prostacyclin receptor.
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP43253.

Gene expression databases

BgeeiENSRNOG00000016756.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI2R_RAT
AccessioniPrimary (citable) accession number: P43253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.