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P43253 (PI2R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostacyclin receptor
Alternative name(s):
Prostaglandin I2 receptor
Short name=PGI receptor
Short name=PGI2 receptor
Prostanoid IP receptor
Gene names
Name:Ptgir
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

Subunit structure

Interacts (non-isoprenylated C-terminus) with PDZK1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413Prostacyclin receptor
PRO_0000070077
Propeptide414 – 4163Removed in mature form Potential
PRO_0000240006

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 6722Helical; Name=1; Potential
Topological domain68 – 8013Cytoplasmic Potential
Transmembrane81 – 10525Helical; Name=2; Potential
Topological domain106 – 12318Extracellular Potential
Transmembrane124 – 14421Helical; Name=3; Potential
Topological domain145 – 16319Cytoplasmic Potential
Transmembrane164 – 18724Helical; Name=4; Potential
Topological domain188 – 21528Extracellular Potential
Transmembrane216 – 23722Helical; Name=5; Potential
Topological domain238 – 26427Cytoplasmic Potential
Transmembrane265 – 28925Helical; Name=6; Potential
Topological domain290 – 30213Extracellular Potential
Transmembrane303 – 32321Helical; Name=7; Potential
Topological domain324 – 41693Cytoplasmic Potential

Amino acid modifications

Modified residue4131Cysteine methyl ester By similarity
Lipidation3361S-palmitoyl cysteine By similarity
Lipidation3391S-palmitoyl cysteine By similarity
Lipidation4131S-farnesyl cysteine By similarity
Glycosylation361N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 194 By similarity
Disulfide bond121 ↔ 199 By similarity

Sequences

Sequence LengthMass (Da)Tools
P43253 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 03171B5ED21C4171

FASTA41644,662
        10         20         30         40         50         60 
MVASGGRPDG PPSITPESPL IVGGREWQGM AGSCWNITYV QDSVGPATST LMFVAGVVGN 

        70         80         90        100        110        120 
GLALGILGAR RRSHPSAFAV LVTGLAVTDL LGTCFLSPAV FVAYARNSSL LGLAHGGTML 

       130        140        150        160        170        180 
CDTFAFAMTF FGLASTLILF AMAVERCLAL SHPYLYAQLD GPRCARLALP AIYAFCCLFC 

       190        200        210        220        230        240 
SLPLLGLGEH QQYCPGSWCF IRMRSPQPGG CAFSLAYASL MALLVTSIFF CNGSVTLSLC 

       250        260        270        280        290        300 
HMYRQQRRHH GSFVPTSRAR EDEVYHLILL ALMTGIMAVC SLPLTIRGFT QAIAPDSREM 

       310        320        330        340        350        360 
GDLHAFRFNA FNPILDPWVF ILFRKAVFQR LKFWLCCLCA RSVHGDLQTP LSRPVSGRRD 

       370        380        390        400        410 
TLAPDSLQAK EGNWVPLSTW GTGQVAPLTA VPLSGGDGCS VGMPSKTEAV VACSLC 

« Hide

References

[1]"Cloning and expression of a cDNA for rat prostacyclin receptor."
Sasaki Y., Usui T., Tanaka I., Nakagawa O., Sando T., Takahashi T., Namba T., Narumiya S., Nakao K.
Biochim. Biophys. Acta 1224:601-605(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D28966 mRNA. Translation: BAA06091.1.
PIRS52078.
RefSeqNP_001071112.1. NM_001077644.1.
UniGeneRn.225777.

3D structure databases

ProteinModelPortalP43253.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000022461.

Chemistry

BindingDBP43253.
ChEMBLCHEMBL3322.
GuidetoPHARMACOLOGY345.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP43253.

Proteomic databases

PRIDEP43253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022461; ENSRNOP00000022461; ENSRNOG00000016756.
GeneID292661.
KEGGrno:292661.
UCSCRGD:1310890. rat.

Organism-specific databases

CTD5739.
RGD1310890. Ptgir.

Phylogenomic databases

eggNOGNOG305292.
GeneTreeENSGT00690000101953.
HOGENOMHOG000115475.
HOVERGENHBG003074.
InParanoidP43253.
KOK04263.
OMACFLSPAV.
OrthoDBEOG72VH6G.
PhylomeDBP43253.

Gene expression databases

GenevestigatorP43253.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio634464.
PROP43253.

Entry information

Entry namePI2R_RAT
AccessionPrimary (citable) accession number: P43253
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries