SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P43253

- PI2R_RAT

UniProt

P43253 - PI2R_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Prostacyclin receptor

Gene
Ptgir
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. negative regulation of platelet-derived growth factor receptor signaling pathway Source: Ensembl
  3. negative regulation of smooth muscle cell proliferation Source: Ensembl
  4. positive regulation of cAMP biosynthetic process Source: Ensembl
  5. positive regulation of cAMP-mediated signaling Source: Ensembl
  6. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostacyclin receptor
Alternative name(s):
Prostaglandin I2 receptor
Short name:
PGI receptor
Short name:
PGI2 receptor
Prostanoid IP receptor
Gene namesi
Name:Ptgir
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1310890. Ptgir.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545Extracellular Reviewed predictionAdd
BLAST
Transmembranei46 – 6722Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini68 – 8013Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei81 – 10525Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini106 – 12318Extracellular Reviewed predictionAdd
BLAST
Transmembranei124 – 14421Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini145 – 16319Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei164 – 18724Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini188 – 21528Extracellular Reviewed predictionAdd
BLAST
Transmembranei216 – 23722Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini238 – 26427Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei265 – 28925Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini290 – 30213Extracellular Reviewed predictionAdd
BLAST
Transmembranei303 – 32321Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini324 – 41693Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Prostacyclin receptorPRO_0000070077Add
BLAST
Propeptidei414 – 4163Removed in mature form Reviewed predictionPRO_0000240006

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 194 By similarity
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi121 ↔ 199 By similarity
Lipidationi336 – 3361S-palmitoyl cysteine By similarity
Lipidationi339 – 3391S-palmitoyl cysteine By similarity
Modified residuei413 – 4131Cysteine methyl ester By similarity
Lipidationi413 – 4131S-farnesyl cysteine By similarity

Post-translational modificationi

Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PRIDEiP43253.

PTM databases

PhosphoSiteiP43253.

Expressioni

Gene expression databases

GenevestigatoriP43253.

Interactioni

Subunit structurei

Interacts (non-isoprenylated C-terminus) with PDZK1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022461.

Structurei

3D structure databases

ProteinModelPortaliP43253.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305292.
GeneTreeiENSGT00690000101953.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43253.
KOiK04263.
OMAiCFLSPAV.
OrthoDBiEOG72VH6G.
PhylomeDBiP43253.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43253-1 [UniParc]FASTAAdd to Basket

« Hide

MVASGGRPDG PPSITPESPL IVGGREWQGM AGSCWNITYV QDSVGPATST    50
LMFVAGVVGN GLALGILGAR RRSHPSAFAV LVTGLAVTDL LGTCFLSPAV 100
FVAYARNSSL LGLAHGGTML CDTFAFAMTF FGLASTLILF AMAVERCLAL 150
SHPYLYAQLD GPRCARLALP AIYAFCCLFC SLPLLGLGEH QQYCPGSWCF 200
IRMRSPQPGG CAFSLAYASL MALLVTSIFF CNGSVTLSLC HMYRQQRRHH 250
GSFVPTSRAR EDEVYHLILL ALMTGIMAVC SLPLTIRGFT QAIAPDSREM 300
GDLHAFRFNA FNPILDPWVF ILFRKAVFQR LKFWLCCLCA RSVHGDLQTP 350
LSRPVSGRRD TLAPDSLQAK EGNWVPLSTW GTGQVAPLTA VPLSGGDGCS 400
VGMPSKTEAV VACSLC 416
Length:416
Mass (Da):44,662
Last modified:November 1, 1995 - v1
Checksum:i03171B5ED21C4171
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28966 mRNA. Translation: BAA06091.1.
PIRiS52078.
RefSeqiNP_001071112.1. NM_001077644.1.
UniGeneiRn.225777.

Genome annotation databases

EnsembliENSRNOT00000022461; ENSRNOP00000022461; ENSRNOG00000016756.
GeneIDi292661.
KEGGirno:292661.
UCSCiRGD:1310890. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28966 mRNA. Translation: BAA06091.1 .
PIRi S52078.
RefSeqi NP_001071112.1. NM_001077644.1.
UniGenei Rn.225777.

3D structure databases

ProteinModelPortali P43253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000022461.

Chemistry

BindingDBi P43253.
ChEMBLi CHEMBL3322.
GuidetoPHARMACOLOGYi 345.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P43253.

Proteomic databases

PRIDEi P43253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022461 ; ENSRNOP00000022461 ; ENSRNOG00000016756 .
GeneIDi 292661.
KEGGi rno:292661.
UCSCi RGD:1310890. rat.

Organism-specific databases

CTDi 5739.
RGDi 1310890. Ptgir.

Phylogenomic databases

eggNOGi NOG305292.
GeneTreei ENSGT00690000101953.
HOGENOMi HOG000115475.
HOVERGENi HBG003074.
InParanoidi P43253.
KOi K04263.
OMAi CFLSPAV.
OrthoDBi EOG72VH6G.
PhylomeDBi P43253.

Miscellaneous databases

NextBioi 634464.
PROi P43253.

Gene expression databases

Genevestigatori P43253.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiPI2R_RAT
AccessioniPrimary (citable) accession number: P43253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi