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P43253

- PI2R_RAT

UniProt

P43253 - PI2R_RAT

Protein

Prostacyclin receptor

Gene

Ptgir

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. negative regulation of platelet-derived growth factor receptor signaling pathway Source: Ensembl
    3. negative regulation of smooth muscle cell proliferation Source: Ensembl
    4. positive regulation of cAMP biosynthetic process Source: Ensembl
    5. positive regulation of cAMP-mediated signaling Source: Ensembl
    6. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostacyclin receptor
    Alternative name(s):
    Prostaglandin I2 receptor
    Short name:
    PGI receptor
    Short name:
    PGI2 receptor
    Prostanoid IP receptor
    Gene namesi
    Name:Ptgir
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1310890. Ptgir.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Prostacyclin receptorPRO_0000070077Add
    BLAST
    Propeptidei414 – 4163Removed in mature formSequence AnalysisPRO_0000240006

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 194PROSITE-ProRule annotation
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi121 ↔ 199PROSITE-ProRule annotation
    Lipidationi336 – 3361S-palmitoyl cysteineBy similarity
    Lipidationi339 – 3391S-palmitoyl cysteineBy similarity
    Modified residuei413 – 4131Cysteine methyl esterBy similarity
    Lipidationi413 – 4131S-farnesyl cysteineBy similarity

    Post-translational modificationi

    Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Prenylation

    Proteomic databases

    PRIDEiP43253.

    PTM databases

    PhosphoSiteiP43253.

    Expressioni

    Gene expression databases

    GenevestigatoriP43253.

    Interactioni

    Subunit structurei

    Interacts (non-isoprenylated C-terminus) with PDZK1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000022461.

    Structurei

    3D structure databases

    ProteinModelPortaliP43253.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini106 – 12318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini145 – 16319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini188 – 21528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 26427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini290 – 30213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 41693CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6722Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10525Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 18724Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23722Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei265 – 28925Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305292.
    GeneTreeiENSGT00690000101953.
    HOGENOMiHOG000115475.
    HOVERGENiHBG003074.
    InParanoidiP43253.
    KOiK04263.
    OMAiCFLSPAV.
    OrthoDBiEOG72VH6G.
    PhylomeDBiP43253.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR000370. Prostglndn_IP_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF7. PTHR11866:SF7. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01788. PROSTANOIDR.
    PR00856. PRSTNOIDIPR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43253-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVASGGRPDG PPSITPESPL IVGGREWQGM AGSCWNITYV QDSVGPATST    50
    LMFVAGVVGN GLALGILGAR RRSHPSAFAV LVTGLAVTDL LGTCFLSPAV 100
    FVAYARNSSL LGLAHGGTML CDTFAFAMTF FGLASTLILF AMAVERCLAL 150
    SHPYLYAQLD GPRCARLALP AIYAFCCLFC SLPLLGLGEH QQYCPGSWCF 200
    IRMRSPQPGG CAFSLAYASL MALLVTSIFF CNGSVTLSLC HMYRQQRRHH 250
    GSFVPTSRAR EDEVYHLILL ALMTGIMAVC SLPLTIRGFT QAIAPDSREM 300
    GDLHAFRFNA FNPILDPWVF ILFRKAVFQR LKFWLCCLCA RSVHGDLQTP 350
    LSRPVSGRRD TLAPDSLQAK EGNWVPLSTW GTGQVAPLTA VPLSGGDGCS 400
    VGMPSKTEAV VACSLC 416
    Length:416
    Mass (Da):44,662
    Last modified:November 1, 1995 - v1
    Checksum:i03171B5ED21C4171
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28966 mRNA. Translation: BAA06091.1.
    PIRiS52078.
    RefSeqiNP_001071112.1. NM_001077644.1.
    UniGeneiRn.225777.

    Genome annotation databases

    EnsembliENSRNOT00000022461; ENSRNOP00000022461; ENSRNOG00000016756.
    GeneIDi292661.
    KEGGirno:292661.
    UCSCiRGD:1310890. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28966 mRNA. Translation: BAA06091.1 .
    PIRi S52078.
    RefSeqi NP_001071112.1. NM_001077644.1.
    UniGenei Rn.225777.

    3D structure databases

    ProteinModelPortali P43253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000022461.

    Chemistry

    BindingDBi P43253.
    ChEMBLi CHEMBL3322.
    GuidetoPHARMACOLOGYi 345.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P43253.

    Proteomic databases

    PRIDEi P43253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022461 ; ENSRNOP00000022461 ; ENSRNOG00000016756 .
    GeneIDi 292661.
    KEGGi rno:292661.
    UCSCi RGD:1310890. rat.

    Organism-specific databases

    CTDi 5739.
    RGDi 1310890. Ptgir.

    Phylogenomic databases

    eggNOGi NOG305292.
    GeneTreei ENSGT00690000101953.
    HOGENOMi HOG000115475.
    HOVERGENi HBG003074.
    InParanoidi P43253.
    KOi K04263.
    OMAi CFLSPAV.
    OrthoDBi EOG72VH6G.
    PhylomeDBi P43253.

    Miscellaneous databases

    NextBioi 634464.
    PROi P43253.

    Gene expression databases

    Genevestigatori P43253.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR000370. Prostglndn_IP_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF7. PTHR11866:SF7. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01788. PROSTANOIDR.
    PR00856. PRSTNOIDIPR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiPI2R_RAT
    AccessioniPrimary (citable) accession number: P43253
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3