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Protein

Matrin-3

Gene

Matr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri799 – 830Matrin-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Matrin-3
Alternative name(s):
Nuclear scaffold protein p130/MAT3
Gene namesi
Name:Matr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3052. Matr3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • nuclear matrix Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000816242 – 845Matrin-3Add BLAST844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei3N6-acetyllysine; alternateBy similarity1
Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei4PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei41PhosphoserineBy similarity1
Modified residuei118PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei150PhosphothreonineBy similarity1
Modified residuei157PhosphoserineBy similarity1
Modified residuei158PhosphotyrosineBy similarity1
Modified residuei164PhosphoserineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei202PhosphotyrosineBy similarity1
Modified residuei206PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei211PhosphoserineBy similarity1
Modified residuei219PhosphotyrosineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Cross-linki487Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei509PhosphoserineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei522N6-acetyllysineBy similarity1
Modified residuei533PhosphoserineBy similarity1
Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei571N6-acetyllysineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei598PhosphoserineCombined sources1
Modified residuei604PhosphoserineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Cross-linki617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei654PhosphoserineBy similarity1
Modified residuei671PhosphoserineBy similarity1
Modified residuei673PhosphoserineBy similarity1
Modified residuei674PhosphoserineBy similarity1
Modified residuei679PhosphothreonineBy similarity1
Modified residuei689PhosphoserineBy similarity1
Cross-linki717Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei739PhosphothreonineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei757PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei834N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP43244.
PRIDEiP43244.

PTM databases

iPTMnetiP43244.
PhosphoSitePlusiP43244.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019875.

Interactioni

Subunit structurei

Part of a complex consisting of SFPQ, NONO and MATR3. Interacts with AGO1 and AGO2 (By similarity). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Interacts with TARDBP (By similarity).By similarity

Protein-protein interaction databases

BioGridi247833. 2 interactors.
STRINGi10116.ENSRNOP00000026949.

Structurei

3D structure databases

ProteinModelPortaliP43244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 473RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini496 – 571RRM 2PROSITE-ProRule annotationAdd BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi708 – 716Nuclear localization signalSequence analysis9

Sequence similaritiesi

Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri799 – 830Matrin-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGPC. Eukaryota.
ENOG410XSPB. LUCA.
HOGENOMiHOG000015369.
HOVERGENiHBG057347.
InParanoidiP43244.
KOiK13213.
PhylomeDBiP43244.
TreeFamiTF333921.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSFQQSSL GRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA
60 70 80 90 100
RLASLMNLGM SSSLNQQGAH SALSSASTSS HNLQSIFNIG SRGPLPLSSQ
110 120 130 140 150
HRGDTDQASN ILASFGLSAR DLDELSRYPE DKITPENLPQ ILLQLKRRRT
160 170 180 190 200
EEGPTLSYGR DGRSATREPP YRVPRDDWEE KRHFRRDSFD DRGPSLNPVL
210 220 230 240 250
DYDHGSRSQE SGYYDRMDYE DDRLRDGERC RDDSFFGETS HNYHKFDSEY
260 270 280 290 300
ERMGRGPGPL QERSLFEKKR GAPPSSNIED FHGLLPKGYP HLCSICDLPV
310 320 330 340 350
HSNKEWSQHI NGASHSRRCQ LLLEIYPEWN PDNDTGHTMG DPFMLQQSTN
360 370 380 390 400
PAPGILGPPP PSFHLGGPAV GPRGNLGAGN GNLQGPRHMQ KGRVETSRVV
410 420 430 440 450
HIMDFQRGKN LRYQLLQLVE PFGVISNHLI LNKINEAFIE MATTEDAQAA
460 470 480 490 500
VDYYTTTPAL VFGKPVRVHL SQKYKRIKKP EGKPDEKFDQ KQELGRVIHL
510 520 530 540 550
SNLPHSGYSD SAVLKLAEPY GKIKNYILMR MKSQAFIEME TREDAMAMVD
560 570 580 590 600
HCLKKALWFQ GRCVKVDLSE KYKKLVLRIP NRGIDLLKKD KSRKRSYSPD
610 620 630 640 650
GKESPSDKKS KTDGAQKTEN PAEGKEQEEK SGEDGEKDTK DDQTEQEPSM
660 670 680 690 700
LLESEDELLV DEEEAAALIE SGSSVGDETD LANLGDVSSD GKKEPSDKAV
710 720 730 740 750
KKDASATSKK KLKKVDKIEE LDQENEAALE NGIKNEENTE PGAESAENAD
760 770 780 790 800
DPNKDASDNS DGQNDENKED YTIPDEYRIG PYQPNVPGGI DYVIPKTGFY
810 820 830 840
CKLCSLFYTN EEVAKNTHCS SLPHYQKLKK FLNKLAEERR QKKES
Length:845
Mass (Da):94,447
Last modified:January 24, 2001 - v2
Checksum:i5EA8D05529171238
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti486E → Q in BAD90681 (Ref. 3) Curated1
Sequence conflicti669I → L in BAD90681 (Ref. 3) Curated1
Sequence conflicti788G → V in BAD90681 (Ref. 3) Curated1
Sequence conflicti845S → T in BAD90681 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63485 mRNA. Translation: AAB63955.1.
AB205483 mRNA. Translation: BAD90681.1.
RefSeqiNP_062022.2. NM_019149.3.
XP_006254596.1. XM_006254534.3.
XP_017456375.1. XM_017600886.1.
XP_017456376.1. XM_017600887.1.
UniGeneiRn.29774.

Genome annotation databases

GeneIDi29150.
KEGGirno:29150.
UCSCiRGD:3052. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63485 mRNA. Translation: AAB63955.1.
AB205483 mRNA. Translation: BAD90681.1.
RefSeqiNP_062022.2. NM_019149.3.
XP_006254596.1. XM_006254534.3.
XP_017456375.1. XM_017600886.1.
XP_017456376.1. XM_017600887.1.
UniGeneiRn.29774.

3D structure databases

ProteinModelPortaliP43244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247833. 2 interactors.
STRINGi10116.ENSRNOP00000026949.

PTM databases

iPTMnetiP43244.
PhosphoSitePlusiP43244.

Proteomic databases

PaxDbiP43244.
PRIDEiP43244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29150.
KEGGirno:29150.
UCSCiRGD:3052. rat.

Organism-specific databases

CTDi9782.
RGDi3052. Matr3.

Phylogenomic databases

eggNOGiENOG410IGPC. Eukaryota.
ENOG410XSPB. LUCA.
HOGENOMiHOG000015369.
HOVERGENiHBG057347.
InParanoidiP43244.
KOiK13213.
PhylomeDBiP43244.
TreeFamiTF333921.

Miscellaneous databases

PROiP43244.

Gene expression databases

BgeeiENSRNOG00000019875.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMATR3_RAT
AccessioniPrimary (citable) accession number: P43244
Secondary accession number(s): O35833, Q5DVW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 24, 2001
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.