Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Matrin-3

Gene

Matr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri799 – 83032Matrin-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Matrin-3
Alternative name(s):
Nuclear scaffold protein p130/MAT3
Gene namesi
Name:Matr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3052. Matr3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • nuclear matrix Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 845844Matrin-3PRO_0000081624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei3 – 31N6-acetyllysine; alternateBy similarity
Cross-linki3 – 3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei118 – 1181PhosphoserineBy similarity
Cross-linki146 – 146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei150 – 1501PhosphothreonineBy similarity
Modified residuei188 – 1881PhosphoserineCombined sources
Modified residuei195 – 1951PhosphoserineCombined sources
Modified residuei206 – 2061PhosphoserineCombined sources
Modified residuei208 – 2081PhosphoserineCombined sources
Modified residuei219 – 2191PhosphotyrosineBy similarity
Cross-linki487 – 487Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki491 – 491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei522 – 5221N6-acetyllysineBy similarity
Modified residuei533 – 5331PhosphoserineBy similarity
Cross-linki554 – 554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei571 – 5711N6-acetyllysineBy similarity
Modified residuei596 – 5961PhosphoserineBy similarity
Modified residuei598 – 5981PhosphoserineCombined sources
Modified residuei604 – 6041PhosphoserineBy similarity
Modified residuei606 – 6061PhosphoserineBy similarity
Cross-linki617 – 617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei654 – 6541PhosphoserineBy similarity
Modified residuei671 – 6711PhosphoserineBy similarity
Modified residuei673 – 6731PhosphoserineBy similarity
Modified residuei674 – 6741PhosphoserineBy similarity
Modified residuei679 – 6791PhosphothreonineBy similarity
Modified residuei689 – 6891PhosphoserineBy similarity
Cross-linki717 – 717Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki734 – 734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei739 – 7391PhosphothreonineCombined sources
Modified residuei745 – 7451PhosphoserineCombined sources
Modified residuei757 – 7571PhosphoserineCombined sources
Modified residuei760 – 7601PhosphoserineCombined sources
Modified residuei834 – 8341N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP43244.
PRIDEiP43244.

PTM databases

iPTMnetiP43244.
PhosphoSiteiP43244.

Interactioni

Subunit structurei

Part of a complex consisting of SFPQ, NONO and MATR3. Interacts with AGO1 and AGO2 (By similarity). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Interacts with TARDBP (By similarity).By similarity

Protein-protein interaction databases

BioGridi247833. 2 interactions.
STRINGi10116.ENSRNOP00000026949.

Structurei

3D structure databases

ProteinModelPortaliP43244.
SMRiP43244. Positions 390-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 47376RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini496 – 57176RRM 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi708 – 7169Nuclear localization signalSequence analysis

Sequence similaritiesi

Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri799 – 83032Matrin-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGPC. Eukaryota.
ENOG410XSPB. LUCA.
HOGENOMiHOG000015369.
HOVERGENiHBG057347.
InParanoidiP43244.
KOiK13213.
OrthoDBiEOG7GJ6C8.
PhylomeDBiP43244.
TreeFamiTF333921.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSFQQSSL GRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA
60 70 80 90 100
RLASLMNLGM SSSLNQQGAH SALSSASTSS HNLQSIFNIG SRGPLPLSSQ
110 120 130 140 150
HRGDTDQASN ILASFGLSAR DLDELSRYPE DKITPENLPQ ILLQLKRRRT
160 170 180 190 200
EEGPTLSYGR DGRSATREPP YRVPRDDWEE KRHFRRDSFD DRGPSLNPVL
210 220 230 240 250
DYDHGSRSQE SGYYDRMDYE DDRLRDGERC RDDSFFGETS HNYHKFDSEY
260 270 280 290 300
ERMGRGPGPL QERSLFEKKR GAPPSSNIED FHGLLPKGYP HLCSICDLPV
310 320 330 340 350
HSNKEWSQHI NGASHSRRCQ LLLEIYPEWN PDNDTGHTMG DPFMLQQSTN
360 370 380 390 400
PAPGILGPPP PSFHLGGPAV GPRGNLGAGN GNLQGPRHMQ KGRVETSRVV
410 420 430 440 450
HIMDFQRGKN LRYQLLQLVE PFGVISNHLI LNKINEAFIE MATTEDAQAA
460 470 480 490 500
VDYYTTTPAL VFGKPVRVHL SQKYKRIKKP EGKPDEKFDQ KQELGRVIHL
510 520 530 540 550
SNLPHSGYSD SAVLKLAEPY GKIKNYILMR MKSQAFIEME TREDAMAMVD
560 570 580 590 600
HCLKKALWFQ GRCVKVDLSE KYKKLVLRIP NRGIDLLKKD KSRKRSYSPD
610 620 630 640 650
GKESPSDKKS KTDGAQKTEN PAEGKEQEEK SGEDGEKDTK DDQTEQEPSM
660 670 680 690 700
LLESEDELLV DEEEAAALIE SGSSVGDETD LANLGDVSSD GKKEPSDKAV
710 720 730 740 750
KKDASATSKK KLKKVDKIEE LDQENEAALE NGIKNEENTE PGAESAENAD
760 770 780 790 800
DPNKDASDNS DGQNDENKED YTIPDEYRIG PYQPNVPGGI DYVIPKTGFY
810 820 830 840
CKLCSLFYTN EEVAKNTHCS SLPHYQKLKK FLNKLAEERR QKKES
Length:845
Mass (Da):94,447
Last modified:January 24, 2001 - v2
Checksum:i5EA8D05529171238
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861E → Q in BAD90681 (Ref. 3) Curated
Sequence conflicti669 – 6691I → L in BAD90681 (Ref. 3) Curated
Sequence conflicti788 – 7881G → V in BAD90681 (Ref. 3) Curated
Sequence conflicti845 – 8451S → T in BAD90681 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63485 mRNA. Translation: AAB63955.1.
AB205483 mRNA. Translation: BAD90681.1.
RefSeqiNP_062022.2. NM_019149.3.
XP_006254596.1. XM_006254534.2.
UniGeneiRn.29774.

Genome annotation databases

GeneIDi29150.
KEGGirno:29150.
UCSCiRGD:3052. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63485 mRNA. Translation: AAB63955.1.
AB205483 mRNA. Translation: BAD90681.1.
RefSeqiNP_062022.2. NM_019149.3.
XP_006254596.1. XM_006254534.2.
UniGeneiRn.29774.

3D structure databases

ProteinModelPortaliP43244.
SMRiP43244. Positions 390-576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247833. 2 interactions.
STRINGi10116.ENSRNOP00000026949.

PTM databases

iPTMnetiP43244.
PhosphoSiteiP43244.

Proteomic databases

PaxDbiP43244.
PRIDEiP43244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29150.
KEGGirno:29150.
UCSCiRGD:3052. rat.

Organism-specific databases

CTDi9782.
RGDi3052. Matr3.

Phylogenomic databases

eggNOGiENOG410IGPC. Eukaryota.
ENOG410XSPB. LUCA.
HOGENOMiHOG000015369.
HOVERGENiHBG057347.
InParanoidiP43244.
KOiK13213.
OrthoDBiEOG7GJ6C8.
PhylomeDBiP43244.
TreeFamiTF333921.

Miscellaneous databases

NextBioi608155.
PROiP43244.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain."
    Belgrader P., Dey R., Berezney R.
    J. Biol. Chem. 266:9893-9899(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Berezney R.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Hibino Y.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188; SER-195; SER-206; SER-208; SER-598; THR-739; SER-745; SER-757 AND SER-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMATR3_RAT
AccessioniPrimary (citable) accession number: P43244
Secondary accession number(s): O35833, Q5DVW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 24, 2001
Last modified: May 11, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.