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P43243

- MATR3_HUMAN

UniProt

P43243 - MATR3_HUMAN

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Protein

Matrin-3

Gene

MATR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri801 – 83232Matrin-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
  3. structural molecule activity Source: ProtInc
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell death Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Matrin-3
Gene namesi
Name:MATR3
Synonyms:KIAA0723
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6912. MATR3.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. nuclear inner membrane Source: ProtInc
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Amyotrophic lateral sclerosis 21 (ALS21) [MIM:606070]: A neurodegenerative disorder affecting upper and lower motor neurons, resulting in muscle weakness and respiratory failure. Some patients may develop myopathic features or dementia.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851S → C in ALS21; results in increased interaction with TARDBP. 2 Publications
Corresponds to variant rs121434591 [ dbSNP | Ensembl ].
VAR_063421
Natural varianti115 – 1151F → C in ALS21. 1 Publication
VAR_071078
Natural varianti154 – 1541P → S in ALS21; unknown pathological significance. 1 Publication
VAR_071079
Natural varianti622 – 6221T → A in ALS21. 1 Publication
VAR_071080

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

MIMi606070. phenotype.
Orphaneti803. Amyotrophic lateral sclerosis.
600. Distal myopathy with vocal cord weakness.
PharmGKBiPA30655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 847846Matrin-3PRO_0000081622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications
Modified residuei3 – 31N6-acetyllysine1 Publication
Modified residuei4 – 41Phosphoserine2 Publications
Modified residuei9 – 91Phosphoserine1 Publication
Modified residuei14 – 141Phosphoserine1 Publication
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei41 – 411Phosphoserine1 Publication
Modified residuei118 – 1181Phosphoserine1 Publication
Modified residuei188 – 1881Phosphoserine7 Publications
Modified residuei195 – 1951Phosphoserine3 Publications
Modified residuei206 – 2061Phosphoserine3 Publications
Modified residuei208 – 2081Phosphoserine3 Publications
Modified residuei219 – 2191Phosphotyrosine1 Publication
Modified residuei522 – 5221N6-acetyllysine1 Publication
Modified residuei533 – 5331Phosphoserine3 Publications
Modified residuei571 – 5711N6-acetyllysine1 Publication
Modified residuei596 – 5961Phosphoserine2 Publications
Modified residuei598 – 5981Phosphoserine3 Publications
Modified residuei604 – 6041Phosphoserine3 Publications
Modified residuei606 – 6061Phosphoserine1 Publication
Modified residuei741 – 7411Phosphothreonine1 Publication
Modified residuei747 – 7471Phosphoserine1 Publication
Modified residuei766 – 7661Phosphoserine2 Publications
Modified residuei836 – 8361N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP43243.
PaxDbiP43243.
PRIDEiP43243.

PTM databases

PhosphoSiteiP43243.

Miscellaneous databases

PMAP-CutDBP43243.

Expressioni

Gene expression databases

BgeeiP43243.
CleanExiHS_MATR3.
ExpressionAtlasiP43243. baseline and differential.
GenevestigatoriP43243.

Organism-specific databases

HPAiCAB033552.
HPA036564.
HPA036565.

Interactioni

Subunit structurei

Part of a complex consisting of SFPQ, NONO and MATR3. Interacts with AGO1 and AGO2. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with TARDBP.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227362EBI-352602,EBI-721550

Protein-protein interaction databases

BioGridi115126. 66 interactions.
IntActiP43243. 50 interactions.
MINTiMINT-4999417.
STRINGi9606.ENSP00000354346.

Structurei

3D structure databases

ProteinModelPortaliP43243.
SMRiP43243. Positions 390-576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 47376RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini496 – 57176RRM 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi710 – 7189Nuclear localization signalSequence Analysis

Sequence similaritiesi

Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri801 – 83232Matrin-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG80010.
GeneTreeiENSGT00760000119324.
HOGENOMiHOG000015369.
HOVERGENiHBG057347.
InParanoidiP43243.
KOiK13213.
OrthoDBiEOG7GJ6C8.
PhylomeDBiP43243.
TreeFamiTF333921.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR015880. Znf_C2H2-like.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P43243-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA
60 70 80 90 100
RLASLMNLGM SSSLNQQGAH SALSSASTSS HNLQSIFNIG SRGPLPLSSQ
110 120 130 140 150
HRGDADQASN ILASFGLSAR DLDELSRYPE DKITPENLPQ ILLQLKRRRT
160 170 180 190 200
EEGPTLSYGR DGRSATREPP YRVPRDDWEE KRHFRRDSFD DRGPSLNPVL
210 220 230 240 250
DYDHGSRSQE SGYYDRMDYE DDRLRDGERC RDDSFFGETS HNYHKFDSEY
260 270 280 290 300
ERMGRGPGPL QERSLFEKKR GAPPSSNIED FHGLLPKGYP HLCSICDLPV
310 320 330 340 350
HSNKEWSQHI NGASHSRRCQ LLLEIYPEWN PDNDTGHTMG DPFMLQQSTN
360 370 380 390 400
PAPGILGPPP PSFHLGGPAV GPRGNLGAGN GNLQGPRHMQ KGRVETSRVV
410 420 430 440 450
HIMDFQRGKN LRYQLLQLVE PFGVISNHLI LNKINEAFIE MATTEDAQAA
460 470 480 490 500
VDYYTTTPAL VFGKPVRVHL SQKYKRIKKP EGKPDQKFDQ KQELGRVIHL
510 520 530 540 550
SNLPHSGYSD SAVLKLAEPY GKIKNYILMR MKSQAFIEME TREDAMAMVD
560 570 580 590 600
HCLKKALWFQ GRCVKVDLSE KYKKLVLRIP NRGIDLLKKD KSRKRSYSPD
610 620 630 640 650
GKESPSDKKS KTDGSQKTES STEGKEQEEK SGEDGEKDTK DDQTEQEPNM
660 670 680 690 700
LLESEDELLV DEEEAAALLE SGSSVGDETD LANLGDVASD GKKEPSDKAV
710 720 730 740 750
KKDGSASAAA KKKLKKVDKI EELDQENEAA LENGIKNEEN TEPGAESSEN
760 770 780 790 800
ADDPNKDTSE NADGQSDENK DDYTIPDEYR IGPYQPNVPV GIDYVIPKTG
810 820 830 840
FYCKLCSLFY TNEEVAKNTH CSSLPHYQKL KKFLNKLAEE RRQKKET
Length:847
Mass (Da):94,623
Last modified:January 24, 2001 - v2
Checksum:i530AA49214BC1611
GO
Isoform 2 (identifier: P43243-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-304: MSKSFQQSSL...ICDLPVHSNK → MLGAQWRRNQPSRAAE

Note: No experimental confirmation available.

Show »
Length:559
Mass (Da):62,576
Checksum:i7E7772B22A7AF741
GO

Sequence cautioni

The sequence AAF17217.1 differs from that shown. Reason: Frameshift at several positions.
The sequence BAA34443.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571P → S in AAF17217. (PubMed:10931946)Curated
Sequence conflicti274 – 2741P → S in AAF17217. (PubMed:10931946)Curated
Sequence conflicti572 – 5721Y → C in AAF17217. (PubMed:10931946)Curated
Sequence conflicti572 – 5721Y → C in M63483. (PubMed:2033075)Curated
Sequence conflicti691 – 6911G → P in M63483. (PubMed:2033075)Curated
Sequence conflicti703 – 7031D → H in M63483. (PubMed:2033075)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851S → C in ALS21; results in increased interaction with TARDBP. 2 Publications
Corresponds to variant rs121434591 [ dbSNP | Ensembl ].
VAR_063421
Natural varianti115 – 1151F → C in ALS21. 1 Publication
VAR_071078
Natural varianti154 – 1541P → S in ALS21; unknown pathological significance. 1 Publication
VAR_071079
Natural varianti622 – 6221T → A in ALS21. 1 Publication
VAR_071080

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 304304MSKSF…VHSNK → MLGAQWRRNQPSRAAE in isoform 2. 1 PublicationVSP_042624Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018266 mRNA. Translation: BAA34443.2. Different initiation.
AF117236 mRNA. Translation: AAF17217.1. Frameshift.
AK316420 mRNA. Translation: BAH14791.1.
AC011404 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62114.1.
CH471062 Genomic DNA. Translation: EAW62115.1.
CH471062 Genomic DNA. Translation: EAW62116.1.
CH471062 Genomic DNA. Translation: EAW62117.1.
BC015031 mRNA. Translation: AAH15031.1.
M63483 mRNA. No translation available.
CCDSiCCDS4210.1. [P43243-1]
CCDS54908.1. [P43243-2]
RefSeqiNP_001181883.1. NM_001194954.1. [P43243-1]
NP_001181884.1. NM_001194955.1. [P43243-1]
NP_001181885.1. NM_001194956.1. [P43243-2]
NP_001269207.1. NM_001282278.1.
NP_061322.2. NM_018834.5. [P43243-1]
NP_954659.1. NM_199189.2. [P43243-1]
UniGeneiHs.268939.
Hs.595110.

Genome annotation databases

EnsembliENST00000361059; ENSP00000354346; ENSG00000015479. [P43243-1]
ENST00000394805; ENSP00000378284; ENSG00000015479. [P43243-1]
ENST00000503811; ENSP00000423587; ENSG00000015479. [P43243-2]
ENST00000509990; ENSP00000423533; ENSG00000015479. [P43243-1]
ENST00000618441; ENSP00000482895; ENSG00000015479. [P43243-1]
GeneIDi9782.
KEGGihsa:9782.
UCSCiuc003ldt.3. human. [P43243-1]
uc011czb.2. human. [P43243-2]

Polymorphism databases

DMDMi12643409.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018266 mRNA. Translation: BAA34443.2 . Different initiation.
AF117236 mRNA. Translation: AAF17217.1 . Frameshift.
AK316420 mRNA. Translation: BAH14791.1 .
AC011404 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62114.1 .
CH471062 Genomic DNA. Translation: EAW62115.1 .
CH471062 Genomic DNA. Translation: EAW62116.1 .
CH471062 Genomic DNA. Translation: EAW62117.1 .
BC015031 mRNA. Translation: AAH15031.1 .
M63483 mRNA. No translation available.
CCDSi CCDS4210.1. [P43243-1 ]
CCDS54908.1. [P43243-2 ]
RefSeqi NP_001181883.1. NM_001194954.1. [P43243-1 ]
NP_001181884.1. NM_001194955.1. [P43243-1 ]
NP_001181885.1. NM_001194956.1. [P43243-2 ]
NP_001269207.1. NM_001282278.1.
NP_061322.2. NM_018834.5. [P43243-1 ]
NP_954659.1. NM_199189.2. [P43243-1 ]
UniGenei Hs.268939.
Hs.595110.

3D structure databases

ProteinModelPortali P43243.
SMRi P43243. Positions 390-576.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115126. 66 interactions.
IntActi P43243. 50 interactions.
MINTi MINT-4999417.
STRINGi 9606.ENSP00000354346.

PTM databases

PhosphoSitei P43243.

Polymorphism databases

DMDMi 12643409.

Proteomic databases

MaxQBi P43243.
PaxDbi P43243.
PRIDEi P43243.

Protocols and materials databases

DNASUi 9782.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361059 ; ENSP00000354346 ; ENSG00000015479 . [P43243-1 ]
ENST00000394805 ; ENSP00000378284 ; ENSG00000015479 . [P43243-1 ]
ENST00000503811 ; ENSP00000423587 ; ENSG00000015479 . [P43243-2 ]
ENST00000509990 ; ENSP00000423533 ; ENSG00000015479 . [P43243-1 ]
ENST00000618441 ; ENSP00000482895 ; ENSG00000015479 . [P43243-1 ]
GeneIDi 9782.
KEGGi hsa:9782.
UCSCi uc003ldt.3. human. [P43243-1 ]
uc011czb.2. human. [P43243-2 ]

Organism-specific databases

CTDi 9782.
GeneCardsi GC05P138609.
HGNCi HGNC:6912. MATR3.
HPAi CAB033552.
HPA036564.
HPA036565.
MIMi 164015. gene.
606070. phenotype.
neXtProti NX_P43243.
Orphaneti 803. Amyotrophic lateral sclerosis.
600. Distal myopathy with vocal cord weakness.
PharmGKBi PA30655.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80010.
GeneTreei ENSGT00760000119324.
HOGENOMi HOG000015369.
HOVERGENi HBG057347.
InParanoidi P43243.
KOi K13213.
OrthoDBi EOG7GJ6C8.
PhylomeDBi P43243.
TreeFami TF333921.

Miscellaneous databases

ChiTaRSi MATR3. human.
GeneWikii MATR3.
GenomeRNAii 9782.
NextBioi 36832.
PMAP-CutDB P43243.
PROi P43243.
SOURCEi Search...

Gene expression databases

Bgeei P43243.
CleanExi HS_MATR3.
ExpressionAtlasi P43243. baseline and differential.
Genevestigatori P43243.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR015880. Znf_C2H2-like.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view ]
SMARTi SM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SM00451. ZnF_U1. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hypothalamus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  7. Bienvenut W.V., Matallanas D., Kolch W.
    Submitted (JUL-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-12; 150-160; 187-207 AND 374-387, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Mammary carcinoma.
  8. "Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain."
    Belgrader P., Dey R., Berezney R.
    J. Biol. Chem. 266:9893-9899(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 432-847 (ISOFORM 1).
  9. "The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs."
    Zhang Z., Carmichael G.G.
    Cell 106:465-475(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN NUCLEAR RETENTION OF A-TO-I EDITED RNAS, IDENTIFICATION IN A COMPLEX WITH SFPQ AND NONO.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
    Hoeck J., Weinmann L., Ender C., Ruedel S., Kremmer E., Raabe M., Urlaub H., Meister G.
    EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AGO1 AND AGO2.
  12. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188 AND SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  15. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188; SER-195; SER-208; SER-533; SER-596; SER-598 AND SER-604, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  18. "Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation."
    Garapaty S., Xu C.F., Trojer P., Mahajan M.A., Neubert T.A., Samuels H.H.
    J. Biol. Chem. 284:7542-7552(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH ZNF335; MKI67; C11ORF30; ZNF335; HSPA8; TUBB2A; CCAR2; ASCL2; RBBP5 AND WDR5.
  19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-3; LYS-522; LYS-571 AND LYS-836, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-14; SER-41; SER-188; SER-195; SER-206; SER-208; SER-533; SER-598; SER-604; SER-606 AND SER-766, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-9; SER-188; SER-195; SER-206; SER-208; TYR-219; SER-533; SER-596; SER-598; SER-604; THR-741; SER-747 AND SER-766, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  24. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. Cited for: INTERACTION WITH TARDBP, VARIANTS ALS21 CYS-85; CYS-115; SER-154 AND ALA-622, CHARACTERIZATION OF VARIANT ALS21 CYS-85.
  26. Cited for: VARIANT ALS21 CYS-85.

Entry informationi

Entry nameiMATR3_HUMAN
AccessioniPrimary (citable) accession number: P43243
Secondary accession number(s): B7ZAV5
, D3DQC3, Q9UHW0, Q9UQ27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 24, 2001
Last modified: October 29, 2014
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3