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P43243

- MATR3_HUMAN

UniProt

P43243 - MATR3_HUMAN

Protein

Matrin-3

Gene

MATR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 158 (01 Oct 2014)
      Sequence version 2 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri801 – 83232Matrin-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. structural molecule activity Source: ProtInc
    5. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrin-3
    Gene namesi
    Name:MATR3
    Synonyms:KIAA0723
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6912. MATR3.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. nuclear inner membrane Source: ProtInc
    3. nuclear matrix Source: UniProtKB-SubCell
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Amyotrophic lateral sclerosis 21 (ALS21) [MIM:606070]: A neurodegenerative disorder affecting upper and lower motor neurons, resulting in muscle weakness and respiratory failure. Some patients may develop myopathic features or dementia.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851S → C in ALS21; results in increased interaction with TARDBP. 2 Publications
    Corresponds to variant rs121434591 [ dbSNP | Ensembl ].
    VAR_063421
    Natural varianti115 – 1151F → C in ALS21. 1 Publication
    VAR_071078
    Natural varianti154 – 1541P → S in ALS21; unknown pathological significance. 1 Publication
    VAR_071079
    Natural varianti622 – 6221T → A in ALS21. 1 Publication
    VAR_071080

    Keywords - Diseasei

    Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

    Organism-specific databases

    MIMi606070. phenotype.
    Orphaneti600. Distal myopathy with vocal cord weakness.
    PharmGKBiPA30655.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 847846Matrin-3PRO_0000081622Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications
    Modified residuei3 – 31N6-acetyllysine1 Publication
    Modified residuei4 – 41Phosphoserine2 Publications
    Modified residuei9 – 91Phosphoserine1 Publication
    Modified residuei14 – 141Phosphoserine1 Publication
    Modified residuei22 – 221Phosphoserine1 Publication
    Modified residuei41 – 411Phosphoserine1 Publication
    Modified residuei118 – 1181Phosphoserine1 Publication
    Modified residuei188 – 1881Phosphoserine7 Publications
    Modified residuei195 – 1951Phosphoserine3 Publications
    Modified residuei206 – 2061Phosphoserine3 Publications
    Modified residuei208 – 2081Phosphoserine3 Publications
    Modified residuei219 – 2191Phosphotyrosine1 Publication
    Modified residuei522 – 5221N6-acetyllysine1 Publication
    Modified residuei533 – 5331Phosphoserine3 Publications
    Modified residuei571 – 5711N6-acetyllysine1 Publication
    Modified residuei596 – 5961Phosphoserine2 Publications
    Modified residuei598 – 5981Phosphoserine3 Publications
    Modified residuei604 – 6041Phosphoserine3 Publications
    Modified residuei606 – 6061Phosphoserine1 Publication
    Modified residuei741 – 7411Phosphothreonine1 Publication
    Modified residuei747 – 7471Phosphoserine1 Publication
    Modified residuei766 – 7661Phosphoserine2 Publications
    Modified residuei836 – 8361N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP43243.
    PaxDbiP43243.
    PRIDEiP43243.

    PTM databases

    PhosphoSiteiP43243.

    Miscellaneous databases

    PMAP-CutDBP43243.

    Expressioni

    Gene expression databases

    ArrayExpressiP43243.
    BgeeiP43243.
    CleanExiHS_MATR3.
    GenevestigatoriP43243.

    Organism-specific databases

    HPAiCAB033552.
    HPA036564.
    HPA036565.

    Interactioni

    Subunit structurei

    Part of a complex consisting of SFPQ, NONO and MATR3. Interacts with AGO1 and AGO2. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with TARDBP.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NR4A1P227362EBI-352602,EBI-721550

    Protein-protein interaction databases

    BioGridi115126. 62 interactions.
    IntActiP43243. 50 interactions.
    MINTiMINT-4999417.
    STRINGi9606.ENSP00000354346.

    Structurei

    3D structure databases

    ProteinModelPortaliP43243.
    SMRiP43243. Positions 390-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini398 – 47376RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 57176RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi710 – 7189Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri801 – 83232Matrin-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG80010.
    HOGENOMiHOG000015369.
    HOVERGENiHBG057347.
    KOiK13213.
    OrthoDBiEOG7GJ6C8.
    PhylomeDBiP43243.
    TreeFamiTF333921.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR015880. Znf_C2H2-like.
    IPR000690. Znf_C2H2_matrin.
    IPR003604. Znf_U1.
    [Graphical view]
    SMARTiSM00360. RRM. 2 hits.
    SM00355. ZnF_C2H2. 1 hit.
    SM00451. ZnF_U1. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    PS50171. ZF_MATRIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43243-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA    50
    RLASLMNLGM SSSLNQQGAH SALSSASTSS HNLQSIFNIG SRGPLPLSSQ 100
    HRGDADQASN ILASFGLSAR DLDELSRYPE DKITPENLPQ ILLQLKRRRT 150
    EEGPTLSYGR DGRSATREPP YRVPRDDWEE KRHFRRDSFD DRGPSLNPVL 200
    DYDHGSRSQE SGYYDRMDYE DDRLRDGERC RDDSFFGETS HNYHKFDSEY 250
    ERMGRGPGPL QERSLFEKKR GAPPSSNIED FHGLLPKGYP HLCSICDLPV 300
    HSNKEWSQHI NGASHSRRCQ LLLEIYPEWN PDNDTGHTMG DPFMLQQSTN 350
    PAPGILGPPP PSFHLGGPAV GPRGNLGAGN GNLQGPRHMQ KGRVETSRVV 400
    HIMDFQRGKN LRYQLLQLVE PFGVISNHLI LNKINEAFIE MATTEDAQAA 450
    VDYYTTTPAL VFGKPVRVHL SQKYKRIKKP EGKPDQKFDQ KQELGRVIHL 500
    SNLPHSGYSD SAVLKLAEPY GKIKNYILMR MKSQAFIEME TREDAMAMVD 550
    HCLKKALWFQ GRCVKVDLSE KYKKLVLRIP NRGIDLLKKD KSRKRSYSPD 600
    GKESPSDKKS KTDGSQKTES STEGKEQEEK SGEDGEKDTK DDQTEQEPNM 650
    LLESEDELLV DEEEAAALLE SGSSVGDETD LANLGDVASD GKKEPSDKAV 700
    KKDGSASAAA KKKLKKVDKI EELDQENEAA LENGIKNEEN TEPGAESSEN 750
    ADDPNKDTSE NADGQSDENK DDYTIPDEYR IGPYQPNVPV GIDYVIPKTG 800
    FYCKLCSLFY TNEEVAKNTH CSSLPHYQKL KKFLNKLAEE RRQKKET 847
    Length:847
    Mass (Da):94,623
    Last modified:January 24, 2001 - v2
    Checksum:i530AA49214BC1611
    GO
    Isoform 2 (identifier: P43243-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-304: MSKSFQQSSL...ICDLPVHSNK → MLGAQWRRNQPSRAAE

    Note: No experimental confirmation available.

    Show »
    Length:559
    Mass (Da):62,576
    Checksum:i7E7772B22A7AF741
    GO

    Sequence cautioni

    The sequence AAF17217.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence BAA34443.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571P → S in AAF17217. (PubMed:10931946)Curated
    Sequence conflicti274 – 2741P → S in AAF17217. (PubMed:10931946)Curated
    Sequence conflicti572 – 5721Y → C in AAF17217. (PubMed:10931946)Curated
    Sequence conflicti572 – 5721Y → C in M63483. (PubMed:2033075)Curated
    Sequence conflicti691 – 6911G → P in M63483. (PubMed:2033075)Curated
    Sequence conflicti703 – 7031D → H in M63483. (PubMed:2033075)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851S → C in ALS21; results in increased interaction with TARDBP. 2 Publications
    Corresponds to variant rs121434591 [ dbSNP | Ensembl ].
    VAR_063421
    Natural varianti115 – 1151F → C in ALS21. 1 Publication
    VAR_071078
    Natural varianti154 – 1541P → S in ALS21; unknown pathological significance. 1 Publication
    VAR_071079
    Natural varianti622 – 6221T → A in ALS21. 1 Publication
    VAR_071080

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 304304MSKSF…VHSNK → MLGAQWRRNQPSRAAE in isoform 2. 1 PublicationVSP_042624Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018266 mRNA. Translation: BAA34443.2. Different initiation.
    AF117236 mRNA. Translation: AAF17217.1. Frameshift.
    AK316420 mRNA. Translation: BAH14791.1.
    AC011404 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62114.1.
    CH471062 Genomic DNA. Translation: EAW62115.1.
    CH471062 Genomic DNA. Translation: EAW62116.1.
    CH471062 Genomic DNA. Translation: EAW62117.1.
    BC015031 mRNA. Translation: AAH15031.1.
    M63483 mRNA. No translation available.
    CCDSiCCDS4210.1. [P43243-1]
    CCDS54908.1. [P43243-2]
    RefSeqiNP_001181883.1. NM_001194954.1. [P43243-1]
    NP_001181884.1. NM_001194955.1. [P43243-1]
    NP_001181885.1. NM_001194956.1. [P43243-2]
    NP_001269207.1. NM_001282278.1.
    NP_061322.2. NM_018834.5. [P43243-1]
    NP_954659.1. NM_199189.2. [P43243-1]
    UniGeneiHs.268939.
    Hs.595110.

    Genome annotation databases

    EnsembliENST00000361059; ENSP00000354346; ENSG00000015479. [P43243-1]
    ENST00000394805; ENSP00000378284; ENSG00000015479. [P43243-1]
    ENST00000503811; ENSP00000423587; ENSG00000015479. [P43243-2]
    ENST00000509990; ENSP00000423533; ENSG00000015479. [P43243-1]
    GeneIDi9782.
    KEGGihsa:9782.
    UCSCiuc003ldt.3. human. [P43243-1]
    uc011czb.2. human. [P43243-2]

    Polymorphism databases

    DMDMi12643409.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018266 mRNA. Translation: BAA34443.2 . Different initiation.
    AF117236 mRNA. Translation: AAF17217.1 . Frameshift.
    AK316420 mRNA. Translation: BAH14791.1 .
    AC011404 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW62114.1 .
    CH471062 Genomic DNA. Translation: EAW62115.1 .
    CH471062 Genomic DNA. Translation: EAW62116.1 .
    CH471062 Genomic DNA. Translation: EAW62117.1 .
    BC015031 mRNA. Translation: AAH15031.1 .
    M63483 mRNA. No translation available.
    CCDSi CCDS4210.1. [P43243-1 ]
    CCDS54908.1. [P43243-2 ]
    RefSeqi NP_001181883.1. NM_001194954.1. [P43243-1 ]
    NP_001181884.1. NM_001194955.1. [P43243-1 ]
    NP_001181885.1. NM_001194956.1. [P43243-2 ]
    NP_001269207.1. NM_001282278.1.
    NP_061322.2. NM_018834.5. [P43243-1 ]
    NP_954659.1. NM_199189.2. [P43243-1 ]
    UniGenei Hs.268939.
    Hs.595110.

    3D structure databases

    ProteinModelPortali P43243.
    SMRi P43243. Positions 390-576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115126. 62 interactions.
    IntActi P43243. 50 interactions.
    MINTi MINT-4999417.
    STRINGi 9606.ENSP00000354346.

    PTM databases

    PhosphoSitei P43243.

    Polymorphism databases

    DMDMi 12643409.

    Proteomic databases

    MaxQBi P43243.
    PaxDbi P43243.
    PRIDEi P43243.

    Protocols and materials databases

    DNASUi 9782.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361059 ; ENSP00000354346 ; ENSG00000015479 . [P43243-1 ]
    ENST00000394805 ; ENSP00000378284 ; ENSG00000015479 . [P43243-1 ]
    ENST00000503811 ; ENSP00000423587 ; ENSG00000015479 . [P43243-2 ]
    ENST00000509990 ; ENSP00000423533 ; ENSG00000015479 . [P43243-1 ]
    GeneIDi 9782.
    KEGGi hsa:9782.
    UCSCi uc003ldt.3. human. [P43243-1 ]
    uc011czb.2. human. [P43243-2 ]

    Organism-specific databases

    CTDi 9782.
    GeneCardsi GC05P138609.
    HGNCi HGNC:6912. MATR3.
    HPAi CAB033552.
    HPA036564.
    HPA036565.
    MIMi 164015. gene.
    606070. phenotype.
    neXtProti NX_P43243.
    Orphaneti 600. Distal myopathy with vocal cord weakness.
    PharmGKBi PA30655.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80010.
    HOGENOMi HOG000015369.
    HOVERGENi HBG057347.
    KOi K13213.
    OrthoDBi EOG7GJ6C8.
    PhylomeDBi P43243.
    TreeFami TF333921.

    Miscellaneous databases

    ChiTaRSi MATR3. human.
    GeneWikii MATR3.
    GenomeRNAii 9782.
    NextBioi 36832.
    PMAP-CutDB P43243.
    PROi P43243.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43243.
    Bgeei P43243.
    CleanExi HS_MATR3.
    Genevestigatori P43243.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR015880. Znf_C2H2-like.
    IPR000690. Znf_C2H2_matrin.
    IPR003604. Znf_U1.
    [Graphical view ]
    SMARTi SM00360. RRM. 2 hits.
    SM00355. ZnF_C2H2. 1 hit.
    SM00451. ZnF_U1. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    PS50171. ZF_MATRIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hypothalamus.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    7. Bienvenut W.V., Matallanas D., Kolch W.
      Submitted (JUL-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-12; 150-160; 187-207 AND 374-387, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Mammary carcinoma.
    8. "Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain."
      Belgrader P., Dey R., Berezney R.
      J. Biol. Chem. 266:9893-9899(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 432-847 (ISOFORM 1).
    9. "The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs."
      Zhang Z., Carmichael G.G.
      Cell 106:465-475(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NUCLEAR RETENTION OF A-TO-I EDITED RNAS, IDENTIFICATION IN A COMPLEX WITH SFPQ AND NONO.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
      Hoeck J., Weinmann L., Ender C., Ruedel S., Kremmer E., Raabe M., Urlaub H., Meister G.
      EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AGO1 AND AGO2.
    12. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188 AND SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: T-cell.
    15. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188; SER-195; SER-208; SER-533; SER-596; SER-598 AND SER-604, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    18. "Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation."
      Garapaty S., Xu C.F., Trojer P., Mahajan M.A., Neubert T.A., Samuels H.H.
      J. Biol. Chem. 284:7542-7552(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH ZNF335; MKI67; C11ORF30; ZNF335; HSPA8; TUBB2A; CCAR2; ASCL2; RBBP5 AND WDR5.
    19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-3; LYS-522; LYS-571 AND LYS-836, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-14; SER-41; SER-188; SER-195; SER-206; SER-208; SER-533; SER-598; SER-604; SER-606 AND SER-766, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-9; SER-188; SER-195; SER-206; SER-208; TYR-219; SER-533; SER-596; SER-598; SER-604; THR-741; SER-747 AND SER-766, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    24. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    25. Cited for: INTERACTION WITH TARDBP, VARIANTS ALS21 CYS-85; CYS-115; SER-154 AND ALA-622, CHARACTERIZATION OF VARIANT ALS21 CYS-85.
    26. Cited for: VARIANT ALS21 CYS-85.

    Entry informationi

    Entry nameiMATR3_HUMAN
    AccessioniPrimary (citable) accession number: P43243
    Secondary accession number(s): B7ZAV5
    , D3DQC3, Q9UHW0, Q9UQ27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 158 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3