Reviewed, UniProtKB/Swiss-Prot P43242 (HMOX2_RABIT)

Names and origin

Protein names

Recommended name:
    Heme oxygenase 2
      Short name=HO-2
    EC=1.14.99.3

Gene names

Name:

HMOX2

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Subcellular location	Microsome. Endoplasmic reticulum.
Sequence similarities	Belongs to the heme oxygenase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Heme oxygenase 2		PRO_0000209693
Regions
	Repeat	260 – 265	6	HRM 1
	Repeat	277 – 282	6	HRM 2
Sites
	Metal binding	41	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43242-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 2D33FF39FA1F5505	FASTA	312	35,373
	10 20 30 40 50 60 MSAEVETSEG VDEPEEKNFG ENHIRMADLS ELLKEGTKEA HDRAENTKFV KDFLKGNIKK 70 80 90 100 110 120 EIFKLATTAL YFTYSALEEE MDRNKDHPAF APLYFPMELH RKEALTKDME YFFGENWEEQ 130 140 150 160 170 180 VQCSEAAQKY VERIHYIGQN EPELLVAHAY TRYMGDLSGG QVLKKVAQRA LKLPSTGEGT 190 200 210 220 230 240 QFYLFENVDN AQQFKQFYRA RMNALDLNLK TKERIVEEAN KAFEYNMQIF SELDQAGSAP 250 260 270 280 290 300 ASETVEDRIP VHDGKGDVRK CPYYAAGQVN GALEGSSCPF RAAMAVLRKP SLQLVLAAAV 310 ALAAGLLAWY YM

References

[1]

"Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: possible heme-binding site?" Rotenberg M.O., Maines M.D. Arch. Biochem. Biophys. 290:336-344(1991) [PubMed: 1929402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S61699 mRNA. Translation: AAB20093.1.
PIR	S18387.
RefSeq	NP_001076216.1.
UniGene	Ocu.3307
3D structure databases
HSSP	HSSP built from PDB template 1IVJ based on UniProtKB P06762.
ModBase	Search...
Genome annotation databases
Ensembl	ENSOCUG00000006018. Oryctolagus cuniculus. [Contig view]
GeneID	100009523.
Phylogenomic databases
HOVERGEN	P43242.
Enzyme and pathway databases
BRENDA	1.14.99.3. 255.
Family and domain databases
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
PANTHER	PTHR10720. Haem_Oase. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMOX2_RABIT

Accession

Primary (citable) accession number: P43242

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)