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P43241

- CDX2_MOUSE

UniProt

P43241 - CDX2_MOUSE

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Protein
Homeobox protein CDX-2
Gene
Cdx2, Cdx-2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi185 – 24460Homeobox
Add
BLAST

GO - Molecular functioni

  1. double-stranded DNA binding Source: Ensembl
  2. protein binding Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. transcription corepressor activity Source: MGI
  6. transcription regulatory region sequence-specific DNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. blastocyst development Source: MGI
  3. blood vessel development Source: MGI
  4. cell differentiation Source: MGI
  5. endosome to lysosome transport Source: MGI
  6. establishment or maintenance of epithelial cell apical/basal polarity Source: MGI
  7. labyrinthine layer development Source: MGI
  8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  9. pattern specification process Source: MGI
  10. placenta development Source: MGI
  11. positive regulation of cell differentiation Source: MGI
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of transcription, DNA-templated Source: Ensembl
  14. regulation of transcription from RNA polymerase II promoter Source: MGI
  15. somatic stem cell maintenance Source: MGI
  16. transcription, DNA-templated Source: UniProtKB-KW
  17. trophectodermal cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-2
Alternative name(s):
Caudal-type homeobox protein 2
Gene namesi
Name:Cdx2
Synonyms:Cdx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:88361. Cdx2.

Subcellular locationi

GO - Cellular componenti

  1. condensed nuclear chromosome Source: MGI
  2. nucleus Source: MGI
  3. protein complex Source: MGI
  4. transcriptional repressor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Homeobox protein CDX-2
PRO_0000048851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation of Ser-60 mediates the transactivation capacity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43241.
PRIDEiP43241.

PTM databases

PhosphoSiteiP43241.

Expressioni

Tissue specificityi

Intestine; expressed specifically in gut epithelium where it is not restricted to a particular cell lineage. Abundant expression is seen in the proximal colon with slightly lower levels in distal colon. Expression in the proximal colon is not restricted either to a particular cell lineage or stage of differentiation while in the distal colon it is more abundant in the differentiated cells towards the top of the crypt.

Gene expression databases

BgeeiP43241.
CleanExiMM_CDX2.
GenevestigatoriP43241.

Interactioni

Protein-protein interaction databases

BioGridi198664. 6 interactions.
STRINGi10090.ENSMUSP00000031650.

Structurei

3D structure databases

ProteinModelPortaliP43241.
SMRiP43241. Positions 189-242.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 538Poly-Ala
Compositional biasi85 – 928Poly-Ala
Compositional biasi247 – 25711Poly-Gln
Add
BLAST

Sequence similaritiesi

Belongs to the Caudal homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG304047.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiP43241.
KOiK09312.
OMAiGPSWPSP.
OrthoDBiEOG71P2BK.
PhylomeDBiP43241.
TreeFamiTF351605.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43241-1 [UniParc]FASTAAdd to Basket

« Hide

MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA    50
ATANLDSAQS PGPSWPTAYG APLREDWNGY APGGAAAANA VAHGLNGGSP 100
AAAMGYSSPA EYHAHHHPHH HPHHPAASPS CASGLLQTLN LGPPGPAATA 150
AAEQLSPSGQ RRNLCEWMRK PAQQSLGSQV KTRTKDKYRV VYTDHQRLEL 200
EKEFHFSRYI TIRRKSELAA TLGLSERQVK IWFQNRRAKE RKIKKKQQQQ 250
QQQQQQQPPQ PPPQPSQPQP GALRSVPEPL SPVTSLQGSV PGSVPGVLGP 300
AGGVLNSTVT Q 311
Length:311
Mass (Da):33,476
Last modified:November 1, 1995 - v1
Checksum:i71FFC4C263462FF3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691Y → H in AAB32251. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00454 Unassigned DNA. Translation: AAA19645.1.
S74520 mRNA. Translation: AAB32251.1.
CCDSiCCDS19878.1.
PIRiA53808.
RefSeqiNP_031699.2. NM_007673.3.
UniGeneiMm.20358.

Genome annotation databases

EnsembliENSMUST00000031650; ENSMUSP00000031650; ENSMUSG00000029646.
GeneIDi12591.
KEGGimmu:12591.
UCSCiuc009anz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00454 Unassigned DNA. Translation: AAA19645.1 .
S74520 mRNA. Translation: AAB32251.1 .
CCDSi CCDS19878.1.
PIRi A53808.
RefSeqi NP_031699.2. NM_007673.3.
UniGenei Mm.20358.

3D structure databases

ProteinModelPortali P43241.
SMRi P43241. Positions 189-242.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198664. 6 interactions.
STRINGi 10090.ENSMUSP00000031650.

PTM databases

PhosphoSitei P43241.

Proteomic databases

MaxQBi P43241.
PRIDEi P43241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031650 ; ENSMUSP00000031650 ; ENSMUSG00000029646 .
GeneIDi 12591.
KEGGi mmu:12591.
UCSCi uc009anz.1. mouse.

Organism-specific databases

CTDi 1045.
MGIi MGI:88361. Cdx2.

Phylogenomic databases

eggNOGi NOG304047.
HOGENOMi HOG000115975.
HOVERGENi HBG005302.
InParanoidi P43241.
KOi K09312.
OMAi GPSWPSP.
OrthoDBi EOG71P2BK.
PhylomeDBi P43241.
TreeFami TF351605.

Miscellaneous databases

NextBioi 281738.
PROi P43241.
SOURCEi Search...

Gene expression databases

Bgeei P43241.
CleanExi MM_CDX2.
Genevestigatori P43241.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium."
    James R.J., Erler T., Kazenwadel J.
    J. Biol. Chem. 269:15229-15237(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
  2. "A homeodomain protein related to caudal regulates intestine-specific gene transcription."
    Suh E., Chen L., Taylor J., Traber P.G.
    Mol. Cell. Biol. 14:7340-7351(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  3. "Homeobox gene expression in the intestinal epithelium of adult mice."
    James R.J., Kazenwadel J.
    J. Biol. Chem. 266:3246-3251(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 204-229.
  4. "Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity."
    Rings E.H., Boudreau F., Taylor J.K., Moffett J., Suh E.R., Traber P.G.
    Gastroenterology 121:1437-1450(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-60.

Entry informationi

Entry nameiCDX2_MOUSE
AccessioniPrimary (citable) accession number: P43241
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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