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Protein

Homeobox protein CDX-2

Gene

Cdx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi185 – 244HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: GO_Central
  • anterior/posterior axis specification Source: GO_Central
  • anterior/posterior pattern specification Source: MGI
  • blastocyst development Source: MGI
  • blood vessel development Source: MGI
  • cell differentiation Source: MGI
  • endosome to lysosome transport Source: MGI
  • establishment or maintenance of epithelial cell apical/basal polarity Source: MGI
  • intestinal epithelial cell differentiation Source: UniProtKB
  • labyrinthine layer development Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • pattern specification process Source: MGI
  • placenta development Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • regulation of somitogenesis Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: MGI
  • somatic stem cell population maintenance Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • trophectodermal cell differentiation Source: MGI

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-2
Alternative name(s):
Caudal-type homeobox protein 2
Gene namesi
Name:Cdx2
Synonyms:Cdx-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88361 Cdx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488511 – 311Homeobox protein CDX-2Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation of Ser-60 mediates the transactivation capacity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP43241
PeptideAtlasiP43241
PRIDEiP43241

PTM databases

iPTMnetiP43241
PhosphoSitePlusiP43241

Expressioni

Tissue specificityi

Intestine; expressed specifically in gut epithelium where it is not restricted to a particular cell lineage. Abundant expression is seen in the proximal colon with slightly lower levels in distal colon. Expression in the proximal colon is not restricted either to a particular cell lineage or stage of differentiation while in the distal colon it is more abundant in the differentiated cells towards the top of the crypt.

Gene expression databases

BgeeiENSMUSG00000029646
CleanExiMM_CDX2
ExpressionAtlasiP43241 baseline and differential
GenevisibleiP43241 MM

Interactioni

Protein-protein interaction databases

BioGridi198664, 6 interactors
STRINGi10090.ENSMUSP00000031650

Structurei

3D structure databases

ProteinModelPortaliP43241
SMRiP43241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 215Interaction with DNABy similarityAdd BLAST31
Regioni227 – 241Interaction with 5-mCpG DNABy similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 53Poly-Ala8
Compositional biasi85 – 92Poly-Ala8
Compositional biasi247 – 257Poly-GlnAdd BLAST11

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0848 Eukaryota
ENOG4111W2J LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000115975
HOVERGENiHBG005302
InParanoidiP43241
KOiK22234
OMAiPSWPSPY
OrthoDBiEOG091G0LXJ
PhylomeDBiP43241
TreeFamiTF351605

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR006820 Caudal_activation_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF04731 Caudal_act, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA
60 70 80 90 100
ATANLDSAQS PGPSWPTAYG APLREDWNGY APGGAAAANA VAHGLNGGSP
110 120 130 140 150
AAAMGYSSPA EYHAHHHPHH HPHHPAASPS CASGLLQTLN LGPPGPAATA
160 170 180 190 200
AAEQLSPSGQ RRNLCEWMRK PAQQSLGSQV KTRTKDKYRV VYTDHQRLEL
210 220 230 240 250
EKEFHFSRYI TIRRKSELAA TLGLSERQVK IWFQNRRAKE RKIKKKQQQQ
260 270 280 290 300
QQQQQQQPPQ PPPQPSQPQP GALRSVPEPL SPVTSLQGSV PGSVPGVLGP
310
AGGVLNSTVT Q
Length:311
Mass (Da):33,476
Last modified:November 1, 1995 - v1
Checksum:i71FFC4C263462FF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69Y → H in AAB32251 (PubMed:7935448).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00454 Unassigned DNA Translation: AAA19645.1
S74520 mRNA Translation: AAB32251.1
CCDSiCCDS19878.1
PIRiA53808
RefSeqiNP_031699.2, NM_007673.3
UniGeneiMm.20358

Genome annotation databases

EnsembliENSMUST00000031650; ENSMUSP00000031650; ENSMUSG00000029646
GeneIDi12591
KEGGimmu:12591
UCSCiuc009anz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCDX2_MOUSE
AccessioniPrimary (citable) accession number: P43241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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