P43238 (ALL12_ARAHY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Allergen Ara h 1, clone P41B Alternative name(s): Allergen Ara h I Allergen=Ara h 1
Organism	Arachis hypogaea (Peanut)
Taxonomic identifier	3818 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Dalbergieae › Arachis

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Induction	Repressed by water stress.
Allergenic properties	Causes an allergic reaction in human. Ref.1
Sequence similarities	Belongs to the 7S seed storage protein family.

Ontologies

Keywords
Disease	Allergen
Domain	Signal
PTM	Glycoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Molecular function	nutrient reservoir activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 626	601	Allergen Ara h 1, clone P41B		PRO_0000032197
Amino acid modifications
	Glycosylation	521	1	N-linked (GlcNAc...) Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P43238 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 1A6BBBE41490D0E3	FASTA	626	71,345
	10 20 30 40 50 60 MRGRVSPLML LLGILVLASV SATHAKSSPY QKKTENPCAQ RCLQSCQQEP DDLKQKACES 70 80 90 100 110 120 RCTKLEYDPR CVYDPRGHTG TTNQRSPPGE RTRGRQPGDY DDDRRQPRRE EGGRWGPAGP 130 140 150 160 170 180 REREREEDWR QPREDWRRPS HQQPRKIRPE GREGEQEWGT PGSHVREETS RNNPFYFPSR 190 200 210 220 230 240 RFSTRYGNQN GRIRVLQRFD QRSRQFQNLQ NHRIVQIEAK PNTLVLPKHA DADNILVIQQ 250 260 270 280 290 300 GQATVTVANG NNRKSFNLDE GHALRIPSGF ISYILNRHDN QNLRVAKISM PVNTPGQFED 310 320 330 340 350 360 FFPASSRDQS SYLQGFSRNT LEAAFNAEFN EIRRVLLEEN AGGEQEERGQ RRWSTRSSEN 370 380 390 400 410 420 NEGVIVKVSK EHVEELTKHA KSVSKKGSEE EGDITNPINL REGEPDLSNN FGKLFEVKPD 430 440 450 460 470 480 KKNPQLQDLD MMLTCVEIKE GALMLPHFNS KAMVIVVVNK GTGNLELVAV RKEQQQRGRR 490 500 510 520 530 540 EEEEDEDEEE EGSNREVRRY TARLKEGDVF IMPAAHPVAI NASSELHLLG FGINAENNHR 550 560 570 580 590 600 IFLAGDKDNV IDQIEKQAKD LAFPGSGEQV EKLIKNQKES HFVSARPQSQ SQSPSSPEKE 610 620 SPEKEDQEEE NQGGKGPLLS ILKAFN

References

[1]	"Recombinant peanut allergen Ara h I expression and IgE binding in patients with peanut hypersensitivity." Burks A.W., Cockrell G., Stanley J.S., Helm R.M., Bannon G.A. J. Clin. Invest. 96:1715-1721(1995) [PubMed: 7560062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN. Strain: cv. Florunner.
[2]	"Structure and organization of the genomic clone of a major peanut allergen gene, Ara h 1." Viquez O.M., Konan K.N., Dodo H.W. Mol. Immunol. 40:565-571(2003) [PubMed: 14597159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. F78-1339.
[3]	"Suppression of seed storage proteins upon water stress in Arachis hypogea var. M-13 seeds." Katam R., Vasanthaiah H.K.N., Basha S.M., McClung S. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 5-18; 96-108; 153-165; 171-181; 203-277; 288-351; 357-367; 387-471; 478-498 AND 541-572, REPRESSION BY WATER STRESS. Strain: cv. M13. Tissue: Seed.
[4]	"N-glycan analysis by matrix-assisted laser desorption/ionization mass spectrometry of electrophoretically separated nonmammalian proteins: application to peanut allergen Ara h 1 and olive pollen allergen Ole e 1." Kolarich D., Altmann F. Anal. Biochem. 285:64-75(2000) [PubMed: 10998264] [Abstract] Cited for: GLYCOSYLATION AT ASN-521.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L34402 mRNA. Translation: AAB00861.1.
AF432231 Genomic DNA. Translation: AAL27476.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3S7E	X-ray	2.71	A/B	170-586	[»]
3S7I	X-ray	2.35	A/B	170-586	[»]

ProteinModelPortal

P43238.

ModBase

Search...

Protein family/group databases

Allergome

3094. Ara h 1.0101.
50. Ara h 1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR006045. Cupin_1.
IPR011051. Cupin_RmlC_type.
IPR014710. RmlC-like_jellyroll.
[Graphical view]

Gene3D

G3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits.

Pfam

PF00190. Cupin_1. 2 hits.
[Graphical view]

SMART

SM00835. Cupin_1. 2 hits.
[Graphical view]

SUPFAM

SSF51182. RmlC_like_cupin. 2 hits.

ProtoNet

Search...

Entry information

Entry name

ALL12_ARAHY

Accession

Primary (citable) accession number: P43238
Secondary accession number(s): Q547W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program