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P43234

- CATO_HUMAN

UniProt

P43234 - CATO_HUMAN

Protein

Cathepsin O

Gene

CTSO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

    Catalytic activityi

    The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321By similarity
    Active sitei269 – 2691By similarity
    Active sitei289 – 2891By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: ProtInc

    GO - Biological processi

    1. proteolysis Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.

    Protein family/group databases

    MEROPSiC01.035.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin O (EC:3.4.22.42)
    Gene namesi
    Name:CTSO
    Synonyms:CTSO1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:2542. CTSO.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27040.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 10784Activation peptidePRO_0000026321Add
    BLAST
    Chaini108 – 321214Cathepsin OPRO_0000026322Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi129 ↔ 170By similarity
    Disulfide bondi163 ↔ 204By similarity
    Disulfide bondi262 ↔ 310By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP43234.
    PRIDEiP43234.

    PTM databases

    PhosphoSiteiP43234.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.

    Gene expression databases

    BgeeiP43234.
    CleanExiHS_CTSO.
    GenevestigatoriP43234.

    Organism-specific databases

    HPAiHPA002041.

    Interactioni

    Protein-protein interaction databases

    BioGridi107899. 1 interaction.
    IntActiP43234. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP43234.
    SMRiP43234. Positions 68-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    HOGENOMiHOG000230774.
    HOVERGENiHBG105050.
    InParanoidiP43234.
    KOiK01374.
    OMAiHVKMGSN.
    OrthoDBiEOG72NRQS.
    PhylomeDBiP43234.
    TreeFamiTF331594.

    Family and domain databases

    InterProiIPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43234-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR    50
    HRYLNSLFPS ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH 100
    MSIPNVSLPL RFDWRDKQVV TQVRNQQMCG GCWAFSVVGA VESAYAIKGK 150
    PLEDLSVQQV IDCSYNNYGC NGGSTLNALN WLNKMQVKLV KDSEYPFKAQ 200
    NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP LVVIVDAVSW 250
    QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY 300
    AHVKMGSNVC GIADSVSSIF V 321
    Length:321
    Mass (Da):35,958
    Last modified:November 1, 1995 - v1
    Checksum:iF48011ECA9E0BC45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77383 mRNA. Translation: CAA54562.1.
    BC049206 mRNA. Translation: AAH49206.1.
    CCDSiCCDS3794.1.
    PIRiA55090.
    RefSeqiNP_001325.1. NM_001334.2.
    UniGeneiHs.75262.

    Genome annotation databases

    EnsembliENST00000433477; ENSP00000414904; ENSG00000256043.
    ENST00000573499; ENSP00000460395; ENSG00000263238.
    GeneIDi1519.
    KEGGihsa:1519.
    UCSCiuc003ipg.3. human.

    Polymorphism databases

    DMDMi1168795.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77383 mRNA. Translation: CAA54562.1 .
    BC049206 mRNA. Translation: AAH49206.1 .
    CCDSi CCDS3794.1.
    PIRi A55090.
    RefSeqi NP_001325.1. NM_001334.2.
    UniGenei Hs.75262.

    3D structure databases

    ProteinModelPortali P43234.
    SMRi P43234. Positions 68-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107899. 1 interaction.
    IntActi P43234. 1 interaction.

    Chemistry

    BindingDBi P43234.

    Protein family/group databases

    MEROPSi C01.035.

    PTM databases

    PhosphoSitei P43234.

    Polymorphism databases

    DMDMi 1168795.

    Proteomic databases

    PaxDbi P43234.
    PRIDEi P43234.

    Protocols and materials databases

    DNASUi 1519.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000433477 ; ENSP00000414904 ; ENSG00000256043 .
    ENST00000573499 ; ENSP00000460395 ; ENSG00000263238 .
    GeneIDi 1519.
    KEGGi hsa:1519.
    UCSCi uc003ipg.3. human.

    Organism-specific databases

    CTDi 1519.
    GeneCardsi GC04M156845.
    HGNCi HGNC:2542. CTSO.
    HPAi HPA002041.
    MIMi 600550. gene.
    neXtProti NX_P43234.
    PharmGKBi PA27040.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4870.
    HOGENOMi HOG000230774.
    HOVERGENi HBG105050.
    InParanoidi P43234.
    KOi K01374.
    OMAi HVKMGSN.
    OrthoDBi EOG72NRQS.
    PhylomeDBi P43234.
    TreeFami TF331594.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.

    Miscellaneous databases

    GeneWikii Cathepsin_O.
    GenomeRNAii 1519.
    NextBioi 6287.
    PROi P43234.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43234.
    CleanExi HS_CTSO.
    Genevestigatori P43234.

    Family and domain databases

    InterProi IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues."
      Velasco G., Ferrando A.A., Puente X.S., Sanchez L.M., Lopez-Otin C.
      J. Biol. Chem. 269:27136-27142(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary carcinoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiCATO_HUMAN
    AccessioniPrimary (citable) accession number: P43234
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3