P43234 (CATO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin O
EC=3.4.22.42

Gene names

Name:	CTSO
Synonyms:	CTSO1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.
Catalytic activity	The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.
Subcellular location	Lysosome.
Tissue specificity	Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type endopeptidase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Propeptide	24 – 107	84	Activation peptide		PRO_0000026321
	Chain	108 – 321	214	Cathepsin O		PRO_0000026322
Sites
	Active site	132	1	By similarity
	Active site	269	1	By similarity
	Active site	289	1	By similarity
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Disulfide bond	129 ↔ 170		By similarity
	Disulfide bond	163 ↔ 204		By similarity
	Disulfide bond	262 ↔ 310		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43234 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: F48011ECA9E0BC45	FASTA	321	35,958
	10 20 30 40 50 60 MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR HRYLNSLFPS 70 80 90 100 110 120 ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH MSIPNVSLPL RFDWRDKQVV 130 140 150 160 170 180 TQVRNQQMCG GCWAFSVVGA VESAYAIKGK PLEDLSVQQV IDCSYNNYGC NGGSTLNALN 190 200 210 220 230 240 WLNKMQVKLV KDSEYPFKAQ NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP 250 260 270 280 290 300 LVVIVDAVSW QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY 310 320 AHVKMGSNVC GIADSVSSIF V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues." Velasco G., Ferrando A.A., Puente X.S., Sanchez L.M., Lopez-Otin C. J. Biol. Chem. 269:27136-27142(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary carcinoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X77383 mRNA. Translation: CAA54562.1. BC049206 mRNA. Translation: AAH49206.1.
IPI	IPI00017257.
PIR	A55090.
RefSeq	NP_001325.1. NM_001334.2.
UniGene	Hs.75262.
3D structure databases
ProteinModelPortal	P43234.
ModBase	Search...
Protein-protein interaction databases
IntAct	P43234. 1 interaction.
Protein family/group databases
MEROPS	C01.035.
PTM databases
PhosphoSite	P43234.
Polymorphism databases
DMDM	1168795.
Proteomic databases
PaxDb	P43234.
PRIDE	P43234.
Protocols and materials databases
DNASU	1519.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000433477; ENSP00000414904; ENSG00000256043. ENST00000573499; ENSP00000460395; ENSG00000263238.
GeneID	1519.
KEGG	hsa:1519.
UCSC	uc003ipg.3. human.
Organism-specific databases
CTD	1519.
GeneCards	GC04M156845.
HGNC	HGNC:2542. CTSO.
HPA	HPA002041.
MIM	600550. gene.
neXtProt	NX_P43234.
PharmGKB	PA27040.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4870.
HOGENOM	HOG000230774.
HOVERGEN	HBG105050.
InParanoid	P43234.
KO	K01374.
OMA	SNVCGIA.
OrthoDB	EOG4V6ZH1.
PhylomeDB	P43234.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	P43234.
CleanEx	HS_CTSO.
Genevestigator	P43234.
GermOnline	ENSG00000151792. Homo sapiens.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. [Graphical view]
PANTHER	PTHR12411. PTHR12411. 1 hit.
Pfam	PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. False negative. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P43234.
ChEMBL	CHEMBL3035.
GenomeRNAi	1519.
NextBio	6287.
SOURCE	Search...

Entry information

Entry name

CATO_HUMAN

Accession

Primary (citable) accession number: P43234

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.