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Protein

Cathepsin O

Gene

CTSO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Catalytic activityi

The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321By similarity
Active sitei269 – 2691By similarity
Active sitei289 – 2891By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: ProtInc

GO - Biological processi

  1. proteolysis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.

Protein family/group databases

MEROPSiC01.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin O (EC:3.4.22.42)
Gene namesi
Name:CTSO
Synonyms:CTSO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 4, Unplaced

Organism-specific databases

HGNCiHGNC:2542. CTSO.

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 10784Activation peptidePRO_0000026321Add
BLAST
Chaini108 – 321214Cathepsin OPRO_0000026322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi129 ↔ 170By similarity
Disulfide bondi163 ↔ 204By similarity
Disulfide bondi262 ↔ 310By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP43234.
PRIDEiP43234.

PTM databases

PhosphoSiteiP43234.

Expressioni

Tissue specificityi

Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.

Gene expression databases

BgeeiP43234.
CleanExiHS_CTSO.
GenevestigatoriP43234.

Organism-specific databases

HPAiHPA002041.

Interactioni

Protein-protein interaction databases

BioGridi107899. 5 interactions.
IntActiP43234. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP43234.
SMRiP43234. Positions 68-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
HOVERGENiHBG105050.
InParanoidiP43234.
KOiK01374.
OMAiHVKMGSN.
OrthoDBiEOG72NRQS.
PhylomeDBiP43234.
TreeFamiTF331594.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR
60 70 80 90 100
HRYLNSLFPS ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH
110 120 130 140 150
MSIPNVSLPL RFDWRDKQVV TQVRNQQMCG GCWAFSVVGA VESAYAIKGK
160 170 180 190 200
PLEDLSVQQV IDCSYNNYGC NGGSTLNALN WLNKMQVKLV KDSEYPFKAQ
210 220 230 240 250
NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP LVVIVDAVSW
260 270 280 290 300
QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY
310 320
AHVKMGSNVC GIADSVSSIF V
Length:321
Mass (Da):35,958
Last modified:November 1, 1995 - v1
Checksum:iF48011ECA9E0BC45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77383 mRNA. Translation: CAA54562.1.
BC049206 mRNA. Translation: AAH49206.1.
CCDSiCCDS3794.1.
PIRiA55090.
RefSeqiNP_001325.1. NM_001334.2.
UniGeneiHs.75262.

Genome annotation databases

EnsembliENST00000433477; ENSP00000414904; ENSG00000256043.
ENST00000573499; ENSP00000460395; ENSG00000263238.
GeneIDi1519.
KEGGihsa:1519.
UCSCiuc003ipg.3. human.

Polymorphism databases

DMDMi1168795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77383 mRNA. Translation: CAA54562.1.
BC049206 mRNA. Translation: AAH49206.1.
CCDSiCCDS3794.1.
PIRiA55090.
RefSeqiNP_001325.1. NM_001334.2.
UniGeneiHs.75262.

3D structure databases

ProteinModelPortaliP43234.
SMRiP43234. Positions 68-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107899. 5 interactions.
IntActiP43234. 1 interaction.

Protein family/group databases

MEROPSiC01.035.

PTM databases

PhosphoSiteiP43234.

Polymorphism databases

DMDMi1168795.

Proteomic databases

PaxDbiP43234.
PRIDEiP43234.

Protocols and materials databases

DNASUi1519.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000433477; ENSP00000414904; ENSG00000256043.
ENST00000573499; ENSP00000460395; ENSG00000263238.
GeneIDi1519.
KEGGihsa:1519.
UCSCiuc003ipg.3. human.

Organism-specific databases

CTDi1519.
GeneCardsiGC04M156845.
HGNCiHGNC:2542. CTSO.
HPAiHPA002041.
MIMi600550. gene.
neXtProtiNX_P43234.
PharmGKBiPA27040.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
HOVERGENiHBG105050.
InParanoidiP43234.
KOiK01374.
OMAiHVKMGSN.
OrthoDBiEOG72NRQS.
PhylomeDBiP43234.
TreeFamiTF331594.

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.

Miscellaneous databases

ChiTaRSiCTSO. human.
GeneWikiiCathepsin_O.
GenomeRNAii1519.
NextBioi6287.
PROiP43234.
SOURCEiSearch...

Gene expression databases

BgeeiP43234.
CleanExiHS_CTSO.
GenevestigatoriP43234.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues."
    Velasco G., Ferrando A.A., Puente X.S., Sanchez L.M., Lopez-Otin C.
    J. Biol. Chem. 269:27136-27142(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary carcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiCATO_HUMAN
AccessioniPrimary (citable) accession number: P43234
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.