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Protein

Cathepsin O

Gene

CTSO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Catalytic activityi

The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132By similarity1
Active sitei269By similarity1
Active sitei289By similarity1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: ProtInc

GO - Biological processi

  • proteolysis Source: ProtInc
  • proteolysis involved in cellular protein catabolic process Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.

Protein family/group databases

MEROPSiC01.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin O (EC:3.4.22.42)
Gene namesi
Name:CTSO
Synonyms:CTSO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000256043.2.
HGNCiHGNC:2542. CTSO.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1519.
OpenTargetsiENSG00000256043.
PharmGKBiPA27040.

Polymorphism and mutation databases

BioMutaiCTSO.
DMDMi1168795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000002632124 – 107Activation peptideAdd BLAST84
ChainiPRO_0000026322108 – 321Cathepsin OAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 170By similarity
Disulfide bondi163 ↔ 204By similarity
Disulfide bondi262 ↔ 310By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP43234.
PeptideAtlasiP43234.
PRIDEiP43234.

PTM databases

iPTMnetiP43234.
PhosphoSitePlusiP43234.

Expressioni

Tissue specificityi

Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.

Gene expression databases

BgeeiENSG00000256043.
CleanExiHS_CTSO.
GenevisibleiP43234. HS.

Organism-specific databases

HPAiHPA002041.

Interactioni

Protein-protein interaction databases

BioGridi107899. 6 interactors.
IntActiP43234. 1 interactor.
STRINGi9606.ENSP00000414904.

Structurei

3D structure databases

ProteinModelPortaliP43234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.
GeneTreeiENSGT00760000118871.
HOGENOMiHOG000230774.
HOVERGENiHBG105050.
InParanoidiP43234.
KOiK01374.
OMAiCHYFSGS.
OrthoDBiEOG091G0AKT.
PhylomeDBiP43234.
TreeFamiTF331594.

Family and domain databases

InterProiView protein in InterPro
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiView protein in Pfam
PF00112. Peptidase_C1. 1 hit.
PRINTSiPR00705. PAPAIN.
SMARTiView protein in SMART
SM00645. Pept_C1. 1 hit.
PROSITEiView protein in PROSITE
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR
60 70 80 90 100
HRYLNSLFPS ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH
110 120 130 140 150
MSIPNVSLPL RFDWRDKQVV TQVRNQQMCG GCWAFSVVGA VESAYAIKGK
160 170 180 190 200
PLEDLSVQQV IDCSYNNYGC NGGSTLNALN WLNKMQVKLV KDSEYPFKAQ
210 220 230 240 250
NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP LVVIVDAVSW
260 270 280 290 300
QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY
310 320
AHVKMGSNVC GIADSVSSIF V
Length:321
Mass (Da):35,958
Last modified:November 1, 1995 - v1
Checksum:iF48011ECA9E0BC45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77383 mRNA. Translation: CAA54562.1.
BC049206 mRNA. Translation: AAH49206.1.
CCDSiCCDS3794.1.
PIRiA55090.
RefSeqiNP_001325.1. NM_001334.2.
UniGeneiHs.75262.

Genome annotation databases

EnsembliENST00000433477; ENSP00000414904; ENSG00000256043.
ENST00000573499; ENSP00000460395; ENSG00000263238.
GeneIDi1519.
KEGGihsa:1519.
UCSCiuc003ipg.4. human.

Similar proteinsi

Entry informationi

Entry nameiCATO_HUMAN
AccessioniPrimary (citable) accession number: P43234
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families