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P43234 (CATO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin O

EC=3.4.22.42
Gene names
Name:CTSO
Synonyms:CTSO1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Catalytic activity

The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

Subcellular location

Lysosome.

Tissue specificity

Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type endopeptidase activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 10784Activation peptide
PRO_0000026321
Chain108 – 321214Cathepsin O
PRO_0000026322

Sites

Active site1321 By similarity
Active site2691 By similarity
Active site2891 By similarity

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation1051N-linked (GlcNAc...) Potential
Disulfide bond129 ↔ 170 By similarity
Disulfide bond163 ↔ 204 By similarity
Disulfide bond262 ↔ 310 By similarity

Sequences

Sequence LengthMass (Da)Tools
P43234 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: F48011ECA9E0BC45

FASTA32135,958
        10         20         30         40         50         60 
MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR HRYLNSLFPS 

        70         80         90        100        110        120 
ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH MSIPNVSLPL RFDWRDKQVV 

       130        140        150        160        170        180 
TQVRNQQMCG GCWAFSVVGA VESAYAIKGK PLEDLSVQQV IDCSYNNYGC NGGSTLNALN 

       190        200        210        220        230        240 
WLNKMQVKLV KDSEYPFKAQ NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP 

       250        260        270        280        290        300 
LVVIVDAVSW QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY 

       310        320 
AHVKMGSNVC GIADSVSSIF V 

« Hide

References

« Hide 'large scale' references
[1]"Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues."
Velasco G., Ferrando A.A., Puente X.S., Sanchez L.M., Lopez-Otin C.
J. Biol. Chem. 269:27136-27142(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary carcinoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77383 mRNA. Translation: CAA54562.1.
BC049206 mRNA. Translation: AAH49206.1.
CCDSCCDS3794.1.
PIRA55090.
RefSeqNP_001325.1. NM_001334.2.
UniGeneHs.75262.

3D structure databases

ProteinModelPortalP43234.
SMRP43234. Positions 68-317.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107899. 1 interaction.
IntActP43234. 1 interaction.

Chemistry

BindingDBP43234.

Protein family/group databases

MEROPSC01.035.

PTM databases

PhosphoSiteP43234.

Polymorphism databases

DMDM1168795.

Proteomic databases

PaxDbP43234.
PRIDEP43234.

Protocols and materials databases

DNASU1519.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000433477; ENSP00000414904; ENSG00000256043.
ENST00000573499; ENSP00000460395; ENSG00000263238.
GeneID1519.
KEGGhsa:1519.
UCSCuc003ipg.3. human.

Organism-specific databases

CTD1519.
GeneCardsGC04M156845.
HGNCHGNC:2542. CTSO.
HPAHPA002041.
MIM600550. gene.
neXtProtNX_P43234.
PharmGKBPA27040.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4870.
HOGENOMHOG000230774.
HOVERGENHBG105050.
InParanoidP43234.
KOK01374.
OMAHVKMGSN.
OrthoDBEOG72NRQS.
PhylomeDBP43234.
TreeFamTF331594.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeP43234.
CleanExHS_CTSO.
GenevestigatorP43234.

Family and domain databases

InterProIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCathepsin_O.
GenomeRNAi1519.
NextBio6287.
PROP43234.
SOURCESearch...

Entry information

Entry nameCATO_HUMAN
AccessionPrimary (citable) accession number: P43234
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM