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Protein

Cathepsin O

Gene

CTSO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Catalytic activityi

The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132By similarity1
Active sitei269By similarity1
Active sitei289By similarity1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: ProtInc

GO - Biological processi

  • proteolysis Source: ProtInc
  • proteolysis involved in cellular protein catabolic process Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPSiC01.035

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin O (EC:3.4.22.42)
Gene namesi
Name:CTSO
Synonyms:CTSO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000256043.2
HGNCiHGNC:2542 CTSO
MIMi600550 gene
neXtProtiNX_P43234

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1519
OpenTargetsiENSG00000256043
PharmGKBiPA27040

Polymorphism and mutation databases

BioMutaiCTSO
DMDMi1168795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000002632124 – 107Activation peptideAdd BLAST84
ChainiPRO_0000026322108 – 321Cathepsin OAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 170By similarity
Disulfide bondi163 ↔ 204By similarity
Disulfide bondi262 ↔ 310By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP43234
PeptideAtlasiP43234
PRIDEiP43234

PTM databases

iPTMnetiP43234
PhosphoSitePlusiP43234

Expressioni

Tissue specificityi

Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.

Gene expression databases

BgeeiENSG00000256043
CleanExiHS_CTSO
GenevisibleiP43234 HS

Organism-specific databases

HPAiHPA002041

Interactioni

Protein-protein interaction databases

BioGridi107899, 6 interactors
IntActiP43234, 1 interactor
STRINGi9606.ENSP00000414904

Structurei

3D structure databases

ProteinModelPortaliP43234
SMRiP43234
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1542 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00900000140859
HOGENOMiHOG000230774
HOVERGENiHBG105050
InParanoidiP43234
KOiK01374
OMAiCHYFSGS
OrthoDBiEOG091G0AKT
PhylomeDBiP43234
TreeFamiTF331594

Family and domain databases

InterProiView protein in InterPro
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR
60 70 80 90 100
HRYLNSLFPS ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH
110 120 130 140 150
MSIPNVSLPL RFDWRDKQVV TQVRNQQMCG GCWAFSVVGA VESAYAIKGK
160 170 180 190 200
PLEDLSVQQV IDCSYNNYGC NGGSTLNALN WLNKMQVKLV KDSEYPFKAQ
210 220 230 240 250
NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP LVVIVDAVSW
260 270 280 290 300
QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY
310 320
AHVKMGSNVC GIADSVSSIF V
Length:321
Mass (Da):35,958
Last modified:November 1, 1995 - v1
Checksum:iF48011ECA9E0BC45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77383 mRNA Translation: CAA54562.1
BC049206 mRNA Translation: AAH49206.1
CCDSiCCDS3794.1
PIRiA55090
RefSeqiNP_001325.1, NM_001334.2
UniGeneiHs.75262

Genome annotation databases

EnsembliENST00000433477; ENSP00000414904; ENSG00000256043
ENST00000573499; ENSP00000460395; ENSG00000263238
GeneIDi1519
KEGGihsa:1519
UCSCiuc003ipg.4 human

Similar proteinsi

Entry informationi

Entry nameiCATO_HUMAN
AccessioniPrimary (citable) accession number: P43234
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health