Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P43230 (PYRF_RHINI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:PYR4
OrganismRhizopus niveus
Taxonomic identifier4844 [NCBI]
Taxonomic lineageEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesMucorineaeRhizopodaceaeRhizopus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Orotidine 5'-phosphate decarboxylase
PRO_0000134676

Regions

Region60 – 623Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site381Substrate By similarity
Binding site2131Substrate By similarity
Binding site2321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P43230 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 87FE1AA5900494FE

FASTA26529,611
        10         20         30         40         50         60 
MNTYKPYSER AKQHSNACAR SLLELMERKQ TNLSVAVDVT TKKELISIAD AIGPYICVLK 

        70         80         90        100        110        120 
THIDIVEDFD ADLIQQLQEL AKKHDFLFFE DRKFADIGNT VKHQYANGIY KIASWSHITN 

       130        140        150        160        170        180 
AHTVPGEGII KGLAEVGLPL GRGLLLLAEM SSKGALTKGS YTTDSVEMAR RNKDFVFGFI 

       190        200        210        220        230        240 
AQNKMNQYDD EDFIVMSPGV GLDVKGDGLG QQYRTPREVI VESGADVIIV GRGIYGQPDK 

       250        260 
LVEQAQRYRQ AGWDAYLERL ALHNK 

« Hide

References

[1]"Cloning of the Rhizopus niveus pyr4 gene and its use for the transformation of Rhizopus delemar."
Horiuchi H., Takaya N., Yanai K., Nakamura M., Ohta A., Takagi M.
Curr. Genet. 27:472-478(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NBRC 4810 / AS 3.4817.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D17362 Genomic DNA. Translation: BAA04179.1.
PIRS55927.

3D structure databases

ProteinModelPortalP43230.
SMRP43230. Positions 5-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_RHINI
AccessionPrimary (citable) accession number: P43230
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways