Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucagon-like peptide 1 receptor

Gene

GLP1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • glucagon receptor activity Source: InterPro
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
SIGNORiP43220.

Protein family/group databases

TCDBi9.A.14.4.6. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:GLP1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4324. GLP1R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 139ExtracellularBy similarityAdd BLAST116
Transmembranei140 – 164Helical; Name=1By similarityAdd BLAST25
Topological domaini165 – 176CytoplasmicBy similarityAdd BLAST12
Transmembranei177 – 201Helical; Name=2By similarityAdd BLAST25
Topological domaini202 – 227ExtracellularBy similarityAdd BLAST26
Transmembranei228 – 251Helical; Name=3By similarityAdd BLAST24
Topological domaini252 – 265CytoplasmicBy similarityAdd BLAST14
Transmembranei266 – 287Helical; Name=4By similarityAdd BLAST22
Topological domaini288 – 305ExtracellularBy similarityAdd BLAST18
Transmembranei306 – 328Helical; Name=5By similarityAdd BLAST23
Topological domaini329 – 352CytoplasmicBy similarityAdd BLAST24
Transmembranei353 – 371Helical; Name=6By similarityAdd BLAST19
Topological domaini372 – 383ExtracellularBy similarityAdd BLAST12
Transmembranei384 – 404Helical; Name=7By similarityAdd BLAST21
Topological domaini405 – 463CytoplasmicBy similarityAdd BLAST59

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2740.
OpenTargetsiENSG00000112164.
PharmGKBiPA28725.

Chemistry databases

ChEMBLiCHEMBL1784.
DrugBankiDB09043. Albiglutide.
DB09045. Dulaglutide.
DB01276. Exenatide.
DB00040. Glucagon recombinant.
DB06655. Liraglutide.
GuidetoPHARMACOLOGYi249.

Polymorphism and mutation databases

BioMutaiGLP1R.
DMDMi311033387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001283524 – 463Glucagon-like peptide 1 receptorAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 71
Disulfide bondi62 ↔ 104
Glycosylationi63N-linked (GlcNAc...)1 Publication1
Glycosylationi82N-linked (GlcNAc...)1 Publication1
Disulfide bondi85 ↔ 126
Glycosylationi115N-linked (GlcNAc...)1 Publication1
Disulfide bondi226 ↔ 296
Modified residuei341ADP-ribosylcysteine1 Publication1
Modified residuei348ADP-ribosylarginine1 Publication1

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.1 Publication

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43220.
PRIDEiP43220.

PTM databases

PhosphoSitePlusiP43220.

Expressioni

Gene expression databases

BgeeiENSG00000112164.
CleanExiHS_GLP1R.
GenevisibleiP43220. HS.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-7466542,EBI-10172290
KRTAP10-8P604103EBI-7466542,EBI-10171774
KRTAP10-9P604113EBI-7466542,EBI-10172052
NOTCH2NLQ7Z3S93EBI-7466542,EBI-945833

Protein-protein interaction databases

BioGridi109002. 47 interactors.
DIPiDIP-29980N.
IntActiP43220. 6 interactors.
MINTiMINT-1217566.
STRINGi9606.ENSP00000362353.

Chemistry databases

BindingDBiP43220.

Structurei

Secondary structure

1463
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 52Combined sources21
Beta strandi57 – 59Combined sources3
Beta strandi79 – 84Combined sources6
Helixi92 – 94Combined sources3
Beta strandi99 – 104Combined sources6
Beta strandi108 – 110Combined sources3
Beta strandi116 – 119Combined sources4
Helixi124 – 126Combined sources3
Helixi137 – 142Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C59X-ray2.30A24-145[»]
3C5TX-ray2.10A24-145[»]
3IOLX-ray2.10A24-145[»]
4ZGMX-ray1.80A24-145[»]
5E94X-ray2.00G/H24-145[»]
ProteinModelPortaliP43220.
SMRiP43220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43220.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP43220.
KOiK04581.
OMAiSECEESK.
OrthoDBiEOG091G0NF8.
PhylomeDBiP43220.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL
60 70 80 90 100
TEDPPPATDL FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV
110 120 130 140 150
YRFCTAEGLW LQKDNSSLPW RDLSECEESK RGERSSPEEQ LLFLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILLGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI
410 420 430 440 450
LYCFVNNEVQ LEFRKSWERW RLEHLHIQRD SSMKPLKCPT SSLSSGATAG
460
SSMYTATCQA SCS
Length:463
Mass (Da):53,026
Last modified:November 2, 2010 - v2
Checksum:iEE7C0EAE29931F5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → V in AAA03614 (PubMed:8405712).Curated1
Sequence conflicti12L → V no nucleotide entry (PubMed:7517895).Curated1
Sequence conflicti12L → V in AAB64013 (PubMed:9213353).Curated1
Sequence conflicti136 – 137SP → WG in AAA03614 (PubMed:8405712).Curated2
Sequence conflicti137P → R no nucleotide entry (PubMed:7517895).Curated1
Sequence conflicti151G → A in AAA03614 (PubMed:8405712).Curated1
Sequence conflicti221Q → L in AAA63787 (PubMed:7843404).Curated1
Sequence conflicti289Y → I in AAA03614 (PubMed:8405712).Curated1
Sequence conflicti316A → G in AAA62471 (PubMed:8404634).Curated1
Sequence conflicti316A → G in AAC50050 (PubMed:8404634).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0189247P → L.1 PublicationCorresponds to variant rs10305420dbSNPEnsembl.1
Natural variantiVAR_01892520R → K.1 PublicationCorresponds to variant rs10305421dbSNPEnsembl.1
Natural variantiVAR_01892644R → H.1 PublicationCorresponds to variant rs2295006dbSNPEnsembl.1
Natural variantiVAR_018927131R → Q.1 PublicationCorresponds to variant rs3765467dbSNPEnsembl.1
Natural variantiVAR_018928168G → S.1 PublicationCorresponds to variant rs6923761dbSNPEnsembl.1
Natural variantiVAR_015098260L → F.6 PublicationsCorresponds to variant rs1042044dbSNPEnsembl.1
Natural variantiVAR_018929316A → T.1 PublicationCorresponds to variant rs10305492dbSNPEnsembl.1
Natural variantiVAR_018930333S → C.1 PublicationCorresponds to variant rs10305493dbSNPEnsembl.1
Natural variantiVAR_018931421R → Q.1 PublicationCorresponds to variant rs10305510dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01104 mRNA. Translation: AAA03614.1.
U01157 mRNA. Translation: AAA62471.1.
U01156 mRNA. Translation: AAC50050.1.
L23503 mRNA. Translation: AAA17021.1.
U10037 mRNA. Translation: AAA63787.1.
AB065685 Genomic DNA. Translation: BAC05908.1.
AY439112 Genomic DNA. Translation: AAR05444.1.
AL035690 Genomic DNA. Translation: CAB71177.1.
BC112126 mRNA. Translation: AAI12127.1.
BC113493 mRNA. Translation: AAI13494.1.
U66062 Genomic DNA. Translation: AAB64013.1.
CCDSiCCDS4839.1.
PIRiI84494.
S71624.
RefSeqiNP_002053.3. NM_002062.4.
UniGeneiHs.351883.
Hs.389103.

Genome annotation databases

EnsembliENST00000373256; ENSP00000362353; ENSG00000112164.
GeneIDi2740.
KEGGihsa:2740.
UCSCiuc003ooj.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Glucagon-like peptide 1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01104 mRNA. Translation: AAA03614.1.
U01157 mRNA. Translation: AAA62471.1.
U01156 mRNA. Translation: AAC50050.1.
L23503 mRNA. Translation: AAA17021.1.
U10037 mRNA. Translation: AAA63787.1.
AB065685 Genomic DNA. Translation: BAC05908.1.
AY439112 Genomic DNA. Translation: AAR05444.1.
AL035690 Genomic DNA. Translation: CAB71177.1.
BC112126 mRNA. Translation: AAI12127.1.
BC113493 mRNA. Translation: AAI13494.1.
U66062 Genomic DNA. Translation: AAB64013.1.
CCDSiCCDS4839.1.
PIRiI84494.
S71624.
RefSeqiNP_002053.3. NM_002062.4.
UniGeneiHs.351883.
Hs.389103.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C59X-ray2.30A24-145[»]
3C5TX-ray2.10A24-145[»]
3IOLX-ray2.10A24-145[»]
4ZGMX-ray1.80A24-145[»]
5E94X-ray2.00G/H24-145[»]
ProteinModelPortaliP43220.
SMRiP43220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109002. 47 interactors.
DIPiDIP-29980N.
IntActiP43220. 6 interactors.
MINTiMINT-1217566.
STRINGi9606.ENSP00000362353.

Chemistry databases

BindingDBiP43220.
ChEMBLiCHEMBL1784.
DrugBankiDB09043. Albiglutide.
DB09045. Dulaglutide.
DB01276. Exenatide.
DB00040. Glucagon recombinant.
DB06655. Liraglutide.
GuidetoPHARMACOLOGYi249.

Protein family/group databases

TCDBi9.A.14.4.6. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP43220.

Polymorphism and mutation databases

BioMutaiGLP1R.
DMDMi311033387.

Proteomic databases

PaxDbiP43220.
PRIDEiP43220.

Protocols and materials databases

DNASUi2740.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373256; ENSP00000362353; ENSG00000112164.
GeneIDi2740.
KEGGihsa:2740.
UCSCiuc003ooj.5. human.

Organism-specific databases

CTDi2740.
DisGeNETi2740.
GeneCardsiGLP1R.
H-InvDBHIX0095000.
HIX0200932.
HGNCiHGNC:4324. GLP1R.
MIMi138032. gene.
neXtProtiNX_P43220.
OpenTargetsiENSG00000112164.
PharmGKBiPA28725.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP43220.
KOiK04581.
OMAiSECEESK.
OrthoDBiEOG091G0NF8.
PhylomeDBiP43220.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.
SIGNORiP43220.

Miscellaneous databases

EvolutionaryTraceiP43220.
GeneWikiiGlucagon-like_peptide_1_receptor.
GenomeRNAii2740.
PROiP43220.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112164.
CleanExiHS_GLP1R.
GenevisibleiP43220. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLP1R_HUMAN
AccessioniPrimary (citable) accession number: P43220
Secondary accession number(s): Q2M229, Q99669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.