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P43220

- GLP1R_HUMAN

UniProt

P43220 - GLP1R_HUMAN

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Protein

Glucagon-like peptide 1 receptor

Gene

GLP1R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. glucagon receptor activity Source: InterPro
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. activation of adenylate cyclase activity Source: ProtInc
  2. cAMP-mediated signaling Source: UniProtKB
  3. energy reserve metabolic process Source: Reactome
  4. learning or memory Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  6. regulation of heart contraction Source: Ensembl
  7. regulation of insulin secretion Source: Reactome
  8. response to stress Source: Ensembl
  9. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Protein family/group databases

TCDBi9.A.14.4.6. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:GLP1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4324. GLP1R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 139116ExtracellularBy similarityAdd
BLAST
Transmembranei140 – 16425Helical; Name=1By similarityAdd
BLAST
Topological domaini165 – 17612CytoplasmicBy similarityAdd
BLAST
Transmembranei177 – 20125Helical; Name=2By similarityAdd
BLAST
Topological domaini202 – 22726ExtracellularBy similarityAdd
BLAST
Transmembranei228 – 25124Helical; Name=3By similarityAdd
BLAST
Topological domaini252 – 26514CytoplasmicBy similarityAdd
BLAST
Transmembranei266 – 28722Helical; Name=4By similarityAdd
BLAST
Topological domaini288 – 30518ExtracellularBy similarityAdd
BLAST
Transmembranei306 – 32823Helical; Name=5By similarityAdd
BLAST
Topological domaini329 – 35224CytoplasmicBy similarityAdd
BLAST
Transmembranei353 – 37119Helical; Name=6By similarityAdd
BLAST
Topological domaini372 – 38312ExtracellularBy similarityAdd
BLAST
Transmembranei384 – 40421Helical; Name=7By similarityAdd
BLAST
Topological domaini405 – 46359CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 463440Glucagon-like peptide 1 receptorPRO_0000012835Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 71
Disulfide bondi62 ↔ 104
Glycosylationi63 – 631N-linked (GlcNAc...)1 Publication
Glycosylationi82 – 821N-linked (GlcNAc...)1 Publication
Disulfide bondi85 ↔ 126
Glycosylationi115 – 1151N-linked (GlcNAc...)1 Publication
Disulfide bondi226 ↔ 296
Modified residuei341 – 3411ADP-ribosylcysteine1 Publication
Modified residuei348 – 3481ADP-ribosylarginine1 Publication

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.1 Publication

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43220.
PRIDEiP43220.

PTM databases

PhosphoSiteiP43220.

Expressioni

Gene expression databases

BgeeiP43220.
CleanExiHS_GLP1R.
GenevestigatoriP43220.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.2 Publications

Protein-protein interaction databases

BioGridi109002. 43 interactions.
DIPiDIP-29980N.
MINTiMINT-1217566.
STRINGi9606.ENSP00000362353.

Structurei

Secondary structure

1
463
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi32 – 5221Combined sources
Beta strandi57 – 593Combined sources
Beta strandi79 – 846Combined sources
Helixi92 – 943Combined sources
Beta strandi99 – 1046Combined sources
Beta strandi108 – 1103Combined sources
Beta strandi114 – 1174Combined sources
Helixi124 – 1263Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3C59X-ray2.30A24-145[»]
3C5TX-ray2.10A24-145[»]
3IOLX-ray2.10A24-145[»]
ProteinModelPortaliP43220.
SMRiP43220. Positions 28-412.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43220.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263329.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP43220.
KOiK04581.
OMAiCIVVSKL.
OrthoDBiEOG7TF78W.
PhylomeDBiP43220.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43220-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL
60 70 80 90 100
TEDPPPATDL FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV
110 120 130 140 150
YRFCTAEGLW LQKDNSSLPW RDLSECEESK RGERSSPEEQ LLFLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILLGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI
410 420 430 440 450
LYCFVNNEVQ LEFRKSWERW RLEHLHIQRD SSMKPLKCPT SSLSSGATAG
460
SSMYTATCQA SCS
Length:463
Mass (Da):53,026
Last modified:November 2, 2010 - v2
Checksum:iEE7C0EAE29931F5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121L → V in AAA03614. (PubMed:8405712)Curated
Sequence conflicti12 – 121L → V no nucleotide entry (PubMed:7517895)Curated
Sequence conflicti12 – 121L → V in AAB64013. (PubMed:9213353)Curated
Sequence conflicti136 – 1372SP → WG in AAA03614. (PubMed:8405712)Curated
Sequence conflicti137 – 1371P → R no nucleotide entry (PubMed:7517895)Curated
Sequence conflicti151 – 1511G → A in AAA03614. (PubMed:8405712)Curated
Sequence conflicti221 – 2211Q → L in AAA63787. (PubMed:7843404)Curated
Sequence conflicti289 – 2891Y → I in AAA03614. (PubMed:8405712)Curated
Sequence conflicti316 – 3161A → G in AAA62471. (PubMed:8404634)Curated
Sequence conflicti316 – 3161A → G in AAC50050. (PubMed:8404634)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71P → L.1 Publication
Corresponds to variant rs10305420 [ dbSNP | Ensembl ].
VAR_018924
Natural varianti20 – 201R → K.1 Publication
Corresponds to variant rs10305421 [ dbSNP | Ensembl ].
VAR_018925
Natural varianti44 – 441R → H.1 Publication
Corresponds to variant rs2295006 [ dbSNP | Ensembl ].
VAR_018926
Natural varianti131 – 1311R → Q.1 Publication
Corresponds to variant rs3765467 [ dbSNP | Ensembl ].
VAR_018927
Natural varianti168 – 1681G → S.1 Publication
Corresponds to variant rs6923761 [ dbSNP | Ensembl ].
VAR_018928
Natural varianti260 – 2601L → F.6 Publications
Corresponds to variant rs1042044 [ dbSNP | Ensembl ].
VAR_015098
Natural varianti316 – 3161A → T.1 Publication
Corresponds to variant rs10305492 [ dbSNP | Ensembl ].
VAR_018929
Natural varianti333 – 3331S → C.1 Publication
Corresponds to variant rs10305493 [ dbSNP | Ensembl ].
VAR_018930
Natural varianti421 – 4211R → Q.1 Publication
Corresponds to variant rs10305510 [ dbSNP | Ensembl ].
VAR_018931

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01104 mRNA. Translation: AAA03614.1.
U01157 mRNA. Translation: AAA62471.1.
U01156 mRNA. Translation: AAC50050.1.
L23503 mRNA. Translation: AAA17021.1.
U10037 mRNA. Translation: AAA63787.1.
AB065685 Genomic DNA. Translation: BAC05908.1.
AY439112 Genomic DNA. Translation: AAR05444.1.
AL035690 Genomic DNA. Translation: CAB71177.1.
BC112126 mRNA. Translation: AAI12127.1.
BC113493 mRNA. Translation: AAI13494.1.
U66062 Genomic DNA. Translation: AAB64013.1.
CCDSiCCDS4839.1.
PIRiI84494.
S71624.
RefSeqiNP_002053.3. NM_002062.3.
XP_006715128.1. XM_006715065.1.
UniGeneiHs.389103.

Genome annotation databases

EnsembliENST00000373256; ENSP00000362353; ENSG00000112164.
GeneIDi2740.
KEGGihsa:2740.
UCSCiuc003ooj.4. human.

Polymorphism databases

DMDMi311033387.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Glucagon-like peptide 1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01104 mRNA. Translation: AAA03614.1 .
U01157 mRNA. Translation: AAA62471.1 .
U01156 mRNA. Translation: AAC50050.1 .
L23503 mRNA. Translation: AAA17021.1 .
U10037 mRNA. Translation: AAA63787.1 .
AB065685 Genomic DNA. Translation: BAC05908.1 .
AY439112 Genomic DNA. Translation: AAR05444.1 .
AL035690 Genomic DNA. Translation: CAB71177.1 .
BC112126 mRNA. Translation: AAI12127.1 .
BC113493 mRNA. Translation: AAI13494.1 .
U66062 Genomic DNA. Translation: AAB64013.1 .
CCDSi CCDS4839.1.
PIRi I84494.
S71624.
RefSeqi NP_002053.3. NM_002062.3.
XP_006715128.1. XM_006715065.1.
UniGenei Hs.389103.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3C59 X-ray 2.30 A 24-145 [» ]
3C5T X-ray 2.10 A 24-145 [» ]
3IOL X-ray 2.10 A 24-145 [» ]
ProteinModelPortali P43220.
SMRi P43220. Positions 28-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109002. 43 interactions.
DIPi DIP-29980N.
MINTi MINT-1217566.
STRINGi 9606.ENSP00000362353.

Chemistry

BindingDBi P43220.
ChEMBLi CHEMBL1784.
DrugBanki DB01276. Exenatide.
DB00040. Glucagon recombinant.
DB06655. Liraglutide.
GuidetoPHARMACOLOGYi 249.

Protein family/group databases

TCDBi 9.A.14.4.6. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei P43220.

Polymorphism databases

DMDMi 311033387.

Proteomic databases

PaxDbi P43220.
PRIDEi P43220.

Protocols and materials databases

DNASUi 2740.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373256 ; ENSP00000362353 ; ENSG00000112164 .
GeneIDi 2740.
KEGGi hsa:2740.
UCSCi uc003ooj.4. human.

Organism-specific databases

CTDi 2740.
GeneCardsi GC06P039063.
H-InvDB HIX0095000.
HIX0200932.
HGNCi HGNC:4324. GLP1R.
MIMi 138032. gene.
neXtProti NX_P43220.
PharmGKBi PA28725.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263329.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi P43220.
KOi K04581.
OMAi CIVVSKL.
OrthoDBi EOG7TF78W.
PhylomeDBi P43220.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

EvolutionaryTracei P43220.
GeneWikii Glucagon-like_peptide_1_receptor.
GenomeRNAii 2740.
NextBioi 10800.
PROi P43220.
SOURCEi Search...

Gene expression databases

Bgeei P43220.
CleanExi HS_GLP1R.
Genevestigatori P43220.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor."
    Thorens B., Porret A., Buehler L., Deng S., Morel P., Widmann C.
    Diabetes 42:1678-1682(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-260.
    Tissue: Pancreatic islet.
  2. "Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor."
    Dillon J.S., Tanizawa Y., Wheeler M.B., Leng X., Ligon B.B., Rabin D.U., Yoo-Warren H., Permutt M., Boyd A.E.
    Endocrinology 133:1907-1910(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-260.
    Tissue: Pancreas.
  3. "Cloning and functional expression of a human glucagon-like peptide-1 receptor."
    Graziano M.P., Hey P.J., Borkowski D., Chicchi G.C., Strader C.D.
    Biochem. Biophys. Res. Commun. 196:141-146(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-260.
    Tissue: Gastric carcinoma.
  4. "Signal transduction of the GLP-1-receptor cloned from a human insulinoma."
    van Eyll B., Lankat-Buttgereit B., Bode H.P., Goeke R., Goeke B.
    FEBS Lett. 348:7-13(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Insulinoma.
  5. "Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences."
    Wei Y., Mojsov S.
    FEBS Lett. 358:219-224(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-260.
    Tissue: Pancreas.
  6. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. NIEHS SNPs program
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-7; LYS-20; HIS-44; GLN-131; SER-168; PHE-260; THR-316; CYS-333 AND GLN-421.
  8. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-260.
  10. "Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene."
    Lankat-Buttgereit B., Goeke B.
    Peptides 18:617-624(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
    Tissue: Placenta.
  11. "Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket."
    Mann R.J., Al-Sabah S., de Maturana R.L., Sinfield J.K., Donnelly D.
    Peptides 31:2289-2293(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BOND.
  12. "Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase."
    Dezelak M., Bavec A.
    Mol. Biol. Rep. 39:4375-4381(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ADP-RIBOSYLATION AT CYS-341 AND ARG-348.
  13. "Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization."
    Whitaker G.M., Lynn F.C., McIntosh C.H., Accili E.A.
    PLoS ONE 7:E32675-E32675(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-63; ASN-82 AND ASN-115, SUBUNIT.
  14. "Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain."
    Runge S., Thogersen H., Madsen K., Lau J., Rudolph R.
    J. Biol. Chem. 283:11340-11347(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 24-145 IN COMPLEX WITH ANTAGONIST EXENDIN-4, DISULFIDE BONDS.

Entry informationi

Entry nameiGLP1R_HUMAN
AccessioniPrimary (citable) accession number: P43220
Secondary accession number(s): Q2M229, Q99669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2010
Last modified: November 26, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3