Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P43219 (GIPR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastric inhibitory polypeptide receptor

Short name=GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene names
Name:Gipr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit structure

May form homodimers and heterodimers with GLP1R By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Present in the pancreas as well as the gut, adipose tissue, heart, pituitary, and inner layers of the adrenal cortex, whereas it is not found in kidney, spleen, or liver. It is also expressed in several brain regions, including the cerebral cortex, hippocampus, and olfactory bulb.

Post-translational modification

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdesensitization of G-protein coupled receptor protein signaling pathway

Inferred from direct assay PubMed 8928774. Source: RGD

endocrine pancreas development

Inferred from electronic annotation. Source: Ensembl

gastric inhibitory peptide signaling pathway

Inferred from direct assay PubMed 8958204. Source: GOC

positive regulation of cAMP biosynthetic process

Inferred from mutant phenotype PubMed 11014226. Source: RGD

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay Ref.1. Source: RGD

positive regulation of insulin secretion

Inferred from mutant phenotype PubMed 11014226. Source: RGD

response to axon injury

Inferred from expression pattern PubMed 19170165. Source: RGD

response to calcium ion

Inferred from mutant phenotype PubMed 9705086. Source: RGD

response to fatty acid

Inferred from expression pattern PubMed 12475913. Source: RGD

response to glucose

Inferred from expression pattern PubMed 12475913. Source: RGD

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 19170165. Source: RGD

   Molecular_functiongastric inhibitory peptide receptor activity

Inferred from direct assay PubMed 8958204. Source: RGD

peptide hormone binding

Inferred from physical interaction PubMed 8958204. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 455437Gastric inhibitory polypeptide receptor
PRO_0000012827

Regions

Topological domain19 – 135117Extracellular Potential
Transmembrane136 – 15823Helical; Name=1; Potential
Topological domain159 – 1668Cytoplasmic Potential
Transmembrane167 – 18620Helical; Name=2; Potential
Topological domain187 – 21428Extracellular Potential
Transmembrane215 – 23925Helical; Name=3; Potential
Topological domain240 – 25112Cytoplasmic Potential
Transmembrane252 – 27524Helical; Name=4; Potential
Topological domain276 – 29015Extracellular Potential
Transmembrane291 – 31626Helical; Name=5; Potential
Topological domain317 – 33822Cytoplasmic Potential
Transmembrane339 – 35921Helical; Name=6; Potential
Topological domain360 – 37415Extracellular Potential
Transmembrane375 – 39521Helical; Name=7; Potential
Topological domain396 – 45560Cytoplasmic Potential

Amino acid modifications

Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation741N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 67 By similarity
Disulfide bond58 ↔ 100 By similarity
Disulfide bond81 ↔ 115 By similarity

Sequences

Sequence LengthMass (Da)Tools
P43219 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5454B0638ABF9A06

FASTA45552,257
        10         20         30         40         50         60 
MPLRLLLLLL WLWGLSLQRA ETDSEGQTTG ELYQRWERYG WECQNTLEAT EPPSGLACNG 

        70         80         90        100        110        120 
SFDMYACWNY TAANTTARVS CPWYLPWYRQ VAAGFVFRQC GSDGQWGSWR DHTQCENPEK 

       130        140        150        160        170        180 
NGAFQDQKLI LERLQVVYTV GYSLSLATLL LALLILSLFR RLHCTRNYIH MNLFTSFMLR 

       190        200        210        220        230        240 
AGAILTRDQL LPPLGPYTGN QTPTLWNQAL AACRTAQILT QYCVGANYTW LLVEGVYLHH 

       250        260        270        280        290        300 
LLVVVRRSEK GHFRCYLLLG WGAPALFVIP WVIVRYLYEN TQCWERNEVK AIWWIIRTPI 

       310        320        330        340        350        360 
LITILINFLI FIRILGILVS KLRTRQMRCP DYRLRLARST LTLMPLLGVH EVVFAPVTEE 

       370        380        390        400        410        420 
QAEGSLRFAK LAFEIFLSSF QGFLVSVLYC FINKEVQSEI RRLRLSLQEQ CPRPHLGQAP 

       430        440        450 
RAVPLSSAPQ EAAIRNALPS GMLHVPGDEV LESYC 

« Hide

References

[1]"Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain."
Usdin T.B., Mezey E., Button D.C., Brownstein M.J., Bonner T.I.
Endocrinology 133:2861-2871(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19660 mRNA. Translation: AAC37637.1.
PIRI53273.
RefSeqNP_036846.1. NM_012714.1.
XP_006228450.1. XM_006228388.1.
UniGeneRn.9676.

3D structure databases

ProteinModelPortalP43219.
SMRP43219. Positions 26-119.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000021456.

Chemistry

BindingDBP43219.
ChEMBLCHEMBL5001.
GuidetoPHARMACOLOGY248.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP43219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860.
GeneID25024.
KEGGrno:25024.
UCSCRGD:2689. rat.

Organism-specific databases

CTD2696.
RGD2689. Gipr.

Phylogenomic databases

eggNOGNOG239460.
GeneTreeENSGT00740000115231.
HOGENOMHOG000008250.
HOVERGENHBG008318.
InParanoidP43219.
KOK04580.
OMATRQMRCP.
OrthoDBEOG7TF78W.
PhylomeDBP43219.
TreeFamTF315710.

Gene expression databases

GenevestigatorP43219.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605153.
PROP43219.

Entry information

Entry nameGIPR_RAT
AccessionPrimary (citable) accession number: P43219
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries