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P43219

- GIPR_RAT

UniProt

P43219 - GIPR_RAT

Protein

Gastric inhibitory polypeptide receptor

Gene

Gipr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. gastric inhibitory peptide receptor activity Source: RGD
    2. peptide hormone binding Source: RGD

    GO - Biological processi

    1. desensitization of G-protein coupled receptor protein signaling pathway Source: RGD
    2. endocrine pancreas development Source: Ensembl
    3. gastric inhibitory peptide signaling pathway Source: GOC
    4. positive regulation of cAMP biosynthetic process Source: RGD
    5. positive regulation of cytosolic calcium ion concentration Source: RGD
    6. positive regulation of insulin secretion Source: RGD
    7. response to axon injury Source: RGD
    8. response to calcium ion Source: RGD
    9. response to fatty acid Source: RGD
    10. response to glucose Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastric inhibitory polypeptide receptor
    Short name:
    GIP-R
    Alternative name(s):
    Glucose-dependent insulinotropic polypeptide receptor
    Gene namesi
    Name:Gipr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2689. Gipr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 455437Gastric inhibitory polypeptide receptorPRO_0000012827Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 67By similarity
    Disulfide bondi58 ↔ 100By similarity
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi81 ↔ 115By similarity

    Post-translational modificationi

    N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP43219.

    Expressioni

    Tissue specificityi

    Present in the pancreas as well as the gut, adipose tissue, heart, pituitary, and inner layers of the adrenal cortex, whereas it is not found in kidney, spleen, or liver. It is also expressed in several brain regions, including the cerebral cortex, hippocampus, and olfactory bulb.

    Gene expression databases

    GenevestigatoriP43219.

    Interactioni

    Subunit structurei

    May form homodimers and heterodimers with GLP1R.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021456.

    Structurei

    3D structure databases

    ProteinModelPortaliP43219.
    SMRiP43219. Positions 26-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 135117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini159 – 1668CytoplasmicSequence Analysis
    Topological domaini187 – 21428ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 25112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini276 – 29015ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini317 – 33822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini360 – 37415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini396 – 45560CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei136 – 15823Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei167 – 18620Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23925Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27524Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31626Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei375 – 39521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239460.
    GeneTreeiENSGT00740000115231.
    HOGENOMiHOG000008250.
    HOVERGENiHBG008318.
    InParanoidiP43219.
    KOiK04580.
    OMAiTRQMRCP.
    OrthoDBiEOG7TF78W.
    PhylomeDBiP43219.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR001749. GPCR_2_GIP_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01129. GIPRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43219-1 [UniParc]FASTAAdd to Basket

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    MPLRLLLLLL WLWGLSLQRA ETDSEGQTTG ELYQRWERYG WECQNTLEAT    50
    EPPSGLACNG SFDMYACWNY TAANTTARVS CPWYLPWYRQ VAAGFVFRQC 100
    GSDGQWGSWR DHTQCENPEK NGAFQDQKLI LERLQVVYTV GYSLSLATLL 150
    LALLILSLFR RLHCTRNYIH MNLFTSFMLR AGAILTRDQL LPPLGPYTGN 200
    QTPTLWNQAL AACRTAQILT QYCVGANYTW LLVEGVYLHH LLVVVRRSEK 250
    GHFRCYLLLG WGAPALFVIP WVIVRYLYEN TQCWERNEVK AIWWIIRTPI 300
    LITILINFLI FIRILGILVS KLRTRQMRCP DYRLRLARST LTLMPLLGVH 350
    EVVFAPVTEE QAEGSLRFAK LAFEIFLSSF QGFLVSVLYC FINKEVQSEI 400
    RRLRLSLQEQ CPRPHLGQAP RAVPLSSAPQ EAAIRNALPS GMLHVPGDEV 450
    LESYC 455
    Length:455
    Mass (Da):52,257
    Last modified:November 1, 1995 - v1
    Checksum:i5454B0638ABF9A06
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19660 mRNA. Translation: AAC37637.1.
    PIRiI53273.
    RefSeqiNP_036846.1. NM_012714.1.
    XP_006228450.1. XM_006228388.1.
    UniGeneiRn.9676.

    Genome annotation databases

    EnsembliENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860.
    GeneIDi25024.
    KEGGirno:25024.
    UCSCiRGD:2689. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19660 mRNA. Translation: AAC37637.1 .
    PIRi I53273.
    RefSeqi NP_036846.1. NM_012714.1.
    XP_006228450.1. XM_006228388.1.
    UniGenei Rn.9676.

    3D structure databases

    ProteinModelPortali P43219.
    SMRi P43219. Positions 26-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021456.

    Chemistry

    BindingDBi P43219.
    ChEMBLi CHEMBL5001.
    GuidetoPHARMACOLOGYi 248.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P43219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021456 ; ENSRNOP00000021456 ; ENSRNOG00000015860 .
    GeneIDi 25024.
    KEGGi rno:25024.
    UCSCi RGD:2689. rat.

    Organism-specific databases

    CTDi 2696.
    RGDi 2689. Gipr.

    Phylogenomic databases

    eggNOGi NOG239460.
    GeneTreei ENSGT00740000115231.
    HOGENOMi HOG000008250.
    HOVERGENi HBG008318.
    InParanoidi P43219.
    KOi K04580.
    OMAi TRQMRCP.
    OrthoDBi EOG7TF78W.
    PhylomeDBi P43219.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 605153.
    PROi P43219.

    Gene expression databases

    Genevestigatori P43219.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR001749. GPCR_2_GIP_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01129. GIPRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain."
      Usdin T.B., Mezey E., Button D.C., Brownstein M.J., Bonner T.I.
      Endocrinology 133:2861-2871(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiGIPR_RAT
    AccessioniPrimary (citable) accession number: P43219
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3