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P43219

- GIPR_RAT

UniProt

P43219 - GIPR_RAT

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Protein
Gastric inhibitory polypeptide receptor
Gene
Gipr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. gastric inhibitory peptide receptor activity Source: RGD
  2. peptide hormone binding Source: RGD
Complete GO annotation...

GO - Biological processi

  1. desensitization of G-protein coupled receptor protein signaling pathway Source: RGD
  2. endocrine pancreas development Source: Ensembl
  3. gastric inhibitory peptide signaling pathway Source: GOC
  4. positive regulation of cAMP biosynthetic process Source: RGD
  5. positive regulation of cytosolic calcium ion concentration Source: RGD
  6. positive regulation of insulin secretion Source: RGD
  7. response to axon injury Source: RGD
  8. response to calcium ion Source: RGD
  9. response to fatty acid Source: RGD
  10. response to glucose Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide receptor
Short name:
GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene namesi
Name:Gipr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2689. Gipr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 135117Extracellular Reviewed prediction
Add
BLAST
Transmembranei136 – 15823Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini159 – 1668Cytoplasmic Reviewed prediction
Transmembranei167 – 18620Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini187 – 21428Extracellular Reviewed prediction
Add
BLAST
Transmembranei215 – 23925Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini240 – 25112Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei252 – 27524Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini276 – 29015Extracellular Reviewed prediction
Add
BLAST
Transmembranei291 – 31626Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini317 – 33822Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei339 – 35921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini360 – 37415Extracellular Reviewed prediction
Add
BLAST
Transmembranei375 – 39521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini396 – 45560Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 455437Gastric inhibitory polypeptide receptor
PRO_0000012827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 67 By similarity
Disulfide bondi58 ↔ 100 By similarity
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi81 ↔ 115 By similarity

Post-translational modificationi

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP43219.

Expressioni

Tissue specificityi

Present in the pancreas as well as the gut, adipose tissue, heart, pituitary, and inner layers of the adrenal cortex, whereas it is not found in kidney, spleen, or liver. It is also expressed in several brain regions, including the cerebral cortex, hippocampus, and olfactory bulb.

Gene expression databases

GenevestigatoriP43219.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GLP1R By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021456.

Structurei

3D structure databases

ProteinModelPortaliP43219.
SMRiP43219. Positions 26-119.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239460.
GeneTreeiENSGT00740000115231.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP43219.
KOiK04580.
OMAiTRQMRCP.
OrthoDBiEOG7TF78W.
PhylomeDBiP43219.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43219-1 [UniParc]FASTAAdd to Basket

« Hide

MPLRLLLLLL WLWGLSLQRA ETDSEGQTTG ELYQRWERYG WECQNTLEAT    50
EPPSGLACNG SFDMYACWNY TAANTTARVS CPWYLPWYRQ VAAGFVFRQC 100
GSDGQWGSWR DHTQCENPEK NGAFQDQKLI LERLQVVYTV GYSLSLATLL 150
LALLILSLFR RLHCTRNYIH MNLFTSFMLR AGAILTRDQL LPPLGPYTGN 200
QTPTLWNQAL AACRTAQILT QYCVGANYTW LLVEGVYLHH LLVVVRRSEK 250
GHFRCYLLLG WGAPALFVIP WVIVRYLYEN TQCWERNEVK AIWWIIRTPI 300
LITILINFLI FIRILGILVS KLRTRQMRCP DYRLRLARST LTLMPLLGVH 350
EVVFAPVTEE QAEGSLRFAK LAFEIFLSSF QGFLVSVLYC FINKEVQSEI 400
RRLRLSLQEQ CPRPHLGQAP RAVPLSSAPQ EAAIRNALPS GMLHVPGDEV 450
LESYC 455
Length:455
Mass (Da):52,257
Last modified:November 1, 1995 - v1
Checksum:i5454B0638ABF9A06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19660 mRNA. Translation: AAC37637.1.
PIRiI53273.
RefSeqiNP_036846.1. NM_012714.1.
XP_006228450.1. XM_006228388.1.
UniGeneiRn.9676.

Genome annotation databases

EnsembliENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860.
GeneIDi25024.
KEGGirno:25024.
UCSCiRGD:2689. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19660 mRNA. Translation: AAC37637.1 .
PIRi I53273.
RefSeqi NP_036846.1. NM_012714.1.
XP_006228450.1. XM_006228388.1.
UniGenei Rn.9676.

3D structure databases

ProteinModelPortali P43219.
SMRi P43219. Positions 26-119.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021456.

Chemistry

BindingDBi P43219.
ChEMBLi CHEMBL5001.
GuidetoPHARMACOLOGYi 248.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P43219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021456 ; ENSRNOP00000021456 ; ENSRNOG00000015860 .
GeneIDi 25024.
KEGGi rno:25024.
UCSCi RGD:2689. rat.

Organism-specific databases

CTDi 2696.
RGDi 2689. Gipr.

Phylogenomic databases

eggNOGi NOG239460.
GeneTreei ENSGT00740000115231.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi P43219.
KOi K04580.
OMAi TRQMRCP.
OrthoDBi EOG7TF78W.
PhylomeDBi P43219.
TreeFami TF315710.

Miscellaneous databases

NextBioi 605153.
PROi P43219.

Gene expression databases

Genevestigatori P43219.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain."
    Usdin T.B., Mezey E., Button D.C., Brownstein M.J., Bonner T.I.
    Endocrinology 133:2861-2871(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiGIPR_RAT
AccessioniPrimary (citable) accession number: P43219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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