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Protein

Gastric inhibitory polypeptide receptor

Gene

Gipr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • gastric inhibitory peptide receptor activity Source: RGD
  • peptide hormone binding Source: RGD

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • desensitization of G-protein coupled receptor protein signaling pathway Source: RGD
  • endocrine pancreas development Source: Ensembl
  • positive regulation of cAMP biosynthetic process Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • response to axon injury Source: RGD
  • response to calcium ion Source: RGD
  • response to fatty acid Source: RGD
  • response to glucose Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide receptor
Short name:
GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene namesi
Name:Gipr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2689. Gipr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 135ExtracellularSequence analysisAdd BLAST117
Transmembranei136 – 158Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini159 – 166CytoplasmicSequence analysis8
Transmembranei167 – 186Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini187 – 214ExtracellularSequence analysisAdd BLAST28
Transmembranei215 – 239Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini240 – 251CytoplasmicSequence analysisAdd BLAST12
Transmembranei252 – 275Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini276 – 290ExtracellularSequence analysisAdd BLAST15
Transmembranei291 – 316Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini317 – 338CytoplasmicSequence analysisAdd BLAST22
Transmembranei339 – 359Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini360 – 374ExtracellularSequence analysisAdd BLAST15
Transmembranei375 – 395Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini396 – 455CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5001.
GuidetoPHARMACOLOGYi248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001282719 – 455Gastric inhibitory polypeptide receptorAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 67By similarity
Disulfide bondi58 ↔ 100By similarity
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi81 ↔ 115By similarity

Post-translational modificationi

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43219.
PRIDEiP43219.

PTM databases

PhosphoSitePlusiP43219.

Expressioni

Tissue specificityi

Present in the pancreas as well as the gut, adipose tissue, heart, pituitary, and inner layers of the adrenal cortex, whereas it is not found in kidney, spleen, or liver. It is also expressed in several brain regions, including the cerebral cortex, hippocampus, and olfactory bulb.

Gene expression databases

BgeeiENSRNOG00000015860.
GenevisibleiP43219. RN.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GLP1R.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021456.

Chemistry databases

BindingDBiP43219.

Structurei

3D structure databases

ProteinModelPortaliP43219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP43219.
KOiK04580.
OMAiGELYQRW.
OrthoDBiEOG091G0NF8.
PhylomeDBiP43219.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLRLLLLLL WLWGLSLQRA ETDSEGQTTG ELYQRWERYG WECQNTLEAT
60 70 80 90 100
EPPSGLACNG SFDMYACWNY TAANTTARVS CPWYLPWYRQ VAAGFVFRQC
110 120 130 140 150
GSDGQWGSWR DHTQCENPEK NGAFQDQKLI LERLQVVYTV GYSLSLATLL
160 170 180 190 200
LALLILSLFR RLHCTRNYIH MNLFTSFMLR AGAILTRDQL LPPLGPYTGN
210 220 230 240 250
QTPTLWNQAL AACRTAQILT QYCVGANYTW LLVEGVYLHH LLVVVRRSEK
260 270 280 290 300
GHFRCYLLLG WGAPALFVIP WVIVRYLYEN TQCWERNEVK AIWWIIRTPI
310 320 330 340 350
LITILINFLI FIRILGILVS KLRTRQMRCP DYRLRLARST LTLMPLLGVH
360 370 380 390 400
EVVFAPVTEE QAEGSLRFAK LAFEIFLSSF QGFLVSVLYC FINKEVQSEI
410 420 430 440 450
RRLRLSLQEQ CPRPHLGQAP RAVPLSSAPQ EAAIRNALPS GMLHVPGDEV

LESYC
Length:455
Mass (Da):52,257
Last modified:November 1, 1995 - v1
Checksum:i5454B0638ABF9A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19660 mRNA. Translation: AAC37637.1.
PIRiI53273.
RefSeqiNP_036846.1. NM_012714.1.
XP_017444289.1. XM_017588800.1.
UniGeneiRn.9676.

Genome annotation databases

EnsembliENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860.
GeneIDi25024.
KEGGirno:25024.
UCSCiRGD:2689. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19660 mRNA. Translation: AAC37637.1.
PIRiI53273.
RefSeqiNP_036846.1. NM_012714.1.
XP_017444289.1. XM_017588800.1.
UniGeneiRn.9676.

3D structure databases

ProteinModelPortaliP43219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021456.

Chemistry databases

BindingDBiP43219.
ChEMBLiCHEMBL5001.
GuidetoPHARMACOLOGYi248.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP43219.

Proteomic databases

PaxDbiP43219.
PRIDEiP43219.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860.
GeneIDi25024.
KEGGirno:25024.
UCSCiRGD:2689. rat.

Organism-specific databases

CTDi2696.
RGDi2689. Gipr.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP43219.
KOiK04580.
OMAiGELYQRW.
OrthoDBiEOG091G0NF8.
PhylomeDBiP43219.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiP43219.

Gene expression databases

BgeeiENSRNOG00000015860.
GenevisibleiP43219. RN.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIPR_RAT
AccessioniPrimary (citable) accession number: P43219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.