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Protein

Gastric inhibitory polypeptide receptor

Gene

Gipr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. gastric inhibitory peptide receptor activity Source: RGD
  2. peptide hormone binding Source: RGD

GO - Biological processi

  1. desensitization of G-protein coupled receptor protein signaling pathway Source: RGD
  2. endocrine pancreas development Source: Ensembl
  3. gastric inhibitory peptide signaling pathway Source: GOC
  4. positive regulation of cAMP biosynthetic process Source: RGD
  5. positive regulation of cytosolic calcium ion concentration Source: RGD
  6. positive regulation of insulin secretion Source: RGD
  7. response to axon injury Source: RGD
  8. response to calcium ion Source: RGD
  9. response to fatty acid Source: RGD
  10. response to glucose Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_235881. Glucagon-type ligand receptors.
REACT_246814. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide receptor
Short name:
GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene namesi
Name:Gipr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2689. Gipr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 135117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei136 – 15823Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini159 – 1668CytoplasmicSequence Analysis
Transmembranei167 – 18620Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini187 – 21428ExtracellularSequence AnalysisAdd
BLAST
Transmembranei215 – 23925Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini240 – 25112CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27524Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini276 – 29015ExtracellularSequence AnalysisAdd
BLAST
Transmembranei291 – 31626Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini317 – 33822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei339 – 35921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini360 – 37415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei375 – 39521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini396 – 45560CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 455437Gastric inhibitory polypeptide receptorPRO_0000012827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 67By similarity
Disulfide bondi58 ↔ 100By similarity
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi81 ↔ 115By similarity

Post-translational modificationi

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP43219.

Expressioni

Tissue specificityi

Present in the pancreas as well as the gut, adipose tissue, heart, pituitary, and inner layers of the adrenal cortex, whereas it is not found in kidney, spleen, or liver. It is also expressed in several brain regions, including the cerebral cortex, hippocampus, and olfactory bulb.

Gene expression databases

GenevestigatoriP43219.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GLP1R.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021456.

Structurei

3D structure databases

ProteinModelPortaliP43219.
SMRiP43219. Positions 26-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239460.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP43219.
KOiK04580.
OMAiTRQMRCP.
OrthoDBiEOG7TF78W.
PhylomeDBiP43219.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43219-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLRLLLLLL WLWGLSLQRA ETDSEGQTTG ELYQRWERYG WECQNTLEAT
60 70 80 90 100
EPPSGLACNG SFDMYACWNY TAANTTARVS CPWYLPWYRQ VAAGFVFRQC
110 120 130 140 150
GSDGQWGSWR DHTQCENPEK NGAFQDQKLI LERLQVVYTV GYSLSLATLL
160 170 180 190 200
LALLILSLFR RLHCTRNYIH MNLFTSFMLR AGAILTRDQL LPPLGPYTGN
210 220 230 240 250
QTPTLWNQAL AACRTAQILT QYCVGANYTW LLVEGVYLHH LLVVVRRSEK
260 270 280 290 300
GHFRCYLLLG WGAPALFVIP WVIVRYLYEN TQCWERNEVK AIWWIIRTPI
310 320 330 340 350
LITILINFLI FIRILGILVS KLRTRQMRCP DYRLRLARST LTLMPLLGVH
360 370 380 390 400
EVVFAPVTEE QAEGSLRFAK LAFEIFLSSF QGFLVSVLYC FINKEVQSEI
410 420 430 440 450
RRLRLSLQEQ CPRPHLGQAP RAVPLSSAPQ EAAIRNALPS GMLHVPGDEV

LESYC
Length:455
Mass (Da):52,257
Last modified:November 1, 1995 - v1
Checksum:i5454B0638ABF9A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19660 mRNA. Translation: AAC37637.1.
PIRiI53273.
RefSeqiNP_036846.1. NM_012714.1.
UniGeneiRn.9676.

Genome annotation databases

EnsembliENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860.
GeneIDi25024.
KEGGirno:25024.
UCSCiRGD:2689. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19660 mRNA. Translation: AAC37637.1.
PIRiI53273.
RefSeqiNP_036846.1. NM_012714.1.
UniGeneiRn.9676.

3D structure databases

ProteinModelPortaliP43219.
SMRiP43219. Positions 26-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021456.

Chemistry

BindingDBiP43219.
ChEMBLiCHEMBL5001.
GuidetoPHARMACOLOGYi248.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP43219.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860.
GeneIDi25024.
KEGGirno:25024.
UCSCiRGD:2689. rat.

Organism-specific databases

CTDi2696.
RGDi2689. Gipr.

Phylogenomic databases

eggNOGiNOG239460.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiP43219.
KOiK04580.
OMAiTRQMRCP.
OrthoDBiEOG7TF78W.
PhylomeDBiP43219.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiREACT_235881. Glucagon-type ligand receptors.
REACT_246814. G alpha (s) signalling events.

Miscellaneous databases

NextBioi605153.
PROiP43219.

Gene expression databases

GenevestigatoriP43219.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR001749. GPCR_2_GIP_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01129. GIPRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain."
    Usdin T.B., Mezey E., Button D.C., Brownstein M.J., Bonner T.I.
    Endocrinology 133:2861-2871(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiGIPR_RAT
AccessioniPrimary (citable) accession number: P43219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.