P43218 (GIPR_MESAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gastric inhibitory polypeptide receptor
Short name=GIP-R

Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor

Gene names

Name:

GIPR

Organism

Mesocricetus auratus (Golden hamster)

Taxonomic identifier

10036 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subunit structure	May form homodimers and heterodimers with GLP1R By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Widely distributed including pancreatic islets, brain and various peripheral tissues.
Post-translational modification	N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	gastric inhibitory peptide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 462	444	Gastric inhibitory polypeptide receptor		PRO_0000012826
Regions
	Topological domain	19 – 135	117	Extracellular Potential
	Transmembrane	136 – 158	23	Helical; Name=1; Potential
	Topological domain	159 – 166	8	Cytoplasmic Potential
	Transmembrane	167 – 186	20	Helical; Name=2; Potential
	Topological domain	187 – 214	28	Extracellular Potential
	Transmembrane	215 – 239	25	Helical; Name=3; Potential
	Topological domain	240 – 251	12	Cytoplasmic Potential
	Transmembrane	252 – 275	24	Helical; Name=4; Potential
	Topological domain	276 – 290	15	Extracellular Potential
	Transmembrane	291 – 316	26	Helical; Name=5; Potential
	Topological domain	317 – 338	22	Cytoplasmic Potential
	Transmembrane	339 – 359	21	Helical; Name=6; Potential
	Topological domain	360 – 374	15	Extracellular Potential
	Transmembrane	375 – 395	21	Helical; Name=7; Potential
	Topological domain	396 – 462	67	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	59	1	N-linked (GlcNAc...) Potential
	Glycosylation	74	1	N-linked (GlcNAc...) Potential
	Disulfide bond	43 ↔ 67		By similarity
	Disulfide bond	58 ↔ 100		By similarity
	Disulfide bond	81 ↔ 115		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43218 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D7A6204BCB9BB688	FASTA	462	52,919
	10 20 30 40 50 60 MPLRPRLLLL CLWGLLLQQA ETDSEGQTTG ELYQRWERYA RECEETLTAA DPPSGMVCNG 70 80 90 100 110 120 SFDMYVCWDY TAANTTAQAS CPWYLPWYRH VAAGYVFRQC GSDGQWGPWR DHTQCENPEK 130 140 150 160 170 180 NGAFQDQRLI LERLQVVYTV GYSLSLGTLL LALLILSLFR RLHCTRNYIH MNVFLSFMLR 190 200 210 220 230 240 AVAILTRDRL LPTLGPYPGD RTLTLRNQAL AACRTAQIVT QYCVGANYTW LLVEGVYLHH 250 260 270 280 290 300 LLVIVGGSEK GHFRCYLLLG WGAPALFVIP WVIVRYLLEN TQCWERNEVK AIWWIIRTPI 310 320 330 340 350 360 LITILINFFI FIRILGILVS KLRTRQMRCP DYRLRLARST LTLVPLLGVH EVVFAPVTEE 370 380 390 400 410 420 QAEGTLRFAK LAFEIFLSSF QGFLVSVLYC FINKEVQSEI RRSWRHRVLH LSLRDERPCP 430 440 450 460 HAELGPQALP SRSAPREVPI TGSTLPSGPL HGPGEEVLES YC

References

[1]

"Hamster gastric inhibitory polypeptide receptor expressed in pancreatic islets and clonal insulin-secreting cells: its structure and functional properties." Yasuda K., Inagaki N., Yamada Y., Kubota A., Seino S., Seino Y. Biochem. Biophys. Res. Commun. 205:1556-1562(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	D38103 mRNA. Translation: BAA07284.1.
3D structure databases
ProteinModelPortal	P43218.
SMR	P43218. Positions 26-119.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG008318.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR001749. GPCR_2_GIP_rcpt. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR01129. GIPRECEPTOR. PR00249. GPCRSECRETIN.
SMART	SM00008. HormR. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GIPR_MESAU

Accession

Primary (citable) accession number: P43218

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program