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Protein

Major pollen allergen Hol l 1

Gene
N/A
Organism
Holcus lanatus (Yorkshire-fog) (Nothoholcus lanatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Hol l 1
Alternative name(s):
Allergen Hol l 1.0101/1.0102
Allergen Hol l I
Allergen: Hol l 1
OrganismiHolcus lanatus (Yorkshire-fog) (Nothoholcus lanatus)
Taxonomic identifieri29679 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaePoodaePoeaePoeae Chloroplast Group 2 (Poeae type)HolcinaeHolcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Causes grass pollen allergy. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei405. Hol l 1.
406. Hol l 1.0101.
407. Hol l 1.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 265240Major pollen allergen Hol l 1PRO_0000008719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP43216.
SMRiP43216. Positions 28-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 169107Expansin-like EG45PROSITE-ProRule annotationAdd
BLAST
Domaini183 – 26482Expansin-like CBDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the expansin family. Expansin B subfamily.Curated
Contains 1 expansin-like CBD domain.PROSITE-ProRule annotation
Contains 1 expansin-like EG45 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
2.60.40.760. 1 hit.
InterProiIPR007118. Expan_Lol_pI.
IPR007112. Expansin/allergen_DPBB_dom.
IPR007117. Expansin_CBD.
IPR005795. LolPI.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF03330. DPBB_1. 1 hit.
PF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSiPR01225. EXPANSNFAMLY.
PR00829. LOLP1ALLERGN.
SMARTiSM00837. DPBB_1. 1 hit.
[Graphical view]
SUPFAMiSSF49590. SSF49590. 1 hit.
SSF50685. SSF50685. 1 hit.
PROSITEiPS50843. EXPANSIN_CBD. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSRSVLL LVAALFAVFL GSAHGIAKVP PGPNITATYG DEWLDAKSTW
60 70 80 90 100
YGKPTGAGPK DNGGACGYKD VDKPPFSGMT GCGNTPIFKD GRGCGSCFEI
110 120 130 140 150
KCTKPESCSG EPVTVHITDD NEEPIAPYHF DLSGHAFGSM AKKGEEQKLR
160 170 180 190 200
SAGELELKFR RVKCKYPDGT KPTFHVEKGS NPNYLALLVK YIDGDGDVVA
210 220 230 240 250
VDIKEKGKDK WIELKESWGA VWRVDTPDKL TGPFTVRYTT EGGTKGEAED
260
VIPEGWKADT AYEAK
Length:265
Mass (Da):28,590
Last modified:November 1, 1995 - v1
Checksum:i1FE23B3EE198AD6D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031T → S in Hol l 1.0102.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27084 mRNA. Translation: CAA81610.1.
Z68893 mRNA. Translation: CAA93121.1.
PIRiS38581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27084 mRNA. Translation: CAA81610.1.
Z68893 mRNA. Translation: CAA93121.1.
PIRiS38581.

3D structure databases

ProteinModelPortaliP43216.
SMRiP43216. Positions 28-264.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei405. Hol l 1.
406. Hol l 1.0101.
407. Hol l 1.0102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
2.60.40.760. 1 hit.
InterProiIPR007118. Expan_Lol_pI.
IPR007112. Expansin/allergen_DPBB_dom.
IPR007117. Expansin_CBD.
IPR005795. LolPI.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF03330. DPBB_1. 1 hit.
PF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSiPR01225. EXPANSNFAMLY.
PR00829. LOLP1ALLERGN.
SMARTiSM00837. DPBB_1. 1 hit.
[Graphical view]
SUPFAMiSSF49590. SSF49590. 1 hit.
SSF50685. SSF50685. 1 hit.
PROSITEiPS50843. EXPANSIN_CBD. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Schramm G.D., Bufe A., Becker W.M., Schlaak M.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Aveneae.
    Tissue: Pollen.
  2. "Mapping of IgE-binding epitopes on the recombinant major group I allergen of velvet grass pollen, rHol l 1."
    Schramm G.D., Bufe A., Petersen A., Haas H., Schlaak M., Becker W.M.
    J. Allergy Clin. Immunol. 99:781-787(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-265.
    Strain: cv. Aveneae.
    Tissue: Pollen.
  3. "Identification and characterization of the major allergens of velvet grass (Holcus lanatus), Hol l 1 and Hol l 5."
    Schramm G.D., Petersen A., Bufe A., Schlaak M., Becker W.M.
    Int. Arch. Allergy Immunol. 110:354-363(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: cv. Aveneae.
    Tissue: Pollen.

Entry informationi

Entry nameiMPAH1_HOLLA
AccessioniPrimary (citable) accession number: P43216
Secondary accession number(s): Q39975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 17, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.