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Protein

Pollen allergen Phl p 2

Gene

PHLPII

Organism
Phleum pratense (Common timothy)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pollen allergen Phl p 2
Alternative name(s):
Allergen Phl p II
Allergen: Phl p 2
Gene namesi
Name:PHLPII
OrganismiPhleum pratense (Common timothy)
Taxonomic identifieri15957 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaePoodaePoeaePoeae Chloroplast Group 2 (Poeae type)PoinaePhleum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Causes grass pollen allergy. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3419. Phl p 2.0101.
555. Phl p 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 12296Pollen allergen Phl p 2PRO_0000008723Add
BLAST

Expressioni

Tissue specificityi

Pollen specific.

Structurei

Secondary structure

1
122
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 346Combined sources
Beta strandi42 – 498Combined sources
Beta strandi50 – 523Combined sources
Beta strandi54 – 607Combined sources
Beta strandi62 – 665Combined sources
Helixi74 – 763Combined sources
Beta strandi77 – 815Combined sources
Beta strandi88 – 969Combined sources
Turni97 – 993Combined sources
Beta strandi101 – 1088Combined sources
Beta strandi114 – 1163Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMWNMR-A27-122[»]
1WHOX-ray1.90A27-122[»]
1WHPX-ray3.00A27-122[»]
2VXQX-ray1.90A27-122[»]
ProteinModelPortaliP43214.
SMRiP43214. Positions 27-120.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43214.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 12080Expansin-like CBDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the expansin family. Expansin B subfamily.Curated
Contains 1 expansin-like CBD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.760. 1 hit.
InterProiIPR005453. Allergen_Lolp2.
IPR007117. Expansin_CBD.
[Graphical view]
PfamiPF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSiPR01637. LOLP2ALLERGN.
SUPFAMiSSF49590. SSF49590. 1 hit.
PROSITEiPS50843. EXPANSIN_CBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMASSSSSS LLAMAVLAAL FAGAWCVPKV TFTVEKGSNE KHLAVLVKYE
60 70 80 90 100
GDTMAEVELR EHGSDEWVAM TKGEGGVWTF DSEEPLQGPF NFRFLTEKGM
110 120
KNVFDDVVPE KYTIGATYAP EE
Length:122
Mass (Da):13,362
Last modified:November 1, 1995 - v1
Checksum:i708B911B25EE26F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75925 mRNA. Translation: CAA53529.1.
PIRiS39457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75925 mRNA. Translation: CAA53529.1.
PIRiS39457.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMWNMR-A27-122[»]
1WHOX-ray1.90A27-122[»]
1WHPX-ray3.00A27-122[»]
2VXQX-ray1.90A27-122[»]
ProteinModelPortaliP43214.
SMRiP43214. Positions 27-120.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3419. Phl p 2.0101.
555. Phl p 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP43214.

Family and domain databases

Gene3Di2.60.40.760. 1 hit.
InterProiIPR005453. Allergen_Lolp2.
IPR007117. Expansin_CBD.
[Graphical view]
PfamiPF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSiPR01637. LOLP2ALLERGN.
SUPFAMiSSF49590. SSF49590. 1 hit.
PROSITEiPS50843. EXPANSIN_CBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of Phl p II, a major timothy grass (Phleum pratense) pollen allergen."
    Dolecek C., Vrtala S., Laffer S., Steinberger P., Kraft D., Scheiner O., Valenta R.
    FEBS Lett. 335:299-304(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
    Tissue: Pollen.
  2. "X-ray crystal structures of birch pollen profilin and Phl p 2."
    Fedorov A.A., Ball T., Valenta R., Almo S.C.
    Int. Arch. Allergy Immunol. 113:109-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
  3. "An immunoglobulin-like fold in a major plant allergen: the solution structure of Phl p 2 from timothy grass pollen."
    De Marino S., Morelli M.A.C., Fraternali F., Tamborini E., Musco G., Vrtala S., Dolecek C., Arosio P., Valenta R., Pastore A.
    Structure 7:943-952(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiMPAP2_PHLPR
AccessioniPrimary (citable) accession number: P43214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 17, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.