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P43213 (MPAP1_PHLPR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pollen allergen Phl p 1
Alternative name(s):
Allergen Phl p I
Allergen=Phl p 1
Gene names
Name:PHLPI
OrganismPhleum pratense (Common timothy)
Taxonomic identifier15957 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Pooideae › Poeae › Alopecurinae › Phleum

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer Probable. Ref.2

Subcellular location

Secreted.

Allergenic properties

Causes an allergic reaction in human. Causes grass pollen allergy. Binds to IgE. Ref.1

Sequence similarities

Belongs to the expansin family. Expansin B subfamily.

Contains 1 expansin-like CBD domain.

Contains 1 expansin-like EG45 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processsexual reproduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 263240Pollen allergen Phl p 1
PRO_0000008722

Regions

Domain61 – 167107Expansin-like EG45
Domain181 – 26282Expansin-like CBD

Amino acid modifications

Glycosylation321N-linked (GlcNAc...) Ref.2
Disulfide bond64 ↔ 92
Disulfide bond95 ↔ 162
Disulfide bond100 ↔ 106

Secondary structure

1 ..................................... 263
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43213 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 046BA249C17BC048

FASTA26328,457
        10         20         30         40         50         60 
MASSSSVLLV VVLFAVFLGS AYGIPKVPPG PNITATYGDK WLDAKSTWYG KPTGAGPKDN 

        70         80         90        100        110        120 
GGACGYKDVD KPPFSGMTGC GNTPIFKSGR GCGSCFEIKC TKPEACSGEP VVVHITDDNE 

       130        140        150        160        170        180 
EPIAPYHFDL SGHAFGAMAK KGDEQKLRSA GELELQFRRV KCKYPEGTKV TFHVEKGSNP 

       190        200        210        220        230        240 
NYLALLVKYV NGDGDVVAVD IKEKGKDKWI ELKESWGAIW RIDTPDKLTG PFTVRYTTEG 

       250        260 
GTKTEAEDVI PEGWKADTSY ESK

« Hide

References

[1]"Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding to group I allergens from eight different grass species."
Laffer S., Valenta R., Vrtala S., Susani M., van Ree R., Kraft D., Scheiner O., Duchene M.
J. Allergy Clin. Immunol. 94:689-698(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
Tissue: Pollen.
[2]"X-ray crystal structures of birch pollen profilin and Phl p 2."
Fedorov A.A., Ball T., Valenta R., Almo S.C.
Int. Arch. Allergy Immunol. 113:109-113(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 24-263, GLYCOSYLATION AT ASN-32, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X78813 mRNA. Translation: CAA55390.1.
PIRS44182.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1N10X-ray2.90A/B24-263[»]
ProteinModelPortalP43213.
SMRP43213. Positions 25-262.
ModBaseSearch...

Protein family/group databases

Allergome549. Phl p 1.
551. Phl p 1.0102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP43213.

Family and domain databases

Gene3D2.40.40.10. 1 hit.
2.60.40.760. 1 hit.
InterProIPR014733. Barwin-like_endoglucanase.
IPR009009. Barwin-related_endoglucanase.
IPR007118. Expan_Lol_pI.
IPR007112. Expansin/allergen_DPBB_dom.
IPR007117. Expansin_CBD.
IPR005795. LolPI.
[Graphical view]
PfamPF03330. DPBB_1. 1 hit.
PF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSPR01225. EXPANSNFAMLY.
PR00829. LOLP1ALLERGN.
SMARTSM00837. DPBB_1. 1 hit.
[Graphical view]
SUPFAMSSF50685. Barwin_like. 1 hit.
SSF49590. Expan_Lol_pI_C. 1 hit.
PROSITEPS50843. EXPANSIN_CBD. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP43213.

Entry information

Entry nameMPAP1_PHLPR
AccessionPrimary (citable) accession number: P43213
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Allergens

Nomenclature of allergens and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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