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Protein

Pollen allergen Phl p 1

Gene

PHLPI

Organism
Phleum pratense (Common timothy)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pollen allergen Phl p 1
Alternative name(s):
Allergen Phl p I
Allergen: Phl p 1
Gene namesi
Name:PHLPI
OrganismiPhleum pratense (Common timothy)
Taxonomic identifieri15957 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaePoodaePoeaePoeae Chloroplast Group 2 (Poeae type)PoinaePhleum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Causes grass pollen allergy. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei549. Phl p 1.
551. Phl p 1.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000872224 – 263Pollen allergen Phl p 1Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...)1 Publication1
Disulfide bondi64 ↔ 92
Disulfide bondi95 ↔ 162
Disulfide bondi100 ↔ 106

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 49Combined sources8
Turni72 – 76Combined sources5
Beta strandi78 – 81Combined sources4
Helixi83 – 86Combined sources4
Helixi87 – 89Combined sources3
Beta strandi95 – 100Combined sources6
Beta strandi111 – 118Combined sources8
Beta strandi123 – 131Combined sources9
Helixi132 – 136Combined sources5
Helixi144 – 148Combined sources5
Beta strandi152 – 159Combined sources8
Beta strandi171 – 174Combined sources4
Beta strandi182 – 188Combined sources7
Beta strandi196 – 203Combined sources8
Turni216 – 218Combined sources3
Beta strandi220 – 223Combined sources4
Beta strandi232 – 241Combined sources10
Beta strandi243 – 250Combined sources8
Beta strandi256 – 261Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N10X-ray2.90A/B23-263[»]
ProteinModelPortaliP43213.
SMRiP43213.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43213.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 167Expansin-like EG45PROSITE-ProRule annotationAdd BLAST107
Domaini181 – 262Expansin-like CBDPROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the expansin family. Expansin B subfamily.Curated
Contains 1 expansin-like CBD domain.PROSITE-ProRule annotation
Contains 1 expansin-like EG45 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
2.60.40.760. 1 hit.
InterProiIPR007118. Expan_Lol_pI.
IPR007112. Expansin/allergen_DPBB_dom.
IPR007117. Expansin_CBD.
IPR005795. LolPI.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF03330. DPBB_1. 1 hit.
PF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSiPR01225. EXPANSNFAMLY.
PR00829. LOLP1ALLERGN.
SMARTiSM00837. DPBB_1. 1 hit.
[Graphical view]
SUPFAMiSSF49590. SSF49590. 1 hit.
SSF50685. SSF50685. 1 hit.
PROSITEiPS50843. EXPANSIN_CBD. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSVLLV VVLFAVFLGS AYGIPKVPPG PNITATYGDK WLDAKSTWYG
60 70 80 90 100
KPTGAGPKDN GGACGYKDVD KPPFSGMTGC GNTPIFKSGR GCGSCFEIKC
110 120 130 140 150
TKPEACSGEP VVVHITDDNE EPIAPYHFDL SGHAFGAMAK KGDEQKLRSA
160 170 180 190 200
GELELQFRRV KCKYPEGTKV TFHVEKGSNP NYLALLVKYV NGDGDVVAVD
210 220 230 240 250
IKEKGKDKWI ELKESWGAIW RIDTPDKLTG PFTVRYTTEG GTKTEAEDVI
260
PEGWKADTSY ESK
Length:263
Mass (Da):28,457
Last modified:November 1, 1995 - v1
Checksum:i046BA249C17BC048
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78813 mRNA. Translation: CAA55390.1.
PIRiS44182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78813 mRNA. Translation: CAA55390.1.
PIRiS44182.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N10X-ray2.90A/B23-263[»]
ProteinModelPortaliP43213.
SMRiP43213.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei549. Phl p 1.
551. Phl p 1.0102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP43213.

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
2.60.40.760. 1 hit.
InterProiIPR007118. Expan_Lol_pI.
IPR007112. Expansin/allergen_DPBB_dom.
IPR007117. Expansin_CBD.
IPR005795. LolPI.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF03330. DPBB_1. 1 hit.
PF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSiPR01225. EXPANSNFAMLY.
PR00829. LOLP1ALLERGN.
SMARTiSM00837. DPBB_1. 1 hit.
[Graphical view]
SUPFAMiSSF49590. SSF49590. 1 hit.
SSF50685. SSF50685. 1 hit.
PROSITEiPS50843. EXPANSIN_CBD. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPAP1_PHLPR
AccessioniPrimary (citable) accession number: P43213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.