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Protein

Major allergen Mal d 1

Gene

MALD1

Organism
Malus domestica (Apple) (Pyrus malus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionPathogenesis-related protein
Biological processPlant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Mal d 1
Alternative name(s):
Allergen Mal d I
Allergen: Mal d 1
Gene namesi
Name:MALD1
OrganismiMalus domestica (Apple) (Pyrus malus)
Taxonomic identifieri3750 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1447. Mal d 1.0101.
1448. Mal d 1.0102.
464. Mal d 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001541902 – 159Major allergen Mal d 1Add BLAST158

Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 14Combined sources12
Helixi16 – 24Combined sources9
Helixi27 – 34Combined sources8
Turni36 – 38Combined sources3
Beta strandi41 – 50Combined sources10
Beta strandi54 – 58Combined sources5
Beta strandi67 – 75Combined sources9
Turni77 – 79Combined sources3
Beta strandi81 – 89Combined sources9
Turni93 – 95Combined sources3
Beta strandi96 – 108Combined sources13
Beta strandi111 – 122Combined sources12
Helixi130 – 153Combined sources24
Turni155 – 158Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MMUNMR-A2-159[»]
ProteinModelPortaliP43211.
SMRiP43211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiView protein in InterPro
IPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
PfamiView protein in Pfam
PF00407. Bet_v_1. 1 hit.
PRINTSiPR00634. BETALLERGEN.
PROSITEiView protein in PROSITE
PS00451. PATHOGENESIS_BETVI. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVYTFENEF TSEIPPSRLF KAFVLDADNL IPKIAPQAIK QAEILEGNGG
60 70 80 90 100
PGTIKKITFG EGSQYGYVKH RIDSIDEASY SYSYTLIEGD ALTDTIEKIS
110 120 130 140 150
YETKLVACGS GSTIKSISHY HTKGNIEIKE EHVKVGKEKA HGLFKLIESY

LKDHPDAYN
Length:159
Mass (Da):17,651
Last modified:January 23, 2007 - v2
Checksum:i2E5447E3343098BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17S → P AA sequence (PubMed:7518715).Curated1
Sequence conflicti112S → A in CAA88833 (PubMed:7677763).Curated1
Sequence conflicti122T → P in CAA88833 (PubMed:7677763).Curated1
Sequence conflicti140A → G in CAA88833 (PubMed:7677763).Curated1
Sequence conflicti153D → G in CAA88833 (PubMed:7677763).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti10F → Y. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83672 mRNA. Translation: CAA58646.1.
Z48969 mRNA. Translation: CAA88833.1.
PIRiJC4276.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMAL11_MALDO
AccessioniPrimary (citable) accession number: P43211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families