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Protein

Major allergen Mal d 1

Gene

MALD1

Organism
Malus domestica (Apple) (Pyrus malus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Mal d 1
Alternative name(s):
Allergen Mal d I
Allergen: Mal d 1
Gene namesi
Name:MALD1
OrganismiMalus domestica (Apple) (Pyrus malus)
Taxonomic identifieri3750 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeMaleaeMalus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1447. Mal d 1.0101.
1448. Mal d 1.0102.
464. Mal d 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 159158Major allergen Mal d 1PRO_0000154190Add
BLAST

Proteomic databases

PRIDEiP43211.

Structurei

3D structure databases

ProteinModelPortaliP43211.
SMRiP43211. Positions 2-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVYTFENEF TSEIPPSRLF KAFVLDADNL IPKIAPQAIK QAEILEGNGG
60 70 80 90 100
PGTIKKITFG EGSQYGYVKH RIDSIDEASY SYSYTLIEGD ALTDTIEKIS
110 120 130 140 150
YETKLVACGS GSTIKSISHY HTKGNIEIKE EHVKVGKEKA HGLFKLIESY

LKDHPDAYN
Length:159
Mass (Da):17,651
Last modified:January 23, 2007 - v2
Checksum:i2E5447E3343098BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171S → P AA sequence (PubMed:7518715).Curated
Sequence conflicti112 – 1121S → A in CAA88833 (PubMed:7677763).Curated
Sequence conflicti122 – 1221T → P in CAA88833 (PubMed:7677763).Curated
Sequence conflicti140 – 1401A → G in CAA88833 (PubMed:7677763).Curated
Sequence conflicti153 – 1531D → G in CAA88833 (PubMed:7677763).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101F → Y.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83672 mRNA. Translation: CAA58646.1.
Z48969 mRNA. Translation: CAA88833.1.
PIRiJC4276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83672 mRNA. Translation: CAA58646.1.
Z48969 mRNA. Translation: CAA88833.1.
PIRiJC4276.

3D structure databases

ProteinModelPortaliP43211.
SMRiP43211. Positions 2-159.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1447. Mal d 1.0101.
1448. Mal d 1.0102.
464. Mal d 1.

Proteomic databases

PRIDEiP43211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Schoening B., Ziegler W.H., Vieths S., Baltes W.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Granny Smith.
  2. "Cloning and sequencing of Mal d 1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet v 1, the major birch pollen allergen."
    Vanek-Krebitz M., Hoffmann-Sommergruber K., Laimer da Camara Machado M., Susani M., Ebner C., Kraft D., Scheiner O., Breiteneder H.
    Biochem. Biophys. Res. Commun. 214:538-551(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Golden Delicious.
    Tissue: Mesocarp.
  3. "Characterization of the 18-kDa apple allergen by two-dimensional immunoblotting and microsequencing."
    Vieths S., Schoening B., Petersen A.
    Int. Arch. Allergy Immunol. 104:399-404(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-26.
    Strain: cv. Golden Delicious.

Entry informationi

Entry nameiMAL11_MALDO
AccessioniPrimary (citable) accession number: P43211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 14, 2015
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.