P43211 (MAL11_MALDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major allergen Mal d 1

Alternative name(s):
Allergen Mal d I
Allergen=Mal d 1

Gene names

Name:

MALD1

Organism

Malus domestica (Apple) (Pyrus malus)

Taxonomic identifier

3750 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Rosaceae › Maloideae › Maleae › Malus

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the BetVI family.

Ontologies

Keywords
Biological process	Plant defense
Disease	Allergen
Molecular function	Pathogenesis-related protein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response Inferred from electronic annotation. Source: UniProtKB-KW response to biotic stimulus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 159	158	Major allergen Mal d 1		PRO_0000154190
Natural variations
	Natural variant	10	1	F → Y.
Experimental info
	Sequence conflict	17	1	S → P AA sequence Ref.3
	Sequence conflict	112	1	S → A in CAA88833. Ref.2
	Sequence conflict	122	1	T → P in CAA88833. Ref.2
	Sequence conflict	140	1	A → G in CAA88833. Ref.2
	Sequence conflict	153	1	D → G in CAA88833. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P43211 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 2E5447E3343098BE	FASTA	159	17,651
	10 20 30 40 50 60 MGVYTFENEF TSEIPPSRLF KAFVLDADNL IPKIAPQAIK QAEILEGNGG PGTIKKITFG 70 80 90 100 110 120 EGSQYGYVKH RIDSIDEASY SYSYTLIEGD ALTDTIEKIS YETKLVACGS GSTIKSISHY 130 140 150 HTKGNIEIKE EHVKVGKEKA HGLFKLIESY LKDHPDAYN

References

[1]	Schoening B., Ziegler W.H., Vieths S., Baltes W. Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Granny Smith.
[2]	"Cloning and sequencing of Mal d 1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet v 1, the major birch pollen allergen." Vanek-Krebitz M., Hoffmann-Sommergruber K., Laimer da Camara Machado M., Susani M., Ebner C., Kraft D., Scheiner O., Breiteneder H. Biochem. Biophys. Res. Commun. 214:538-551(1995) [PubMed: 7677763] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Golden Delicious. Tissue: Mesocarp.
[3]	"Characterization of the 18-kDa apple allergen by two-dimensional immunoblotting and microsequencing." Vieths S., Schoening B., Petersen A. Int. Arch. Allergy Immunol. 104:399-404(1994) [PubMed: 7518715] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-26. Strain: cv. Golden Delicious.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83672 mRNA. Translation: CAA58646.1. Z48969 mRNA. Translation: CAA88833.1.
PIR	JC4276.
3D structure databases
ProteinModelPortal	P43211.
SMR	P43211. Positions 2-159.
ModBase	Search...
Protein family/group databases
Allergome	1447. Mal d 1.0101. 1448. Mal d 1.0102. 464. Mal d 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000916. Bet_v_I_dom. IPR023393. START-like_dom. [Graphical view]
Gene3D	G3DSA:3.30.530.20. G3DSA:3.30.530.20. 1 hit.
Pfam	PF00407. Bet_v_1. 1 hit. [Graphical view]
PROSITE	PS00451. PATHOGENESIS_BETVI. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MAL11_MALDO

Accession

Primary (citable) accession number: P43211

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program