Reviewed,
UniProtKB/Swiss-Prot P43210 (HEM2_SOYBN)
Last modified
October 13, 2009.
Version 61.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Delta-aminolevulinic acid dehydratase, chloroplastic Short name=ALADH EC=4.2.1.24 Alternative name(s): Porphobilinogen synthase | ||||
| Gene names |
| ||||
| Organism | Glycine max (Soybean) | ||||
| Taxonomic identifier | 3847 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine |
Protein attributes
| Sequence length | 412 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Is committed to plant tetrapyrrole synthesis. |
| Catalytic activity | 2 5-aminolevulinate = porphobilinogen + 2 H2O. |
| Cofactor | Magnesium. |
| Pathway | |
| Subunit structure | Homooctamer By similarity. |
| Subcellular location | |
| Tissue specificity | Leaves and root nodules. |
| Sequence similarities | Belongs to the ALADH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Chlorophyll biosynthesis Porphyrin biosynthesis |
| Cellular component | Chloroplast Plastid |
| Domain | Transit peptide |
| Ligand | Magnesium |
| Molecular function | Lyase |
| Gene Ontology (GO) | |
| Biological process | chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 48 | 48 | Chloroplast Potential | ||||||
| Chain | 49 – 412 | 364 | Delta-aminolevulinic acid dehydratase, chloroplastic | PRO_0000013320 | |||||
Regions | |||||||||
| Region | 201 – 219 | 19 | Magnesium-binding By similarity | ||||||
Sites | |||||||||
| Active site | 333 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Plant delta-aminolevulinic acid dehydratase. Expression in soybean root nodules and evidence for a bacterial lineage of the Alad gene." Kaczor C.M., Smith M.W., Sangwan I., O'Brian M.R. Plant Physiol. 104:1411-1417(1994) [PubMed: 8016269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leaf. |
Cross-references
Sequence databases | |
|---|---|
| U04525 mRNA. Translation: AAA18342.1. | |
| PIR | T06351. |
| UniGene | Gma.6038 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1E51 based on UniProtKB P13716. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 4.2.1.24. 299. |
Gene expression databases | |
| Genevestigator | P43210. |
Family and domain databases | |
| InterPro | IPR001731. 4pyrrol_synth_porphobiln_synth. IPR013785. Aldolase_TIM. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR11458. AlaD_dehydratase. 1 hit. |
| Pfam | PF00490. ALAD. 1 hit. [Graphical view] |
| PRINTS | PR00144. DALDHYDRTASE. |
| ProDom | PD002304. AlaD_dehydratase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HEM2_SOYBN | ||||||||
| Accession | Primary (citable) accession number: P43210 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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