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P43187

- ALLB3_BETPN

UniProt

P43187 - ALLB3_BETPN

Protein

Calcium-binding allergen Bet v 3

Gene

BETVIII

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    • Comment

    Functioni

    Could be involved in calcium metabolism in pollen. Binds 3 calcium ions.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi49 – 60121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi143 – 154122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi181 – 192123PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-binding allergen Bet v 3
    Alternative name(s):
    Allergen Bet v III
    Allergen: Bet v 3
    Gene namesi
    Name:BETVIII
    OrganismiBetula pendula (European white birch) (Betula verrucosa)
    Taxonomic identifieri3505 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei128. Bet v 3.
    3137. Bet v 3.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Calcium-binding allergen Bet v 3PRO_0000073662Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP43187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 7136EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini72 – 10736EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 16536EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 20336EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF00036. EF-hand_1. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 3 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43187-1 [UniParc]FASTAAdd to Basket

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    MPCSTEAMEK AGHGHASTPR KRSLSNSSFR LRSESLNTLR LRRIFDLFDK    50
    NSDGIITVDE LSRALNLLGL ETDLSELEST VKSFTREGNI GLQFEDFISL 100
    HQSLNDSYFA YGGEDEDDNE EDMRKSILSQ EEADSFGGFK VFDEDGDGYI 150
    SARELQMVLG KLGFSEGSEI DRVEKMIVSV DSNRDGRVDF FEFKDMMRSV 200
    LVRSS 205
    Length:205
    Mass (Da):23,142
    Last modified:November 1, 1995 - v1
    Checksum:i390BE386C0FEF05C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79267 mRNA. Translation: CAA55854.1.
    PIRiS46233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79267 mRNA. Translation: CAA55854.1 .
    PIRi S46233.

    3D structure databases

    ProteinModelPortali P43187.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 128. Bet v 3.
    3137. Bet v 3.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF00036. EF-hand_1. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 3 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 3 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a birch pollen allergen, Bet v III, representing a novel class of Ca2+ binding proteins: specific expression in mature pollen and dependence of patients' IgE binding on protein-bound Ca2+."
      Seiberler S., Scheiner O., Kraft D., Lonsdale D., Valenta R.
      EMBO J. 13:3481-3486(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF CALCIUM-BINDING SITES.
      Tissue: Pollen.

    Entry informationi

    Entry nameiALLB3_BETPN
    AccessioniPrimary (citable) accession number: P43187
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3