P43187 (ALLB3_BETPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium-binding allergen Bet v 3

Alternative name(s):
Allergen Bet v III
Allergen=Bet v 3

Gene names

Name:

BETVIII

Organism

Betula pendula (European white birch) (Betula verrucosa)

Taxonomic identifier

3505 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fagales › Betulaceae › Betula

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could be involved in calcium metabolism in pollen. Binds 3 calcium ions.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Contains 4 EF-hand domains.

Ontologies

Keywords
Disease	Allergen
Domain	Repeat
Ligand	Calcium Metal-binding
Gene Ontology (GO)
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Calcium-binding allergen Bet v 3		PRO_0000073662
Regions
	Domain	36 – 71	36	EF-hand 1
	Domain	72 – 107	36	EF-hand 2
	Domain	130 – 165	36	EF-hand 3
	Domain	168 – 203	36	EF-hand 4
	Calcium binding	49 – 60	12	1 Potential
	Calcium binding	143 – 154	12	2 Potential
	Calcium binding	181 – 192	12	3 Potential

Sequences

	Sequence		Length	Mass (Da)
	P43187 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 390BE386C0FEF05C	FASTA	205	23,142
	10 20 30 40 50 60 MPCSTEAMEK AGHGHASTPR KRSLSNSSFR LRSESLNTLR LRRIFDLFDK NSDGIITVDE 70 80 90 100 110 120 LSRALNLLGL ETDLSELEST VKSFTREGNI GLQFEDFISL HQSLNDSYFA YGGEDEDDNE 130 140 150 160 170 180 EDMRKSILSQ EEADSFGGFK VFDEDGDGYI SARELQMVLG KLGFSEGSEI DRVEKMIVSV 190 200 DSNRDGRVDF FEFKDMMRSV LVRSS

References

[1]

"Characterization of a birch pollen allergen, Bet v III, representing a novel class of Ca2+ binding proteins: specific expression in mature pollen and dependence of patients' IgE binding on protein-bound Ca2+." Seiberler S., Scheiner O., Kraft D., Lonsdale D., Valenta R. EMBO J. 13:3481-3486(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF CALCIUM-BINDING SITES. Tissue: Pollen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X79267 mRNA. Translation: CAA55854.1.
PIR	S46233.
3D structure databases
ProteinModelPortal	P43187.
ModBase	Search...
Protein family/group databases
Allergome	128. Bet v 3. 3137. Bet v 3.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. [Graphical view]
Pfam	PF13499. EF_hand_5. 1 hit. PF00036. efhand. 1 hit. [Graphical view]
SMART	SM00054. EFh. 3 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 3 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALLB3_BETPN

Accession

Primary (citable) accession number: P43187

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program