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P43187

- ALLB3_BETPN

UniProt

P43187 - ALLB3_BETPN

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Protein

Calcium-binding allergen Bet v 3

Gene

BETVIII

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Could be involved in calcium metabolism in pollen. Binds 3 calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi49 – 60121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi143 – 154122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi181 – 192123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding allergen Bet v 3
Alternative name(s):
Allergen Bet v III
Allergen: Bet v 3
Gene namesi
Name:BETVIII
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei128. Bet v 3.
3137. Bet v 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Calcium-binding allergen Bet v 3PRO_0000073662Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 7136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini72 – 10736EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 16536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini168 – 20336EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43187-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPCSTEAMEK AGHGHASTPR KRSLSNSSFR LRSESLNTLR LRRIFDLFDK
60 70 80 90 100
NSDGIITVDE LSRALNLLGL ETDLSELEST VKSFTREGNI GLQFEDFISL
110 120 130 140 150
HQSLNDSYFA YGGEDEDDNE EDMRKSILSQ EEADSFGGFK VFDEDGDGYI
160 170 180 190 200
SARELQMVLG KLGFSEGSEI DRVEKMIVSV DSNRDGRVDF FEFKDMMRSV

LVRSS
Length:205
Mass (Da):23,142
Last modified:November 1, 1995 - v1
Checksum:i390BE386C0FEF05C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79267 mRNA. Translation: CAA55854.1.
PIRiS46233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79267 mRNA. Translation: CAA55854.1 .
PIRi S46233.

3D structure databases

ProteinModelPortali P43187.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 128. Bet v 3.
3137. Bet v 3.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a birch pollen allergen, Bet v III, representing a novel class of Ca2+ binding proteins: specific expression in mature pollen and dependence of patients' IgE binding on protein-bound Ca2+."
    Seiberler S., Scheiner O., Kraft D., Lonsdale D., Valenta R.
    EMBO J. 13:3481-3486(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF CALCIUM-BINDING SITES.
    Tissue: Pollen.

Entry informationi

Entry nameiALLB3_BETPN
AccessioniPrimary (citable) accession number: P43187
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3