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P43187

- ALLB3_BETPN

UniProt

P43187 - ALLB3_BETPN

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Protein
Calcium-binding allergen Bet v 3
Gene
BETVIII
Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Could be involved in calcium metabolism in pollen. Binds 3 calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi49 – 60121 Reviewed prediction
Add
BLAST
Calcium bindingi143 – 154122 Reviewed prediction
Add
BLAST
Calcium bindingi181 – 192123 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding allergen Bet v 3
Alternative name(s):
Allergen Bet v III
Allergen: Bet v 3
Gene namesi
Name:BETVIII
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei128. Bet v 3.
3137. Bet v 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Calcium-binding allergen Bet v 3
PRO_0000073662Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43187.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 7136EF-hand 1
Add
BLAST
Domaini72 – 10736EF-hand 2
Add
BLAST
Domaini130 – 16536EF-hand 3
Add
BLAST
Domaini168 – 20336EF-hand 4
Add
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43187-1 [UniParc]FASTAAdd to Basket

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MPCSTEAMEK AGHGHASTPR KRSLSNSSFR LRSESLNTLR LRRIFDLFDK    50
NSDGIITVDE LSRALNLLGL ETDLSELEST VKSFTREGNI GLQFEDFISL 100
HQSLNDSYFA YGGEDEDDNE EDMRKSILSQ EEADSFGGFK VFDEDGDGYI 150
SARELQMVLG KLGFSEGSEI DRVEKMIVSV DSNRDGRVDF FEFKDMMRSV 200
LVRSS 205
Length:205
Mass (Da):23,142
Last modified:November 1, 1995 - v1
Checksum:i390BE386C0FEF05C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79267 mRNA. Translation: CAA55854.1.
PIRiS46233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79267 mRNA. Translation: CAA55854.1 .
PIRi S46233.

3D structure databases

ProteinModelPortali P43187.
ModBasei Search...

Protein family/group databases

Allergomei 128. Bet v 3.
3137. Bet v 3.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a birch pollen allergen, Bet v III, representing a novel class of Ca2+ binding proteins: specific expression in mature pollen and dependence of patients' IgE binding on protein-bound Ca2+."
    Seiberler S., Scheiner O., Kraft D., Lonsdale D., Valenta R.
    EMBO J. 13:3481-3486(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF CALCIUM-BINDING SITES.
    Tissue: Pollen.

Entry informationi

Entry nameiALLB3_BETPN
AccessioniPrimary (citable) accession number: P43187
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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