P43186 (BEV1M_BETPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major pollen allergen Bet v 1-M/N

Alternative name(s):
Allergen Bet v I-M/N
Allergen=Bet v 1-M/N

Gene names

Name:	BETV1M
AND
Name:	BETV1N

Organism

Betula pendula (European white birch) (Betula verrucosa)

Taxonomic identifier

3505 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fagales › Betulaceae › Betula

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a general steroid carrier protein By similarity.
Subcellular location	Cytoplasm.
Allergenic properties	Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR.
Sequence similarities	Belongs to the BetVI family.

Ontologies

Keywords
Biological process	Plant defense
Cellular component	Cytoplasm
Disease	Allergen
Molecular function	Pathogenesis-related protein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: UniProtKB-KW response to biotic stimulus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 160	159	Major pollen allergen Bet v 1-M/N		PRO_0000154184
Sites
	Binding site	95	1	Substrate By similarity
	Binding site	121	1	Substrate By similarity
	Binding site	127	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43186 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 54F5D4F174F91CC2	FASTA	160	17,522
	10 20 30 40 50 60 MGVFNYESET TSVIPAARLF KAFILDGDNL IPKVAPQAIS SVENIEGNGG PGTIKKITFP 70 80 90 100 110 120 EGSPFKYVKE RVDEVDHANF KYSYSMIEGG ALGDTLEKIC NEIKIVATPD GGSILKISNK 130 140 150 160 YHTKGDHEMK AEHMKAIKEK GEALLRAVES YLLAHSDAYN

References

[1]

"Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning." Swoboda I., Jilek A., Ferreira F., Engel E., Hoffman-Sommergruber K., Scheiner O., Kraft D., Breiteneder H., Pittenauer E., Schmid E., Vicente O., Heberle-Bors E., Ahorn H., Breitenbach M. J. Biol. Chem. 270:2607-2613(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Pollen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X81972 mRNA. Translation: CAA57497.1. X82028 mRNA. Translation: CAA57550.1.
PIR	A57427.
3D structure databases
ProteinModelPortal	P43186.
SMR	P43186. Positions 2-160.
ModBase	Search...
Protein family/group databases
Allergome	107. Bet v 1.1401. 89. Bet v 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.530.20. 1 hit.
InterPro	IPR024949. Bet_v_I_allergen. IPR000916. Bet_v_I_dom. IPR023393. START-like_dom. [Graphical view]
Pfam	PF00407. Bet_v_1. 1 hit. [Graphical view]
PRINTS	PR00634. BETALLERGEN.
PROSITE	PS00451. PATHOGENESIS_BETVI. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BEV1M_BETPN

Accession

Primary (citable) accession number: P43186

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program