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P43186

- BEV1M_BETPN

UniProt

P43186 - BEV1M_BETPN

Protein

Major pollen allergen Bet v 1-M/N

Gene

BETV1M

more
Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May be a general steroid carrier protein.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei95 – 951SubstrateBy similarity
    Binding sitei121 – 1211SubstrateBy similarity
    Binding sitei127 – 1271SubstrateBy similarity

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. response to biotic stimulus Source: UniProtKB-KW

    Keywords - Molecular functioni

    Pathogenesis-related protein

    Keywords - Biological processi

    Plant defense

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major pollen allergen Bet v 1-M/N
    Alternative name(s):
    Allergen Bet v I-M/N
    Allergen: Bet v 1-M/N
    Gene namesi
    Name:BETV1M
    AND
    Name:BETV1N
    OrganismiBetula pendula (European white birch) (Betula verrucosa)
    Taxonomic identifieri3505 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei107. Bet v 1.0204.
    89. Bet v 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 160159Major pollen allergen Bet v 1-M/NPRO_0000154184Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP43186.
    SMRiP43186. Positions 2-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BetVI family.Curated

    Family and domain databases

    Gene3Di3.30.530.20. 1 hit.
    InterProiIPR024949. Bet_v_I_allergen.
    IPR000916. Bet_v_I_dom.
    IPR023393. START-like_dom.
    [Graphical view]
    PfamiPF00407. Bet_v_1. 1 hit.
    [Graphical view]
    PRINTSiPR00634. BETALLERGEN.
    PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43186-1 [UniParc]FASTAAdd to Basket

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    MGVFNYESET TSVIPAARLF KAFILDGDNL IPKVAPQAIS SVENIEGNGG    50
    PGTIKKITFP EGSPFKYVKE RVDEVDHANF KYSYSMIEGG ALGDTLEKIC 100
    NEIKIVATPD GGSILKISNK YHTKGDHEMK AEHMKAIKEK GEALLRAVES 150
    YLLAHSDAYN 160
    Length:160
    Mass (Da):17,522
    Last modified:January 23, 2007 - v2
    Checksum:i54F5D4F174F91CC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81972 mRNA. Translation: CAA57497.1.
    X82028 mRNA. Translation: CAA57550.1.
    PIRiA57427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81972 mRNA. Translation: CAA57497.1 .
    X82028 mRNA. Translation: CAA57550.1 .
    PIRi A57427.

    3D structure databases

    ProteinModelPortali P43186.
    SMRi P43186. Positions 2-160.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 107. Bet v 1.0204.
    89. Bet v 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.530.20. 1 hit.
    InterProi IPR024949. Bet_v_I_allergen.
    IPR000916. Bet_v_I_dom.
    IPR023393. START-like_dom.
    [Graphical view ]
    Pfami PF00407. Bet_v_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00634. BETALLERGEN.
    PROSITEi PS00451. PATHOGENESIS_BETVI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning."
      Swoboda I., Jilek A., Ferreira F., Engel E., Hoffman-Sommergruber K., Scheiner O., Kraft D., Breiteneder H., Pittenauer E., Schmid E., Vicente O., Heberle-Bors E., Ahorn H., Breitenbach M.
      J. Biol. Chem. 270:2607-2613(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Pollen.

    Entry informationi

    Entry nameiBEV1M_BETPN
    AccessioniPrimary (citable) accession number: P43186
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3