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Protein

Major pollen allergen Bet v 1-L

Gene

BETV1L

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a general steroid carrier protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei70BrassinosteroidCombined sources1 Publication1
Binding sitei95BrassinosteroidCombined sources1 Publication1
Binding sitei121BrassinosteroidCombined sources1 Publication1
Binding sitei127BrassinosteroidCombined sources1 Publication1

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Bet v 1-L
Alternative name(s):
Allergen Bet v I-L
Allergen: Bet v 1-L
Gene namesi
Name:BETV1L
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei103. Bet v 1.0107.
89. Bet v 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001541832 – 160Major pollen allergen Bet v 1-LAdd BLAST159

Interactioni

Subunit structurei

Interacts with brassinosteroids such as brassinolide and 24-epicastasterone.1 Publication

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 14Combined sources12
Helixi16 – 23Combined sources8
Turni24 – 26Combined sources3
Helixi27 – 34Combined sources8
Turni36 – 38Combined sources3
Beta strandi41 – 46Combined sources6
Beta strandi48 – 50Combined sources3
Beta strandi54 – 58Combined sources5
Beta strandi63 – 76Combined sources14
Turni77 – 80Combined sources4
Beta strandi81 – 89Combined sources9
Turni93 – 95Combined sources3
Beta strandi96 – 107Combined sources12
Beta strandi113 – 124Combined sources12
Turni131 – 134Combined sources4
Helixi135 – 154Combined sources20
Turni156 – 159Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FM4X-ray1.97A2-160[»]
ProteinModelPortaliP43185.
SMRiP43185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43185.

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFNYETEA TSVIPAARMF KAFILDGDKL VPKVAPQAIS SVENIEGNGG
60 70 80 90 100
PGTIKKINFP EGFPFKYVKD RVDEVDHTNF KYNYSVIEGG PVGDTLEKIS
110 120 130 140 150
NEIKIVATPD GGCVLKISNK YHTKGNHEVK AEQVKASKEM GETLLRAVES
160
YLLAHSDAYN
Length:160
Mass (Da):17,539
Last modified:January 23, 2007 - v2
Checksum:i21D034A53627272D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77273 mRNA. Translation: CAA54489.1.
PIRiI55699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77273 mRNA. Translation: CAA54489.1.
PIRiI55699.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FM4X-ray1.97A2-160[»]
ProteinModelPortaliP43185.
SMRiP43185.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei103. Bet v 1.0107.
89. Bet v 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP43185.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBEV1L_BETPN
AccessioniPrimary (citable) accession number: P43185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.