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Protein

Major pollen allergen Bet v 1-L

Gene

BETV1L

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a general steroid carrier protein.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701BrassinosteroidCombined sources1 Publication
Binding sitei95 – 951BrassinosteroidCombined sources1 Publication
Binding sitei121 – 1211BrassinosteroidCombined sources1 Publication
Binding sitei127 – 1271BrassinosteroidCombined sources1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Bet v 1-L
Alternative name(s):
Allergen Bet v I-L
Allergen: Bet v 1-L
Gene namesi
Name:BETV1L
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei103. Bet v 1.0107.
89. Bet v 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 160159Major pollen allergen Bet v 1-LPRO_0000154183Add
BLAST

Interactioni

Subunit structurei

Interacts with brassinosteroids such as brassinolide and 24-epicastasterone.1 Publication

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1412Combined sources
Helixi16 – 238Combined sources
Turni24 – 263Combined sources
Helixi27 – 348Combined sources
Turni36 – 383Combined sources
Beta strandi41 – 466Combined sources
Beta strandi48 – 503Combined sources
Beta strandi54 – 585Combined sources
Beta strandi63 – 7614Combined sources
Turni77 – 804Combined sources
Beta strandi81 – 899Combined sources
Turni93 – 953Combined sources
Beta strandi96 – 10712Combined sources
Beta strandi113 – 12412Combined sources
Turni131 – 1344Combined sources
Helixi135 – 15420Combined sources
Turni156 – 1594Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FM4X-ray1.97A2-160[»]
ProteinModelPortaliP43185.
SMRiP43185. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43185.

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFNYETEA TSVIPAARMF KAFILDGDKL VPKVAPQAIS SVENIEGNGG
60 70 80 90 100
PGTIKKINFP EGFPFKYVKD RVDEVDHTNF KYNYSVIEGG PVGDTLEKIS
110 120 130 140 150
NEIKIVATPD GGCVLKISNK YHTKGNHEVK AEQVKASKEM GETLLRAVES
160
YLLAHSDAYN
Length:160
Mass (Da):17,539
Last modified:January 23, 2007 - v2
Checksum:i21D034A53627272D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77273 mRNA. Translation: CAA54489.1.
PIRiI55699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77273 mRNA. Translation: CAA54489.1.
PIRiI55699.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FM4X-ray1.97A2-160[»]
ProteinModelPortaliP43185.
SMRiP43185. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei103. Bet v 1.0107.
89. Bet v 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP43185.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning."
    Swoboda I., Jilek A., Ferreira F., Engel E., Hoffman-Sommergruber K., Scheiner O., Kraft D., Breiteneder H., Pittenauer E., Schmid E., Vicente O., Heberle-Bors E., Ahorn H., Breitenbach M.
    J. Biol. Chem. 270:2607-2613(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pollen.
  2. "Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier."
    Markovic-Housley Z., Degano M., Lamba D., von Roepenack-Lahaye E., Clemens S., Susani M., Ferreira F., Scheiner O., Breiteneder H.
    J. Mol. Biol. 325:123-133(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 2-160 IN COMPLEX WITH DEOXYCHOLATE, FUNCTION, INTERACTION WITH STEROIDS.

Entry informationi

Entry nameiBEV1L_BETPN
AccessioniPrimary (citable) accession number: P43185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.