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Protein

Major pollen allergen Bet v 1-E

Gene

BETV1E

Organism
Betula pendula (European white birch) (Betula verrucosa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a general steroid carrier protein.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951BrassinosteroidBy similarity
Binding sitei121 – 1211BrassinosteroidBy similarity
Binding sitei127 – 1271BrassinosteroidBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Bet v 1-E
Alternative name(s):
Allergen Bet v I-E
Allergen: Bet v 1-E
Gene namesi
Name:BETV1E
OrganismiBetula pendula (European white birch) (Betula verrucosa)
Taxonomic identifieri3505 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesBetulaceaeBetula

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei89. Bet v 1.
97. Bet v 1.0103.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 160159Major pollen allergen Bet v 1-EPRO_0000154178Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43178.
SMRiP43178. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFNYETEA TSVIPAARLF KAFILDGDNL FPKVAPQAIS SVENIEGNGG
60 70 80 90 100
PGTIKKISFP EGIPFKYVKG RVDEVDHTNF KYSYSVIEGG PVGDTLEKIS
110 120 130 140 150
NEIKIVATPN GGSILKINNK YHTKGDHEVK AEQIKASKEM GETLLRAVES
160
YLLAHSDAYN
Length:160
Mass (Da):17,448
Last modified:January 23, 2007 - v2
Checksum:iC120E54A1DB139AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77267 mRNA. Translation: CAA54483.1.
PIRiD55699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77267 mRNA. Translation: CAA54483.1.
PIRiD55699.

3D structure databases

ProteinModelPortaliP43178.
SMRiP43178. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei89. Bet v 1.
97. Bet v 1.0103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
SMARTiSM01037. Bet_v_1. 1 hit.
[Graphical view]
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning."
    Swoboda I., Jilek A., Ferreira F., Engel E., Hoffman-Sommergruber K., Scheiner O., Kraft D., Breiteneder H., Pittenauer E., Schmid E., Vicente O., Heberle-Bors E., Ahorn H., Breitenbach M.
    J. Biol. Chem. 270:2607-2613(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Pollen.

Entry informationi

Entry nameiBEV1E_BETPN
AccessioniPrimary (citable) accession number: P43178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.